The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis
Open accessAbstract
SUMMARY Interleukin-17 (IL-17) secreted by T helper 17 (Th17) cells is essential in the development of experimental autoimmune encephalomyelitis (EAE). However, it remains unclear how IL-17-mediated signaling in different cellular compartments participates in the central nervous system (CNS) inflammatory process. We examined CNS inflammation in mice with specific deletion of Act1, a critical component required for IL-17 signaling, in endothelial cells, macrophages and microglia, and neuroectoderm (neurons, astrocytes, and oligodendrocytes). In Act1-deficient mice, Th17 cells showed normal infiltration into the CNS but failed to recruit lymphocytes, neutrophils, and macrophages. Act1 deficiency in endothelial cells or in macrophages and microglia did not substantially impact the development of EAE. However, targeted Act1 deficiency in neuroectoderm derived CNS resident cells resulted in markedly reduced severity in EAE. Specifically, Act1-deficient astrocytes showed impaired IL-17-mediated inflammatory gene induction. Thus, astroctyes are critical in IL-17-Act1 mediated leukocyte recruitment during autoimmune induced inflammation of the CNS.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“such as its previously identified actions on astrocytes that may alter astrocyteneuronal interactions (52).”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [52]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Astrocytes can respond to IL-17 and release mediators that promote tissue damage [129].”
From The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders (2023) · cites this paper as [129]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906
Interleukin-17 Family Members and Inflammation
Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,371
Immunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K., Orban, P. C., Bock, R., Klein, R., & Schütz, G. (1999) · Nature Genetics · doi:10.1038/12703 · Cited by 1,841
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759
Cited by
Sorted by citations
Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803
Innate IL-17-producing cells: the sentinels of the immune system
Cua, D. J., & Tato, C. M. (2010) · Nature reviews. Immunology · doi:10.1038/nri2800 · Cited by 1,640
Astrocyte barriers to neurotoxic inflammation
Sofroniew, M. V. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3898 · Cited by 1,202
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
Brinkmann, V., Billich, A., Baumruker, T., Heining, P., Schmouder, R., Francis, G., Aradhye, S., & Burtin, P. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3248 · Cited by 1,273
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,153
Astrocyte Crosstalk in CNS Inflammation
Linnerbauer, M., Wheeler, M. A., & Quintana, F. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.012 · Cited by 989
Astrocytes: Key Regulators of Neuroinflammation
Colombo, E., & Farina, C. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.06.006 · Cited by 936
The blood-brain barrier in Alzheimer’s disease
Zenaro, E., Piacentino, G., & Constantin, G. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.007 · Cited by 767
Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease
Argaw, A. T., Asp, L., Zhang, J., Navrazhina, K., Pham, T., Mariani, J. N., Mahase, S., Dutta, D. J., Seto, J., Kramer, E. G., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60842 · Cited by 733
Meng, F., Wang, K., Aoyama, T., Grivennikov, S. I., Paik, Y., Scholten, D., Cong, M., Iwaisako, K., Liu, X., Zhang, M., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.049 · Cited by 711
Cytokine networks in neuroinflammation
Becher, B., Spath, S., & Goverman, J. M. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.123 · Cited by 707
Function and therapeutic value of astrocytes in neurological diseases
Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662
Glial Cells: Role of the Immune Response in Ischemic Stroke
Xu, S., Lü, J., Shao, A., Zhang, J. H., & Zhang, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00294 · Cited by 626
IL-17 family: Cytokines, receptors and signaling
Gu, C., Wu, L., & Li, X. (2013) · Cytokine · doi:10.1016/j.cyto.2013.07.022 · Cited by 623
Self-citationThe Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders
Knezevic, E., Nenic, K., Milanovic, V., & Knezevic, N. N. (2023) · Cells · doi:10.3390/cells12232726 · Cited by 564
“Astrocytes can respond to IL-17 and release mediators that promote tissue damage [129].”
BackgroundSOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation
Qin, H., Holdbrooks, A. T., Liu, Y., Reynolds, S. L., Yanagisawa, L. L., & Benveniste, E. N. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201168 · Cited by 458
Self-citationKirby, L., Jin, J., Cardona, J. G., Smith, M. D., Martin, K. A., Wang, J., Strasburger, H., Herbst, L., Alexis, M., Karnell, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11638-3 · Cited by 436
Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair
Domingues, H. S., Portugal, C. C., Socodato, R., & Relvas, J. B. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00071 · Cited by 460
How do immune cells overcome the blood-brain barrier in multiple sclerosis?
Larochelle, C., Alvarez, J. I., & Prat, A. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.066 · Cited by 405
Starossom, S. C., Mascanfroni, I. D., Imitola, J., Cao, L., Raddassi, K., Hernandez, S. F., Bassil, R., Croci, D. O., Cerliani, J. P., Delacour, D., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.023 · Cited by 356
The role of IL-17 in CNS diseases
Waisman, A., Hauptmann, J., & Regen, T. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1402-7 · Cited by 343
Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory
Ribeiro, M., Brigas, H. C., Temido-Ferreira, M., Pousinha, P. A., Regen, T., Santa, C., Coelho, J. E., Marques-Morgado, I., Valente, C. A., Omenetti, S., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aay5199 · Cited by 335
Yan, Z., Gibson, S. A., Buckley, J. A., Qin, H., & Benveniste, E. N. (2018) · Clinical Immunology · doi:10.1016/j.clim.2016.09.014 · Cited by 318
Self-citationBarcoded viral tracing of single-cell interactions in central nervous system inflammation
Clark, I. C., Gutiérrez-Vázquez, C., Wheeler, M. A., Li, Z., Rothhammer, V., Linnerbauer, M., Sanmarco, L. M., Guo, L., Blain, M., Zandee, S. E. J., et al. (2021) · Science · doi:10.1126/science.abf1230 · Cited by 285
IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential
Zhu, S., & Qian, Y. (2012) · Clinical Science · doi:10.1042/cs20110496 · Cited by 291
The role of antigen presenting cells in multiple sclerosis
Chastain, E. M. L., Duncan, D. S., Rodgers, J. M., & Miller, S. D. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.07.008 · Cited by 271
Qin, H., Yeh, W.-I., Sarno, P. D., Holdbrooks, A. T., Liu, Y., Muldowney, M., Reynolds, S. L., Yanagisawa, L. L., Fox, T. H., Park, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117218109 · Cited by 271
Self-citationInterleukin-17 in chronic inflammatory neurological diseases
Milovanovic, J., Arsenijevic, A., Stojanovic, B., Kanjevac, T., Arsenijevic, D., Radosavljevic, G., Milovanovic, M., & Arsenijevic, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00947 · Cited by 250
The astrocyte in multiple sclerosis revisited
Brosnan, C. F., & Raine, C. S. (2013) · Glia · doi:10.1002/glia.22443 · Cited by 274
Inflammatory T helper 17 cells promote depression-like behavior in mice
Beurel, E., Harrington, L. E., & Jope, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.021 · Cited by 254
McGinley, A. M., Sutton, C. E., Edwards, S. C., Leane, C. M., DeCourcey, J., Teijeiro, A., Hamilton, J. A., Boon, L., Djouder, N., & Mills, K. H. G. (2020) · Immunity · doi:10.1016/j.immuni.2020.01.002 · Cited by 248
Brambilla, R. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01980-7 · Cited by 246
Neuroinflammation: An astrocyte perspective
Lee, H., Lee, J.-H., Flausino, L. E., & Quintana, F. J. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi7828 · Cited by 253
T Helper Cells: The Modulators of Inflammation in Multiple Sclerosis
Kunkl, M., Frascolla, S., Amormino, C., Volpe, E., & Tuosto, L. (2020) · Cells · doi:10.3390/cells9020482 · Cited by 248
Sun, D., Novotny, M., Bulek, K., Liu, C., Li, X., & Hamilton, T. (2011) · Nature Immunology · doi:10.1038/ni.2081 · Cited by 232
Self-citationAct1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells
Kang, Z., Wang, C., Zepp, J., Wu, L., Sun, K., Zhao, J., Chandrasekharan, U., DiCorleto, P. E., Trapp, B. D., Ransohoff, R. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3505 · Cited by 218
Self-citationAnti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke
Mizuma, A., & Yenari, M. A. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00467 · Cited by 228
Astrocyte-immune cell interactions in physiology and pathology
Han, R. T., Kim, R. D., Molofsky, A. V., & Liddelow, S. A. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.013 · Cited by 223
IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease
Zepp, J. A., Wu, L., & Li, X. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.02.007 · Cited by 227
Self-citationAstrocytes: Integrative Regulators of Neuroinflammation in Stroke and Other Neurological Diseases
Cekanaviciute, E., & Buckwalter, M. S. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0477-8 · Cited by 229
Control of autoimmune CNS inflammation by astrocytes
Rothhammer, V., & Quintana, F. J. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0515-3 · Cited by 214
The activation and regulation of IL-17 receptor mediated signaling
Song, X., & Qian, Y. (2013) · Cytokine · doi:10.1016/j.cyto.2013.03.014 · Cited by 206
Immune Players in the CNS: The Astrocyte
Jensen, C., Massie, A., & Keyser, J. D. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9480-6 · Cited by 216
Lian, G., Gnanaprakasam, J. R., Wang, T., Wu, R., Chen, X., Liu, L., Shen, Y., Yang, M., Yang, J. J. J., Chen, Y., et al. (2018) · eLife · doi:10.7554/elife.36158 · Cited by 199
Self-citationInterleukin-17 enhances immunosuppression by mesenchymal stem cells
Han, X., Yang, Q., Lin, L., Xu, C., Zheng, C., Chen, X., Han, Y., Li, M., Cao, W., Cao, K., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.85 · Cited by 194
The innate immune system in demyelinating disease
Mayo, L., Quintana, F. J., & Weiner, H. L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01135.x · Cited by 192
Repositioning TH cell polarization from single cytokines to complex help
Tuzlak, S., Dejean, A. S., Iannacone, M., Quintana, F. J., Waisman, A., Ginhoux, F., Korn, T., & Becher, B. (2021) · Nature Immunology · doi:10.1038/s41590-021-01009-w · Cited by 171
T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis
Martin, B. N., Wang, C., Zhang, C.-J., Kang, Z., Gulen, M. F., Zepp, J. A., Zhao, J., Bian, G., Do, J., Min, B., et al. (2016) · Nature Immunology · doi:10.1038/ni.3389 · Cited by 159
Self-citationBrambilla, R., Morton, P. D., Ashbaugh, J. J., Karmally, S., Lambertsen, K. L., & Bethea, J. R. (2013) · Glia · doi:10.1002/glia.22616 · Cited by 161
Interleukin-17A: The Key Cytokine in Neurodegenerative Diseases
Chen, J., Liu, X., & Zhong, Y. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.566922 · Cited by 157
Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide
Colombo, E., Dario, M. D., Capitolo, E., Chaabane, L., Newcombe, J., Martino, G., & Farina, C. (2014) · Annals of Neurology · doi:10.1002/ana.24217 · Cited by 151
Myelin Recovery in Multiple Sclerosis: The Challenge of Remyelination
Podbielska, M., Banik, N. L., Kurowska, E., & Hogan, E. (2013) · Brain Sciences · doi:10.3390/brainsci3031282 · Cited by 171
IL-17-induced NF-κB Activation via CIKS/Act1
Sønder, S. U., Saret, S., Tang, W., Sturdevant, D. E., Porcella, S. F., & Siebenlist, U. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199547 · Cited by 148
Hunter, S. F., Bowen, J. D., & Reder, A. T. (2015) · CNS Drugs · doi:10.1007/s40263-015-0297-0 · Cited by 146
The IL‐17 pathway as a major therapeutic target in autoimmune diseases
Hu, Y., Shen, F., Crellin, N. K., & Ouyang, W. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05825.x · Cited by 149
Zhu, S., Pan, W. Q., Shi, P., Gao, H., Zhao, F., Song, X., Liu, Y., Zhao, L., Li, X., Shi, Y., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100703 · Cited by 142
Self-citationLipocalin-2 Protein Deficiency Ameliorates Experimental Autoimmune Encephalomyelitis
Nam, Y., Kim, J.-H., Seo, M., Kim, J., Jin, M., Jeon, S., Seo, J.-W., Lee, W., Bing, S. J., Jee, Y., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.542282 · Cited by 137
IL-17 in the Pathogenesis of Disease: Good Intentions Gone Awry
Majumder, S., & McGeachy, M. J. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-092536 · Cited by 139
Wong, H., & Hoeffer, C. A. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.010 · Cited by 131
Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties
Prajeeth, C. K., Kronisch, J., Khorooshi, R., Knier, B., Toft‐Hansen, H., Gudi, V., Floess, S., Huehn, J., Owens, T., Korn, T., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0978-3 · Cited by 137
Pathogenic T cell cytokines in multiple sclerosis
Wagner, C. A., Roqué, P. J., & Goverman, J. M. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190460 · Cited by 132
Functional immune cell–astrocyte interactions
Sanmarco, L. M., Polonio, C. M., Wheeler, M. A., & Quintana, F. J. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202715 · Cited by 134
Haroon, F., Drögemüller, K., Händel, U., Brunn, A., Reinhold, D., Nishanth, G., Müller, W., Trautwein, C., Ernst, M., Deckert, M., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001135 · Cited by 122
Macrophages participate in IL‐17‐mediated inflammation
Barin, J. G., Baldeviano, G. C., Talor, M. V., Wu, L., Ong, S., Quader, F., Chen, P., Zheng, D., Caturegli, P., Rose, N. R., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201141737 · Cited by 120
IL-17 signaling in host defense and inflammatory diseases
Qian, Y., Kang, Z., Liu, C., & Li, X. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.27 · Cited by 124
Self-citationWang, C., Zhang, C.-J., Martin, B. N., Bulek, K., Kang, Z., Zhao, J., Bian, G., Carman, J., Gao, J., Dongré, A. R., et al. (2017) · Nature Communications · doi:10.1038/ncomms15508 · Cited by 123
Self-citationRelapsing–Remitting Central Nervous System Autoimmunity Mediated by GFAP-Specific CD8 T Cells
Sasaki, K., Bean, A., Shah, S., Schutten, E., Huseby, P. G., Peters, B., Shen, Z. T., Vanguri, V. K., Liggitt, D., & Huseby, E. S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302911 · Cited by 118
Liu, Z., Huang, Y., Cao, B.-B., Qiu, Y.-H., & Peng, Y.-P. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0249-9 · Cited by 112
Duffy, S. S., Lees, J. G., & Moalem‐Taylor, G. (2014) · Multiple Sclerosis International · doi:10.1155/2014/285245 · Cited by 118
Toft‐Hansen, H., Füchtbauer, L. M., & Owens, T. (2010) · Glia · doi:10.1002/glia.21088 · Cited by 113
Curcumin has bright prospects for the treatment of multiple sclerosis
Xie, L., Li, X., & Takahara, S. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.08.013 · Cited by 117
Self-citationRegulation of CCL20 expression in astrocytes by IL‐6 and IL‐17
Meares, G. P., Ma, X., Qin, H., & Benveniste, E. N. (2012) · Glia · doi:10.1002/glia.22307 · Cited by 117
Self-citationWhat we know and do not know about the cannabinoid receptor 2 (CB2)
Malfitano, A. M., Basu, S., Maresz, K., Bifulco, M., & Dittel, B. N. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.04.002 · Cited by 117
Wang, C., Wu, L., Bulek, K., Martin, B. N., Zepp, J. A., Kang, Z., Liu, C., Herjan, T., Misra, S., Carman, J., et al. (2012) · Nature Immunology · doi:10.1038/ni.2479 · Cited by 108
Self-citationNF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications
Leibowitz, S., & Yan, J. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00084 · Cited by 98
The Emerging Role of p38 Mitogen-Activated Protein Kinase in Multiple Sclerosis and Its Models
Krementsov, D. N., Thornton, T. M., Teuscher, C., & Rincón, M. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00688-13 · Cited by 107
Guerrini, M. M., Okamoto, K., Komatsu, N., Sawa, S., Danks, L., Penninger, J. M., Nakashima, T., & Takayanagi, H. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.017 · Cited by 100
HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization
Herjan, T., Yao, P., Qian, W., Li, X., Liu, C., Bulek, K., Sun, D., Yang, W.-P., Zhu, J., He, A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203315 · Cited by 95
Self-citationChronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
Peng, Z., Peng, S., Lin, K., Zhao, B., Wei, L., Tuo, Q., Liao, D., Yuan, T., & Shi, Z. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02543-6 · Cited by 95
Setiadi, A. F., Abbas, A. R., Jeet, S., Wong, K., Bischof, A., Peng, I., Lee, J., Bremer, M. C. D., Eggers, E. L., DeVoss, J., et al. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.04.011 · Cited by 92
Jiang, S., Maphis, N. M., Binder, J., Chisholm, D., Weston, L., Duran, W., Peterson, C., Zimmerman, A., Mandell, M. A., Jett, S. D., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109720 · Cited by 92
Gong, Z., Guo, J., Liu, B., Guo, Y., Cheng, C., Jiang, Y., Liang, N., Hu, M., Song, T., Yang, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1287857 · Cited by 97
Th17 cells in central nervous system autoimmunity
Sie, C., Korn, T., & Mitsdoerffer, M. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.03.009 · Cited by 95
CNS-specific Therapy for Ongoing EAE by Silencing IL-17 Pathway in Astrocytes
Yan, Y., Ding, X., Li, K., Ćirić, B., Wu, S., Xu, H., Gran, B., Rostami, A. M., & Zhang, G. (2012) · Molecular Therapy · doi:10.1038/mt.2012.12 · Cited by 89
IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability
Hindinger, C., Bergmann, C. C., Hinton, D. R., Phares, T. W., Parra, G. I., Hussain, S., Savarin, C., Atkinson, R., & Stohlman, S. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042088 · Cited by 92
Self-citationWang, X., Deckert, M., Xuân, N. T., Nishanth, G., Just, S., Waisman, A., Naumann, M., & Schlüter, D. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1183-9 · Cited by 92
Du, C., Duan, Y., Wei, W., Cai, Y., Chai, H., Lv, J., Du, X., Zhu, J., & Xie, X. (2016) · Nature Communications · doi:10.1038/ncomms11120 · Cited by 86
Preininger, M. K., & Kaufer, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116217 · Cited by 87
Liu, X., He, F., Pang, R., Zhao, D., Qiu, W., Shan, K., Zhang, J., Lu, Y., Li, Y., & Wang, Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.577429 · Cited by 85
Roy, M., Richard, J.-F., Dumas, A., & Vallières, L. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-18 · Cited by 83
Dumas, A., Amiable, N., Vaccari, J. P. D. R., Chae, J. J., Keane, R. W., Lacroix, S., & Vallières, L. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004150 · Cited by 85
Remyelination Therapy in Multiple Sclerosis
Harlow, D. E., Honce, J. M., & Miravalle, A. A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00257 · Cited by 89
Regulation by glycogen synthase kinase-3 of inflammation and T cells in CNS diseases
Beurel, E. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00018 · Cited by 82
Aberrant Upregulation of Astroglial Ceramide Potentiates Oligodendrocyte Injury
Kim, S.-J., Steelman, A. J., Zhang, Y., Kinney, H. C., & Li, J. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00501.x · Cited by 82
Yu, M., Zhou, H., Zhao, J., Xiao, N., Roychowdhury, S., Schmitt, D. C., Hu, B., Ransohoff, R. M., Harding, C. V., Hise, A. G., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131314 · Cited by 81
Self-citationIL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination
Kang, Z., Liu, L., Spangler, R., Spear, C., Wang, C., Gulen, M. F., Veenstra, M., Ouyang, W., Ransohoff, R. M., & Li, X. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0841-12.2012 · Cited by 78
Self-citationInteraction of astrocytes and T cells in physiological and pathological conditions
Xie, L., & Yang, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.026 · Cited by 80
Kruglov, A., Lampropoulou, V., Fillatreau, S., & Nedospasov, S. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100663 · Cited by 75
Liu, X., Zhou, F., Yang, Y., Wang, W., Niu, L., Zuo, D., Li, X., Hua, H., Zhang, B., Kou, Y., et al. (2018) · Glia · doi:10.1002/glia.23530 · Cited by 76
Self-citationZimmermann, J., Krauthausen, M., Hofer, M. J., Heneka, M. T., Campbell, I. L., & Müller, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057307 · Cited by 78
Metadata
- Authors
- Kang, Z., Altuntas, C. Z., Gulen, M. F., Liu, C., Giltiay, N., Qin, H., Liu, L., Qian, W., Ransohoff, R. M., Bergmann, C., Stohlman, S., Tuohy, V. K., & Li, X.
- Affiliations
- Cleveland Clinic (US)
- University of Alabama at Birmingham (US)
- Corresponding author
- Tuohy, Vincent K.
- Li, Xiaoxia
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 32
- Issue
- 3
- Pages
- 414-425
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3073618
- OpenAlex
- W2026778930
- Semantic Scholar
- f4c926ee0558c380c2f9303d6eee5cc35e0466eb
- Cited by
- 297
- References
- 64
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 15 · 2023: 18 · 2022: 17 · 2021: 25 · 2020: 15 · 2019: 17 · 2018: 15 · 2017: 16 · 2016: 18 · 2015: 21 · 2014: 23 · 2013: 21 · 2012: 29
- FWCI
- 17.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1234 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 AI065470)
- National Multiple Sclerosis Society (RG 4056-A-1)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- IL-17, Act1, experimental autoimmune encephalomyelitis, astrocytes, Th17 cells, neuroinflammation, leukocyte recruitment, endothelial cells, macrophages, microglia, neuroectoderm
- MeSH terms
- Animals, Astrocytes, Cell Survival, Encephalomyelitis, Autoimmune, Experimental, Gene Expression Regulation, T-Lymphocytes, Helper-Inducer, Macrophages, Mice, Inbred C57BL, Signal Transduction, Mice, Knockout, Interleukin-17, Adaptor Proteins, Signal Transducing, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
