The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Open accessAbstract
Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manipulation of these cells could bear therapeutic potential. However, specific ontogenies of individual populations and the overall functional organization of this cellular network are not well defined. Here we report a fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression. We have demonstrated that major tissue-resident macrophage populations, including liver Kupffer cells and lung alveolar, splenic, and peritoneal macrophages, are established prior to birth and maintain themselves subsequently during adulthood independent of replenishment by blood monocytes. Furthermore, we have established that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly6C(-) cells and that the abundance of Ly6C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Cx3cr1, which marks both monocyte-derived and resident macrophages20-22, was particularly enriched in cluster 1, together with proinflammatory genes such as Il1b (Fig. 1J).”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [20]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, the majority of these peripheral cells are short lived and turn over within 4 weeks because of ongoing, lifelong hematopoiesis.10–12”
From A comparative analysis of microglial inducible Cre lines (2023) · cites this paper as [11]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Our findings are consistent with reports that macrophage progenitors develop from the primitive ectoderm of the yolk sac4 and give rise to tissue macrophages that do not have a monocytic progenitor16,17.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [17]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Ly6Clo monocytes, which differentiate from recruited CCR2+Ly6Chi monocytes in the bloodstream, would no longer be recruited to this function [323, 359]”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [359]
The cited source says what the claim attributes to it.
In the citing paper
“the P2ry12 signal co-localized on CX3CR1GFP microglia in which GFP is expressed in resident microglia17,23 (Fig. 4e).”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [17]
In the citing paper
“These tissue resident macrophages sustain their local populations by rapid proliferation during injury events (Fig. 2b) [13].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [13]
In the citing paper
“a significant expansion of Pdgfra+ fibroblasts after bleomycin treatment has been reported in a study analyzing the fibroblast compartment in this model of fibrosis 35”
From Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage (2019) · cites this paper as [35]
In the citing paper
“The specificity of Cx3cr1 for microglia is incomplete, and we cannot exclude a non-brain-resident macrophage contribution to the miRNA eluted from the FLAG-Ago2 mice using this promoter (Yona et al., 2013).”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Yona et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Self-citationCre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
Self-citationJung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Self-citationA Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570
Nomenclature of monocytes and dendritic cells in blood
Ziegler‐Heitbrock, L., Ancuța, P., Crowe, S. M., Dalod, M., Grau, V., Hart, D. N. J., Leenen, P. J. M., Liu, Y.-J., MacPherson, G. G., Randolph, G. J., et al. (2010) · Blood · doi:10.1182/blood-2010-02-258558 · Cited by 2,436
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
Transcriptional regulation of macrophage polarization: enabling diversity with identity
Lawrence, T., & Natoli, G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3088 · Cited by 2,284
Flagged first, then by citations
Research works printed but not linked: 1
- van Furth, 1972, [Mononuclear phagocytic system: new classification of macrophages, monocytes and of their cell line], Bull. World Health Organ., 47, 651
Cited by
Sorted by citations
Items 701–800 of 1,027
Bain, C. C., Gibson, D. A., Steers, N. J., Boufea, K., Louwe, P. A., Doherty, C., González-Huici, V., Gentek, R., Magalhaes-Pinto, M., Shaw, T., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abc4466 · Cited by 97
Watanabe, S., Markov, N. S., Lu, Z., Aillon, R. P., Soberanes, S., Runyan, C. E., Ren, Z., Grant, R. A., Maciel, M., Abdala‐Valencia, H., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2101100118 · Cited by 99
Self-citationMicroglia modulate stable wakefulness via the thalamic reticular nucleus in mice
Liu, H., Wang, X., Chen, L., Chen, L., Tsirka, S. E., Ge, S., & Xiong, Q. (2021) · Nature Communications · doi:10.1038/s41467-021-24915-x · Cited by 99
Tedesco, S., Bolego, C., Toniolo, A., Nassi, A., Fadini, G. P., Locati, M., & Cignarella, A. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.12.008 · Cited by 97
Infiltrating monocytes in liver injury and repair
Brempelis, K. J., & Crispe, I. N. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.62 · Cited by 97
Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages
Liebold, I., Al Jawazneh, A., Casar, C., Lanzloth, C., Leyk, S., Hamley, M., Wong, M. N., Kylies, D., Gräfe, S. K., Edenhofer, I., et al. (2024) · Science · doi:10.1126/science.abo7027 · Cited by 96
Alveolar Macrophages in Allergic Asthma: the Forgotten Cell Awakes
Draijer, C., & Peters-Golden, M. L. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0681-6 · Cited by 95
Upregulation of Microglial ZEB1 Ameliorates Brain Damage after Acute Ischemic Stroke
Li, D., Lang, W., Zhou, C., Wu, C., Zhang, F., Liu, Q., Yang, S., & Hao, J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.011 · Cited by 95
Innate immunity as the trigger of systemic autoimmune diseases
Saferding, V., & Blüml, S. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102382 · Cited by 108
Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes
Culemann, S., Knab, K., Euler, M., Wegner, A., Garibagaoglu, H., Ackermann, J. A., Fischer, K., Kienhöfer, D., Crainiciuc, G., Hahn, J., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20220525 · Cited by 98
The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
Chaintreuil, P., Kerreneur, E., Bourgoin, M., Savy, C., Favreau, C., Robert, G., Jacquel, A., & Auberger, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1178337 · Cited by 102
Nagelkerke, S. Q., Bruggeman, C. W., den Haan, J. M. M., Mul, E. P. J., van den Berg, T. K., van Bruggen, R., & Kuijpers, T. W. (2018) · Blood Advances · doi:10.1182/bloodadvances.2017015008 · Cited by 99
Luo, J., Qian, A., Oetjen, L. K., Yu, W., Yang, P., Feng, J., Xie, Z., Liu, S., Yin, S., Dryn, D. O., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.021 · Cited by 97
The Endless Saga of Monocyte Diversity
Canè, S., Ugel, S., Trovato, R., Marigo, I., Sanctis, F. D., Sartoris, S., & Bronte, V. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01786 · Cited by 100
Thibaut, R., Gage, M., Pineda‐Torra, I., Chabrier, G., Venteclef, N., & Alzaïd, F. (2021) · FEBS Journal · doi:10.1111/febs.15877 · Cited by 97
Yan, P., Kim, K.-W., Xiao, Q., Ma, X., Czerniewski, L. R., Liu, H., Rawnsley, D. R., Yan, Y., Randolph, G. J., Epelman, S., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci152565 · Cited by 95
Self-citationSocodato, R., Portugal, C. C., Canedo, T., Rodrigues, A., Almeida, T. O., Henriques, J. F., Vaz, S. H., Magalhães, J., Silva, C. M., Baptista, F. I., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107796 · Cited by 94
Myeloid cell dysfunction and the pathogenesis of the diabetic chronic wound
Wicks, K., Torbica, T., & Mace, K. A. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.04.006 · Cited by 93
Monocyte heterogeneity in cardiovascular disease
Libby, P., Nahrendorf, M., & Świrski, F. K. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0387-3 · Cited by 97
Finkernagel, F., Reinartz, S., Lieber, S., Adhikary, T., Wortmann, A., Hoffmann, N., Bieringer, T., Nist, A., Stiewe, T., Jansen, J. M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12180 · Cited by 95
Anderson, S., Roberts, J. M., Zhang, J., Steele, M. R., Romero, C. O., Bosco, A., & Vetter, M. L. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.062 · Cited by 96
Paschalis, E. I., Lei, F., Zhou, C., Kapoulea, V., Dana, R., Chodosh, J., Vavvas, D. G., & Dohlman, C. H. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1807123115 · Cited by 91
Cytomegalovirus subverts macrophage identity
Baasch, S., Giansanti, P., Kolter, J., Riedl, A., Forde, A. J., Runge, S., Zenke, S., Elling, R., Halenius, A., Brabletz, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.009 · Cited by 92
New insights into mononuclear phagocyte biology from the visual system
Reyes, N. S., O’Koren, E. G., & Saban, D. R. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.13 · Cited by 95
Zheng, Z., Chiu, S. F., Akbarpour, M., Sun, H., Reyfman, P. A., Anekalla, K. R., Abdala‐Valencia, H., Edgren, D., Li, W., Kreisel, D., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal4508 · Cited by 94
Self-citationEndocardially Derived Macrophages Are Essential for Valvular Remodeling
Shigeta, A., Huang, V. H., Zuo, J., Besada, R. H., Nakashima, Y., Lu, Y., Ding, Y., Pellegrini, M. A., Kulkarni, R. P., Hsiai, T. K., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.021 · Cited by 93
Jiang, S., Maphis, N. M., Binder, J., Chisholm, D., Weston, L., Duran, W., Peterson, C., Zimmerman, A., Mandell, M. A., Jett, S. D., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109720 · Cited by 92
Targeting Microglia Using Cx3cr1-Cre Lines: Revisiting the Specificity
Zhao, X.-F., Alam, M. M., Liao, Y., Huang, T., Mathur, R., Zhu, X., & Huang, Y. (2019) · eneuro · doi:10.1523/eneuro.0114-19.2019 · Cited by 92
Drosophila as a model for the two myeloid blood cell systems in vertebrates
Gold, K. S., & Brückner, K. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.06.002 · Cited by 99
Metzger, M. W., Walser, S. M., Aprile-Garcia, F., Dedic, N., Chen, A., Holsboer, F., ARZT, E. S., Wurst, W., & Deussing, J. M. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9546-z · Cited by 98
Kerntke, C., Nimmerjahn, F., & Biburger, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00118 · Cited by 92
Biomaterials-Mediated Regulation of Macrophage Cell Fate
Liu, Y., & Segura, T. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.609297 · Cited by 92
Patsalos, A., Halász, L., Medina-Serpas, M. A., Berger, W. K., Dániel, B., Tzerpos, P., Kiss, M., Nagy, G., Fischer, C., Simándi, Z., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210420 · Cited by 94
Chen, H., Chen, C., Kuo, Y.-M., Chen, B., Kuan, I. S., Huang, H., Lee, J., Anthony, N. R., Kuan, C.-Y., & Sun, Y. (2021) · Theranostics · doi:10.7150/thno.64033 · Cited by 96
Oncofetal reprogramming in tumour development and progression
Sharma, A., Blériot, C., Currenti, J., & Ginhoux, F. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00497-8 · Cited by 104
Baer, J. M., Zuo, C., Kang, L., de la Lastra, A. A., Borcherding, N. C., Knolhoff, B. L., Bogner, S. J., Zhu, Y., Yang, L., Poursine‐Laurent, J., et al. (2022) · Nature Immunology · doi:10.1038/s41590-023-01579-x · Cited by 104
Self-citationMyelin and macrophages in the PNS: An intimate relationship in trauma and disease
Klein, D., & Martini, R. (2015) · Brain Research · doi:10.1016/j.brainres.2015.11.033 · Cited by 89
Microglia and brain macrophages: An update
Sasaki, A. (2016) · Neuropathology · doi:10.1111/neup.12354 · Cited by 91
Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation
Pinto, A. R., Godwin, J. W., & Rosenthal, N. A. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.06.004 · Cited by 94
Sun, W. S., Zhang, H., Wang, H., Chiu, Y. G., Wang, M., Ritchlin, C. T., Kiernan, A. E., Boyce, B. F., & Xing, L. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3117 · Cited by 91
Fractalkine Modulates Microglia Metabolism in Brain Ischemia
Lauro, C., Chece, G., Monaco, L., Antonangeli, F., Peruzzi, G., Rinaldo, S., Paone, A., Cutruzzolà, F., & Limatola, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00414 · Cited by 91
Leishmaniasis immunopathology—impact on design and use of vaccines, diagnostics and drugs
Kaye, P. M., Cruz, I., Picado, A., Bocxlaer, K. V., & Croft, S. L. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00788-y · Cited by 91
Liver innate immune cells and insulin resistance: the multiple facets of Kupffer cells
Jager, J., Aparicio‐Vergara, M., & Aouadi, M. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12483 · Cited by 90
White matter microglia heterogeneity in the CNS
Amor, S., McNamara, N. B., Gerrits, E., Marzin, M. C., Kooistra, S. M., Miron, V. E., & Nutma, E. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02389-x · Cited by 89
Skeletal muscle inflammation and atrophy in heart failure
Lavine, K. J., & Sierra, O. L. (2017) · Heart Failure Reviews · doi:10.1007/s10741-016-9593-0 · Cited by 96
A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis
Doron, H., Pukrop, T., & Erez, N. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-1805 · Cited by 95
Microglia in action: how aging and injury can change the brain’s guardians
Lourbopoulos, A. I., Ertürk, A., & Hellal, F. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00054 · Cited by 97
Macrophage depletion ameliorates nephritis induced by pathogenic antibodies
Chalmers, S. A., Chiţu, V., Herlitz, L., Sahu, R. K., Stanley, E. R., & Putterman, C. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.11.007 · Cited by 89
Lu, X., Perrard, X. D., Perrard, J. L., Yang, D., Xiao, X., Teng, B.-B., Simon, S. I., Ballantyne, C. M., & Wu, H. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305609 · Cited by 91
Hawley, C. A., Rojo, R., Raper, A., Sauter, K. A. D., Lisowski, Z. M., Grabert, K., Bain, C. C., Davis, G. M., Louwe, P. A., Ostrowski, M. C., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701488 · Cited by 91
Self-citationProtective features of peripheral monocytes/macrophages in stroke
Gliem, M., Schwaninger, M., & Jander, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.004 · Cited by 88
The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells
Ipseiz, N., Uderhardt, S., Scholtysek, C., Steffen, M., Schabbauer, G., Bözec, A., Schett, G. A., & Krönke, G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303377 · Cited by 90
Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics
Peng, M., Li, N., Wang, H., Li, Y., Liu, H., Luo, Y., Lang, B., Zhang, W., Li, S., Tian, L., et al. (2025) · MedComm · doi:10.1002/mco2.70304 · Cited by 98
Lückoff, A., Caramoy, A., Scholz, R., Prinz, M., Kalinke, U., & Langmann, T. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505994 · Cited by 89
Linton, P., & Thoman, M. L. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.017 · Cited by 87
The origins and non-canonical functions of macrophages in development and regeneration
Théret, M., Mounier, R., & Rossi, F. M. V. (2019) · Development · doi:10.1242/dev.156000 · Cited by 90
Origin and Differentiation of Nerve-Associated Macrophages
Kolter, J., Kierdorf, K., & Henneke, P. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901077 · Cited by 91
Resolution of Deep Venous Thrombosis: Proposed Immune Paradigms
Nicklas, J. M., Gordon, A. E., & Henke, P. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062080 · Cited by 89
Macrophage function in the elderly and impact on injury repair and cancer
Duong, L., Radley‐Crabb, H. G., Lee, B. R., Dye, D. E., Pixley, F. J., Grounds, M. D., Nelson, D. J., & Jackaman, C. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00215-2 · Cited by 93
Spiteri, A. G., Ni, D., Ling, Z. L., Macia, L., Campbell, I. L., Hofer, M. J., & King, N. J. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.851556 · Cited by 85
Adachi, A., Honda, T., Egawa, G., Kanameishi, S., Takimoto‐Ito, R., Miyake, T., Hossain, M. R., Komine, M., Ohtsuki, M., Gunzer, M., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.03.028 · Cited by 89
Plasma iron controls neutrophil production and function
Frost, J. N., Wideman, S. K., Preston, A. E., Teh, M. R., Ai, Z., Wang, L., Cross, A. R., White, N., Yazicioglu, Y. F., Bonadonna, M., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq5384 · Cited by 89
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity
Fixsen, B. R., Han, C. Z., Zhou, Y., Spann, N. J., Saisan, P., Shen, Z., Balak, C., Sakai, M., Cobo, I., Holtman, I. R., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01528-8 · Cited by 87
Cai, Z., Li, W., Hager, S., Wilson, J. L., Afjehi-Sadat, L., Heiß, E. H., Weichhart, T., Heffeter, P., & Weckwerth, W. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01134-0 · Cited by 91
Marcovecchio, P., Thomas, G. D., Mikulski, Z., Ehinger, E., Mueller, K. A. L., Blatchley, A., Wu, R., Miller, Y. I., Nguyen, A. T., Taylor, A. M., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309123 · Cited by 89
Neuron–microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration
Tsuda, M., & Inoue, K. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.042 · Cited by 88
Gebremariam, T., Alkhazraji, S., Soliman, S. S. M., Gu, Y., Jeon, H. H., Zhang, L., French, S. W., Stevens, D. A., Edwards, J. E., Filler, S. G., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw1327 · Cited by 86
Salei, N., Rambichler, S., Salvermoser, J., Papaioannou, N. E., Schuchert, R., Pakalniškytė, D., Li, N., Marschner, J. A., Lichtnekert, J., Stremmel, C., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019040419 · Cited by 89
Tissue-Resident Macrophages in the Control of Infection and Resolution of Inflammation
Mu, X., Li, Y., & Fan, G. (2020) · Shock · doi:10.1097/shk.0000000000001601 · Cited by 93
Dagher, R., Copenhaver, A. M., Besnard, V., Berlin, A. A., Hamidi, F., Maret, M., Wang, J., Qu, X., Shrestha, Y., Wu, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18466-w · Cited by 89
Zhan, L., Fan, L., Kodama, L., Sohn, P., Wong, M. Y., Mousa, G. A., Zhou, Y., Li, Y., & Gan, L. (2020) · eLife · doi:10.7554/elife.51796 · Cited by 80
Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset
Hanlon, M. M., Smith, C. M., Canavan, M., Neto, N. G. B., Song, Q., Lewis, M., O’Rourke, A. M., Tynan, O., Barker, B. E., Gallagher, P., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj1252 · Cited by 86
Aychek, T., Mildner, A., Yona, S., Kim, K.-W., Lampl, N., Reich-Zeliger, S., Boon, L., Yogev, N., Waisman, A., Cua, D. J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7525 · Cited by 88
Self-citationDevelopmental control of macrophage function
Bonnardel, J., & Guilliams, M. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.12.001 · Cited by 87
Self-citationThe Mononuclear Phagocytic System. Generation of Diversity
Gordon, S., & Plüddemann, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01893 · Cited by 89
Intestinal Macrophages in Resolving Inflammation
Hine, A. M., & Loke, P. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900345 · Cited by 85
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease
Kimura, K., Subramanian, A., Yin, Z., Khalilnezhad, A., Wu, Y., He, D., Dixon, K. O., Chitta, U. K., Ding, X., Adhikari, N., et al. (2025) · Nature · doi:10.1038/s41586-025-08852-z · Cited by 85
Jacquelin, S., Licata, F., Dorgham, K., Hermand, P., Poupel, L., Guyon, E., Déterre, P., Hume, D. A., Combadière, C., & Boissonnas, A. (2013) · Blood · doi:10.1182/blood-2013-01-480749 · Cited by 89
Self-citationDysregulated Functions of Lung Macrophage Populations in COPD
Kapellos, T. S., Bassler, K. E., Aschenbrenner, A. C., Fujii, W., & Schultze, J. L. (2018) · Journal of Immunology Research · doi:10.1155/2018/2349045 · Cited by 87
Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling
Chiţu, V., Biundo, F., Shlager, G. G. L., Park, E. S., Wang, P., Gulinello, M. E., Gökhan, Ş., Ketchum, H. C., Saha, K., Deture, M. A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.028 · Cited by 77
TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity.
Fu, W., Hu, W.-H., Yi, Y.-S., Hettinghouse, A., Sun, G.-D., Bi, Y., He, W., Zhang, L., Gao, G., Liu, J., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144016 · Cited by 64
Rahman, M. S., & Woollard, K. J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-57613-8_7 · Cited by 87
The journey from stem cell to macrophage
Pittet, M. J., Nahrendorf, M., & Świrski, F. K. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12393 · Cited by 89
Effects of dyslipidaemia on monocyte production and function in cardiovascular disease
Rahman, M. S., Murphy, A. J., & Woollard, K. J. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.34 · Cited by 86
Eckert, C., Klein, N., Kornek, M., & Kornek, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00179 · Cited by 84
Pennig, J., Scherrer, P., Gissler, M. C., Anto-Michel, N., Hoppe, N., Füner, L., Härdtner, C., Stachon, P., Wolf, D., Hilgendorf, I., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-54224-9 · Cited by 83
New Insights and Novel Therapeutic Potentials for Macrophages in Myocardial Infarction
Zhang, Z., Tang, J., Cui, X., Qin, B., Zhang, J., Zhang, H., Zhang, H., Liu, G., Wang, W., & Zhang, J. (2021) · Inflammation · doi:10.1007/s10753-021-01467-2 · Cited by 86
Delidakis, G., Kim, J. E., George, K., & Georgiou, G. (2022) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-082721-024500 · Cited by 87
Fetal liver endothelium regulates the seeding of tissue-resident macrophages
Rantakari, P., Jäppinen, N., Lokka, E., Mokkala, E., Gerke, H., Peuhu, E., Ivaska, J., Elima, K., Auvinen, K., & Salmi, M. (2016) · Nature · doi:10.1038/nature19814 · Cited by 85
Specific Contributions of CSF-1 and GM-CSF to the Dynamics of the Mononuclear Phagocyte System
Louis, C., Cook, A. D., Lacey, D. C., Fleetwood, A. J., Vlahos, R., Anderson, G. P., & Hamilton, J. A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500369 · Cited by 88
Gut–liver axis and sterile signals in the development of alcoholic liver disease
Szabó, G., & Petrášek, J. (2017) · Alcohol and Alcoholism · doi:10.1093/alcalc/agx025 · Cited by 85
Jarjour, N. N., Schwarzkopf, E. A., Bradstreet, T. R., Shchukina, I., Lin, C., Huang, S. C., Lai, C., Cook, M. E., Taneja, R., Stappenbeck, T. S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0382-5 · Cited by 82
Brioschi, S., Belk, J. A., Peng, V., Molgora, M., Rodrigues, P. F., Nguyen, K. M., Wang, S., Du, S., Wang, W.-L., Grajales‐Reyes, G. E., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.028 · Cited by 86
Ocañas, S. R., Pham, K. D., Cox, J. E. J., Keck, A. W., Ko, S.-H., Ampadu, F. A., Porter, H. L., Ansere, V. A., Kulpa, A. M., Kellogg, C. M., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02870-2 · Cited by 85
Monocytes and macrophages in cardiac injury and repair
Sager, H. B., Kessler, T., & Schunkert, H. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.11.17 · Cited by 85
C/EBPβ is required for survival of Ly6C− monocytes
Tamura, A., Hirai, H., Yokota, A., Kamio, N., Sato, A., Shoji, T., Kashiwagi, T., Torikoshi, Y., Miura, Y., Tenen, D. G., et al. (2017) · Blood · doi:10.1182/blood-2017-03-772962 · Cited by 84
The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou, X., Chen, G., Bracamonte-Baran, W., Choi, H. S., Diny, N. L., Sung, J., Hughes, D., Won, T., Wood, M. K., Talor, M. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.007 · Cited by 83
Lymph node macrophages: Scavengers, immune sentinels and trophic effectors
Bellomo, A., Gentek, R., Bajénoff, M., & Baratin, M. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.010 · Cited by 82
Walsh, C. P., Bovbjerg, D. H., & Marsland, A. L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.013 · Cited by 87
Macrophage Polarization: An Important Candidate Regulator for Lung Diseases
Deng, L., Jian, Z., Xu, T., Li, F., Deng, H., Zhou, Y., Lai, S., Xu, Z., & Zhu, L. (2023) · Molecules · doi:10.3390/molecules28052379 · Cited by 85
Metadata
- Authors
- Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., Hume, D. A., Perlman, H., Malissen, B., Zelzer, E., & Jung, S.
- Affiliations
- Weizmann Institute of Science (IL)
- Centre National de la Recherche Scientifique (FR)
- Northwestern University (US)
- Roslin Institute (GB)
- Corresponding author
- Jung, Steffen
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 38
- Issue
- 1
- Pages
- 79-91
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3908543
- OpenAlex
- W2153406260
- Cited by
- 3,245
- References
- 72
- Citations by year
- 2026: 167 · 2025: 221 · 2024: 289 · 2023: 299 · 2022: 305 · 2021: 291 · 2020: 313 · 2019: 254 · 2018: 250 · 2017: 224 · 2016: 192 · 2015: 182 · 2014: 168 · 2013: 68
- FWCI
- 58.75
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-05-23)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (acceptedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- Minerva Foundation
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche (ANR-10-EQPX-0011)
- Israel Science Foundation
- Biotechnology and Biological Sciences Research Council (BBS/E/D/20251969, BBS/E/D/20221657)
- National Institute of Allergy and Infectious Diseases (R21AI092490)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050250, R01AR054796)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- monocytes, tissue macrophages, monocyte-to-macrophage differentiation, Kupffer cells, alveolar macrophages, splenic macrophages, peritoneal macrophages, Ly6C+ monocytes, CX3CR1, fate mapping, mononuclear phagocytes, tissue homeostasis
- MeSH terms
- CX3C Chemokine Receptor 1, Animals, Antigens, Ly, Homeostasis, Macrophages, Mice, Transgenic, Monocytes, Immunophenotyping, Receptors, Chemokine, Myeloid Progenitor Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
