Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

Vieira, Vanessa; Prieto, Miguel A.; Barros, Lillian; Coutinho, João A.P.; Ferreira, Isabel C.F.R.; Ferreira, Olga

doi:10.1016/j.indcrop.2018.02.029

Cited by 147Ionic liquids properties and applicationsPhytochemicals and Antioxidant ActivitiesAgricultural and Biological Research

Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

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Vieira, Vanessa, Prieto, Miguel A., Barros, Lillian, Coutinho, João A.P., Ferreira, Isabel C.F.R., Ferreira, Olga·2018·Industrial Crops and Products

DOI 10.1016/j.indcrop.2018.02.029

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Abstract

The extraction of phenolic compounds from walnut leaves (Juglans regia L.) was optimized using heat-assisted extraction and deep eutectic solvents based on choline chloride and carboxylic acids. A preliminary solvent screening was performed using a selected group of carboxylic acids as hydrogen bond donors, showing that the highest extraction yield of phenolic compounds was obtained using choline chloride mixtures with butyric or phenylpropionic acid at a mole ratio 1:2, with 20% of water (w/w). The extraction conditions (time, temperature and water proportion) were then optimized by an experimental design, assisted by response surface methodology. To evaluate the response, the three most abundant compounds identified by HPLC (neochlorogenic acid, quercetin 3-O-glucoside and quercetin O-pentoside) were quantified. Additionally, the solid/liquid ratio effect at the optimal conditions, in dose-response format, was studied in view of its upscale, not showing any significant decrease until 140 g/L. The results here presented provide valuable information towards the design of a process in a pre-industrial form for the extraction of phenolic compounds from J. regia leaves using deep eutectic solvents.

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Seaweed antioxidant capacity in vitro is attributed to the presence of new antioxidant compounds like carotenoids, certain polysaccharides, and polyphenols, which show scavenger activity and can neutralize reactive oxygen species through their own oxidation.
“Different researches have demonstrated seaweed antioxidant capacity in vitro, attributed to the presence of new antioxidant compounds like carotenoids, certain polysaccharides, and polyphenols, which show scavenger activity, being able to neutralize those reactive oxygen species through their own oxidation, since their affinity to those oxidative compounds is very high [56,68,80,81,82,83,84,85].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [85]

Deep Eutectic Solvents (DESs) and Their Applications
Smith, E. L., Abbott, A. P., & Ryder, K. S. (2014) · Chemical Reviews · doi:10.1021/cr300162p · Cited by 7,378 · see citing works
Response surface methodology (RSM) as a tool for optimization in analytical chemistry
Bezerra, M. A., Santelli, R. E., Oliveira, E. P., Villar, L. S., & Escaleira, L. A. (2008) · Talanta · doi:10.1016/j.talanta.2008.05.019 · Cited by 6,075 · see citing works
Novel solvent properties of choline chloride/urea mixturesElectronic supplementary information (ESI) available: spectroscopic data. See http://www.rsc.org/suppdata/cc/b2/b210714g/
Abbott, A. P., Capper, G., Davies, D. L., Rasheed, R. K., & Tambyrajah, V. (2003) · Chemical Communications · doi:10.1039/b210714g · Cited by 5,738 · see citing works
Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties
Dai, J., & Mumper, R. J. (2010) · Molecules · doi:10.3390/molecules15107313 · Cited by 4,541 · see citing works
Deep eutectic solvents formed between choline chloride and carboxylic acids: Versatile alternatives to ionic liquids
Abbott, A. P., Boothby, D., Capper, G., Davies, D. L., & Rasheed, R. K. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048266j · Cited by 4,340 · see citing works
Box-Behnken design: An alternative for the optimization of analytical methods
Ferreira, S. L. C., Bruns, R. E., Ferreira, H. S., Matos, G. D., David, J. M., Brandão, G. C., da Silva, E. G. P., Portugal, L. A., dos Reis, P. S., Souza, A. S., et al. (2007) · Analytica Chimica Acta · doi:10.1016/j.aca.2007.07.011 · Cited by 3,214 · see citing works
Multi-Factor Experimental Designs for Exploring Response Surfaces
Box, G. E. P., & Hunter, J. S. (1957) · The Annals of Mathematical Statistics · doi:10.1214/aoms/1177707047 · Cited by 1,440 · see citing works
Low-transition-temperature mixtures (LTTMs): A new generation of designer solvents
Francisco, M., van den Bruinhorst, A., & Kroon, M. C. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201207548 · Cited by 1,378 · see citing works
Are Natural Deep Eutectic Solvents the Missing Link in Understanding Cellular Metabolism and Physiology?
Choi, Y. H., van Spronsen, J., Dai, Y., Verberne, M., Hollmann, F., Arends, I. W. C. E., Witkamp, G.-J., & Verpoorte, R. (2011) · Plant Physiology · doi:10.1104/pp.111.178426 · Cited by 1,368 · see citing works
New natural and renewable low transition temperature mixtures (LTTMs): Screening as solvents for lignocellulosic biomass processing
Francisco, M., van den Bruinhorst, A., & Kroon, M. C. (2012) · Green Chemistry · doi:10.1039/c2gc35660k · Cited by 814 · see citing works
Application of Deep Eutectic Solvents (DES) for Phenolic Compounds Extraction: Overview, Challenges, and Opportunities
Ruesgas-Ramón, M., Figueroa-Espinoza, M. C., & Durand, E. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b01054 · Cited by 790 · see citing works
Applications of deep eutectic solvents in biotechnology and bioengineering—Promises and challenges
Mbous, Y. P. V., Hayyan, M., Hayyan, A., Wong, W. F., Hashim, M. A., & Looi, C. Y. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.11.006 · Cited by 553 · see citing works
Nonlinear least-squares data fitting in Excel spreadsheets
Kemmer, G. C., & Keller, S. (2010) · Nature Protocols · doi:10.1038/nprot.2009.182 · Cited by 536 · see citing works
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Nam, M. W., Zhao, J., Lee, M. S., Jeong, J. H., & Lee, J. (2015) · Green Chemistry · doi:10.1039/c4gc01556h · Cited by 467 · see citing works
Ionic liquids and deep eutectic mixtures: Sustainable solvents for extraction processes
Pena‐Pereira, F., & Namieśnik, J. (2014) · ChemSusChem · doi:10.1002/cssc.201301192 · Cited by 432 · see citing works
Response surface analysis and simulation as a tool for bioprocess design and optimization
Kalil, S. J., Maugeri, F., & Rodrigues, M. I. (2000) · Process Biochemistry · doi:10.1016/s0032-9592(99)00101-6 · Cited by 429 · see citing works
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Dai, Y., Rozema, E., Verpoorte, R., & Choi, Y. H. (2016) · Journal of Chromatography A · doi:10.1016/j.chroma.2016.01.037 · Cited by 416 · see citing works
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García, A., Rodríguez-Juan, E., Rodríguez-Gutiérrez, G., Rios, J. J., & Fernández-Bolaños, J. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2015.10.131 · Cited by 409 · see citing works
Clean recovery of antioxidant compounds from plant foods, by-products and algae assisted by ultrasounds processing. Modeling approaches to optimize processing conditions
Roselló-Soto, E., Galanakis, C. M., Brnčić, M., Orlien, V., Trujillo, F. J., Mawson, R., Knoerzer, K., Tiwari, B. K., & Barba, F. J. (2015) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2015.01.002 · Cited by 356 · see citing works
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Kerton, F. M. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559524 · Cited by 340 · see citing works
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Barros, L., Pereira, E., Calhelha, R. C., Dueñas, M., Carvalho, A. M., Santos‐Buelga, C., & Ferreira, I. C. F. R. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.07.019 · Cited by 333 · see citing works
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Carvalho, M. C., Ferreira, P. J., Mendes, V., Silva, R., Pereira, J. A., Jerónimo, C., & Silva, B. M. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.10.043 · Cited by 299 · see citing works
Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine
Erdemoğlu, N., Küpeli̇, E., & Yeşilada, E. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00282-4 · Cited by 254 · see citing works
Optimization of ultrasound-assisted extraction to obtain mycosterols from Agaricus bisporus L. by response surface methodology and comparison with conventional Soxhlet extraction
Heleno, S. A., Diz, P. D. C. C., Prieto, M. A., Barros, L., Rodrigues, A. E., Barreiro, M. F., & Ferreira, I. C. F. R. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.11.108 · Cited by 186 · see citing works
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Deep eutectic solvents as novel extraction media for phenolic compounds from model oil
Gu, T., Zhang, M., Tan, T., Chen, J., Zhan, L., Zhang, Q., & Qiu, H. (2014) · Chemical Communications · doi:10.1039/c4cc04661g · Cited by 142 · see citing works
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Zuo, J., Geng, S., Kong, Y., Ma, P., Fan, Z., Zhang, Y., & Dong, A. (2021) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2021.1946659 · Cited by 78 · see citing works
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Bisht, M., Martins, M., Dias, A. C., Ventura, S. P. M., & Coutinho, J. A. P. (2021) · Green Chemistry · doi:10.1039/d1gc01432c · Cited by 77 · see citing works
Self-citation
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Shang, X., Tan, J., Du, Y., Liu, X., & Zhang, Z. (2018) · Molecules · doi:10.3390/molecules23092110 · Cited by 76 · see citing works
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González‐Laredo, R. F., Sayago‐Monreal, V. I., Moreno‐Jiménez, M. R., Rocha‐Guzmán, N. E., Gallegos‐Infante, J. A., Landeros‐Macías, L. F., & Rosales‐Castro, M. (2023) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16641 · Cited by 73 · see citing works
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Tang, W., Wu, Y., Wang, M., Row, K. H., Qiu, H., & Zhou, J. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117137 · Cited by 71 · see citing works
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Bourais, I., Elmarrkechy, S., Taha, D., Mourabit, Y., Bouyahya, A., Elyadini, M., Machich, O., Hajjaji, S. E., Boury, H. E., Dakka, N., et al. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2094401 · Cited by 69 · see citing works
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Self-citation
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Silva, B., Gonzaga, L. V., Fett, R., & Costa, A. C. O. (2018) · Journal of Chromatography A · doi:10.1016/j.chroma.2018.11.072 · Cited by 37 · see citing works
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Self-citation
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Self-citation
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Self-citation
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Rahman, A. M. A., Bakar, A. R. A., Yee, A. Q., Zainudin, M. A. M., Daud, N. M. A. N., Gunny, A. A. N., Sarip, M. S. M., Peron, R. V., & Khairuddin, N. H. (2025) · RSC Advances · doi:10.1039/d5ra00097a · Cited by 21 · see citing works
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Percevault, L., Delhaye, T., Chaumont, A., Schurhammer, R., Paquin, L., & Rondeau, D. (2021) · Journal of Mass Spectrometry · doi:10.1002/jms.4725 · Cited by 12 · see citing works
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Chagnoleau, J.-B., Ferreira, A. M., Coutinho, J. A. P., Fernàndez, X., Azoulay, S., & Papaïconomou, N. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.133992 · Cited by 12 · see citing works
Self-citation
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Kamiloğlu, A., Kutlu, N., Abca, T. E., & Yılmaz, Ö. (2024) · Food and Bioprocess Technology · doi:10.1007/s11947-024-03714-4 · Cited by 10 · see citing works
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Tailloring deep eutectic solvents for the extraction of valuable compounds from natural sources using choline chloride and carboxylic acids mixtures: optimization of the extraction of phenolic compounds from Juglans regia L. leaves
Vieira, V. A. A., Lage, M. A. P., Barros, L., Ferreira, I. C. F. R., Ferreira, O., & Coutinho, J. P. L. (2017) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Self-citation
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Self-citation
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Bildik, F. (2021) · European Journal of Technic · doi:10.36222/ejt.960412 · Cited by 8 · see citing works

Authors: Vieira, V., Prieto, M. A., Barros, L., Coutinho, J. A. P., Ferreira, I. C. F. R., & Ferreira, O.
Affiliations: Universidade Politécnica de Bragança (PT)
Laboratório Associado CICECO – Instituto de Materiais de Aveiro (PT)
Corresponding author: Ferreira, Isabel C.F.R.
Ferreira, Olga
ORCID: Vieira, Vanessa
Prieto, Miguel A.
Barros, Lillian
Coutinho, João A.P.
Ferreira, Isabel C.F.R.
Ferreira, Olga
Venue: Industrial Crops and Products
Publisher: Elsevier BV
Published: 2018-05
Volume: 115
Pages: 261-271
ISSN: 0926-6690 (ISSN-L)
DOI: 10.1016/j.indcrop.2018.02.029
OpenAlex: W2789362899
Cited by: 147
References: 42
Citations by year: 2026: 8 · 2025: 19 · 2024: 19 · 2023: 20 · 2022: 25 · 2021: 18 · 2020: 19 · 2019: 15 · 2018: 4
FWCI: 3.35
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Industrial Crops and Products (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Investigo Institutional repository of UVigo (Universidade de Vigo) (submittedVersion)
Topics: Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
Keywords: phenolic compounds, Juglans regia, walnut leaves, deep eutectic solvents, choline chloride, carboxylic acids, heat-assisted extraction, solvent screening, extraction optimization, neochlorogenic acid, quercetin glycosides, solid-to-liquid ratio, green extraction

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Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

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