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Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation
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Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well characterized. Here we identify four populations of cardiac macrophages. At steady state, resident macrophages were primarily maintained through local proliferation. However, after macrophage depletion or during cardiac inflammation, Ly6c(hi) monocytes contributed to all four macrophage populations, whereas resident macrophages also expanded numerically through proliferation. Genetic fate mapping revealed that yolk-sac and fetal monocyte progenitors gave rise to the majority of cardiac macrophages, and the heart was among a minority of organs in which substantial numbers of yolk-sac macrophages persisted in adulthood. CCR2 expression and dependence distinguished cardiac macrophages of adult monocyte versus embryonic origin. Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis. These data highlight the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size.
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“During the course of experimental autoimmune myocarditis (EAM), a significant increase in the number of pro-inflammatory Ly6Chi monocytes and recruited CCR2+ macrophages is observed throughout the cardiac tissue [7,8,10].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
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“Microglia in the developing brain proliferate locally at a low rate and are not normally replaced by other monocytes and macrophages from outside the brain, in contrast to most other tissue-resident macrophages (which also initially originate from yolk sac-derived macrophages, but are partially or fully replaced by fetal liver- or blood monocyte-derived macrophages [Bain et al., 2014, Calderon et”
From A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response (2017) · cites this paper as Epelman et al., 2014
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“Clusters 1 and 5 had high expression of Ccr2, a marker of monocyte-derived macrophages that infiltrate from the circulation17-19 (Fig. 1J and Extended Data Fig. 1C-E).”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [18]
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“Macrophages, which constitute a highly heterogeneous cell population, are key mediators in both maintaining homeostasis and the pathogenesis of myocardial injury [7,8].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
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“In the heart, two main lineages of macrophages with distinct origins and functions are distinguished: tissue-resident macrophages (TRMs; typically CCR2-), predominantly derived from embryonic development, and recruited monocyte-derived macrophages (CCR2+), which infiltrate from the bloodstream in response to injury [7,8,9,10].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
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“Species-specific differences in macrophage ontogeny, cytokine networks, and the composition of the cardiac immune niche may limit direct extrapolation of findings [7].”
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Self-citation
Metadata
- Authors
- Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., Schilling, J. D., Schwendener, R., Sergin, I., Razani, B., Forsberg, E. C., Yokoyama, W. M., Unanue, E. R., Colonna, M., Randolph, G. J., & Mann, D. L.
- Affiliations
- Washington University in St. Louis (US)
- University of California, Santa Cruz (US)
- University of Zurich (CH)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Mann, Douglas L.
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 40
- Issue
- 1
- Pages
- 91-104
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3923301
- OpenAlex
- W2010484682
- Cited by
- 1,494
- References
- 34
- Citations by year
- 2026: 101 · 2025: 113 · 2024: 131 · 2023: 135 · 2022: 140 · 2021: 147 · 2020: 147 · 2019: 117 · 2018: 128 · 2017: 117 · 2016: 80 · 2015: 77 · 2014: 59
- FWCI
- 76.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- HAL (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute (K08HL112826, R01HL111094, T32HL007081)
- National Cancer Institute (T32CA009547)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100917)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- cardiac macrophages, tissue-resident macrophages, monocyte-derived macrophages, embryonic macrophages, yolk sac macrophages, monocyte proliferation, Ly6C+ monocytes, CCR2, cardiac inflammation, efferocytosis, antigen sampling, macrophage homeostasis
- MeSH terms
- Animals, Antigens, Ly, Cell Differentiation, Cells, Cultured, Heart, Homeostasis, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Myocarditis, Myocardium, Phagocytosis, Yolk Sac, Cell Death, Antigen Presentation, Cell Lineage, Myocytes, Cardiac, Fetal Development, Mice, Receptors, CCR2, Transcriptome
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