T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections

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T cell exhaustion

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Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

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Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

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Defining ‘T cell exhaustion’

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Mechanisms of resistance to immune checkpoint inhibitors

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Pan-cancer single-cell landscape of tumor-infiltrating T cells

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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

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Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

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Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy

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CD8+ T cell differentiation and dysfunction in cancer

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Clinical implications of T cell exhaustion for cancer immunotherapy

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NR4A transcription factors limit CAR T cell function in solid tumours

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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

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TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8 + T cell exhaustion

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De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation

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TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision

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Intratumoral activity of the cxcr3 chemokine system is required for the efficacy of anti-PD-1 therapy

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Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

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Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells

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Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

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Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

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Understanding subset diversity in T cell memory

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The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

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CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment

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Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes

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Genomic correlates of response to immune checkpoint blockade

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T Cell Exhaustion

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Combination anti–CTLA-4 plus anti–PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies

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Mechanisms regulating T-cell infiltration and activity in solid tumors

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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

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High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors

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cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

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Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics

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Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity

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Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation

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T cell factor 1: A master regulator of the T cell response in disease

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Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo

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Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity

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Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes

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Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC

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PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation

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Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology

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AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells

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Cellular and molecular mechanisms of CD8(+) T cell differentiation, dysfunction and exhaustion

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Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection

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Tissue-resident memory CD8 + T cells cooperate with CD4 + T cells to drive compartmentalized immunopathology in the CNS

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HCV-Specific T Cell Responses During and After Chronic HCV Infection

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The Role of WNT Signaling in Mature T Cells: T Cell Factor Is Coming Home

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T‐cell memory in tissues

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Wnt3a/β-Catenin Signaling Conditions Differentiation of Partially Exhausted T-effector Cells in Human Cancers

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Pretreatment Innate Cell Populations and CD4 T Cells in Blood Are Associated With Response to Immune Checkpoint Blockade in Melanoma Patients

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Learning from the nexus of autoimmunity and cancer

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Transient “rest” induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

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Quantitative Proteomics Identifies TCF1 as a Negative Regulator of Foxp3 Expression in Conventional T Cells

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