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Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation
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Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well characterized. Here we identify four populations of cardiac macrophages. At steady state, resident macrophages were primarily maintained through local proliferation. However, after macrophage depletion or during cardiac inflammation, Ly6c(hi) monocytes contributed to all four macrophage populations, whereas resident macrophages also expanded numerically through proliferation. Genetic fate mapping revealed that yolk-sac and fetal monocyte progenitors gave rise to the majority of cardiac macrophages, and the heart was among a minority of organs in which substantial numbers of yolk-sac macrophages persisted in adulthood. CCR2 expression and dependence distinguished cardiac macrophages of adult monocyte versus embryonic origin. Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis. These data highlight the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size.
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“During the course of experimental autoimmune myocarditis (EAM), a significant increase in the number of pro-inflammatory Ly6Chi monocytes and recruited CCR2+ macrophages is observed throughout the cardiac tissue [7,8,10].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
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“Microglia in the developing brain proliferate locally at a low rate and are not normally replaced by other monocytes and macrophages from outside the brain, in contrast to most other tissue-resident macrophages (which also initially originate from yolk sac-derived macrophages, but are partially or fully replaced by fetal liver- or blood monocyte-derived macrophages [Bain et al., 2014, Calderon et”
From A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response (2017) · cites this paper as Epelman et al., 2014
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“Clusters 1 and 5 had high expression of Ccr2, a marker of monocyte-derived macrophages that infiltrate from the circulation17-19 (Fig. 1J and Extended Data Fig. 1C-E).”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [18]
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“Macrophages, which constitute a highly heterogeneous cell population, are key mediators in both maintaining homeostasis and the pathogenesis of myocardial injury [7,8].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
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“In the heart, two main lineages of macrophages with distinct origins and functions are distinguished: tissue-resident macrophages (TRMs; typically CCR2-), predominantly derived from embryonic development, and recruited monocyte-derived macrophages (CCR2+), which infiltrate from the bloodstream in response to injury [7,8,9,10].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
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“Species-specific differences in macrophage ontogeny, cytokine networks, and the composition of the cardiac immune niche may limit direct extrapolation of findings [7].”
From Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. (2026) · cites this paper as [7]
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Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311 · cited 3×
“transplanted monocytes, indicating local macrophage expansion in these niches despite genotoxic injury (Hashimoto et al., 2013).”
BackgroundResultInfluentialSelf-citationNahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972
Self-citationSerbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658
Jenkins, S. J., Rückerl, D., Cook, P. C., Jackson-Jones, L. H., Finkelman, F. D., van Rooijen, N., MacDonald, A. S., & Allen, J. E. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,404
Guilliams, M., de Kleer, I., Henri, S., Post, S., Vanhoutte, L., Prijck, S. D., Deswarte, K., MALISSEN, B., Hammad, H., & Lambrecht, B. N. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131199 · Cited by 1,342
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Bazgir, F., Nau, J., Nakhaei‐Rad, S., Amin, E., Wolf, M. J., Saucerman, J. J., Lorenz, K., & Ahmadian, M. R. (2023) · Cells · doi:10.3390/cells12131780 · Cited by 106
Baer, J. M., Zuo, C., Kang, L., de la Lastra, A. A., Borcherding, N. C., Knolhoff, B. L., Bogner, S. J., Zhu, Y., Yang, L., Poursine‐Laurent, J., et al. (2022) · Nature Immunology · doi:10.1038/s41590-023-01579-x · Cited by 104
Self-citationAge-related changes in tissue macrophages precede cardiac functional impairment
Pinto, A. R., Godwin, J. W., Chandran, A. R., Hersey, L., Ilinykh, A., Debuque, R. J., Wang, L., & Rosenthal, N. A. (2014) · Aging · doi:10.18632/aging.100669 · Cited by 99
Skeletal muscle inflammation and atrophy in heart failure
Lavine, K. J., & Sierra, O. L. (2017) · Heart Failure Reviews · doi:10.1007/s10741-016-9593-0 · Cited by 96
Self-citationWei, X., Zou, S., Xie, Z., Wang, Z., Huang, N., Cen, Z., Hao, Y., Zhang, C., Chen, Z., Zhao, F., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab269 · Cited by 102
Is the Macrophage Phenotype Determinant for Fibrosis Development?
Lis-López, L., Bauset, C., Seco-Cervera, M., & Cosín‐Roger, J. (2021) · Biomedicines · doi:10.3390/biomedicines9121747 · Cited by 104
Occurrences and Functions of Ly6Chi and Ly6Clo Macrophages in Health and Disease
Li, Y., Zhang, Y., Pan, G., Xiang, L., Luo, D., & Shao, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.901672 · Cited by 109
Nahrendorf, M., & Swirski, F. K. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv453 · Cited by 95
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Thomas, D., Choi, S., Alamana, C., Parker, K. K., & Wu, J. C. (2022) · Circulation Research · doi:10.1161/circresaha.122.320305 · Cited by 100
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Chaintreuil, P., Kerreneur, E., Bourgoin, M., Savy, C., Favreau, C., Robert, G., Jacquel, A., & Auberger, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1178337 · Cited by 102
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Draijer, C., & Peters-Golden, M. L. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0681-6 · Cited by 95
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Landau, S., Zhao, Y., Hamidzada, H., Kent, G. M., Okhovatian, S., Lu, R. X. Z., Liu, C., Wagner, K. T., Cheung, K., Shawky, S. A., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.05.011 · Cited by 96
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Raddatz, M. A., Madhur, M. S., & Merryman, W. D. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00100.2019 · Cited by 97
Wang, B., Wang, Z., Ji, J., Gan, W., Zhang, A., Shi, H., Wang, H., Lv, L., Li, Z., Tang, T., et al. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.10.011 · Cited by 93
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Adamo, L., Resende, C. R., Lin, C., Evans, S., Williams, J. W., Dun, H., Li, W., Mpoy, C., Andhey, P. S., Rogers, B. E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134700 · Cited by 93
Self-citationGM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease
Stock, A. T., Hansen, J. A., Sleeman, M. A., McKenzie, B. S., & Wicks, I. P. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151853 · Cited by 92
Ramanathan, N., Tan, E. T., Loh, L. J., Soh, B.-S., & Yap, W. N. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0244-4 · Cited by 92
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Wang, X., & Zhou, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.952249 · Cited by 101
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Liu, Y., & Segura, T. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.609297 · Cited by 92
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Shigeta, A., Huang, V. H., Zuo, J., Besada, R. H., Nakashima, Y., Lu, Y., Ding, Y., Pellegrini, M. A., Kulkarni, R. P., Hsiai, T. K., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.021 · Cited by 93
Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation
Pinto, A. R., Godwin, J. W., & Rosenthal, N. A. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.06.004 · Cited by 94
Telocytes and putative stem cells in ageing human heart
Popescu, L. M., Curici, A., Wang, E., Zhang, H., Hu, S., & Gherghiceanu, M. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12509 · Cited by 89
Yang, Z., Lin, S., Feng, W., Liu, Y., Song, Z., Pan, G., Zhang, Y., Dai, X., Ding, X., Chen, L., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.999179 · Cited by 92
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Chen, B., & Frangogiannis, N. G. (2016) · Microcirculation · doi:10.1111/micc.12305 · Cited by 93
Wang, Y., Sano, S., Oshima, K., Sano, M., Watanabe, Y., Katanasaka, Y., Yura, Y., Jung, C. H., Anzai, A., Świrski, F. K., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.038820 · Cited by 88
Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
Weinberger, T., Esfandyari, D., Messerer, D., Perçin, G. I., Schleifer, C., Thaler, R., Liu, L., Stremmel, C., Schneider, V., Vagnozzi, R. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18287-x · Cited by 93
Yura, Y., Miura-Yura, E., Katanasaka, Y., Min, K.-D., Chavkin, N., Polizio, A. H., Ogawa, H., Horitani, K., Doviak, H., Evans, M. A., et al. (2021) · Circulation Research · doi:10.1161/circresaha.121.319314 · Cited by 87
Intestinal resident macrophages: Multitaskers of the gut
Viola, M. F., & Boeckxstaens, G. E. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13843 · Cited by 93
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Mu, X., Li, Y., & Fan, G. (2020) · Shock · doi:10.1097/shk.0000000000001601 · Cited by 93
Yoshida, Y., Matsunaga, N., Nakao, T., Hamamura, K., Kondo, H., Ide, T., Tsutsui, H., Tsuruta, A., Kurogi, M., Nakaya, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23050-x · Cited by 87
Guo, Y., You, Y., Shang, F., Wang, X., Huang, B., Zhao, B., Lv, D., Yang, S., Xie, M., Kong, L., et al. (2023) · Theranostics · doi:10.7150/thno.84049 · Cited by 88
Linton, P., & Thoman, M. L. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.017 · Cited by 87
Vajen, T., Koenen, R. R., Werner, I., Staudt, M., Projahn, D., Curaj, A., Sönmez, T. T., Simsekyilmaz, S., Schumacher, D., Möllmann, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29026-0 · Cited by 86
Lee, S. H., Chaves, M. M., Kamenyeva, O., Gazzinelli-Guimarães, P. H., Kang, B., Pessenda, G., Passelli, K., Tacchini‐Cottier, F., Kabát, J., Jacobsen, E. A., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz4415 · Cited by 88
Rahman, M. S., & Woollard, K. J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-57613-8_7 · Cited by 87
Role of adipose tissue macrophages in obesity-related disorders
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Weisheit, C. K., Zhang, Y., Faron, A., Köpke, O., Weisheit, G., Steinsträßer, A., Frede, S., Meyer, R., Boehm, O., Hoeft, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112710 · Cited by 87
The origins and non-canonical functions of macrophages in development and regeneration
Théret, M., Mounier, R., & Rossi, F. M. V. (2019) · Development · doi:10.1242/dev.156000 · Cited by 90
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de Couto, G., Jaghatspanyan, E., DeBerge, M., Liu, W., Luther, K. M., Wang, Y., Tang, J., Thorp, E. B., & Marbán, E. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313115 · Cited by 87
Salei, N., Rambichler, S., Salvermoser, J., Papaioannou, N. E., Schuchert, R., Pakalniškytė, D., Li, N., Marschner, J. A., Lichtnekert, J., Stremmel, C., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019040419 · Cited by 89
Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset
Hanlon, M. M., Smith, C. M., Canavan, M., Neto, N. G. B., Song, Q., Lewis, M., O’Rourke, A. M., Tynan, O., Barker, B. E., Gallagher, P., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj1252 · Cited by 86
Developmental control of macrophage function
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Zhang, Z., Tang, J., Cui, X., Qin, B., Zhang, J., Zhang, H., Zhang, H., Liu, G., Wang, W., & Zhang, J. (2021) · Inflammation · doi:10.1007/s10753-021-01467-2 · Cited by 86
Myocardial Inflammation in Heart Failure With Reduced and Preserved Ejection Fraction
Alcaide, P., Kallikourdis, M., Emig, R., & Prabhu, S. D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323659 · Cited by 90
Effects of dyslipidaemia on monocyte production and function in cardiovascular disease
Rahman, M. S., Murphy, A. J., & Woollard, K. J. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.34 · Cited by 86
The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou, X., Chen, G., Bracamonte-Baran, W., Choi, H. S., Diny, N. L., Sung, J., Hughes, D., Won, T., Wood, M. K., Talor, M. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.007 · Cited by 83
The journey from stem cell to macrophage
Pittet, M. J., Nahrendorf, M., & Świrski, F. K. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12393 · Cited by 89
Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury
Adamo, L., Staloch, L. J., Resende, C. R., Matkovich, S. J., Jiang, W., Bajpai, G., Weinheimer, C. J., Kovács, A., Schilling, J. D., Barger, P. M., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120137 · Cited by 85
Self-citationDelineating the roles of neutrophils and macrophages in zebrafish regeneration models
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Fetal liver endothelium regulates the seeding of tissue-resident macrophages
Rantakari, P., Jäppinen, N., Lokka, E., Mokkala, E., Gerke, H., Peuhu, E., Ivaska, J., Elima, K., Auvinen, K., & Salmi, M. (2016) · Nature · doi:10.1038/nature19814 · Cited by 85
Waqas, S. F. H., Noble, A. M., Hoang, A. C., Ampem, G., Popp, M., Strauß, S., Guille, M., & Rőszer, T. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.1a0317-082rr · Cited by 81
Transcriptional control of apoptotic cell clearance by macrophage nuclear receptors
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Self-citationRauch, P. J., Gopakumar, J., Silver, A. J., Nachun, D. C., Ahmad, H., McConkey, M. E., Nakao, T., Bosse, M. M., Rentz, T., Gonzalez, N. V., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00326-7 · Cited by 83
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Rasheed, A., & Rayner, K. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab004 · Cited by 83
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Sager, H. B., Kessler, T., & Schunkert, H. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.11.17 · Cited by 85
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Garbi, N., & Lambrecht, B. N. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1965-3 · Cited by 89
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Monocyte heterogeneity in cardiovascular disease
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Petz, A., Grandoch, M., Gorski, D. J., Abrams, M., Piroth, M., Schneckmann, R., Homann, S., Müller, J., Hartwig, S., Lehr, S., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.313285 · Cited by 77
Carroll, L., Braeutigam, S., Dawes, J. M., Krsnik, Ž., Kostović, I., Coutinho, E., Dewing, J. M., Horton, C. A., Gómez‐Nicola, D., & Menassa, D. A. (2020) · The Neuroscientist · doi:10.1177/1073858420921378 · Cited by 79
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Lee, E., Eo, J.-C., Lee, C., & Yu, J. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0060 · Cited by 83
The Elusive Antifibrotic Macrophage
Adhyatmika, A., Putri, K. S. S., Beljaars, L., & Melgert, B. N. (2015) · Frontiers in Medicine · doi:10.3389/fmed.2015.00081 · Cited by 77
Role of the immune system in cardiac tissue damage and repair following myocardial infarction
Saparov, A., Ogay, V. B., Nurgozhin, T. S., Chen, W. C. W., Mansurov, N., Issabekova, A., & Zhakupova, J. (2017) · Inflammation Research · doi:10.1007/s00011-017-1060-4 · Cited by 79
Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications
Carnevale, D. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00678-w · Cited by 77
Alshoubaki, Y. K., Nayer, B., Lu, Y., Salimova, E., Lau, S., Tan, J. L., Amann‐Zalcenstein, D., Hickey, P. F., del Monte‐Nieto, G., Vasanthakumar, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50806-y · Cited by 77
Single-cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes
Wang, L., Yang, Y., Ma, H., Xie, Y., Xu, J., Near, D., Wang, H., Garbutt, T. A., Li, Y., Liu, J., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab134 · Cited by 73
Development and Function of Arterial and Cardiac Macrophages
Świrski, F. K., Robbins, C. S., & Nahrendorf, M. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.11.004 · Cited by 78
Diabetic Cardiomyopathy: An Immunometabolic Perspective
Mishra, P. K., Ying, W., Nandi, S. S., Bandyopadhyay, G. K., Patel, K. P., & Mahata, S. K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00072 · Cited by 74
Yang, M., Song, L., Wang, L., Yukht, A., Ruther, H., Li, F., Qin, M., Ghiasi, H., Sharifi, B. G., & Shah, P. K. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.061 · Cited by 73
Leach, S. M., Gibbings, S. L., Tewari, A., Atif, S. M., Vestal, B. E., Danhorn, T., Janssen, W. J., Wager, T. D., & Jakubzick, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108337 · Cited by 74
Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure
Li, H., Chen, C., & Wang, D. W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.695047 · Cited by 73
Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation
Knab, K., Chambers, D., & Krönke, G. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.862161 · Cited by 77
Cardiac repair after myocardial infarction: A two-sided role of inflammation-mediated
Li, T., Yan, Z., Fan, Y., Fan, X., Li, A., Qi, Z., & Zhang, J. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1077290 · Cited by 76
Lefer, D. J., & Marbán, E. (2017) · Circulation · doi:10.1161/circulationaha.116.027039 · Cited by 72
Cellular cross-talks in the diseased and aging heart
Wagner, J. U. G., & Dimmeler, S. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.11.152 · Cited by 77
Wang, L., Li, Y., Wang, X., Wang, P., Essandoh, K., Cui, S.-N., Huang, W. C., Mu, X., Liu, Z., Wang, Y., et al. (2020) · Cells · doi:10.3390/cells9010120 · Cited by 71
Notch and TLR signaling coordinate monocyte cell fate and inflammation
Gamrekelashvili, J., Kapanadze, T. G., Sablotny, S., Rațiu, C., Dastagir, K., Lochner, M., Karbach, S. H., Wenzel, P., Sitnow, A., Fleig, S. V., et al. (2020) · eLife · doi:10.7554/elife.57007 · Cited by 73
Cui, Q. N., Stein, L. M., Fortin, S. M., & Hayes, M. R. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15683 · Cited by 72
The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis
Wacleche, V. S., Tremblay, C. L., Routy, J., & Ancuța, P. (2018) · Viruses · doi:10.3390/v10020065 · Cited by 82
The Evolving Roles of Macrophages in Organ Transplantation
Li, J., Li, C., Zhuang, Q., Peng, B., Zhu, Y., Ye, Q., & Ming, Y. (2019) · Journal of Immunology Research · doi:10.1155/2019/5763430 · Cited by 76
Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction
Jung, M., Dodsworth, M., & Thum, T. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0712-z · Cited by 73
Macrophage Activities in Myocardial Infarction and Heart Failure
Duncan, S. E., Gao, S., Michael, S., Coffie, J. W., Linhua, D., Bao, X., Zhang, J., Li, S., Guo, R., Su, J., et al. (2020) · Cardiology Research and Practice · doi:10.1155/2020/4375127 · Cited by 72
Lantz, C. W., Radmanesh, B., Liu, E., Thorp, E. B., & Lin, J. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70353-y · Cited by 69
Macrophage reprogramming for therapy
Bart, V. M. T., Pickering, R. J., Taylor, P. R., & Ipseiz, N. (2020) · Immunology · doi:10.1111/imm.13300 · Cited by 73
Sharma, P. M., Kumar, A., Dey, A. D., Behl, T., & Chadha, S. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118932 · Cited by 70
Johnson, R., & Camelliti, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030866 · Cited by 73
Role of Macrophages in Cardioprotection
Yap, J., Cabrera-Fuentes, H. A., Irei, J. S., Hausenloy, D. J., & Boisvert, W. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102474 · Cited by 72
Walter, W., Alonso-Herranz, L., Trappetti, V., Crespo, I., Ibberson, M. R., Cedenilla, M., Karaszewska, A., Núñez, V., Xénarios, I., Arroyo, A. G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.029 · Cited by 71
Yamashita, T., Zheng, F., Finkelstein, D., Kellard, Z., Carter, R., Rosencrance, C. D., Sugino, K., Easton, J. B., Gawad, C., & Zuo, J. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007552 · Cited by 69
Metadata
- Authors
- Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., Schilling, J. D., Schwendener, R., Sergin, I., Razani, B., Forsberg, E. C., Yokoyama, W. M., Unanue, E. R., Colonna, M., Randolph, G. J., & Mann, D. L.
- Affiliations
- Washington University in St. Louis (US)
- University of California, Santa Cruz (US)
- University of Zurich (CH)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Mann, Douglas L.
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 40
- Issue
- 1
- Pages
- 91-104
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3923301
- OpenAlex
- W2010484682
- Cited by
- 1,494
- References
- 34
- Citations by year
- 2026: 101 · 2025: 113 · 2024: 131 · 2023: 135 · 2022: 140 · 2021: 147 · 2020: 147 · 2019: 117 · 2018: 128 · 2017: 117 · 2016: 80 · 2015: 77 · 2014: 59
- FWCI
- 76.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- HAL (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute (K08HL112826, R01HL111094, T32HL007081)
- National Cancer Institute (T32CA009547)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100917)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- cardiac macrophages, tissue-resident macrophages, monocyte-derived macrophages, embryonic macrophages, yolk sac macrophages, monocyte proliferation, Ly6C+ monocytes, CCR2, cardiac inflammation, efferocytosis, antigen sampling, macrophage homeostasis
- MeSH terms
- Animals, Antigens, Ly, Cell Differentiation, Cells, Cultured, Heart, Homeostasis, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Myocarditis, Myocardium, Phagocytosis, Yolk Sac, Cell Death, Antigen Presentation, Cell Lineage, Myocytes, Cardiac, Fetal Development, Mice, Receptors, CCR2, Transcriptome
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