The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation
Open accessAbstract
Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well characterized. Here we identify four populations of cardiac macrophages. At steady state, resident macrophages were primarily maintained through local proliferation. However, after macrophage depletion or during cardiac inflammation, Ly6c(hi) monocytes contributed to all four macrophage populations, whereas resident macrophages also expanded numerically through proliferation. Genetic fate mapping revealed that yolk-sac and fetal monocyte progenitors gave rise to the majority of cardiac macrophages, and the heart was among a minority of organs in which substantial numbers of yolk-sac macrophages persisted in adulthood. CCR2 expression and dependence distinguished cardiac macrophages of adult monocyte versus embryonic origin. Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis. These data highlight the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“During the course of experimental autoimmune myocarditis (EAM), a significant increase in the number of pro-inflammatory Ly6Chi monocytes and recruited CCR2+ macrophages is observed throughout the cardiac tissue [7,8,10].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Microglia in the developing brain proliferate locally at a low rate and are not normally replaced by other monocytes and macrophages from outside the brain, in contrast to most other tissue-resident macrophages (which also initially originate from yolk sac-derived macrophages, but are partially or fully replaced by fetal liver- or blood monocyte-derived macrophages [Bain et al., 2014, Calderon et”
From A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response (2017) · cites this paper as Epelman et al., 2014
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Clusters 1 and 5 had high expression of Ccr2, a marker of monocyte-derived macrophages that infiltrate from the circulation17-19 (Fig. 1J and Extended Data Fig. 1C-E).”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [18]
The cited source says what the claim attributes to it.
In the citing paper
“Macrophages, which constitute a highly heterogeneous cell population, are key mediators in both maintaining homeostasis and the pathogenesis of myocardial injury [7,8].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
The cited source says what the claim attributes to it.
In the citing paper
“In the heart, two main lineages of macrophages with distinct origins and functions are distinguished: tissue-resident macrophages (TRMs; typically CCR2-), predominantly derived from embryonic development, and recruited monocyte-derived macrophages (CCR2+), which infiltrate from the bloodstream in response to injury [7,8,9,10].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Species-specific differences in macrophage ontogeny, cytokine networks, and the composition of the cardiac immune niche may limit direct extrapolation of findings [7].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311 · cited 3×
“transplanted monocytes, indicating local macrophage expansion in these niches despite genotoxic injury (Hashimoto et al., 2013).”
BackgroundResultInfluentialSelf-citationNahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972
Self-citationSerbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658
Jenkins, S. J., Rückerl, D., Cook, P. C., Jackson-Jones, L. H., Finkelman, F. D., van Rooijen, N., MacDonald, A. S., & Allen, J. E. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,404
Guilliams, M., de Kleer, I., Henri, S., Post, S., Vanhoutte, L., Prijck, S. D., Deswarte, K., MALISSEN, B., Hammad, H., & Lambrecht, B. N. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131199 · Cited by 1,342
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 1,002
Osteopontin promotes infarct repair
Rotem, I., Konfino, T., Caller, T., Schary, Y., Shaihov–Teper, O., Palevski, D., Lewis, N., Lendengolts, D., Naftali‐Shani, N., & Leor, J. (2022) · Basic Research in Cardiology · doi:10.1007/s00395-022-00957-0 · Cited by 39
Pan, W., Zhou, G., Hu, M., Li, G., Zhang, M., Yang, H., Li, K., Li, J., Liu, T., Wang, Y., et al. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-03729-x · Cited by 38
Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis
Zhang, S., Yeap, X., Grigoryeva, L. S., Dehn, S., DeBerge, M., Tye, M. Y., Rostlund, E., Schrijvers, D. M., Zhang, Z. J., Sumagin, R., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.08.009 · Cited by 40
Laurence, J. C., Elhadad, S., Robison, T., Terry, H., Varshney, R., Woolington, S., Ghafoory, S., Choi, M. E., & Ahamed, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187185 · Cited by 38
Unified nexus of macrophages and maresins in cardiac reparative mechanisms
Jadapalli, J. K., & Halade, G. V. (2018) · The FASEB Journal · doi:10.1096/fj.201800254r · Cited by 39
Zhao, Q., Zhang, L., Hai, B., Wang, J., Baetge, C. L., Deveau, M. A., Kapler, G. M., Feng, J. Q., & Liu, F. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0503 · Cited by 38
Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state
Swiecki, M. K., Miller, H. L., Sesti‐Costa, R., Cella, M., Gilfillan, S., & Colonna, M. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.99 · Cited by 38
Self-citationRoles of Macrophage Subtypes in Bowel Anastomotic Healing and Anastomotic Leakage
Shi, J., Wu, Z., Li, Z., & Ji, J. (2018) · Journal of Immunology Research · doi:10.1155/2018/6827237 · Cited by 39
Lin, Y., Banno, K., Gil, C.-H., Myslinski, J., Hato, T., Shelley, W. C., Gao, H., Xuei, X., Liu, Y., Basile, D. P., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.164781 · Cited by 37
Targeting Interactions between Fibroblasts and Macrophages to Treat Cardiac Fibrosis
Yang, B., Qiao, Y., Dong, Y., & Meng, Q. (2024) · Cells · doi:10.3390/cells13090764 · Cited by 39
Li, R., Hanna, A., Huang, S., Hernández, S. C., Tuleta, I., Kubota, A., Humeres, C. D., Chen, B., Liu, Y., Zheng, D., et al. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.07.010 · Cited by 38
Advances in macrophage metabolic reprogramming in myocardial ischemia-reperfusion
Ao-Di, F., Han-Qing, L., Xi-Zheng, W., Yang, K., Hong-Xin, G., Hai-xia, Z., Guan-Wei, F., & Li-Lan (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111370 · Cited by 38
O’Hern, C., Caywood, S., Aminova, S., Kiselev, A. M., Volmert, B. D., Cao, W., Wang, F., Dionise, M., Sewavi, M.-L., Skoric, M., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.09.011 · Cited by 39
DeBerge, M., Zhang, S., Glinton, K. E., Grigoryeva, L., Hussein, I., Vorovich, E., Ho, K. J., Luo, X., & Thorp, E. B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01428 · Cited by 40
Immune cell diversity contributes to the pathogenesis of myocarditis
Hua, X., & Song, J. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09799-w · Cited by 37
Emerging Roles for G-protein Coupled Receptors in Development and Activation of Macrophages
Wang, X., Iyer, A., Lyons, A. B., Körner, H., & Wei, W. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02031 · Cited by 39
Yolk sac hematopoiesis: does it contribute to the adult hematopoietic system?
Wittamer, V., & Bertrand, J. Y. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03527-6 · Cited by 38
Recent insights into zebrafish cardiac regeneration
Sanz-Morejón, A., & Mercader, N. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.05.020 · Cited by 38
Macrophages in Skeletal Muscle Dystrophies, An Entangled Partner
Théret, M., Saclier, M., Messina, G., & Rossi, F. M. V. (2021) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-210737 · Cited by 41
Kieu, T. Q., Tazawa, K., Kawashima, N., Noda, S., Fujii, M., Nara, K., Hashimoto, K., Han, P., & Okiji, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-08987-3 · Cited by 40
Xu, X., Hua, X., Han, M., Hu, S., & Song, J. (2023) · Basic Research in Cardiology · doi:10.1007/s00395-022-00972-1 · Cited by 38
Fetal origin confers radioresistance on liver macrophages via p21
Soysa, R., Lampert, S., Yuen, S. Y., Douglass, A. N., Li, W., Pfeffer, K., & Crispe, I. N. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.04.015 · Cited by 37
Eigsti, R. L., Zhanbolat, B., Wilson, M. E., & Graff, J. W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.599316 · Cited by 36
Bruce, A. C., Kelly‐Goss, M. R., Heuslein, J. L., Meisner, J. K., Price, R. J., & Peirce, S. M. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303399 · Cited by 36
Dissecting the role of myeloid and mesenchymal fibroblasts in age-dependent cardiac fibrosis
Trial, J., Heredia, C. P., Taffet, G. E., Entman, M. L., & Cieslik, K. A. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0623-4 · Cited by 37
Stem cells and heart disease - Brake or accelerator?
Steinhoff, G., Nesteruk, J., Wolfien, M., Große, J., Ruch, U., Vasudevan, P., & Müller, P. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.007 · Cited by 37
Male Macrophages and Fibroblasts from C57/BL6J Mice Are More Susceptible to Inflammatory Stimuli
Barcena, M. L., Niehues, M. H., Christiansen, C., Estepa, M., Haritonow, N., Sadighi, A. H., Müller‐Werdan, U., Ladilov, Y. V., & Regitz‐Zagrosek, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.758767 · Cited by 36
The origin and repopulation of microglia
Zhang, L., Cao, Y., Zhang, X., Gu, X., Mao, Y. Q., & Peng, B. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22862 · Cited by 42
CCR2 imaging in human ST-segment elevation myocardial infarction
Lavine, K. J., Sultan, D. H., Luehmann, H. P., Detering, L., Zhang, X., Heo, G. S., Zhang, X., Hoelscher, M., Harrison, K., Combadière, C., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00335-6 · Cited by 35
Self-citationMacrophages in Vascular Inflammation: Origins and Functions
Decano, J. L., Mattson, P. C., & Aikawa, M. (2016) · Current Atherosclerosis Reports · doi:10.1007/s11883-016-0585-2 · Cited by 35
Dendritic Cells in the Immune System—History, Lineages, Tissues, Tolerance, and Immunity
Austyn, J. M. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0046-2016 · Cited by 35
Specialized functions of resident macrophages in brain and heart
Nicolás-Ávila, J. Á., Hidalgo, A., & Ballesteros, I. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.6mr0118-041r · Cited by 36
Chen, Y., Zuo, J., Chen, W., Yang, Z., Zhang, Y., Hua, F., Shao, L., Li, J., Chen, Y., Yu, Y., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1392-9 · Cited by 35
Imaging resident and recruited macrophage contribution to Wallerian degeneration
Boissonnas, A., Louboutin, F., Laviron, M., Loyher, P.-L., Reboussin, É., Barthélémy, S., Goazigo, A. R.-L., Lobsiger, C. S., Combadière, B., Parsadaniantz, S. M., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200471 · Cited by 35
Ovchinnikov, A. G., Arefieva, T. I., Potekhina, A. V., Filatova, A. Y., Ageev, F. T., & Boytsov, S. A. (2020) · Acta Naturae · doi:10.32607/actanaturae.10990 · Cited by 36
Gula, G., Rumiński, S., Niderla‐Bielińska, J., Jasińska-Nowacka, A., Kiernozek, E., Jankowska-Steifer, E. A., Flaht‐Zabost, A., & Ratajska, A. (2020) · Histochemistry and Cell Biology · doi:10.1007/s00418-020-01934-1 · Cited by 36
Neo, W. H., Lie‐A‐Ling, M., Fadlullah, M. Z. H., & Lacaud, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.631699 · Cited by 37
Human cardiac fibroblasts produce pro-inflammatory cytokines upon TLRs and RLRs stimulation
Li, Z., Nguyen, T. T., & Valaperti, A. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04157-7 · Cited by 34
An mTORC1‐Dependent Mouse Model for Cardiac Sarcoidosis
Bueno‐Beti, C., Lim, C. X., Protonotarios, A., Szabo, P. L., Westaby, J., Mazic, M., Sheppard, M. N., Behr, E., Hamza, O., Kiss, A., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.030478 · Cited by 34
Laera, N., Malerba, P., Vacanti, G., Nardin, S., Pagnesi, M., & Nardin, M. (2023) · Life · doi:10.3390/life13112128 · Cited by 34
Cardiac macrophage metabolism in health and disease
Kopecky, B. J., & Lavine, K. J. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.10.011 · Cited by 35
Self-citationKim, S. H., White, Z., Gainullina, A., Kang, S., Kim, J., Dominguez, J. R., Choi, Y., Cabrera, I., Plaster, M., Takahama, M., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.004 · Cited by 34
Multifunctional MR monitoring of the healing process after myocardial infarction
Bönner, F., Jacoby, C., Temme, S., Borg, N., Ding, Z., Schrader, J., & Flögel, U. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0430-0 · Cited by 34
Kubota, A., Suto, A., Suzuki, K., Kobayashi, Y., & Nakajima, H. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.04.007 · Cited by 34
Yolk-sac-derived macrophages progressively expand in the mouse kidney with age
Ide, S., Yahara, Y., Kobayashi, Y., Strausser, S. A., Ide, K., Watwe, A., Xu-Vanpala, S., Privratsky, J. R., Crowley, S. D., Shinohara, M. L., et al. (2020) · eLife · doi:10.7554/elife.51756 · Cited by 35
Neuroimmune interactions in cardiovascular diseases
Carnevale, D., & Lembo, G. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa151 · Cited by 34
Mallat, Z. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304794 · Cited by 34
Biology of myocardial recovery in advanced heart failure with long-term mechanical support
Tseliou, E., Lavine, K. J., Wever‐Pinzon, O., Topkara, V. K., Meyns, B. P., Adachi, I., Zimpfer, D., Birks, E. J., Burkhoff, D., & Drakos, S. G. (2022) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2022.07.007 · Cited by 34
Self-citationFrieler, R. A., Nadimpalli, S., Boland, L. K., Xie, A., Kooistra, L. J., Song, J., Chung, Y., Cho, K. W., Lumeng, C. N.-K., Wang, M. M., et al. (2015) · Brain Research · doi:10.1016/j.brainres.2015.07.011 · Cited by 34
Lee, S. H., Kang, B., Kamenyeva, O., Ferreira, T. R., Cho, K., Khillan, J. S., Kabát, J., Kelsall, B. L., & Sacks, D. L. (2023) · Nature Communications · doi:10.1038/s41467-023-43588-2 · Cited by 33
Resilience of dermis resident macrophages to inflammatory challenges
Lee, S. H., & Sacks, D. L. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01313-z · Cited by 34
Non‐coding RNAs in cardiac hypertrophy
Ottaviani, L., & Martins, P. A. D. C. (2017) · The Journal of Physiology · doi:10.1113/jp273129 · Cited by 33
Distinct origins and functions of cardiac orthotopic macrophages
Wang, Z., Lu, Y., Zhao, W., Zhong, J., Lin, X., Sun, Z., He, Y., Miao, C., & Zheng, L. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-019-0769-3 · Cited by 33
Yang, F., Feng, W., Wang, H., Wang, L., Liu, X., Wang, R., Chen, C., Yang, X. Q., Zhang, D., Ren, Q., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0034 · Cited by 34
Komai, K., Ito, M., Nomura, S., Shichino, S., Katoh, M., Yamada, S., Ko, T., Iizuka-Koga, M., Nakatsukasa, H., & Yoshimura, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763647 · Cited by 33
The Roles of Macrophages in Heart Regeneration and Repair After Injury
Gao, Y., Qian, N., Xu, J., & Wang, Y. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.744615 · Cited by 33
Crosstalk between macrophages and innate lymphoid cells (ILCs) in diseases
Yin, G., Zhao, C., & Pei, W. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108937 · Cited by 33
Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction
Simón-Chica, A., Wülfers, E. M., & Kohl, P. K. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00184.2023 · Cited by 34
Chan, M. W. Y., & Viswanathan, S. (2019) · Cytotherapy · doi:10.1016/j.jcyt.2019.02.002 · Cited by 34
Double Roles of Macrophages in Human Neuroimmune Diseases and Their Animal Models
Fan, X., Zhang, H., Cheng, Y., Jiang, X., Zhu, J., & Jin, T. (2016) · Mediators of Inflammation · doi:10.1155/2016/8489251 · Cited by 34
Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling
Yerra, V. G., & Advani, A. (2022) · Biomedicines · doi:10.3390/biomedicines10030661 · Cited by 37
Muscat, S. N., Nichols, A. E. C., Gira, E., & Loiselle, A. E. (2022) · The FASEB Journal · doi:10.1096/fj.202201162r · Cited by 34
Epigenetic Regulation of Macrophage Polarization in Cardiovascular Diseases
Komal, S., Han, S., Cui, L.-G., Zhai, M.-M., Zhou, Y.-J., Wang, P., Shakeel, M., & Zhang, L. (2023) · Pharmaceuticals · doi:10.3390/ph16020141 · Cited by 33
Monocytes differentiate along two alternative pathways during sterile inflammation
Villar, J., Ouaknin, L., Cros, A., & Segura, É. (2023) · EMBO Reports · doi:10.15252/embr.202256308 · Cited by 32
Human Induced Pluripotent Stem Cell–Derived Macrophages for Unraveling Human Macrophage Biology
Zhang, H., & Reilly, M. P. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309195 · Cited by 32
A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart
Ahmed, M. S., Rodell, C. B., Hulsmans, M., Köhler, R. H., Aguirre, A. D., Nahrendorf, M., & Weissleder, R. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00882 · Cited by 32
Jiang, Y., Yu, W., Hu, T., Peng, H., Hu, F., Yuan, Y., Liu, X., Lai, S., Zhou, J., & Dong, X. S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1335333 · Cited by 32
Unravelling monocyte functions: from the guardians of health to the regulators of disease
Mildner, A., Kim, K.-W., & Yona, S. (2024) · Discovery Immunology · doi:10.1093/discim/kyae014 · Cited by 35
The Mononuclear Phagocyte System in Organ Transplantation
Ochando, J., Kwan, W.-H., Ginhoux, F., Hutchinson, J. A., Hashimoto, D., & Collin, M. P. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13627 · Cited by 33
Macrophages and regeneration: Lessons from the heart
Leor, J., Palevski, D., Amit, U., & Konfino, T. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.04.012 · Cited by 33
Prostaglandin E 2 Receptor 2 Modulates Macrophage Activity for Cardiac Repair
Wu, J. M. F., Cheng, Y., Tang, T. W.-H., Shih, C., Chen, J.-H., & Hsieh, P. C. H. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009216 · Cited by 31
Diabetes changes gene expression but not DNA methylation in cardiac cells
Lother, A., Bondareva, O., Saadatmand, A. R., Pollmeier, L., Härdtner, C., Hilgendorf, I., Weichenhan, D., Eckstein, V., Plass, C., Bode, C., et al. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.11.004 · Cited by 32
Cardiac Macrophages and Their Effects on Arrhythmogenesis
Xia, R., Tomsits, P., Loy, S., Zhang, Z., Pauly, V., Schüttler, D., & Clauß, S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.900094 · Cited by 34
Beyond cardiomyocytes: Cellular diversity in the heart's response to exercise
Trager, L. E., Lyons, M., Kuznetsov, A., Sheffield, C., Roh, K., Freeman, R., Rhee, J., Guseh, J. S., Li, H., & Rosenzweig, A. (2022) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.12.011 · Cited by 35
Alveolar macrophages in pulmonary alveolar proteinosis: origin, function, and therapeutic strategies
Huang, X., Cao, M., & Xiao, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1195988 · Cited by 31
Transcriptional Regulation and Macrophage Differentiation
Hume, D. A., SUMMERS, K. M., & Rehli, M. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0024-2015 · Cited by 33
Lugrin, J., Parapanov, R., Milano, G., Cavin, S., Debonneville, A., Krueger, T., & Liaudet, L. (2023) · Scientific Reports · doi:10.1038/s41598-023-30662-4 · Cited by 31
Yokomizo, T., & Suda, T. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.06.007 · Cited by 30
Grune, J., Bajpai, G., Ocak, P. T., Kaufmann, E., Mentkowski, K. I., Pabel, S., Kumowski, N., Pulous, F. E., Tran, K. A., Rohde, D., et al. (2024) · Circulation · doi:10.1161/circulationaha.123.066433 · Cited by 31
Dissecting and Visualizing the Functional Diversity of Cardiac Macrophages
Holt, M., Lin, J., Cicka, M., Wong, A., Epelman, S., & Lavine, K. J. (2024) · Circulation Research · doi:10.1161/circresaha.124.323817 · Cited by 32
Self-citationSingle-cell multiomic analysis identifies macrophage subpopulations in promoting cardiac repair
Fu, M., Jia, S., Xu, L., Li, X., Lv, Y., Zhong, Y., & Ai, S. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175297 · Cited by 30
Neuroendocrine Control of Macrophage Development and Function
Jurberg, A. D., Cotta-de-Almeida, V., Temerozo, J. R., Savino, W., Bou‐Habib, D. C., & Riederer, I. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01440 · Cited by 32
Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis
Lee, J., & Choi, J. (2020) · Immune Network · doi:10.4110/in.2020.20.e22 · Cited by 30
Considering Cause and Effect of Immune Cell Aging on Cardiac Repair after Myocardial Infarction
Tobin, S. W., Alibhai, F. J., Weisel, R. D., & Li, R. (2020) · Cells · doi:10.3390/cells9081894 · Cited by 30
The Role of Macrophages in Nonischemic Heart Failure
Chen, B., & Frangogiannis, N. G. (2018) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.03.001 · Cited by 30
Cardiac fibrogenesis: an immuno-metabolic perspective
Hoque, M. M., Gbadegoye, J. O., Hassan, F. O., Raafat, A., & Lebeche, D. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1336551 · Cited by 30
Roles of macrophages in lupus nephritis
Cheng, Y., Liu, L., Ye, Y., He, Y., Hu, W., Ke, H., Guo, Z., & Shao, G. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1477708 · Cited by 30
Lörchner, H., Hou, Y., Adrian-Segarra, J. M., Kulhei, J., Detzer, J., Günther, S., Gajawada, P., Warnecke, H., Niessen, H. W. M., Pöling, J., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy126 · Cited by 31
Variety matters: Diverse functions of monocyte subtypes in vascular inflammation and atherogenesis
Vlacil, A.-K., Schuett, J., Schieffer, B., & Grote, K. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.12.002 · Cited by 29
Macrophages in the pancreas: Villains by circumstances, not necessarily by actions
Cruz, A. F., Rohban, R., & Esni, F. (2020) · Immunity Inflammation and Disease · doi:10.1002/iid3.345 · Cited by 30
Zhuang, L., Lu, L., Zhang, R., Chen, K., & Yan, X. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.615161 · Cited by 29
Zhang, X., Han, X.-W., Jiang, Y., Wang, Y., He, X.-L., Liu, D., Huang, J., Liu, H.-H., Ye, T., Li, S.-J., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110747 · Cited by 29
The role of macrophages in gastric cancer
Zhang, J., Hu, C., Zhang, R., Xu, J., Zhang, Y., Li, Y., Zhang, S., Pan, S., Cao, M., Qin, J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1282176 · Cited by 30
CD206 + IL-4Rα + Macrophages Are Drivers of Adverse Cardiac Remodeling in Ischemic Cardiomyopathy
Wang, Q., Ismahil, M. A., Zhu, Y., Rokosh, G. D., Hamid, T., Zhou, G., Pogwizd, S. M., & Prabhu, S. D. (2025) · Circulation · doi:10.1161/circulationaha.124.072411 · Cited by 30
Macrophage NOS2 in Tumor Leukocytes
Brüne, B., Courtial, N., Dehne, N., Syed, S. N., & Weigert, A. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6811 · Cited by 28
Lozanoska‐Ochser, B., Benedetti, A., Rizzo, G., Marrocco, V., Maggio, R. D., Fiore, P. F., & Bouché, M. (2017) · The Journal of Pathology · doi:10.1002/path.5016 · Cited by 30
Kordon, A. O., Abdelhamed, H., Ahmed, H. A., Park, J. Y., Karsi, A., & Pinchuk, L. M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02638 · Cited by 28
Monopoiesis in humans and mice
Kawamura, S., & Ohteki, T. (2018) · International Immunology · doi:10.1093/intimm/dxy063 · Cited by 29
Impact of BDNF Val66Met Polymorphism on Myocardial Infarction: Exploring the Macrophage Phenotype
Sandrini, L., Castiglioni, L., Amadio, P., Werba, J. P., Eligini, S., Fiorelli, S., Zarà, M., Castiglioni, S., Bellosta, S., Lee, F. S., et al. (2020) · Cells · doi:10.3390/cells9051084 · Cited by 28
B cells modulate the expression of MHC-II on cardiac CCR2− macrophages
Resende, C. R., Pani, F., & Adamo, L. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.05.003 · Cited by 28
Metadata
- Authors
- Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., Schilling, J. D., Schwendener, R., Sergin, I., Razani, B., Forsberg, E. C., Yokoyama, W. M., Unanue, E. R., Colonna, M., Randolph, G. J., & Mann, D. L.
- Affiliations
- Washington University in St. Louis (US)
- University of California, Santa Cruz (US)
- University of Zurich (CH)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Mann, Douglas L.
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 40
- Issue
- 1
- Pages
- 91-104
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3923301
- OpenAlex
- W2010484682
- Cited by
- 1,494
- References
- 34
- Citations by year
- 2026: 101 · 2025: 113 · 2024: 131 · 2023: 135 · 2022: 140 · 2021: 147 · 2020: 147 · 2019: 117 · 2018: 128 · 2017: 117 · 2016: 80 · 2015: 77 · 2014: 59
- FWCI
- 76.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- HAL (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute (K08HL112826, R01HL111094, T32HL007081)
- National Cancer Institute (T32CA009547)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100917)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- cardiac macrophages, tissue-resident macrophages, monocyte-derived macrophages, embryonic macrophages, yolk sac macrophages, monocyte proliferation, Ly6C+ monocytes, CCR2, cardiac inflammation, efferocytosis, antigen sampling, macrophage homeostasis
- MeSH terms
- Animals, Antigens, Ly, Cell Differentiation, Cells, Cultured, Heart, Homeostasis, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Myocarditis, Myocardium, Phagocytosis, Yolk Sac, Cell Death, Antigen Presentation, Cell Lineage, Myocytes, Cardiac, Fetal Development, Mice, Receptors, CCR2, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
