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Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Open accessAbstract
Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manipulation of these cells could bear therapeutic potential. However, specific ontogenies of individual populations and the overall functional organization of this cellular network are not well defined. Here we report a fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression. We have demonstrated that major tissue-resident macrophage populations, including liver Kupffer cells and lung alveolar, splenic, and peritoneal macrophages, are established prior to birth and maintain themselves subsequently during adulthood independent of replenishment by blood monocytes. Furthermore, we have established that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly6C(-) cells and that the abundance of Ly6C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.
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“Cx3cr1, which marks both monocyte-derived and resident macrophages20-22, was particularly enriched in cluster 1, together with proinflammatory genes such as Il1b (Fig. 1J).”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [20]
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“However, the majority of these peripheral cells are short lived and turn over within 4 weeks because of ongoing, lifelong hematopoiesis.10–12”
From A comparative analysis of microglial inducible Cre lines (2023) · cites this paper as [11]
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“Our findings are consistent with reports that macrophage progenitors develop from the primitive ectoderm of the yolk sac4 and give rise to tissue macrophages that do not have a monocytic progenitor16,17.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [17]
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“Ly6Clo monocytes, which differentiate from recruited CCR2+Ly6Chi monocytes in the bloodstream, would no longer be recruited to this function [323, 359]”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [359]
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“the P2ry12 signal co-localized on CX3CR1GFP microglia in which GFP is expressed in resident microglia17,23 (Fig. 4e).”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [17]
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“These tissue resident macrophages sustain their local populations by rapid proliferation during injury events (Fig. 2b) [13].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [13]
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“a significant expansion of Pdgfra+ fibroblasts after bleomycin treatment has been reported in a study analyzing the fibroblast compartment in this model of fibrosis 35”
From Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage (2019) · cites this paper as [35]
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“The specificity of Cx3cr1 for microglia is incomplete, and we cannot exclude a non-brain-resident macrophage contribution to the miRNA eluted from the FLAG-Ago2 mice using this promoter (Yona et al., 2013).”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Yona et al., 2013
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Metadata
- Authors
- Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., Hume, D. A., Perlman, H., Malissen, B., Zelzer, E., & Jung, S.
- Affiliations
- Weizmann Institute of Science (IL)
- Centre National de la Recherche Scientifique (FR)
- Northwestern University (US)
- Roslin Institute (GB)
- Corresponding author
- Jung, Steffen
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 38
- Issue
- 1
- Pages
- 79-91
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3908543
- OpenAlex
- W2153406260
- Cited by
- 3,245
- References
- 72
- Citations by year
- 2026: 167 · 2025: 221 · 2024: 289 · 2023: 299 · 2022: 305 · 2021: 291 · 2020: 313 · 2019: 254 · 2018: 250 · 2017: 224 · 2016: 192 · 2015: 182 · 2014: 168 · 2013: 68
- FWCI
- 58.75
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-05-23)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (acceptedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- Minerva Foundation
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche (ANR-10-EQPX-0011)
- Israel Science Foundation
- Biotechnology and Biological Sciences Research Council (BBS/E/D/20251969, BBS/E/D/20221657)
- National Institute of Allergy and Infectious Diseases (R21AI092490)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050250, R01AR054796)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- monocytes, tissue macrophages, monocyte-to-macrophage differentiation, Kupffer cells, alveolar macrophages, splenic macrophages, peritoneal macrophages, Ly6C+ monocytes, CX3CR1, fate mapping, mononuclear phagocytes, tissue homeostasis
- MeSH terms
- CX3C Chemokine Receptor 1, Animals, Antigens, Ly, Homeostasis, Macrophages, Mice, Transgenic, Monocytes, Immunophenotyping, Receptors, Chemokine, Myeloid Progenitor Cells, Mice
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