The choreography of neuroinflammation in Huntington's disease

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

Shah, M. A., Datson, N. A., Srinidhi, L., Stanton, V. P., MacDonald, M. E., Allard, M. W., Youngman, S., Am, F., Mott, R., Draths, K., et al. (1993) · Cell · Cited by 3,055 · see citing works

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578 · see citing works

Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558 · see citing works

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., & Amit, I. (2014) · Cell · doi:10.1016/j.cell.2014.11.018 · Cited by 2,167 · see citing works

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works

Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045 · see citing works

Microglial physiology: unique stimuli, specialized responses

Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736 · see citing works

Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

Rhee, S. G., Chae, H. Z., & Kim, K. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.026 · Cited by 1,409 · see citing works

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

Chung, W.-S., Clarke, L. E., Wang, G. X., Stafford, B. K., Sher, A., Chakraborty, C., Joung, J., Foo, L. C., Thompson, A., Chen, C., et al. (2013) · Nature · doi:10.1038/nature12776 · Cited by 1,377 · cited 1× · see citing works

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

Gosselin, D., Link, V. M., Romanoski, C. E., Fonseca, G. J., Eichenfield, D. Z., Spann, N. J., Stender, J. D., Chun, H. B., Garner, H., Geissmann, F., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.023 · Cited by 1,307 · see citing works

Parkinson's disease

Samii, A., Nutt, J. G., & Ransom, B. R. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16305-8 · Cited by 1,305 · see citing works

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

Takahashi, K., Rochford, C. D. P., & Neumann, H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041611 · Cited by 1,124 · see citing works

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.014 · Cited by 1,004 · see citing works

Astrocytes and Brain Injury

Chen, Y., & Swanson, R. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000044631.80210.3c · Cited by 895 · see citing works

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

Browne, S. E., Bowling, A. C., Macgarvey, U., Baik, M. J., Berger, S. C., Muquit, M. M. K., Bird, E. D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410514 · Cited by 885 · see citing works

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

Saijo, K., Winner, B., Carson, C. T., Collier, J. G., Boyer, L., Rosenfeld, M. G., Gage, F. H., & Glass, C. K. (2009) · Cell · doi:10.1016/j.cell.2009.01.038 · Cited by 859 · see citing works

Microglia: Scapegoat, saboteur, or something else?

Aguzzi, A., Barres, B. A., & Bennett, M. L. (2013) · Science · doi:10.1126/science.1227901 · Cited by 836 · see citing works

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Kleinberger, G., Yamanishi, Y., Suárez-Calvet, M., Czirr, E., Lohmann, E., Cuyvers, E., Struyfs, H., Pettkus, N., Wenninger-Weinzierl, A., Mazaheri, F., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009093 · Cited by 798 · see citing works

Free radicals and aging

Barja, G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.005 · Cited by 653 · see citing works

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

Björkqvist, M., Wild, E. J., Thiele, J., Silvestroni, A., André, R., Lahiri, N., Raibon, E., Lee, R. V., Benn, C., Soulet, D., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080178 · Cited by 646 · see citing works

Microglial dysfunction in brain aging and Alzheimer's disease

Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618 · see citing works

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

Tong, X., Ao, Y., Faas, G. C., Nwaobi, S. E., Xu, J., Haustein, M. D., Anderson, M. A., Mody, I., Olsen, M. L., Sofroniew, M. V., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3691 · Cited by 592 · see citing works

Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain

Sapp, E., Kegel, K. B., D, N. A. M., Hashikawa, T., Uchiyama, Y., Tohyama, K., Bhide, P. G., Vonsattel, J., & DiFiglia, M. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.2.161 · Cited by 537 · see citing works

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

Curtis, A. R. J., Fey, C., Morris, C. M., Bindoff, L. A., Ince, P. G., Chinnery, P. F., Coulthard, A., Jackson, M. J., Jackson, A. P., McHale, D. P., et al. (2001) · Nature Genetics · doi:10.1038/ng571 · Cited by 537 · see citing works

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

Wyttenbach, A. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.9.1137 · Cited by 494 · see citing works

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

Shin, J., Fang, Z.-H., Yu, Z.-X., Wang, C.-E., Li, S., & Li, X. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200508072 · Cited by 475 · see citing works

Microglial activation in presymptomatic Huntington's disease gene carriers

Tai, Y. F., Pavese, N., Gerhard, A., Tabrizi, S. J., Barker, R. A., Brooks, D. J., & Piccini, P. (2007) · Brain · doi:10.1093/brain/awm044 · Cited by 440 · see citing works

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

Shirendeb, U. P., Reddy, A. P., Mańczak, M., Calkins, M. J., Mao, P., Tagle, D. A., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr024 · Cited by 410 · see citing works

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

Palazuelos, J., Aguado, T., Pazos, M. R., Julien, B., Carrasco, C., Resel, E., Sagredo, O., Benito, C., Romero, J., Azcoitia, I., et al. (2009) · Brain · doi:10.1093/brain/awp239 · Cited by 382 · see citing works

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

Yang, W. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.23.2905 · Cited by 371 · see citing works

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

Chu, Y., Jin, X., Parada, I., Pesic, A., Stevens, B., Barres, B., & Prince, D. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913449107 · Cited by 364 · see citing works

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

Bradford, J. W., Shin, J., Redd, M. A., Wang, C.-E., Li, X.-J., & Li, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911503106 · Cited by 362 · see citing works

Beyond the brain: widespread pathology in Huntington's disease

van der Burg, J. M. M., Björkqvist, M., & Brundin, P. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70178-4 · Cited by 362 · see citing works

The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer’s and Huntington’s diseases

Ben Haim, L., Ceyzériat, K., Carrillo-de Sauvage, M. A., Aubry, F., Auregan, G., Guillermier, M., Ruiz, M., Petit, F., Houitte, D., Faivre, E., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3516-14.2015 · Cited by 335 · see citing works

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

Crotti, A., Benner, C., Kerman, B. E., Gosselin, D., Lagier-Tourenne, C., Zuccato, C., Cattaneo, E., Gage, F. H., Cleveland, D. W., & Glass, C. K. (2014) · Nature Neuroscience · doi:10.1038/nn.3668 · Cited by 333 · see citing works

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

Giorgini, F., Guidetti, P., Nguyen, Q., Bennett, S. C., & Muchowski, P. J. (2005) · Nature Genetics · doi:10.1038/ng1542 · Cited by 325 · see citing works

Impaired Glutamate Uptake in the R6 Huntington's Disease Transgenic Mice

Liévens, J.-C., Woodman, B., Mahal, A., Spasić-Bošković, O., Samuel, D., Goff, L. K., & Bates, G. P. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0430 · Cited by 315 · see citing works

Increased Complement Biosynthesis By Microglia and Complement Activation on Neurons in Huntington's Disease

Singhrao, S. K., Neal, J., Morgan, B. P., & Gasque, P. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7170 · Cited by 313 · see citing works

Kynurenine Pathway Measurements in Huntington's Disease Striatum: Evidence for Reduced Formation of Kynurenic Acid

Beal, M. F., Matson, W. R., Swartz, K. J., Gamache, P. H., & Bird, E. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb03143.x · Cited by 312 · see citing works

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

Sorolla, M. A., Reverter‐Branchat, G., Tamarit, J., Ferrer, I., Ros, J., & Cabiscol, E. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.014 · Cited by 300 · see citing works

Altered white matter microstructure in the corpus callosum in Huntington's disease: Implications for cortical “disconnection”

Rosas, H. D., Lee, S. Y., Bender, A. C., Zaleta, A. K., Vangel, M. G., Yu, P., Fischl, B. R., Pappu, V., Onorato, C., Cha, J.-H. J., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.015 · Cited by 279 · see citing works

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

Simmons, D. A., Casale, M., Alcon, B., Pham, N., Narayan, N., & LYNCH, G. S. (2007) · Glia · doi:10.1002/glia.20526 · Cited by 277 · see citing works

Microglia in ischemic brain injury

Weinstein, J. R., Koerner, I. P., & Möller, T. (2009) · Future Neurology · doi:10.2217/fnl.10.1 · Cited by 268 · see citing works

Regional Mitochondrial Respiratory Activity in Huntington's Disease Brain

Brennan, W. A., Bird, E. D., & Aprille, J. R. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07192.x · Cited by 265 · see citing works

Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation

Hensley, K. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1414 · Cited by 250 · see citing works

The genetics and neuropathology of Alzheimer’s disease

Schellenberg, G. D., & Montine, T. J. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0996-2 · Cited by 242 · see citing works

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

Hsiao, H., Chen, Y., Chen, H., Tu, P., & Chern, Y. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt036 · Cited by 241 · see citing works

Expression of The Kynurenine Pathway Enzymes in Human Microglia and Macrophages

Guillemin, G. J., Smith, D. G., Smythe, G. A., Armati, P. J., & Brew, G. J. (2003) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4615-0135-0_12 · Cited by 229 · see citing works

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

Hilditch-Maguire, P. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.19.2789 · Cited by 226 · see citing works

Proteomic Profiling of Plasma in Huntington's Disease Reveals Neuroinflammatory Activation and Biomarker Candidates

Dalrymple, A., Wild, E. J., Joubert, R., Sathasivam, K., Björkqvist, M., Petersén, Å., Jackson, G. S., Isaacs, J. D., Kristiansen, M., Bates, G. P., et al. (2007) · Journal of Proteome Research · doi:10.1021/pr0700753 · Cited by 223 · see citing works

Distinct neuroinflammatory profile in post-mortem human Huntington's disease

Silvestroni, A., Faull, R. L. M., Strand, A. D., & Möller, T. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832e34ee · Cited by 204 · see citing works

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease

Wang, N., Gray, M., Lu, X., Cantle, J. P., Holley, S. M., Greiner, E. R., Gu, X., Shirasaki, D., Cepeda, C., Li, Y., et al. (2014) · Nature Medicine · doi:10.1038/nm.3514 · Cited by 201 · see citing works

Cannabinoid CB₂receptor agonists protect the striatum against malonate toxicity: Relevance for Huntington's disease

Sagredo, O., González, S., Aroyo, I., Pazos, M. R., Benito, C., Lastres‐Becker, I., Romero, J. P., Tolón, R. M., Mechoulam, R., Brouillet, E., et al. (2009) · Glia · doi:10.1002/glia.20838 · Cited by 201 · see citing works

Clinical correlates of levodopa-induced dopamine release in Parkinson disease

Pavese, N., Evans, A., Tai, Y. F., Hotton, G. R., Brooks, D., Lees, A., & Piccini, P. (2006) · Neurology · doi:10.1212/01.wnl.0000242888.30755.5d · Cited by 201 · see citing works

Mutant huntingtin is present in neuronal grafts in huntington disease patients

Cicchetti, F., Lacroix, S., Cisbani, G., Vallières, N., Saint‐Pierre, M., St‐Amour, I., Tolouei, R., Skepper, J. N., Hauser, R. A., Mantovani, D., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24174 · Cited by 193 · see citing works

HTT-lowering reverses Huntington’s disease immune dysfunction caused by NFκB pathway dysregulation

Träger, U., André, R., Lahiri, N., Magnusson, A., Weiss, A., Grueninger, S., McKinnon, C., Sirinathsinghji, E. C., Kahlon, S., Pfister, E. L., et al. (2014) · Brain · doi:10.1093/brain/awt355 · Cited by 191 · see citing works

Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

Pecho‐Vrieseling, E., Rieker, C., Fuchs, S., Bleckmann, D., Esposito, M. S., Botta, P., Goldstein, C., Bernhard, M., Galimberti, I., Müller, M. M., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3761 · Cited by 185 · see citing works

Dendritic spine pathology and deficits in experience‐dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice

Spires‐Jones, T. L., Grote, H., Garry, S., Cordery, P. M., van Dellen, A., Blakemore, C. B., & Hannan, A. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03374.x · Cited by 184 · see citing works

Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease

Schwarcz, R. M., Guidetti, P., Sathyasaikumar, K. V., & Muchowski, P. J. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.005 · Cited by 175 · see citing works

Plasma inflammatory biomarkers for Huntington’s disease patients and mouse model

Chang, K., Wu, Y., Chen, Y., & Chen, C. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.011 · Cited by 151 · see citing works

Mutant huntingtin impairs immune cell migration in Huntington disease

Kwan, W., Träger, U., Davalos, D., Chou, A., Bouchard, J. J., André, R., Miller, A., Weiss, A., Giorgini, F., Cheah, C. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64484 · Cited by 145 · see citing works

Engulfing Astrocytes Protect Neurons from Contact-Induced Apoptosis following Injury

Lööv, C., Hillered, L., Ebendal, T., & Erlandsson, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033090 · Cited by 144 · see citing works

Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression

Weiss, A., Träger, U., Wild, E. J., Grueninger, S., Farmer, R. E., Landles, C., Scahill, R. I., Lahiri, N., Salman, H., Macdonald, D., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64565 · Cited by 143 · see citing works

Glutathione peroxidase activity is neuroprotective in models of Huntington's disease

Mason, R. P., Casu, M., Butler, N. J., Breda, C., Campesan, S., Clapp, J., Green, E. W., Dhulkhed, D., Kyriacou, C. P., & Giorgini, F. (2013) · Nature Genetics · doi:10.1038/ng.2732 · Cited by 138 · see citing works

Imaging microglial activation in Huntington's disease

Tai, Y., Pavese, N., Gerhard, A., Tabrizi, S. J., Barker, R. A., Brooks, D. J., & Piccini, P. P. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.10.029 · Cited by 137 · see citing works

Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood

Runne, H., Kuhn, A., Wild, E. J., Pratyaksha, W., Kristiansen, M., Isaacs, J. D., Régulier, E., Delorenzi, M., Tabrizi, S. J., & Luthi‐Carter, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703652104 · Cited by 137 · see citing works

Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease

Hsiao, H., Chiu, F., Chen, C., Wu, Y., Chen, H., Chen, Y., Kuo, H., & Chern, Y. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu151 · Cited by 135 · see citing works

Cannabinoid Receptor 2 Signaling in Peripheral Immune Cells Modulates Disease Onset and Severity in Mouse Models of Huntington's Disease

Bouchard, J. J., Truong, J. K., Bouchard, K. E., Dunkelberger, D. L., Desrayaud, S., Moussaoui, S. M., Tabrizi, S. J., Stella, N., & Muchowski, P. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4008-12.2012 · Cited by 133 · see citing works

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

Franciosi, S., Ryu, J. K., Shim, Y. A., Hill, A. M., Connolly, C., Hayden, M. R., McLarnon, J. G., & Leavitt, B. R. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.09.003 · Cited by 124 · see citing works

Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease

Gu, X., André, V. M., Cepeda, C., Li, S., Li, X., Levine, M. S., & Yang, X. W. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-8 · Cited by 124 · see citing works

Abnormal peripheral chemokine profile in Huntington’s disease

Wild, E. J., Magnusson, A., Lahiri, N., Krus, U., Orth, M., Tabrizi, S. J., & Björkqvist, M. (2011) · PLoS Currents · doi:10.1371/currents.rrn1231 · Cited by 119 · see citing works

HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

Jia, H., Morris, C. D., Williams, R. M., Loring, J. F., & Thomas, E. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415195112 · Cited by 116 · see citing works

Expanded-Polyglutamine Huntingtin Protein Suppresses the Secretion and Production of a Chemokine (CCL5/RANTES) by Astrocytes

Chou, S., Weng, J.-Y., Lai, H., Liao, F., Sun, S. H., Tu, P., Dickson, D. W., & Chern, Y. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0116-08.2008 · Cited by 115 · see citing works

Striatal Potassium Channel Dysfunction in Huntington's Disease Transgenic Mice

Ariano, M. A., Cepeda, C., Calvert, C. R., Flores‐Hernández, J., Hernández, E., Klapstein, G. J., Chandler, S. H., D, N. A. M., DiFiglia, M., & Levine, M. S. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00791.2004 · Cited by 113 · see citing works

In Vitro and in Vivo Aggregation of a Fragment of Huntingtin Protein Directly Causes Free Radical Production

Hands, S. L., Sajjad, M. U., Newton, M. J., & Wyttenbach, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.307587 · Cited by 103 · see citing works

Histone Deacetylase Inhibition Modulates Kynurenine Pathway Activation in Yeast, Microglia, and Mice Expressing a Mutant Huntingtin Fragment

Giorgini, F., Möller, T., Kwan, W., Zwilling, D., Wacker, J. L., Hong, S. Y., Tsai, L. L., Cheah, C. S., Schwarcz, R. M., Guidetti, P., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708192200 · Cited by 97 · see citing works

Joint-encoding of motion and depth by visual cortical neurons: neural basis of the Pulfrich effect

Anzai, A., Ohzawa, I., & Freeman, R. D. (2001) · Nature Neuroscience · doi:10.1038/87462 · Cited by 95 · see citing works

Huntington’s Disease

Zuccato, C., & Cattaneo, E. F. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-45106-5_14 · Cited by 92 · see citing works

Corticostriatal dysfunction and glutamate transporter 1 (GLT1) in Huntington’s disease: Interactions between neurons and astrocytes

Estrada‐Sánchez, A. M., & Rebec, G. V. (2012) · Basal Ganglia · doi:10.1016/j.baga.2012.04.029 · Cited by 92 · see citing works

Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington’s Disease: Role of CB1 and CB2 Receptors

Valdeolivas, S., Satta, V., Pertwee, R. G., Fernández‐Ruíz, J., & Sagredo, O. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn200114w · Cited by 92 · see citing works

Oxidative stress and inflammation biomarkers in the blood of patients with Huntington’s disease

Sánchez‐López, F., Tasset, I., Agüera, E., Feijóo, M., Fernández‐Bolaños, R., Sánchez, F. M., Ruiz, M. C., Cruz, A. H., Gascón, F., & Túnez, I. (2012) · Neurological Research · doi:10.1179/1743132812y.0000000073 · Cited by 87 · see citing works

Bone Marrow Transplantation Confers Modest Benefits in Mouse Models of Huntington's Disease

Kwan, W., Magnusson, A., Chou, A., Adame, A., Carson, M. J., Kohsaka, S., Masliah, E., Möller, T., Ransohoff, R., Tabrizi, S. J., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4846-11.2012 · Cited by 75 · see citing works

Huntingtin inclusion bodies are iron‐dependent centers of oxidative events

Firdaus, W. J. J., Wyttenbach, A., Giuliano, P., Kretz‐Remy, C., Currie, R. W., & Arrigo, A. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05537.x · Cited by 71 · see citing works

Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein

Fox, J. H., Connor, T., Stiles, M. A., Kama, J. A., Lü, Z., Dorsey, K., Liebermann, G., Sapp, E., Cherny, R. A., Banks, M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199448 · Cited by 68 · see citing works

Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models

Träger, U., André, R., Magnusson, A., Miller, J. R. C., Connolly, C., Weiss, A., Grueninger, S., Silajdžić, E., Smith, D. L., Leavitt, B. R., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.10.012 · Cited by 63 · see citing works

The role of immunity in Huntington's disease

Soulet, D., & Cicchetti, F. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.28 · Cited by 62 · see citing works

Antigliadin antibodies in Huntington’s disease

Bushara, K. O., NANCE, M. A., & Gomez, C. M. (2004) · Neurology · doi:10.1212/wnl.62.1.132 · Cited by 60 · see citing works

Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington's disease brain

Dowie, M. J., Grimsey, N. L., Hoffman, T., Faull, R. L. M., & Glass, M. (2014) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2014.06.004 · Cited by 44 · see citing works

Investigation into the Role of Macrophages in the Formation and Degradation of β2-Microglobulin Amyloid Fibrils

Morten, I. J., Gosal, W. S., Radford, S. E., & Hewitt, E. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705004200 · Cited by 32 · see citing works

Changes of peripheral TGF-β1 depend on monocytes-derived macrophages in Huntington disease

Pardo, A. D., Alberti, S., Maglione, V., Amico, E., Cortes, E. P., Elifani, F., Battaglia, G., Busceti, C., Nicoletti, F., Vonsattel, J., et al. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-55 · Cited by 29 · see citing works

Genetic Deficiency of Complement Component 3 does not Alter Disease Progression in a Mouse Model of Huntington's Disease

Larkin, P. B., & Muchowski, P. J. (2012) · Journal of Huntington s Disease · doi:10.3233/jhd-2012-120021 · Cited by 26 · see citing works

Increase of angiotensin II type 1 receptor auto-antibodies in Huntington’s disease

Lee, D.-H., Heidecke, H., Schröder, A., Paul, F., Wachter, R., Hoffmann, R., Ellrichmann, G., Dragun, D., Waschbisch, A., Stegbauer, J., et al. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-49 · Cited by 26 · see citing works

JAK/STAT Signalling in Huntington’s Disease Immune Cells

Träger, U., Magnusson, A., Lahiri, N., Wild, E. J., North, J. M., Lowdell, M. W., & Björkqvist, M. (2013) · PLoS Currents · doi:10.1371/currents.hd.5791c897b5c3bebeed93b1d1da0c0648 · Cited by 22 · see citing works

The Role of Iron Imaging in Huntington’s Disease

van den Bogaard, S. J. A., Dumas, E. M., & Roos, R. A. C. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-410502-7.00011-9 · Cited by 18 · see citing works

AAV-Dominant Negative Tumor Necrosis Factor (DN-TNF) Gene Transfer to the Striatum Does Not Rescue Medium Spiny Neurons in the YAC128 Mouse Model of Huntington's Disease

Alto, L. T., Chen, X., Ruhn, K. A., Treviño, I., & Tansey, M. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096544 · Cited by 10 · see citing works

Increased activity of surviving locus ceruleus neurons in Alzheimer's disease

Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1

Inflammation as a central mechanism in Alzheimer's disease

Kinney, J. W., Bemiller, S. M., Murtishaw, A. S., Leisgang, A. M., Salazar, A. M., & Lamb, B. T. (2018) · Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions · doi:10.1016/j.trci.2018.06.014 · Cited by 2,253 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

Maiorino, M., Conrad, M., & Ursini, F. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7115 · Cited by 709 · see citing works

Targeting Huntingtin Expression in Patients with Huntington’s Disease

Tabrizi, S. J., Leavitt, B. R., Landwehrmeyer, G. B., Wild, E. J., Saft, C., Barker, R. A., Blair, N. F., Craufurd, D., Priller, J., Rickards, H., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1900907 · Cited by 708 · see citing works

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

Joshi, A. U., Minhas, P. S., Liddelow, S. A., Haileselassie, B., Andreasson, K. I., Dorn, G. W., & Mochly-Rosen, D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0486-0 · Cited by 571 · see citing works

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

Plaza-Zabala, A., Sierra-Torre, V., & Sierra, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030598 · Cited by 323 · see citing works

Innate Immunity and Neurodegeneration

Labzin, L. I., Heneka, M. T., & Latz, E. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-050715-104343 · Cited by 319 · see citing works

Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss

Matheis, F., Muller, P. A., Graves, C. L., Gabanyi, I., Kerner, Z. J., Costa-Borges, D., Ahrends, T., Rosenstiel, P. C., & Mucida, D. (2020) · Cell · doi:10.1016/j.cell.2019.12.002 · Cited by 303 · see citing works

Immunometabolism in the Brain: How Metabolism Shapes Microglial Function

Bernier, L., York, E. M., & MacVicar, B. A. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.08.008 · Cited by 295 · see citing works

The Role of Microglia and Astrocytes in Huntington’s Disease

Palpagama, T. H., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00258 · Cited by 241 · see citing works

Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches

Hussain, R., Zubair, H., Sarah, P., & Shahab, M. (2018) · Brain Sciences · doi:10.3390/brainsci8090177 · Cited by 233 · see citing works

Neurodegenerative Disease and the NLRP3 Inflammasome

Holbrook, J. A., Jarosz-Griffiths, H., Caseley, E. A., Reyna, S. J. L., Poulter, J. A., Williams‐Gray, C. H., Peckham, D. G., & McDermott, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.643254 · Cited by 197 · see citing works

How inflammation affects the brain in depression: a review of functional and structural MRI studies

Han, K.-M., & Ham, B.-J. (2021) · Journal of Clinical Neurology · doi:10.3988/jcn.2021.17.4.503 · Cited by 187 · see citing works

IDO and Kynurenine Metabolites in Peripheral and CNS Disorders

Huang, Y.-S., Ogbechi, J., Clanchy, F. I., Williams, R. O., & Stone, T. W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00388 · Cited by 187 · see citing works

Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease

Wilton, D. K., Mastro, K. J., Heller, M. D., Gergits, F. W., Willing, C. R., Fahey, J. B., Frouin, A., Daggett, A., Gu, X., Kim, Y. A., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02566-3 · Cited by 179 · see citing works

From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington’s Disease Research

Jiang, A., Handley, R. R., Lehnert, K., & Snell, R. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241613021 · Cited by 168 · see citing works

Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease

Crapser, J. D., Ochaba, J., Soni, N., Reidling, J. C., Thompson, L. M., & Green, K. N. (2020) · Brain · doi:10.1093/brain/awz363 · Cited by 157 · see citing works

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

Sharma, M., Rajendrarao, S., Shahani, N., Ramírez-Jarquín, U. N., & Subramaniam, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002144117 · Cited by 155 · see citing works

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

Rustenhoven, J., Smith, A. M., Smyth, L. C., Jansson, D., Scotter, E. L., Swanson, M. E. V., Aalderink, M., Coppieters, N., Narayan, P., Handley, R., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0277-1 · Cited by 155 · see citing works

Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation

Chu, E., Mychasiuk, R., Hibbs, M. L., & Semple, B. D. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02325-6 · Cited by 152 · see citing works

Microglial activation in the pathogenesis of Huntington's disease

Yang, H.-M., Yang, S., Huang, S.-S., Tang, B.-S., & Guo, J.-F. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00193 · Cited by 151 · see citing works

The fate of the brain cholinergic neurons in neurodegenerative diseases

Pepeu, G., & Giovannini, M. G. (2017) · Brain Research · doi:10.1016/j.brainres.2017.06.023 · Cited by 144 · see citing works

The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases

Chiurchiù, V., van der Stelt, M., Centonze, D., & Maccarrone, M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.007 · Cited by 140 · see citing works

Natural Withanolides in the Treatment of Chronic Diseases

White, P. T., Subramanian, C., Motiwala, H. F., & Cohen, M. S. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-41334-1_14 · Cited by 139 · see citing works

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

Festa, B. P., Siddiqi, F. H., Jimenez-Sanchez, M., Won, H., Rob, M., Djajadikerta, A., Stamatakou, E., & Rubinsztein, D. C. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.006 · Cited by 129 · see citing works

Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation

Kasatkina, L. A., Rittchen, S., & Sturm, E. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115431 · Cited by 129 · see citing works

Significance of the cGAS-STING Pathway in Health and Disease

Zhou, J., Zhuang, Z., Li, J., & Feng, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713316 · Cited by 121 · see citing works

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

Riguet, N., Mahul-Mellier, A.-L., Maharjan, N., Burtscher, J., Croisier, M., Knott, G., Hastings, J., Patin, A., Reiterer, V., Farhan, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26684-z · Cited by 118 · see citing works

Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective

Harder, J. M., Braine, C., Williams, P. A., Zhu, X., MacNicoll, K. H., Sousa, G. L., Buchanan, R. A., Smith, R. S., Libby, R. T., Howell, G. R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608769114 · Cited by 114 · see citing works

Diagnostic function of the neuroinflammatory biomarker YKL-40 in Alzheimer’s disease and other neurodegenerative diseases

Baldacci, F., Lista, S., Cavedo, E., Bonuccelli, U., & Hampel, H. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1304217 · Cited by 113 · see citing works

Mast Cells in Neurodegenerative Disease

Jones, M. K., Nair, A. A., & Gupta, M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00171 · Cited by 109 · see citing works

Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases

Novellino, F., Saccà, V., Donato, A., Zaffino, P., Spadea, M. F., Vismara, M. F. M., Arcidiacono, B., Malara, N., Presta, I., & Donato, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031115 · Cited by 104 · see citing works

Insights into GABA A ergic system alteration in Huntington's disease

Hsu, Y., Chang, Y., & Chern, Y. (2018) · Open Biology · doi:10.1098/rsob.180165 · Cited by 97 · see citing works

Neuroimmunology of Huntington’s Disease: Revisiting Evidence from Human Studies

Rocha, N. P., Ribeiro, F. M., Furr-Stimming, E. E., & Teixeira, A. L. (2016) · Mediators of Inflammation · doi:10.1155/2016/8653132 · Cited by 95 · see citing works

Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model: Astrocytic Nrf2 Hyperactivation Prevents the Formation of Demyelinating Lesions

Draheim, T., Liessem, A., Scheld, M., Wilms, F., Weißflog, M., Denecke, B., Kensler, T. W., Zendedel, A., Beyer, C., Kipp, M., et al. (2016) · Glia · doi:10.1002/glia.23058 · Cited by 95 · see citing works

Mitochondrial Dysfunctions: A Red Thread across Neurodegenerative Diseases

Stanga, S., Caretto, A., Boido, M., & Vercelli, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103719 · Cited by 90 · see citing works

Role of TRPM2 in brain tumours and potential as a drug target

Ji, D., Luo, Z., Ovcjak, A., Alanazi, R., Bao, M., Feng, Z., & Sun, H. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00679-4 · Cited by 90 · see citing works

Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease

Sanchís, A., García-Gimeno, M. A., Martínez, A. J. C., Sequedo, M. D., Millán, J. M., Sanz, P., & Vázquez‐Manrique, R. P. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0264-9 · Cited by 89 · see citing works

An Overview on the Differential Interplay Among Neurons–Astrocytes–Microglia in CA1 and CA3 Hippocampus in Hypoxia/Ischemia

Lana, D., Ugolini, F., & Giovannini, M. G. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.585833 · Cited by 85 · see citing works

Sterile Neuroinflammation and Strategies for Therapeutic Intervention

Banjara, M., & Ghosh, C. (2017) · International Journal of Inflammation · doi:10.1155/2017/8385961 · Cited by 87 · see citing works

Inflammation in Huntington's disease: A few new twists on an old tale

Valadão, P. A. C., Almeida‐Santos, A. F., Ferreira-Vieira, T. H., Cordeiro, T. M. E., Teixeira, A. L., Guatimosim, C., & de Miranda, A. S. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577380 · Cited by 81 · see citing works

C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease

Ma, L., Yang, C., Zhang, X., Li, Y., Wang, S. L., Zheng, L., & Huang, K. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.003 · Cited by 77 · see citing works

Molecular Pathogenesis in Huntington’s Disease

Illarioshkin, S. N., Klyushnikov, S. A., Vigont, V. A., Seliverstov, Y. A., & Kaznacheyeva, E. V. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918090043 · Cited by 74 · see citing works

Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease

Wu, Y., Chiu, F., Yeh, C.-S., & Kuo, H. (2019) · Open Biology · doi:10.1098/rsob.180177 · Cited by 75 · see citing works

Rod microglia and their role in neurological diseases

Holloway, O. G., Canty, A. J., King, A. E., & Ziebell, J. M. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.02.005 · Cited by 71 · see citing works

Anti-inflammatory role of GM1 and other gangliosides on microglia

Galleguillos, D., Wang, Q., Steinberg, N., Zaidi, A. K., Shrivastava, G., Dhami, K., Daskhan, G. C., Schmidt, E. N., Dworsky-Fried, Z., Giuliani, F., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02374-x · Cited by 74 · see citing works

Ex vivo gene therapy for the treatment of neurological disorders

Gowing, G., Svendsen, S. P., & Svendsen, C. N. (2017) · Progress in brain research · doi:10.1016/bs.pbr.2016.11.003 · Cited by 72 · see citing works

Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation

Peña‐Altamira, E., Prati, F., Massenzio, F., Virgili, M., Contestabile, A., Bolognesi, M. L., & Monti, B. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1121237 · Cited by 70 · see citing works

Protective Effect of Natural Products against Huntington’s Disease: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

Lum, P. T., Sekar, M., Gan, S. H., Bonam, S. R., & Shaikh, M. F. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00824 · Cited by 68 · see citing works

Loganin prevents BV‐2 microglia cells from Aβ1‐42‐induced inflammation via regulating TLR4/TRAF6/NF‐κB axis

Cui, Y., Wang, Y., Zhao, D., Feng, X., Zhang, L., & Liu, C. (2018) · Cell Biology International · doi:10.1002/cbin.11060 · Cited by 68 · see citing works

Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease

Garcia‐Miralles, M., Hong, X., Tan, L. J., Caron, N. S., Huang, Y., To, X. V., Lin, R. Y., Franciosi, S., Papapetropoulos, S., Hayardeny, L., et al. (2016) · Scientific Reports · doi:10.1038/srep31652 · Cited by 66 · see citing works

Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cells

Garrido‐Gil, P., Rodriguez-Perez, A. I., Fernandez‐Rodriguez, P., Lanciego, J. L., & Labandeira-García, J. L. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1357-z · Cited by 64 · see citing works

Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases

Huang, J., Huang, N., Xu, S., Luo, Y., Li, Y., Jin, H. D., Yu, C., Shi, J., & Jin, F. J. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108552 · Cited by 63 · see citing works

The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease

Beaumont, V., Mrzljak, L., Dijkman, U., Freije, R., Heins, M., Rassoulpour, A., Tombaugh, G. C., Gelman, S., Bradaïa, A., Steidl, E., et al. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.005 · Cited by 61 · see citing works

Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons

Li, Y., Sibon, O. C. M., & Dijkers, P. F. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1278-2 · Cited by 57 · see citing works

Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases

Han, T., Xu, Y., Sun, L., Hashimoto, M., & Wei, J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385845 · Cited by 60 · see citing works

Regulation of Immune Cell Function by PPARs and the Connection with Metabolic and Neurodegenerative Diseases

Menn, G. L., & Neels, J. G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061575 · Cited by 60 · see citing works

Potential biomarkers to follow the progression and treatment response of Huntington’s disease

Disatnik, M.-H., Joshi, A. U., Saw, N. L., Shamloo, M., Leavitt, B. R., Qi, X., & Mochly-Rosen, D. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20160776 · Cited by 58 · see citing works

Systemic application of AAV vectors targeting GFAP-expressing astrocytes in Z -Q175-KI Huntington's disease mice

Vagner, T., Dvorzhak, A., Wójtowicz, A. M., Harms, C., & Grantyn, R. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.10.007 · Cited by 58 · see citing works

Conditioned medium from amniotic cells protects striatal degeneration and ameliorates motor deficits in the R6/2 mouse model of Huntington's disease

Giampà, C., Alvino, A., Magatti, M., Silini, A. R., Cardinale, A., Paldino, E., Fusco, F. R., & Parolini, O. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14113 · Cited by 57 · see citing works

Modelling microglial function with induced pluripotent stem cells: an update

Pocock, J. M., & Piers, T. M. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0030-3 · Cited by 57 · see citing works

The role of mitochondrial dysfunction in Huntington’s disease: Implications for therapeutic targeting

Joshi, D. C., Chavan, M. B., Gurow, K., Gupta, M., Dhaliwal, J. S., & Ming, L. C. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117827 · Cited by 60 · see citing works

Iron and Alzheimer’s Disease: From Pathology to Imaging

Tran, D. Q., DiGiacomo, P., Born, D. E., Georgiadis, M., & Zeineh, M. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.838692 · Cited by 57 · see citing works

Molecular insights into cortico-striatal miscommunications in Huntington's disease

Veldman, M. B., & Yang, X. W. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.019 · Cited by 49 · see citing works

Neurodegenerative Disorders

Yacoubian, T. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802810-0.00001-5 · Cited by 52 · see citing works

The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain

Agus, F., Crespo, D., Myers, R. H., & Labadorf, A. T. (2019) · BMC Medical Genomics · doi:10.1186/s12920-019-0581-9 · Cited by 51 · see citing works

Anti-inflammatory effects of ellagic acid and vanillic acid against quinolinic acid-induced rat model of Huntington's disease by targeting IKK-NF-κB pathway

Bains, M., Kaur, J., Akhtar, A., Kuhad, A., & Sah, S. P. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175316 · Cited by 48 · see citing works

Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system

Ni, R., Mu, L., & Ametamey, S. M. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0035-5 · Cited by 49 · see citing works

Stress and Alzheimer’s disease: A senescence link?

Lyons, C. E., & Bartolomucci, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.010 · Cited by 47 · see citing works

Early Intrathecal T Helper 17.1 Cell Activity in Huntington Disease

von Essen, M. R., Hellem, M. N. N., Vinther‐Jensen, T., Ammitzbøll, C., Hansen, R. H., Hjermind, L. E., Nielsen, T. T., Nielsen, J. E., & Sellebjerg, F. T. (2019) · Annals of Neurology · doi:10.1002/ana.25647 · Cited by 46 · see citing works

Medicinal chemistry perspective on cGAS-STING signaling pathway with small molecule inhibitors

Tian, X., Xu, F., Zhu, Q., Feng, Z., Dai, W., Zhou, Y.-L., You, Q., & Xu, X. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114791 · Cited by 44 · see citing works

TSPO–PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington’s disease: preclinical evidence with the p75NTR ligand LM11A-31

Simmons, D. A., James, M. L., Belichenko, N. P., Semaan, S., Condon, C., Kuan, J., Shuhendler, A. J., Miao, Z., Chin, F. T., & Longo, F. M. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy202 · Cited by 44 · see citing works

High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration

Al‐Ramahi, I., Lu, B., Paola, S. D., Pang, K., de Haro, M., Peluso, I., Gallego‐Flores, T., Malik, N. T., Erikson, K., Bleiberg, B. A., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.05.010 · Cited by 44 · see citing works

Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases

Wang, X., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189902 · Cited by 43 · see citing works

Nanoparticle-Based and Bioengineered Probes and Sensors to Detect Physiological and Pathological Biomarkers in Neural Cells

Maysinger, D., Ji, J. X., Hutter, E., & COOPER, E. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00480 · Cited by 43 · see citing works

The Molecular Clock and Neurodegenerative Disease: A Stressful Time

Carter, B., Justin, H. S., Gulick, D., & Gamsby, J. J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.644747 · Cited by 42 · see citing works

Brain Microbiota in Huntington’s Disease Patients

Alonso, R., Pisa, D., & Carrasco, L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02622 · Cited by 42 · see citing works

Neuroinflammation — using big data to inform clinical practice

Dendrou, C. A., McVean, G., & Fugger, L. H. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.171 · Cited by 41 · see citing works

Neuroprotective effects of acetyl- l -carnitine on lipopolysaccharide-induced neuroinflammation in mice: Involvement of brain-derived neurotrophic factor

Kazak, F., & Yarım, G. F. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.059 · Cited by 41 · see citing works

Neuroinflammation in CNS diseases: Molecular mechanisms and the therapeutic potential of plant derived bioactive molecules

Welcome, M. O. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100176 · Cited by 41 · see citing works

Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease

Garcia‐Miralles, M., Yusof, N. A. B. M., Tan, J. Y., Radulescu, C. I., Sidik, H., Tan, L. J., Belinson, H., Zach, N., Hayden, M. R., & Pouladi, M. A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1393-1 · Cited by 40 · see citing works

Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington's disease-like phenotype in BACHD mice

Petkau, T. L., Hill, A., Connolly, C., Lu, G., Wagner, P., Kosior, N., Blanco, J., & Leavitt, B. R. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz009 · Cited by 37 · see citing works

mtDNA Maintenance and Alterations in the Pathogenesis of Neurodegenerative Diseases

Shang, D., Huang, M., Wang, B., Yan, X., Wu, Z., & Zhang, X. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220810114644 · Cited by 41 · see citing works

Parthenolide ameliorates 3-nitropropionic acid-induced Huntington’s disease-like aberrations via modulating NLRP3 inflammasome, reducing microglial activation and inducing astrocyte shifting

Noureldeen, M. E., Shahin, N. N., Amin, H. A. A., El‐Sawalhi, M. M., & Ghaiad, H. R. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00917-5 · Cited by 37 · see citing works

Cerebrospinal fluid sCD27 levels indicate active T cell-mediated inflammation in premanifest Huntington's disease

Niemelä, V., Burman, J., Blennow, K., Zetterberg, H., Larsson, A. O., & Sundblom, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193492 · Cited by 35 · see citing works

Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives

Varghese, S. M., Patel, S., Nandan, A., Jose, A., Ghosh, S., Sah, R. K., Menon, B., Athira, K. V., & Chakravarty, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04205-5 · Cited by 37 · see citing works

New Directions in Therapeutics for Huntington Disease

Potkin, K. T., & Potkin, S. G. (2018) · Future Neurology · doi:10.2217/fnl-2017-0035 · Cited by 36 · see citing works

Huntington’s Disease: Latest Frontiers in Therapeutics

Saade, J., & Mestre, T. (2024) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-024-01345-y · Cited by 34 · see citing works

Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP + cells loss induced by restraint stress in mice

Perez-Urrutia, N., Mendoza, C., Alvarez-Ricartes, N., Oliveros-Matus, P., Echeverria, F., Grizzell, J. A., Barreto, G. E., Iarkov, A., & Echeverrı́a, V. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.06.016 · Cited by 34 · see citing works

Brain pericyte activation occurs early in Huntington's disease

Padel, T., Roth, M., Gaceb, A., Li, J., Björkqvist, M., & Paul, G. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.03.015 · Cited by 34 · see citing works

Emerging therapies in Huntington’s disease

Bashir, H. H. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1631161 · Cited by 34 · see citing works

Early Reactive A1 Astrocytes Induction by the Neurotoxin 3-Nitropropionic Acid in Rat Brain

López‐Sánchez, C., García‐Martínez, V., Poejo, J., García‐López, V., Salazar, J., & Gutiérrez‐Merino, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103609 · Cited by 34 · see citing works

Is the Immunological Response a Bottleneck for Cell Therapy in Neurodegenerative Diseases?

Salado-Manzano, C., Perpiñá, U., Straccia, M., Molina-Ruiz, F. J., Cozzi, E., Rosser, A., & Canals, J. M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00250 · Cited by 34 · see citing works

Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective

Banerjee, R., Rai, A., Iyer, S., Narwal, S., & Tare, M. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12209 · Cited by 34 · see citing works

Phosphoinositides: Roles in the Development of Microglial-Mediated Neuroinflammation and Neurodegeneration

Ernest James Phillips, T., & Maguire, E. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.652593 · Cited by 33 · see citing works

Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington’s disease mice

Griffioen, K. J. S., Mattson, M. P., & Okun, E. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00508 · Cited by 33 · see citing works

Are immunotherapies for Huntington’s disease a realistic option?

Denis, H. L., Lauruol, F., & Cicchetti, F. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0021-9 · Cited by 32 · see citing works

Implantation of the clinical-grade human neural stem cell line, CTX0E03 , rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington's disease

Yoon, Y., Kim, H. S., Jeon, I., Noh, J., Park, H.-J., Lee, S., Park, I., Stevanato, L., Hicks, C. A., Corteling, R. L., et al. (2020) · Stem Cells · doi:10.1002/stem.3191 · Cited by 32 · see citing works

Multi‐omics analysis suggests enhanced epileptogenesis in the Cornu Ammonis 3 of the pilocarpine model of mesial temporal lobe epilepsy

do Canto, A. M., de Matos, A. H. B., Godoi, A. B., Vieira, A. S., Aoyama, B. B., Rocha, C. S., Henning, B., Carvalho, B. S., Pascoal, V., Veiga, D. F. T., et al. (2020) · Hippocampus · doi:10.1002/hipo.23268 · Cited by 30 · see citing works

Neurodegenerative diseases and neuroinflammation-induced apoptosis

Huang, S., Lu, Y., Fang, W., Huang, Y., Li, Q., & Xu, Z. (2025) · Open Life Sciences · doi:10.1515/biol-2022-1051 · Cited by 31 · see citing works

Neuroinflammation in Huntington's disease: Causes, consequences, and treatment strategies

Blusch, A., & Björkqvist, M. (2025) · Journal of Huntington s Disease · doi:10.1177/18796397251338207 · Cited by 13 · see citing works

Neuroinflammation in Huntington’s disease

Möller, T. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0430-7 · Cited by 174 · see citing works

Huntington’s Disease

Labadorf, A. T., Hoss, A. G., & Myers, R. H. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_33 · Cited by 3 · see citing works

Neuroinflammatory Proteins in Huntington’s Disease: Insights into Mechanisms, Diagnosis, and Therapeutic Implications

Li, X., Tong, H., Xu, S., Zhou, G., Yang, T., Yin, S., Yang, S., Li, X., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111787 · Cited by 30 · see citing works

Neuroinflammation in Huntington’s disease: From animal models to clinical therapeutics

Jia, Q., Li, S., Li, X.-J., & Yin, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1088124 · Cited by 70 · see citing works