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Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation
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Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well characterized. Here we identify four populations of cardiac macrophages. At steady state, resident macrophages were primarily maintained through local proliferation. However, after macrophage depletion or during cardiac inflammation, Ly6c(hi) monocytes contributed to all four macrophage populations, whereas resident macrophages also expanded numerically through proliferation. Genetic fate mapping revealed that yolk-sac and fetal monocyte progenitors gave rise to the majority of cardiac macrophages, and the heart was among a minority of organs in which substantial numbers of yolk-sac macrophages persisted in adulthood. CCR2 expression and dependence distinguished cardiac macrophages of adult monocyte versus embryonic origin. Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis. These data highlight the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size.
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“During the course of experimental autoimmune myocarditis (EAM), a significant increase in the number of pro-inflammatory Ly6Chi monocytes and recruited CCR2+ macrophages is observed throughout the cardiac tissue [7,8,10].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
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“Microglia in the developing brain proliferate locally at a low rate and are not normally replaced by other monocytes and macrophages from outside the brain, in contrast to most other tissue-resident macrophages (which also initially originate from yolk sac-derived macrophages, but are partially or fully replaced by fetal liver- or blood monocyte-derived macrophages [Bain et al., 2014, Calderon et”
From A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response (2017) · cites this paper as Epelman et al., 2014
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“Clusters 1 and 5 had high expression of Ccr2, a marker of monocyte-derived macrophages that infiltrate from the circulation17-19 (Fig. 1J and Extended Data Fig. 1C-E).”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [18]
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“Macrophages, which constitute a highly heterogeneous cell population, are key mediators in both maintaining homeostasis and the pathogenesis of myocardial injury [7,8].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
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“In the heart, two main lineages of macrophages with distinct origins and functions are distinguished: tissue-resident macrophages (TRMs; typically CCR2-), predominantly derived from embryonic development, and recruited monocyte-derived macrophages (CCR2+), which infiltrate from the bloodstream in response to injury [7,8,9,10].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
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“Species-specific differences in macrophage ontogeny, cytokine networks, and the composition of the cardiac immune niche may limit direct extrapolation of findings [7].”
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311 · cited 3×
“transplanted monocytes, indicating local macrophage expansion in these niches despite genotoxic injury (Hashimoto et al., 2013).”
BackgroundResultInfluentialSelf-citationNahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972
Self-citationSerbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658
Jenkins, S. J., Rückerl, D., Cook, P. C., Jackson-Jones, L. H., Finkelman, F. D., van Rooijen, N., MacDonald, A. S., & Allen, J. E. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,404
Guilliams, M., de Kleer, I., Henri, S., Post, S., Vanhoutte, L., Prijck, S. D., Deswarte, K., MALISSEN, B., Hammad, H., & Lambrecht, B. N. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131199 · Cited by 1,342
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Pang, J., & Koh, T. J. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad093 · Cited by 21
Salvatori, F., D’Aversa, E., Serino, M. L., Singh, A. V., Secchiero, P., Zauli, G., Tisato, V., & Gemmati, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713268 · Cited by 22
Mangione, M. C., Wen, J., & Cao, D. J. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.10.011 · Cited by 20
Targeting Macrophages in Organ Transplantation: A Step Toward Personalized Medicine
Owen, M. C., & Kopecky, B. J. (2024) · Transplantation · doi:10.1097/tp.0000000000004978 · Cited by 21
Novel tracers to assess myocardial inflammation with radionuclide imaging
Lucinian, Y. A., Martineau, P., Abikhzer, G., Harel, F., & Pelletier‐Galarneau, M. (2024) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2024.102012 · Cited by 21
THE CARDIOSPLENIC AXIS IS ESSENTIAL FOR THE PATHOGENESIS OF ISCHEMIC HEART FAILURE.
Prabhu, S. D. (2018) · Europe PMC (PubMed Central) · Cited by 20
Xu, L., Balzarolo, M., Robinson, E. L., Lorenz, V., Verde, G. D., Joray, L., Mochizuki, M., Kaufmann, B. A., Valstar, G., de Jager, S. C. A., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab349 · Cited by 20
Cardiac Macrophages: How to Mend a Broken Heart
Cohen, H. B., & Mosser, D. M. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.005 · Cited by 20
Mon2 predicts poor outcome in ST ‐elevation myocardial infarction
Shantsila, E., Ghattas, A., Griffiths, H. R., & Lip, G. Y. H. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12847 · Cited by 19
Resende, C. R., Yang, W., Li, W., Kreisel, D., Adamo, L., & Mann, D. L. (2020) · JCI Insight · doi:10.1172/jci.insight.139377 · Cited by 19
Self-citationImmuno-metabolic interfaces in cardiac disease and failure
Bertero, E., Dudek, J., Cochain, C., Delgobo, M., Ramos, G. C., Gerull, B., Higuchi, T., Vaeth, M., Zernecke, A., Frantz, S., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab036 · Cited by 19
Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5
Liu, N. M., Kawahira, N., Nakashima, Y., Nakano, H., Iwase, A., Uchijima, Y., Wang, M., Wu, S. M., Minamisawa, S., Kurihara, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41039-6 · Cited by 19
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Sheng, Y., Wang, Y., Yuan, C., Ye, D., Wu, L., Kang, H., Zhang, X., Cheng, X. J., Li, B., Zhu, D., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.09.012 · Cited by 21
Kanuri, B., Sreejit, G., Biswas, P., Murphy, A. J., & Nagareddy, P. R. (2024) · iScience · doi:10.1016/j.isci.2024.110274 · Cited by 19
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Franklin, R. A., & Li, M. O. (2014) · OncoImmunology · doi:10.4161/21624011.2014.955346 · Cited by 19
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Park, I., Kassiteridi, C., & Monaco, C. G. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.10.005 · Cited by 19
Liu, Y., Lu, H., Zhang, C., Hu, J., & Xu, D. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.01.005 · Cited by 19
Ge, T., Yu, Y., Cui, J., & Cai, L. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00123.2019 · Cited by 19
Aguiar, C., Gawdat, K., Legere, S. A., Marshall, J. S., Hassan, A., Kienesberger, P. C., Pulinilkunnil, T., Castonguay, M., Brunt, K. R., & Légaré, J. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-02162-5 · Cited by 19
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Munshi, N. V. (2017) · Cell · doi:10.1016/j.cell.2017.04.002 · Cited by 19
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Awad, A. B., & Bradford, P. G. (2009) · CRC Press eBooks · doi:10.1201/9781420091311 · Cited by 20
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Wang, Y., Singh, K., Lokman, A. B., Deng, S., Sunitha, B., Lima, J. C., Jr., Beglov, J., Kelly, M., Blease, A., Fung, J. C. K., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adq3516 · Cited by 18
Lin, R., Zhu, Y., Liu, Y.-J., Guo, Z., Wei, J., Li, Y., & Yu, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107936 · Cited by 18
Rovina, D., Castiglioni, E., Niro, F., Mallia, S., Pompilio, G., & Gowran, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21196997 · Cited by 18
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Schlitzer, A., & Schultze, J. L. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.82 · Cited by 20
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Critical roles of macrophages in pressure overload-induced cardiac remodeling
Yang, D., Liu, H., Liu, F.-Y., Tang, N., Guo, Z., Ma, S., An, P., Wang, M., Wu, H., Yang, Z., et al. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-02002-w · Cited by 18
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Wen, Y. H., Zhang, Y., Tang, Y., & Chen, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-28808-7 · Cited by 17
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Simón-Chica, A., Klesen, A., Emig, R., Chan, A., Greiner, J., Grün, D., Lother, A., Hilgendorf, I., Rog‐Zielinska, E. A., Ravens, U., et al. (2024) · The Journal of Physiology · doi:10.1113/jp284805 · Cited by 18
Kundu, S., Gairola, S., Verma, S., Mugale, M. N., & Sahu, B. D. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-024-01056-y · Cited by 17
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Morikawa, S., Iribar, H., Gutiérrez‐Rivera, A., Ezaki, T., & Izeta, A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-16908-4_1 · Cited by 17
Krstevski, C., Cohen, C. D., Dona, M. S. I., & Pinto, A. R. (2020) · Biochemical Society Transactions · doi:10.1042/bst20191255 · Cited by 17
Giryes, S., & McGonagle, D. (2022) · Autoimmunity Reviews · doi:10.1016/j.autrev.2022.103240 · Cited by 17
Pascual‐Gil, S., Abizanda, G., Iglesias, E., Garbayo, E., Prósper, F., & Blanco‐Prieto, M. J. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1531417 · Cited by 17
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Russell‐Hallinan, A., Watson, C. J., & Baugh, J. A. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170029 · Cited by 17
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Liu, Z., Lei, Y., Zuo, J., Zhang, R., Du, H., Hu, H., Zheng, J., Yang, P., & Zhao, D. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116892 · Cited by 16
Intercellular communication after myocardial infarction: Macrophage as the centerpiece
Li, A., Guo, K.-Z., Yu, L.-R., Ge, J., Zhou, W., & Zhang, J.-P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102757 · Cited by 17
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Gan, J., Chen, Y., Tang, L., Dong, H., Gao, X., Huang, Y., Yang, P., Hong, J. H., Bai, Z., Chen, X., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113440 · Cited by 17
Li, Y., Li, P., Wang, W., Zhang, Y., Li, X., Dong, L., & Lin, Q. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1657300 · Cited by 20
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Deren, D. A. V., De, S., Xu, B., Eschenbacher, K. M., Zhang, S., & Capecchi, M. R. (2022) · Development · doi:10.1242/dev.200200 · Cited by 18
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Feng, Y., Yuan, Y., Xia, H., Wang, Z., Che, Y., Hu, Z., Deng, J.-Y., Li, F., Wu, Q., Bian, Z., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04163-x · Cited by 16
Yin, W., Chen, Y., Wang, W., Guo, M., Tong, L., Zhang, M., Wang, Z., & Yuan, H. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31372 · Cited by 16
Yang, Y., Ai, W., Deng, A.-N., Liu, H., Lan, Q., Mazhar, M., Xue, J.-Y., Chen, M., Luo, G., & Liu, M. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113562 · Cited by 17
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Callaghan, N. I., Hadipour‐Lakmehsari, S., Lee, S., Gramolini, A. O., & Simmons, C. A. (2019) · APL Bioengineering · doi:10.1063/1.5055873 · Cited by 19
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Sanwlani, R., & Camelliti, P. (2025) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-025-07828-5 · Cited by 16
Vasamsetti, S. B., Sadaf, S., Uddin, M. A., Shen, J., Johny, E., Mondal, A., Florentin, J., Lei, L., Mannan, A., Rao, K. M. K., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69196-4 · Cited by 16
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Krow‐Lucal, E., & McCune, J. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00314 · Cited by 15
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Toor, I. S., Rückerl, D., Mair, I., Thomson, A. J. W., Rossi, A. G., Newby, D. E., Allen, J. E., & Gray, G. A. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13330 · Cited by 15
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Metadata
- Authors
- Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., Schilling, J. D., Schwendener, R., Sergin, I., Razani, B., Forsberg, E. C., Yokoyama, W. M., Unanue, E. R., Colonna, M., Randolph, G. J., & Mann, D. L.
- Affiliations
- Washington University in St. Louis (US)
- University of California, Santa Cruz (US)
- University of Zurich (CH)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Mann, Douglas L.
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 40
- Issue
- 1
- Pages
- 91-104
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3923301
- OpenAlex
- W2010484682
- Cited by
- 1,494
- References
- 34
- Citations by year
- 2026: 101 · 2025: 113 · 2024: 131 · 2023: 135 · 2022: 140 · 2021: 147 · 2020: 147 · 2019: 117 · 2018: 128 · 2017: 117 · 2016: 80 · 2015: 77 · 2014: 59
- FWCI
- 76.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- HAL (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute (K08HL112826, R01HL111094, T32HL007081)
- National Cancer Institute (T32CA009547)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100917)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- cardiac macrophages, tissue-resident macrophages, monocyte-derived macrophages, embryonic macrophages, yolk sac macrophages, monocyte proliferation, Ly6C+ monocytes, CCR2, cardiac inflammation, efferocytosis, antigen sampling, macrophage homeostasis
- MeSH terms
- Animals, Antigens, Ly, Cell Differentiation, Cells, Cultured, Heart, Homeostasis, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Myocarditis, Myocardium, Phagocytosis, Yolk Sac, Cell Death, Antigen Presentation, Cell Lineage, Myocytes, Cardiac, Fetal Development, Mice, Receptors, CCR2, Transcriptome
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