The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Open accessAbstract
Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manipulation of these cells could bear therapeutic potential. However, specific ontogenies of individual populations and the overall functional organization of this cellular network are not well defined. Here we report a fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression. We have demonstrated that major tissue-resident macrophage populations, including liver Kupffer cells and lung alveolar, splenic, and peritoneal macrophages, are established prior to birth and maintain themselves subsequently during adulthood independent of replenishment by blood monocytes. Furthermore, we have established that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly6C(-) cells and that the abundance of Ly6C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Cx3cr1, which marks both monocyte-derived and resident macrophages20-22, was particularly enriched in cluster 1, together with proinflammatory genes such as Il1b (Fig. 1J).”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [20]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, the majority of these peripheral cells are short lived and turn over within 4 weeks because of ongoing, lifelong hematopoiesis.10–12”
From A comparative analysis of microglial inducible Cre lines (2023) · cites this paper as [11]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Our findings are consistent with reports that macrophage progenitors develop from the primitive ectoderm of the yolk sac4 and give rise to tissue macrophages that do not have a monocytic progenitor16,17.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [17]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Ly6Clo monocytes, which differentiate from recruited CCR2+Ly6Chi monocytes in the bloodstream, would no longer be recruited to this function [323, 359]”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [359]
The cited source says what the claim attributes to it.
In the citing paper
“the P2ry12 signal co-localized on CX3CR1GFP microglia in which GFP is expressed in resident microglia17,23 (Fig. 4e).”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [17]
In the citing paper
“These tissue resident macrophages sustain their local populations by rapid proliferation during injury events (Fig. 2b) [13].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [13]
In the citing paper
“a significant expansion of Pdgfra+ fibroblasts after bleomycin treatment has been reported in a study analyzing the fibroblast compartment in this model of fibrosis 35”
From Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage (2019) · cites this paper as [35]
In the citing paper
“The specificity of Cx3cr1 for microglia is incomplete, and we cannot exclude a non-brain-resident macrophage contribution to the miRNA eluted from the FLAG-Ago2 mice using this promoter (Yona et al., 2013).”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Yona et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Self-citationCre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
Self-citationJung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Self-citationA Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570
Nomenclature of monocytes and dendritic cells in blood
Ziegler‐Heitbrock, L., Ancuța, P., Crowe, S. M., Dalod, M., Grau, V., Hart, D. N. J., Leenen, P. J. M., Liu, Y.-J., MacPherson, G. G., Randolph, G. J., et al. (2010) · Blood · doi:10.1182/blood-2010-02-258558 · Cited by 2,436
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
Transcriptional regulation of macrophage polarization: enabling diversity with identity
Lawrence, T., & Natoli, G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3088 · Cited by 2,284
Flagged first, then by citations
Research works printed but not linked: 1
- van Furth, 1972, [Mononuclear phagocytic system: new classification of macrophages, monocytes and of their cell line], Bull. World Health Organ., 47, 651
Cited by
Sorted by citations
Items 801–900 of 1,027
Pepe, G., Braga, D., Renzi, T. A., Villa, A., Bolego, C., D’Avila, F., Barlassina, C., Maggi, A., Locati, M., & Vegeto, E. (2017) · Scientific Reports · doi:10.1038/srep44270 · Cited by 80
Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation
Wolf, Y., Shemer, A., Polonsky, M., Gross, M., Mildner, A., Yona, S., David, E., Kim, K.-W., Goldmann, T., Amit, I., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160499 · Cited by 82
Self-citationDicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain
Varol, D., Mildner, A., Blank, T., Shemer, A., Barashi, N., Yona, S., David, E., Boura-Halfon, S., Segal-Hayoun, Y., Chappell-Maor, L., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.05.003 · Cited by 81
Self-citationWaqas, S. F. H., Noble, A. M., Hoang, A. C., Ampem, G., Popp, M., Strauß, S., Guille, M., & Rőszer, T. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.1a0317-082rr · Cited by 81
Understanding the Origin and Diversity of Macrophages to Tailor Their Targeting in Solid Cancers
Kielbassa-Elkadi, K., Vegna, S., Ramirez, C. F. A., & Akkari, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02215 · Cited by 82
Hauptmann, J., Johann, L., Marini, F., Kitic, M., Colombo, E., Mufazalov, I. A., Krueger, M. W., Karram, K., Moos, S., Wanke, F., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02187-x · Cited by 85
Belgiovine, C., Digifico, E., Anfray, C., Ummarino, A., & Torres, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103226 · Cited by 86
Keerthivasan, S., Şenbabaoğlu, Y., Martinez-Martín, N., Husain, B., Verschueren, E., Wong, A., Yang, Y. A., Sun, Y., Pham, V. C., Hinkle, T. B., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.06.012 · Cited by 82
Targeting the Monocyte–Macrophage Lineage in Solid Organ Transplantation
van den Bosch, T. P. P., Kannegieter, N. M., Hesselink, D. A., Baan, C. C., & Rowshani, A. T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00153 · Cited by 82
Chou, A., Krukowski, K., Morganti, J. M., Riparip, L., & Rosi, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061616 · Cited by 78
He, T., Li, W., Song, Y., Li, Z., Tang, Y., Zhang, Z., & Yang, G. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01987-y · Cited by 80
Histamine in cancer immunology and immunotherapy. Current status and new perspectives
Sarasola, M. D. L. P., Delgado, M. A. T., Nicoud, M. B., & Medina, V. A. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.778 · Cited by 79
Reprogramming of macrophages — new opportunities for therapeutic targeting
Schultze, J. L. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.007 · Cited by 79
Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity
Peschke, K., Achleitner, M., Frenzel, K., Gerbaulet, A., Ada, S.-R., Zeller, N., Lienenklaus, S., Lesche, M., Poulet, C. E., Naumann, R., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600722 · Cited by 82
Location, function, and ontogeny of pulmonary macrophages during the steady state
Garbi, N., & Lambrecht, B. N. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1965-3 · Cited by 89
The biology of serous cavity macrophages
Bain, C. C., & Jenkins, S. J. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.003 · Cited by 78
Microglia Express Mu Opioid Receptor: Insights From Transcriptomics and Fluorescent Reporter Mice
Maduna, T., Audouard, E., Dembélé, D., Mouzaoui, N., Reiss, D. J., Massotte, D., & Gavériaux‐Ruff, C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00726 · Cited by 78
Burns, J. C., Cotleur, B., Walther, D. M., Bajrami, B., Rubino, S. J., Wei, R., Franchimont, N., Cotman, S. L., Ransohoff, R. M., & Mingueneau, M. (2020) · eLife · doi:10.7554/elife.57495 · Cited by 82
Deciphering glial scar after spinal cord injury
Zhang, Y., Yang, S., Liu, C., Han, X., Gu, X., & Zhou, S. (2021) · Burns & Trauma · doi:10.1093/burnst/tkab035 · Cited by 80
Necrotic reshaping of the glioma microenvironment drives disease progression
Markwell, S. M., Ross, J., Olson, C. L., & Brat, D. J. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02401-4 · Cited by 81
Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain
Siret, C., van Lessen, M., Bavais, J., Jeong, H., Samawar, S. K. R., Kapupara, K., Wang, S., Simic, M., de Fabritus, L., Tchoghandjian, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35166-9 · Cited by 80
Monocyte heterogeneity in cardiovascular disease
Ruder, A. V., Wetzels, S., Temmerman, L., Biessen, E. A. L., & Goossens, P. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad069 · Cited by 79
Falkenham, A., de Antueno, R., Rosin, N. L., Betsch, D. M., Lee, T. D. G., Duncan, R., & Légaré, J. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.11.027 · Cited by 77
Newson, J., Motwani, M. P., Kendall, A. C., Nicolaou, A., Muccioli, G. G., Alhouayek, M., Bennett, M., van de Merwe, R. C., Naomi-James, S., Maeyer, R. P. H. D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.098 · Cited by 78
Myeloid cell responses after spinal cord injury
David, S., Kroner, A., Greenhalgh, A. D., Zarruk, J. G., & López‐Vales, R. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.06.003 · Cited by 81
Fetal-derived macrophages dominate in adult mammary glands
Jäppinen, N., Félix, I., Lokka, E., Tyystjärvi, S., Pynttäri, A., Lahtela, T., Gerke, H., Elima, K., Rantakari, P., & Salmi, M. (2019) · Nature Communications · doi:10.1038/s41467-018-08065-1 · Cited by 80
At the Forefront of the Mucosal Barrier: The Role of Macrophages in the Intestine
Ruder, B., & Becker, C. (2020) · Cells · doi:10.3390/cells9102162 · Cited by 80
Diversity and Function of Glial Cell Types in Multiple Sclerosis
Schirmer, L., Schafer, D. P., Bartels, T., Rowitch, D. H., & Calabresi, P. A. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.01.005 · Cited by 78
Pathogenicity and virulence of Hepatitis B virus
Chuang, Y.-C., Tsai, K.-N., & Ou, J. J. (2022) · Virulence · doi:10.1080/21505594.2022.2028483 · Cited by 83
Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis
Yang, J., Pan, X., Wang, L., & Yu, G. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00223-w · Cited by 79
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth
Zhang, N., Kim, S. H., Gainullina, A., Erlich, E. C., Onufer, E. J., Kim, J., Czepielewski, R. S., Helmink, B. A., Dominguez, J. R., Saunders, B. T., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210924 · Cited by 75
Self-citationMa, S., Zhang, J., Liu, H., Li, S., & Wang, Q. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.896591 · Cited by 81
Persistent Lung Inflammation and Fibrosis in Serum Amyloid P Component (Apcs-/-) Knockout Mice
Pilling, D., & Gomer, R. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093730 · Cited by 80
Antifibrotic Therapies in the Liver
Schuppan, D., & Mehal, W. Z. (2015) · Seminars in Liver Disease · doi:10.1055/s-0035-1550055 · Cited by 76
A gene expression-based study on immune cell subtypes and glioma prognosis
Zhong, Q.-Y., Fan, E., Feng, G., Chen, Q., Gou, X., Yue, G., & Zhang, G.-H. (2019) · BMC Cancer · doi:10.1186/s12885-019-6324-7 · Cited by 75
Haubruck, P., Pinto, M. M., Moradi, B., Little, C. B., & Gentek, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763702 · Cited by 83
Lu, H., Zhang, C., Wu, W. H., Chen, H., Lin, R., Sun, R., Gao, X., Li, G., He, Q., Gao, H., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-327183 · Cited by 78
Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages
Gonzalez, M. A., Lu, D., Yousefi, M., Kroll, A. V., Lo, C. H., Briseño, C. G., Watson, J. E. V., Novitskiy, S. V., Arias, V., Zhou, H., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221472 · Cited by 75
Tissue-resident immune cells: from defining characteristics to roles in diseases
Li, J., Chu, X., Li, C., & He, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02050-5 · Cited by 87
Sources of heterogeneity in human monocyte subsets
Appleby, L. J., Nausch, N., Midzi, N., Mduluza, T., Allen, J. E., & Mutapi, F. (2013) · Immunology Letters · doi:10.1016/j.imlet.2013.03.004 · Cited by 75
The Elusive Antifibrotic Macrophage
Adhyatmika, A., Putri, K. S. S., Beljaars, L., & Melgert, B. N. (2015) · Frontiers in Medicine · doi:10.3389/fmed.2015.00081 · Cited by 77
Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles
Ergen, C., Heymann, F., Rawashdeh, W. A., Gremse, F., Bartneck, M., Panzer, U., Pola, R., Pechar, M., Storm, G., Mohr, N., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.009 · Cited by 77
Liao, C., Prabhu, K. S., & Paulson, R. F. (2018) · Blood · doi:10.1182/blood-2018-06-856831 · Cited by 78
The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia
Bhattacherjee, A., Jung, J., Zia, S., Ho, M. F. S., Eskandari‐Sedighi, G., Laurent, C. D. S., McCord, K. A., Bains, A., Sidhu, G., Sarkar, S., et al. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00443-6 · Cited by 77
Hwang, H.-W., Saito, Y., Park, C. Y., Blachère, N. E., Tajima, Y., Fak, J. J., Zucker-Scharff, I., & Darnell, R. B. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.024 · Cited by 74
Elsegood, C. L., Chan, C. W., Degli‐Esposti, M. A., Wikström, M. E., Domenichini, A., Lazarus, K. A., van Rooijen, N., Ganß, R., Olynyk, J. K., & Yeoh, G. C. (2015) · Hepatology · doi:10.1002/hep.27977 · Cited by 76
2014 Jeffrey M. Hoeg Award Lecture
Zhu, Y. P., Thomas, G. D., & Hedrick, C. C. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.304054 · Cited by 77
Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology
Bailey, J. D., Shaw, A., McNeill, E., NICOL, T., Diotallevi, M., Chuaiphichai, S., Patel, J., Hale, A., Channon, K. M., & Crabtree, M. J. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.04.005 · Cited by 74
Lee, J., Boyce, S., Powers, J., Baer, C. E., Sassetti, C. M., & Behar, S. M. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008621 · Cited by 70
Dallio, M., Sangineto, M., Romeo, M., Villani, R., Romano, A. D., Loguercio, C., Serviddio, G., & Federico, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010436 · Cited by 77
Macrophage Responses to Environmental Stimuli During Homeostasis and Disease
Rasheed, A., & Rayner, K. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab004 · Cited by 83
Beneficial and detrimental functions of microglia during viral encephalitis
Waltl, I., & Kalinke, U. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.11.004 · Cited by 74
Xia, Q., Gao, S., Han, T., Mao, M., Zhan, G., Wang, Y., & Li, X. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02665-x · Cited by 76
Development and Function of Arterial and Cardiac Macrophages
Świrski, F. K., Robbins, C. S., & Nahrendorf, M. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.11.004 · Cited by 78
Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages
Chen, S., Kammerl, I. E., Vosyka, O., Baumann, T., Yu, Y., Wu, Y., Irmler, M., Overkleeft, H. S., Beckers, J., Eickelberg, O., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.3 · Cited by 74
LRP1 expression in microglia is protective during CNS autoimmunity
Chuang, T.-Y., Guo, Y. X., Seki, S. M., Rosen, A. M., Johanson, D. M., Mandell, J. W., Lucchinetti, C. F., & Gaultier, A. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0343-2 · Cited by 74
Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity
Guillermier, C., Fazeli, P. K., Kim, S., Lun, M., Zuflacht, J. P., Milian, J., Lee, H., François‐Saint‐Cyr, H., Horréard, F., Larson, D. J., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.90349 · Cited by 77
Lantz, C. W., Radmanesh, B., Liu, E., Thorp, E. B., & Lin, J. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70353-y · Cited by 69
More than meets the eye: The role of microglia in healthy and diseased retina
Murenu, E., Gerhardt, M.-J., Biel, M., & Michalakis, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1006897 · Cited by 73
Microglia promote remyelination independent of their role in clearing myelin debris
Baaklini, C. S., Ho, M. F. S., Lange, T., Hammond, B. P., Panda, S. P., Zirngibl, M., Zia, S., Himmelsbach, K., Rana, H., Phillips, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113574 · Cited by 73
P2 receptors, microglial cytokines and chemokines, and neuropathic pain
Tsuda, M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23816 · Cited by 72
A new approach for ratiometric in vivo calcium imaging of microglia
Brawek, B., Liang, Y., Savitska, D., Li, K., Fomin-Thunemann, N., Kovalchuk, Y., Zirdum, E., Jakobsson, J., & Garaschuk, O. (2017) · Scientific Reports · doi:10.1038/s41598-017-05952-3 · Cited by 74
Yang, M., Song, L., Wang, L., Yukht, A., Ruther, H., Li, F., Qin, M., Ghiasi, H., Sharifi, B. G., & Shah, P. K. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.061 · Cited by 73
Contribution of Macrophage Efferocytosis to Liver Homeostasis and Disease
Horst, A. K., Tiegs, G., & Diehl, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02670 · Cited by 74
Wang, Y., Shi, J., Xin, M., Kahkoska, A. R., Wang, J., & Gu, Z. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01230-6 · Cited by 82
Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation
Matt, S. M., & Johnson, R. W. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.10.009 · Cited by 75
The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases
Cuda, C. M., Pope, R. M., & Perlman, H. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.132 · Cited by 78
Self-citationDiabetic Cardiomyopathy: An Immunometabolic Perspective
Mishra, P. K., Ying, W., Nandi, S. S., Bandyopadhyay, G. K., Patel, K. P., & Mahata, S. K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00072 · Cited by 74
Sepsis Induces a Long-Lasting State of Trained Immunity in Bone Marrow Monocytes
Bomans, K., Schenz, J., Sztwiertnia, I., Schaack, D., Weigand, M. A., & Uhle, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02685 · Cited by 73
Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model
Reed-Geaghan, E. G., Croxford, A. L., Becher, B., & Landreth, G. E. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191374 · Cited by 72
Groves, A. M., Johnston, C. J., Misra, R. S., Williams, J. P., & Finkelstein, J. N. (2016) · International Journal of Radiation Biology · doi:10.1080/09553002.2016.1222094 · Cited by 73
The Whole Body as the System in Systems Immunology
Poon, M. M. L., & Färber, D. L. (2020) · iScience · doi:10.1016/j.isci.2020.101509 · Cited by 77
Macrophages and cancer stem cells: a malevolent alliance
Allavena, P., Digifico, E., & Belgiovine, C. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00383-3 · Cited by 76
McCowan, J., Fercoq, F., Kirkwood, P. M., T’Jonck, W., Hegarty, L. M., Mawer, C. M., Cunningham, R., Mirchandani, A. S., Hoy, A. M., Humphries, D. C., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abj2132 · Cited by 72
Self-citationCNS border-associated macrophages in the homeostatic and ischaemic brain
Gerganova, G., Riddell, A., & Miller, A. A. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108220 · Cited by 72
Progress in preclinical studies of macrophage autophagy in the regulation of ALI/ARDS
Liu, C., Xiao, K., & Xie, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.922702 · Cited by 75
Monocyte-neutrophil entanglement in glioblastoma
Friedmann‐Morvinski, D., & Hambardzumyan, D. (2023) · Journal of Clinical Investigation · doi:10.1172/jci163451 · Cited by 71
Innate immune regulation by STAT ‐mediated transcriptional mechanisms
Li, H. S., & Watowich, S. S. (2014) · Immunological Reviews · doi:10.1111/imr.12198 · Cited by 72
Yue, S., Zhou, H., Wang, X., Busuttil, R. W., Kupiec‐Weglinski, J. W., & Zhai, Y. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601428 · Cited by 72
Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease
Caër, C., & Wick, M. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00410 · Cited by 76
Hepatic Macrophage as a Key Player in Fatty Liver Disease
Xu, L., Liu, W., Bai, F., Xu, Y., Liang, X., Ma, C., & Gao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708978 · Cited by 73
Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation
Knab, K., Chambers, D., & Krönke, G. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.862161 · Cited by 77
Antigen Presentation in the Lung
Kawasaki, T., Ikegawa, M., & Kawai, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.860915 · Cited by 78
Li, X., Kolling, F., Aridgides, D. S., Mellinger, D., Ashare, A., & Jakubzick, C. (2022) · Life Science Alliance · doi:10.26508/lsa.202201458 · Cited by 76
Benhar, I., Ding, J., Yan, W., Whitney, I. E., Jacobi, A., Sud, M., Burgin, G., Shekhar, K., Tran, N. M., Wang, C., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01437-w · Cited by 69
Bedolla, A., Wegman, E., Weed, M., Stevens, M. K., Ware, K., Paranjpe, A., Alkhimovitch, A., Ifergan, I., Таранов, А., Peter, J. D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49596-0 · Cited by 85
Cole, J., Aberdein, J., Jubrail, J., & Dockrell, D. H. (2014) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2014.08.004 · Cited by 71
A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines
Zhao, Q., Kim, T., Pang, J., Sun, W. Y., Yang, X., Wang, J., Song, Y., Zhang, H., Sun, H., Rangan, V. S., et al. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.5a0717-302 · Cited by 71
Fatty acid-binding protein 5 limits the anti-inflammatory response in murine macrophages
Moore, S. M., Holt, V. V., Malpass, L. R., Hines, I. N., & Wheeler, M. D. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.06.001 · Cited by 71
Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions
Cardoso, A. L., Guedes, J. R., & de Lima, M. C. P. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.001 · Cited by 71
Transcriptional control of monocyte and macrophage development
Kurotaki, D., Sasaki, H., & Tamura, T. (2017) · International Immunology · doi:10.1093/intimm/dxx016 · Cited by 75
The estrogen–macrophage interplay in the homeostasis of the female reproductive tract
Pepe, G., Locati, M., Torre, S. D., Mornata, F., Cignarella, A., Maggi, A. C., & Vegeto, E. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy026 · Cited by 78
Macrophages: The Potent Immunoregulatory Innate Immune Cells
Kumar, V. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88013 · Cited by 76
Notch and TLR signaling coordinate monocyte cell fate and inflammation
Gamrekelashvili, J., Kapanadze, T. G., Sablotny, S., Rațiu, C., Dastagir, K., Lochner, M., Karbach, S. H., Wenzel, P., Sitnow, A., Fleig, S. V., et al. (2020) · eLife · doi:10.7554/elife.57007 · Cited by 73
Foster, M., Hill, P. C., Setiabudiawan, T. P., Koeken, V. A. C. M., Alisjahbana, B., & van Crevel, R. (2021) · Immunological Reviews · doi:10.1111/imr.12965 · Cited by 74
CNS Border-Associated Macrophages: Ontogeny and Potential Implication in Disease
Dermitzakis, I., Theotokis, P., Evangelidis, P., Delilampou, E., Evangelidis, N., Chatzisavvidou, A., Avramidou, E., & Μanthou, M. E. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45050272 · Cited by 74
Macrophage based drug delivery: Key challenges and strategies
Guo, Q., & Qian, Z. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.04.004 · Cited by 81
Pervizaj-Oruqaj, L., Ferrero, M. R., Matt, U., & Herold, S. (2024) · European Respiratory Review · doi:10.1183/16000617.0263-2023 · Cited by 78
Macrophages and T cells in metabolic disorder-associated cancers
Taranto, D., Kloosterman, D. J., & Akkari, L. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00743-1 · Cited by 81
Fernández-Velasco, M., González-Ramos, S., & Boscá, L. (2014) · Biochemical Journal · doi:10.1042/bj20131501 · Cited by 70
Metadata
- Authors
- Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., Hume, D. A., Perlman, H., Malissen, B., Zelzer, E., & Jung, S.
- Affiliations
- Weizmann Institute of Science (IL)
- Centre National de la Recherche Scientifique (FR)
- Northwestern University (US)
- Roslin Institute (GB)
- Corresponding author
- Jung, Steffen
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 38
- Issue
- 1
- Pages
- 79-91
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3908543
- OpenAlex
- W2153406260
- Cited by
- 3,245
- References
- 72
- Citations by year
- 2026: 167 · 2025: 221 · 2024: 289 · 2023: 299 · 2022: 305 · 2021: 291 · 2020: 313 · 2019: 254 · 2018: 250 · 2017: 224 · 2016: 192 · 2015: 182 · 2014: 168 · 2013: 68
- FWCI
- 58.75
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-05-23)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (acceptedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- Minerva Foundation
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche (ANR-10-EQPX-0011)
- Israel Science Foundation
- Biotechnology and Biological Sciences Research Council (BBS/E/D/20251969, BBS/E/D/20221657)
- National Institute of Allergy and Infectious Diseases (R21AI092490)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050250, R01AR054796)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- monocytes, tissue macrophages, monocyte-to-macrophage differentiation, Kupffer cells, alveolar macrophages, splenic macrophages, peritoneal macrophages, Ly6C+ monocytes, CX3CR1, fate mapping, mononuclear phagocytes, tissue homeostasis
- MeSH terms
- CX3C Chemokine Receptor 1, Animals, Antigens, Ly, Homeostasis, Macrophages, Mice, Transgenic, Monocytes, Immunophenotyping, Receptors, Chemokine, Myeloid Progenitor Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
