Adolescents with major depression demonstrate increased amygdala activation

Yang, Tony T.; Simmons, Alan N.; Matthews, Scott C.; Tapert, Susan F.; Frank, Guido K.; Max, Jeffrey E.; Bischoff-Grethe, Amanda; Lansing, Amy E.; Brown, Gregory; Strigo, Irina A.; Wu, Jing; Paulus, Martin P.

doi:10.1016/j.jaac.2009.09.004

Cited by 176Neural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesFunctional Brain Connectivity Studies

Adolescents with major depression demonstrate increased amygdala activation

Open access

Yang, Tony T., Simmons, Alan N., Matthews, Scott C., Tapert, Susan F., Frank, Guido K., Max, Jeffrey E., Bischoff-Grethe, Amanda, Lansing, Amy E. +4 more·2010·Journal of the American Academy of Child & Adolescent Psychiatry

DOI 10.1016/j.jaac.2009.09.004PMC PMC2935523

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jaac.2009.09.004

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In the RDoC matrix, generalized and social anxiety and depression symptomatology are linked to dysfunction in the same neurocircuitry, such as sustained limbic hyperreactivity and reduced adaptive flexibility of the default mode network (DMN).
“In the RDoC matrix, it is also evident that generalized and social anxiety and depression symptomatology are linked to dysfunction in the same neurocircuitry, such as sustained limbic hyperreactivity (18–20) and reduced adaptive flexibility of the default mode network (DMN) (20–22).”
From Feasibility and preliminary efficacy of a novel RDoC-based treatment program for adolescent depression: "Training for Awareness Resilience and Action" (TARA)-A pilot study (2017) · cites this paper as [18]
The Discussion (page unavailable) reports heightened amygdala activation in adolescents with depression and discusses similar findings in adolescents with anxiety, including generalized anxiety disorder. It also says amygdala responses vary with the attention condition, so it does not establish sustained hyperreactivity. The cited passages do not address social anxiety specifically or reduced adaptive flexibility of the default mode network. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Depressed adolescents demonstrate increased hyperactivation of the amygdala and aberrant functional connectivity between the amygdala and other emotional regulation areas.
“Previous and current fMRI studies from our group and others consistently show that depressed adolescents demonstrate increased hyperactivation of the amygdala, a key limbic structure involved in emotion generative processing (18) and aberrant functional connectivity between the amygdala and other emotional regulation areas (19, 23, 24).”
From Feasibility and preliminary efficacy of a novel RDoC-based treatment program for adolescent depression: "Training for Awareness Resilience and Action" (TARA)-A pilot study (2017) · cites this paper as [18]
The Abstract Results and Discussion report significantly greater left amygdala activation in depressed adolescents than in controls. The paper also reports greater ACC activation, but not aberrant functional connectivity between the amygdala and emotion-regulation areas. Its Abstract Conclusions note that earlier pediatric fMRI studies had mixed findings, so it does not support the claim that studies consistently show amygdala hyperactivation. (LLM, conf=0.88)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900 · see citing works
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913 · see citing works
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565 · see citing works
Co-planar stereotaxic atlas of the human brain : 3-dimensional proportional system : an approach to cerebral imaging
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058 · see citing works
A Children's Global Assessment Scale (CGAS)
Shaffer, D. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790100074010 · Cited by 3,716 · see citing works
NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): Description, Differences From Previous Versions, and Reliability of Some Common Diagnoses
SHAFFER, D., FISHER, P., LUCAS, C. P., DULCAN, M. K., & SCHWAB-STONE, M. E. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200001000-00014 · Cited by 3,505 · see citing works
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340 · see citing works
The Multidimensional Anxiety Scale for Children (MASC): factor structure, reliability, and validity
MARCH, J. S., PARKER, J. D. A., SULLIVAN, K., STALLINGS, P., & CONNERS, C. K. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199704000-00019 · Cited by 2,236 · see citing works
Childhood and adolescent depression: a review of the past 10 years, Part I
BIRMAHER, B., RYAN, N. D., WILLIAMSON, D. E., BRENT, D. A., KAUFMAN, J., DAHL, R. E., PEREL, J., & NELSON, B. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199611000-00011 · Cited by 2,076 · see citing works
A functional anatomical study of unipolar depression
Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03628.1992 · Cited by 1,266 · see citing works
Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment
Mayberg, H. S. (2003) · British Medical Bulletin · doi:10.1093/bmb/65.1.193 · Cited by 1,166 · cited 2× · see citing works
“JOURNAL OF THE AMERICAN ACADEMY OF CHILD & ADOLESCENT PSYCHIATRY VOLUME 49 NUMBER 1 JANUARY 2010 42 of the adult functional neuroimaging studies, several models of adult depression involving the amygdala have been proposed by researchers such as Drevets 8 and Mayberg.”
Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders
Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works
The development of depression in children and adolescents.
Cicchetti, D., & Toth, S. L. (1998) · American Psychologist · doi:10.1037//0003-066x.53.2.221 · Cited by 989 · see citing works
The Amygdala Response to Emotional Stimuli: A Comparison of Faces and Scenes
Hariri, A. R., Tessitore, A., Mattay, V. S., Fera, F., & Weinberger, D. R. (2002) · NeuroImage · doi:10.1006/nimg.2002.1179 · Cited by 984 · see citing works
A Susceptibility Gene for Affective Disorders and the Response of the Human Amygdala
Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., & Weinberger, D. R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.146 · Cited by 815 · see citing works
Parametric Analysis of fMRI Data Using Linear Systems Methods
Cohen, M. S. (1997) · NeuroImage · doi:10.1006/nimg.1997.0278 · Cited by 723 · see citing works
Characterizing evoked hemodynamics with fMRI.
Friston, K. J., Frith, C., Turner, R., & Frackowiak, R. (1995) · NeuroImage · doi:10.1006/nimg.1995.1018 · Cited by 711 · see citing works
The development of depression in children and adolescents.
Cicchetti, D., & Toth, S. L. (1998) · American Psychologist · doi:10.1037/0003-066x.53.2.221 · Cited by 705 · see citing works
Amygdala and Ventrolateral Prefrontal Cortex Activation to Masked Angry Faces in Children and Adolescents With Generalized Anxiety Disorder
Monk, C. S., Telzer, E. H., Mogg, K., Bradley, B. P., Mai, X., Louro, H. M. C., Chen, G., McClure-Tone, E. B., Ernst, M., & Pine, D. S. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.568 · Cited by 682 · see citing works
A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder
Surguladze, S., Brammer, M. J., Keedwell, P., Giampietro, V., Young, A. W., Travis, M. J., Williams, S. C. R., & Phillips, M. L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.028 · Cited by 633 · see citing works
SPSS 6.1 base system user's guide
Norušis, M. J. (1990) · Medical Entomology and Zoology · Cited by 625 · see citing works
Amygdala Response to Fearful Faces in Anxious and Depressed Children
Thomas, K. M. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.1057 · Cited by 582 · see citing works
Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism
Drevets, W. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00102-5 · Cited by 581 · see citing works
Altered Emotional Interference Processing in Affective and Cognitive-Control Brain Circuitry in Major Depression
Fales, C. L., Barch, D. M., Rundle, M. M., Mintun, M. A., Snyder, A. Z., Cohen, J. D., Mathews, J., & Sheline, Y. I. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.012 · Cited by 517 · cited 2× · see citing works
“This finding is consistent ith adult positron emission tomographic(5) and MRI studies.(6,7,39,40) This result is also consistent ith the majority of fMRI pediatric depression tudies.”
Psychometric evaluation of the Customary Drinking and Drug Use Record (CDDR): a measure of adolescent alcohol and drug involvement.
Brown, S. A., Myers, M. G., Lippke, L., Tapert, S. F., Stewart, D. G., & Vik, P. W. (1998) · Journal of Studies on Alcohol · doi:10.15288/jsa.1998.59.427 · Cited by 466 · see citing works
Self-citation
Children’s Depression Rating Scale – Revised (CDRS-R)
Keller, F., Grieb, J., Ernst, M., Spröber, N., Fegert, J. M., & Kölch, M. G. (2011) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000090 · Cited by 453 · see citing works
Childhood and Adolescent Depression
Bhatia, S. K., & Bhatia, S. C. (2011) · PsycEXTRA Dataset · doi:10.1037/e552642011-001 · Cited by 447 · see citing works
Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
McClure, E. B., Monk, C. S., Nelson, E. E., Parrish, J. M., Adler, A., Blair, R. J. R., Fromm, S., Charney, D. S., Leibenluft, E., Ernst, M., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.97 · Cited by 431 · see citing works
A Depression Rating Scale for Children
Poznanski, E. O., Cook, S. C., & Carroll, B. J. (1979) · PEDIATRICS · doi:10.1542/peds.64.4.442 · Cited by 392 · see citing works
Beyond affect: A role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task
Canli, T., Omura, K., Haas, B. W., Fallgatter, A. J., Constable, R. T., & Lesch, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503880102 · Cited by 353 · see citing works
Neural correlates of epigenesis
Canli, T., Qiu, M., Omura, K., Congdon, E., Haas, B. W., Amin, Z., Herrmann, M., Constable, R. T., & Lesch, K. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0601674103 · Cited by 338 · see citing works
Amygdala and Nucleus Accumbens Activation to Emotional Facial Expressions in Children and Adolescents at Risk for Major Depression
Monk, C. S., Klein, R. G., Telzer, E. H., Schroth, E. A., Mannuzza, S., Moulton, J. L., Guardino, M., Masten, C. L., McClure-Tone, E. B., Fromm, S., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111917 · Cited by 335 · see citing works
K-SADS-PL
Kaufman, J., Birmaher, B. B., Brent, D. A., Ryan, N. D., & Rao, U. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200010000-00002 · Cited by 326 · see citing works
Dose-Dependent Decrease of Activation in Bilateral Amygdala and Insula by Lorazepam During Emotion Processing
Paulus, M. P., Feinstein, J. S., Castillo, G., Simmons, A. N., & Stein, M. B. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.282 · Cited by 314 · see citing works
Self-citation
DSM-III Disorders from Age 11 to Age 15 Years
McGee, R. O., Feehan, M., Williams, S., & Anderson, J. C. (1992) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199201000-00009 · Cited by 307 · see citing works
Reward‐related decision‐making in pediatric major depressive disorder: an fMRI study
Forbes, E. E., Christopher May, J., Siegle, G. J., Ladouceur, C. D., Ryan, N. D., Carter, C. S., Birmaher, B., Axelson, D. A., & Dahl, R. E. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01673.x · Cited by 299 · see citing works
Dysfunction in the neural circuitry of emotional self-regulation in major depressive disorder
Beauregard, M., Paquette, V., & Le´vesque, J. (2006) · Neuroreport · doi:10.1097/01.wnr.0000220132.32091.9f · Cited by 254 · see citing works
Common and Distinct Amygdala-Function Perturbations in Depressed vs Anxious Adolescents
Beesdo, K., Lau, J. Y. F., Guyer, A. E., McClure-Tone, E. B., Monk, C. S., Nelson, E. E., Fromm, S. J., Goldwin, M. A., Wittchen, H.-U., Leibenluft, E., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.545 · Cited by 250 · see citing works
Untitled work
(1992) · PubMed · Cited by 226 · see citing works
Laterality effect on emotional faces processing: ALE meta-analysis of evidence
Fusar‐Poli, P., Placentino, A., Carletti, F., Allen, P., Landi, P., Abbamonte, M., Barale, F., Pérez, J., McGuire, P. K., & Politi, P. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.065 · Cited by 220 · see citing works
Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder
Matthews, S. C., Strigo, I. A., Simmons, A. N., Yang, T. T., & Paulus, M. P. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.05.022 · Cited by 190 · see citing works
Self-citation
Increased Amygdala Activity During Successful Memory Encoding in Adolescent Major Depressive Disorder: An fMRI Study
Roberson-Nay, R., McClure, E. B., Monk, C. S., Nelson, E. E., Guyer, A. E., Fromm, S. J., Charney, D. S., Leibenluft, E., Blair, J., Ernst, M., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.018 · Cited by 164 · see citing works
Mental Health Disorders from Age 15 to Age 18 Years
Feehan, M., McGee, R. O., & Williams, S. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199311000-00003 · Cited by 138 · see citing works
Amygdala Function and 5-HTT Gene Variants in Adolescent Anxiety and Major Depressive Disorder
Lau, J. Y. F., Goldman, D., Buzas, B., Fromm, S. J., Guyer, A. E., Hodgkinson, C., Monk, C. S., Nelson, E. E., Shen, P.-H., Pine, D. S., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.037 · Cited by 113 · see citing works
Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects
Yang, T. T., Simmons, A. N., Matthews, S. C., Tapert, S. F., Bischoff‐Grethe, A., Frank, G., Arce, E., & Paulus, M. P. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.09.039 · Cited by 89 · see citing works
Self-citation
Depressed adolescents demonstrate greater subgenual anterior cingulate activity
Yang, T. T., Simmons, A. N., Matthews, S. C., Tapert, S. F., Frank, G., Bischoff‐Grethe, A., Lansing, A. E., Wu, J., Brown, G. G., & Paulus, M. P. (2009) · Neuroreport · doi:10.1097/wnr.0b013e3283262e10 · Cited by 58 · see citing works
Self-citation
「不安障害児とうつ病児における恐怖表情に対する扁桃体の反応」, Thomas KM, Drevets WC, Dahl RE, et al, Amygdala response to fearful faces in anxious and depressed children., Arch Gen Psychiatry 58, 1057-1063, 2001
栗田, 征. (2002) · 心身医学 · doi:10.15064/jjpm.42.7_458 · Cited by 17 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[29]Tanner JM Growth and Adolescence Oxford Blackwell 1962

Sorted by citations

Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging
Dannlowski, U., Stuhrmann, A., Beutelmann, V., Zwanzger, P., Lenzen, T., Grotegerd, D., Domschke, K., Hohoff, C., Ohrmann, P., Bauer, J., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.021 · Cited by 954 · see citing works
Emotion Regulation as a Transdiagnostic Factor in the Development of Internalizing and Externalizing Psychopathology: Current and Future Directions
Aldao, A., Gee, D. G., De Los Reyes, A., & Seager, I. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000638 · Cited by 636 · see citing works
Facial emotion processing in major depression: a systematic review of neuroimaging findings
Stuhrmann, A., Suslow, T., & Dannlowski, U. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-10 · Cited by 440 · see citing works
Understanding Emotion in Adolescents: A Review of Emotional Frequency, Intensity, Instability, and Clarity
Bailen, N. H., Green, L. M., & Thompson, R. J. (2019) · Emotion Review · doi:10.1177/1754073918768878 · Cited by 427 · see citing works
Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents
Connolly, C. G., Wu, J., Ho, T. C., Hoeft, F., Wolkowitz, O., Eisendrath, S., Frank, G., Hendren, R., Max, J. E., Paulus, M. P., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.036 · Cited by 356 · see citing works
Self-citation
Functional brain imaging studies of youth depression: A systematic review
Kerestes, R., Davey, C. G., Stephanou, K., Whittle, S., & Harrison, B. J. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.11.009 · Cited by 307 · see citing works
Arrested development? Reconsidering dual-systems models of brain function in adolescence and disorders
Pfeifer, J. H., & Allen, N. B. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.04.011 · Cited by 299 · see citing works
Defining biotypes for depression and anxiety based on large-scale circuit dysfunction: a theoretical review of the evidence and future directions for clinical translation
Williams, L. M. (2016) · Depression and Anxiety · doi:10.1002/da.22556 · Cited by 290 · see citing works
Systematic review of the neural basis of social cognition in patients with mood disorders
Cusi, A. M., Nazarov, A., Holshausen, K., MacQueen, G. M., & McKinnon, M. C. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100179 · Cited by 278 · see citing works
Meta-analysis of functional neuroimaging of major depressive disorder in youth
Miller, C. H., Hamilton, J. P., Sacchet, M. D., & Gotlib, I. H. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.1376 · Cited by 229 · see citing works
Common and distinct neural correlates of emotional processing in Bipolar Disorder and Major Depressive Disorder: A voxel-based meta-analysis of functional magnetic resonance imaging studies
Delvecchio, G., Fossati, P., Boyer, P., Brambilla, P., Falkai, P., Gruber, O., Hietala, J. A., Lawrie, S. M., Martinot, J., McIntosh, A. M., et al. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.003 · Cited by 230 · see citing works
Noise and mental health: evidence, mechanisms, and consequences
Hahad, O., Kuntić, M., Al-Kindi, S. G., Kuntić, I., Gilan, D., Petrowski, K., Daiber, A., & Münzel, T. F. (2024) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-024-00642-5 · Cited by 218 · see citing works
Amygdala Reactivity to Emotional Faces in the Prediction of General and Medication-Specific Responses to Antidepressant Treatment in the Randomized iSPOT-D Trial
Williams, L. M., Korgaonkar, M. S., Song, Y. C., Paton, R., Eagles, S., Goldstein-Piekarski, A., Grieve, S. M., Harris, A. W. F., Usherwood, T., & Etkin, A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.89 · Cited by 195 · see citing works
Amygdala response and functional connectivity during emotion regulation: A study of 14 depressed adolescents
Perlman, G., Simmons, A. N., Wu, J., Hahn, K. S., Tapert, S. F., Max, J. E., Paulus, M. P., Brown, G. G., Frank, G. K., Campbell-Sills, L., et al. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.01.044 · Cited by 190 · see citing works
Self-citation
Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression
Connolly, C. G., Ho, T. C., Blom, E. H., LeWinn, K. Z., Sacchet, M. D., Tymofiyeva, O., Simmons, A. N., & Yang, T. T. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.026 · Cited by 177 · see citing works
Self-citation
Age-related changes in the structure and function of prefrontal cortex–amygdala circuitry in children and adolescents: A multi-modal imaging approach
Swartz, J. R., Carrasco, M., Wiggins, J. L., Thomason, M. E., & Monk, C. S. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.08.018 · Cited by 158 · see citing works
Prone to excitement: Adolescent females with Non-suicidal self-injury (NSSI) show altered cortical pattern to emotional and NSS-related material
Plener, P. L., Bubalo, N., Fladung, A. K., Ludolph, A. G., & Lulé, D. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.12.012 · Cited by 149 · see citing works
Neural Correlates of Rumination in Adolescents with Remitted Major Depressive Disorder and Healthy Controls
Burkhouse, K. L., Jacobs, R. H., Peters, A., Ajilore, O., Watkins, E., & Langenecker, S. (2016) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-016-0486-4 · Cited by 145 · see citing works
A preliminary study of the dysregulation of the resting networks in first-episode medication-naive adolescent depression
Jin, C., Gao, C., Chen, C., Ma, S., Netra, R., Wang, Y., Zhang, M., & Li, D. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.08.017 · Cited by 136 · see citing works
Attachment in the brain: adult attachment representations predict amygdala and behavioral responses to infant crying.
Riem, M. M. E., Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., Out, D., & Rombouts, S. A. R. B. (2012) · Attachment & Human Development · doi:10.1080/14616734.2012.727252 · Cited by 134 · see citing works
A review of fMRI studies during visual emotive processing in major depressive disorder
Jaworska, N., Yang, X.-R., Knott, V., & MacQueen, G. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.885659 · Cited by 133 · see citing works
New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder
Hu, P., Lü, Y., Pan, B., & Zhang, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911076 · Cited by 134 · see citing works
White Matter Correlates of Adolescent Depression: Structural Evidence for Frontolimbic Disconnectivity
LeWinn, K. Z., Connolly, C. G., Wu, J., Drahos, M., Hoeft, F., Ho, T. C., Simmons, A. N., & Yang, T. T. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.04.021 · Cited by 117 · see citing works
Self-citation
Brain Activity in Adolescent Major Depressive Disorder Before and After Fluoxetine Treatment
Tao, R., Calley, C. S., Hart, J., Mayes, T. L., Nakonezny, P. A., Lu, H., Kennard, B. D., Tamminga, C. A., & Emslie, G. J. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11040615 · Cited by 114 · see citing works
The Limbic System in Youth Depression: Brain Structural and Functional Alterations in Adolescent In-patients with Severe Depression
Redlich, R., Opel, N., Bürger, C., Dohm, K., Grotegerd, D., Förster, K., Zaremba, D., Meinert, S. L., Repple, J., Enneking, V., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.246 · Cited by 111 · see citing works
Neural correlates of reversal learning in severe mood dysregulation and pediatric bipolar disorder
Adleman, N. E., Kayser, R., Dickstein, D., Blair, R. J. R., Pine, D., & Leibenluft, E. (2011) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2011.07.011 · Cited by 106 · see citing works
Immune mechanisms of depression in rheumatoid arthritis
Brock, J., Basu, N., Schlachetzki, J. C. M., Schett, G. A., McInnes, I. B., & Cavanagh, J. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01037-w · Cited by 107 · see citing works
The ABCD Study of Neurodevelopment: Identifying Neurocircuit Targets for Prevention and Treatment of Adolescent Substance Abuse
Bjork, J. M., Straub, L. K., Provost, R. G., & Neale, M. C. (2017) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-017-0108-y · Cited by 99 · see citing works
Discriminating unipolar and bipolar depression by means of fMRI and pattern classification: a pilot study
Grotegerd, D., Suslow, T., Bauer, J., Ohrmann, P., Arolt, V., Stuhrmann, A., Heindel, W. L., Kugel, H., & Dannlowski, U. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0329-4 · Cited by 100 · see citing works
A Preliminary Study of White Matter in Adolescent Depression: Relationships with Illness Severity, Anhedonia, and Irritability
Henderson, S. E., Johnson, A. R., Vallejo, A. I., Katz, L., Wong, E. W., & Gabbay, V. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00152 · Cited by 101 · see citing works
Long-Term Isolation Elicits Depression and Anxiety-Related Behaviors by Reducing Oxytocin-Induced GABAergic Transmission in Central Amygdala
Han, R. T., Kim, Y., Park, E. H., Kim, J. Y., Ryu, C., Kim, H. Y., Lee, J., Pahk, K., Cui, S., Kim, H., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00246 · Cited by 93 · see citing works
Oxytocin and Stress: Neural Mechanisms, Stress-Related Disorders, and Therapeutic Approaches
Matsushita, H., Latt, H. M., Koga, Y., Nishiki, T., & Matsui, H. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.07.046 · Cited by 92 · see citing works
Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis.
Li, X., & Wang, J. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00299-2 · Cited by 89 · see citing works
Dimensional depression severity in women with major depression and post-traumatic stress disorder correlates with fronto-amygdalar hypoconnectivty
Satterthwaite, T. D., Cook, P. A., Bruce, S. E., Conway, C. R., Mikkelsen, E., Satchell, E. K., Vandekar, S., Durbin, T. J., Shinohara, R. T., & Sheline, Y. I. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.149 · Cited by 90 · see citing works
An fMRI study of emotional face processing in adolescent major depression
Hall, L. M. J., Klimes‐Dougan, B., Hunt, R. H., Thomas, K. M., Houri, A. K., Noack, E., Mueller, B. A., Lim, K. O., & Cullen, K. R. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.037 · Cited by 87 · see citing works
Altered Cerebral Perfusion in Executive, Affective, and Motor Networks During Adolescent Depression
Ho, T. C., Wu, J., Shin, D. D., Liu, T. T., Tapert, S. F., Yang, G., Connolly, C. G., Frank, G., Max, J. E., Wolkowitz, O. M., et al. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.07.008 · Cited by 81 · see citing works
Self-citation
Identifying biological markers for improved precision medicine in psychiatry
Quinlan, E. B., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., Desrivières, S., Flor, H., Frouin, V., Garavan, H., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0555-5 · Cited by 74 · see citing works
Postnatal development of the amygdala: A stereological study in macaque monkeys
Chareyron, L. J., Lavenex, P. B., Amaral, D. G., & Lavenex, P. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.23023 · Cited by 72 · see citing works
Neural correlates of depression in women across the reproductive lifespan – An fMRI review
Stickel, S., Wagels, L., Wudarczyk, O. A., Jaffee, S. R., Habel, U., Schneider, F. W., & Chechko, N. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.12.133 · Cited by 70 · see citing works
Functional and structural brain correlates of risk for major depression in children with familial depression
Chai, X. J., Hirshfeld-Becker, D., Biederman, J., Uchida, M., Doehrmann, O., Leonard, J. A., Salvatore, J., Kenworthy, T., Brown, A., Kagan, E., et al. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.05.004 · Cited by 70 · see citing works
Effect of meditation on neurophysiological changes in stress mediated depression
Kasala, E. R., Bodduluru, L. N., Maneti, Y., & Thipparaboina, R. (2013) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2013.10.001 · Cited by 66 · see citing works
Disrupted Amygdala Reactivity in Depressed 4- to 6-Year-Old Children
Gaffrey, M. S., Barch, D. M., Singer, J., Shenoy, R., & Luby, J. L. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.04.009 · Cited by 62 · see citing works
The development of an RDoC-based treatment program for adolescent depression: “Training for Awareness, Resilience, and Action” (TARA)
Henje, E., Duncan, L. G., Ho, T. C., Connolly, C. G., LeWinn, K. Z., Chesney, M. A., Hecht, F. M., & Yang, T. T. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00630 · Cited by 63 · see citing works
Self-citation
The thalamus is the causal hub of intervention in patients with major depressive disorder: Evidence from the Granger causality analysis
Yang, C., Xiao, K., Ao, Y., Cui, Q., Jing, X., & Wang, Y. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103295 · Cited by 59 · see citing works
Human amygdala engagement moderated by early life stress exposure is a biobehavioral target for predicting recovery on antidepressants
Goldstein-Piekarski, A. N., Korgaonkar, M., Green, E. M., Suppes, T., Schatzberg, A., Hastie, T., Nemeroff, C., & Williams, L. (2016) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1606671113 · Cited by 55 · see citing works
How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders
Kaul, D., Schwab, S. G., Mechawar, N., & Matosin, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.025 · Cited by 56 · see citing works
Neural correlates of successful psychotherapy of depression in adolescents
Straub, J., Plener, P. L., Sproeber, N., Sprenger, L., Kölch, M. G., Groen, G., & Abler, B. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.05.020 · Cited by 56 · see citing works
The amygdala, top-down effects, and selective attention to features.
Jacobs, R. H. A. H., Renken, R., Aleman, A., & Cornelissen, F. (2012) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.011 · Cited by 63 · see citing works
Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data?
Puryear, C. B., Brooks, J. M., Tan, L. A., Smith, K. L., Li, Y., Cunningham, J. I., Todtenkopf, M. S., Dean, R. L., & Sánchez, C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.007 · Cited by 56 · see citing works
Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: A pilot fMRI study
Diler, R. S., Almeida, J., Ladouceur, C. D., Birmaher, B. B., Axelson, D., & Phillips, M. L. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.06.013 · Cited by 55 · see citing works
Altered insular activation and increased insular functional connectivity during sad and happy face processing in adolescent major depressive disorder
Henje, E., Connolly, C. G., Ho, T. C., LeWinn, K. Z., Mobayed, N., Han, L. K. M., Paulus, M. P., Wu, J., Simmons, A. N., & Yang, T. T. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.012 · Cited by 55 · see citing works
Self-citation
HPA axis genetic variation, pubertal status, and sex interact to predict amygdala and hippocampus responses to negative emotional faces in school-age children
Pagliaccio, D., Luby, J. L., Bogdan, R., Arpana Agrawal, A., Gaffrey, M. S., Belden, A. C., Botteron, K. N., Harms, M. P., & Barch, D. M. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.01.017 · Cited by 55 · see citing works
Abnormal Functional and Structural Connectivity of Amygdala-Prefrontal Circuit in First-Episode Adolescent Depression: A Combined fMRI and DTI Study
Wu, F., Tu, Z., Sun, J., Geng, H., Zhou, Y., Jiang, X., Li, H., & Kong, L. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00983 · Cited by 54 · see citing works
Shifting priorities: highly conserved behavioral and brain network adaptations to chronic stress across species
Nikolova, Y. S., Misquitta, K. A., Rocco, B. R., Prévot, T. D., Knodt, A. R., Ellegood, J., Voineskos, A. N., Lerch, J. P., Hariri, A. R., Sibille, E. L., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0083-5 · Cited by 51 · see citing works
Anomalous functional brain activation following negative mood induction in children with pre-school onset major depression
Pagliaccio, D., Luby, J. L., Gaffrey, M., Belden, A. C., Botteron, K. N., Gotlib, I. H., & Barch, D. M. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.11.008 · Cited by 50 · see citing works
Sex-specific effects of psychedelic drug exposure on central amygdala reactivity and behavioral responding
Effinger, D. P., Quadir, S. G., Ramage, M. C., Cone, M. G., & Herman, M. A. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02414-5 · Cited by 50 · see citing works
Traffic-related air pollution and brain development
Woodward, N. C., Finch, C. E., & Morgan, T. E. (2015) · AIMS environmental science · doi:10.3934/environsci.2015.2.353 · Cited by 48 · see citing works
Amygdala activation during emotional face processing in adolescents with affective disorders: the role of underlying depression and anxiety symptoms
van den Bulk, B. G., Meens, P. H. F., van Lang, N. D. J., de Voogd, E. L., van der Wee, N. J. A., Rombouts, S. A. R. B., Crone, E. A., & Vermeiren, R. R. J. M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00393 · Cited by 48 · see citing works
Implicating neuroinflammation in hippocampus, prefrontal cortex and amygdala with cognitive deficit: a narrative review
Blossom, V., Ullal, S. D., D’Souza, M. M., Ranade, A. V., Kumar, N. A., & Rai, R. (2025) · 3 Biotech · doi:10.1007/s13205-025-04468-2 · Cited by 54 · see citing works
Psychosocial Stress and Brain Function in Adolescent Psychopathology
Quinlan, E. B., Cattrell, A., Jia, T., Eric Artiges, A., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., Brühl, R., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.16040464 · Cited by 47 · see citing works
Amygdala-prefrontal cortex white matter tracts are widespread, variable and implicated in amygdala modulation in adolescents
Goetschius, L. G., Hein, T. C., Mattson, W. I., Lopez‐Duran, N. L., Dotterer, H. L., Welsh, R. C., Mitchell, C. M., Hyde, L. W., & Monk, C. S. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.02.009 · Cited by 46 · see citing works
Brain–behavior relationships in the experience and regulation of negative emotion in healthy children: Implications for risk for childhood depression
Pagliaccio, D., Luby, J. L., Luking, K. R., Belden, A. C., & Barch, D. M. (2014) · Development and Psychopathology · doi:10.1017/s0954579414001035 · Cited by 44 · see citing works
Cognitive and attentional vulnerability to depression in youth: A review
Kertz, S. J., Petersen, D., & Stevens, K. T. (2019) · Clinical Psychology Review · doi:10.1016/j.cpr.2019.01.004 · Cited by 44 · see citing works
Na+, K+ ATPase Activity Is Reduced in Amygdala of Rats with Chronic Stress-Induced Anxiety-Like Behavior
Crema, L. M., Schlabitz, M. K., Tagliari, B., da Cunha, A. A., Simão, F., Krolow, R., Pettenuzzo, L. F., Salbego, C. G., Vendite, D., Wyse, Â. T. D. S., et al. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0245-9 · Cited by 43 · see citing works
Multilevel assessment of the neurobiological threat system in depressed adolescents: Interplay between the limbic system and hypothalamic–pituitary–adrenal axis
Klimes‐Dougan, B., Eberly, L. E., Schreiner, M. W., Kurkiewicz, P., Houri, A. K., Schlesinger, A., Thomas, K. M., Mueller, B. A., Lim, K. O., & Cullen, K. R. (2014) · Development and Psychopathology · doi:10.1017/s0954579414001059 · Cited by 41 · see citing works
Balancing act: Neural correlates of affect dysregulation in youth depression and substance use – A systematic review of functional neuroimaging studies
Rakesh, D., Allen, N. B., & Whittle, S. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100775 · Cited by 40 · see citing works
Clinical neuroprediction: Amygdala reactivity predicts depressive symptoms 2 years later
Mattson, W. I., Hyde, L. W., Shaw, D. S., Forbes, E. E., & Monk, C. S. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw018 · Cited by 40 · see citing works
‘Mom—I don’t want to hear it’: brain response to maternal praise and criticism in adolescents with major depressive disorder
Silk, J. S., Lee, K. H., Elliott, R. D., Hooley, J. M., Dahl, R. E., Barber, A., & Siegle, G. J. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx014 · Cited by 39 · see citing works
The neuroscience and context of adolescent depression
Henje, E., Ho, T. C., Connolly, C. G., LeWinn, K. Z., Sacchet, M. D., Tymofiyeva, O., Weng, H. Y., & Yang, T. T. (2015) · Acta Paediatrica · doi:10.1111/apa.13299 · Cited by 42 · see citing works
Self-citation
The neural correlates of emotional face-processing in adolescent depression: a dimensional approach focusing on anhedonia and illness severity
Henderson, S., Vallejo, A. I., Ely, B. A., Kang, G., Roy, A. K., Pine, D. S., Stern, E. R., & Gabbay, V. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.09.006 · Cited by 38 · see citing works
Bidirectional regulation of synaptic plasticity in the basolateral amygdala induced by the D1‐like family of dopamine receptors and group II metabotropic glutamate receptors
Li, C., & Rainnie, D. G. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.277715 · Cited by 39 · see citing works
Elevated amygdala activity to negative faces in young adults with early onset major depressive disorder
Mingtian, Z., Shuqiao, Y., Xiongzhao, Z., Jinyao, Y., Xueling, Z., Xiang, W., Yingzi, L., Jian, L., & Wei, W. (2012) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2011.06.003 · Cited by 37 · see citing works
Executive functions in mood and anxiety disorders
Edidin, J. P., & Hunter, S. J. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511977954.013 · Cited by 37 · see citing works
The paraventricular thalamus input to central amygdala controls depression-related behaviors
Zhao, D., Liu, C., Cui, M., Liu, J., Meng, F., Lian, H., Wang, D., Hu, F., Liu, D., & Li, C. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113744 · Cited by 37 · see citing works
Attachment and Developmental Psychopathology
Fearon, P. R. M., Groh, A. M., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., & Roisman, G. I. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy108 · Cited by 38 · see citing works
A theory of the neural mechanisms underlying negative cognitive bias in major depression
Jiang, Y. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1348474 · Cited by 38 · see citing works
Integrating sleep, neuroimaging, and computational approaches for precision psychiatry
Goldstein‐Piekarski, A. N., Holt-Gosselin, B., O’Hora, K., & Williams, L. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0483-8 · Cited by 38 · see citing works
Deficient prefrontal-amygdalar connectivity underlies inefficient face processing in adolescent major depressive disorder
Willinger, D., Karipidis, I. I., Häberling, I. S., Berger, G. E., Walitza, S., & Brem, S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01955-5 · Cited by 35 · see citing works
Application of machine learning to structural connectome to predict symptom reduction in depressed adolescents with cognitive behavioral therapy (CBT)
Tymofiyeva, O., Yuan, J. P., Huang, C., Connolly, C. G., Blom, E. H., Xu, D., & Yang, T. T. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101914 · Cited by 34 · see citing works
Self-citation
Brain function and clinical characterization in the Boston adolescent neuroimaging of depression and anxiety study
Hubbard, N., Siless, V., Frosch, I. R., Goncalves, M., Lo, N., Wang, J., Bauer, C. C., Conroy, K., Cosby, E., Hay, A., et al. (2020) · NeuroImage: Clinical · doi:10.1016/j.nicl.2020.102240 · Cited by 39 · see citing works
Amygdala-Function Perturbations in Healthy Mid-Adolescents With Familial Liability for Depression
Pilhatsch, M., Vetter, N. C., Hübner, T., Ripke, S., Müller, K. U., Marxen, M., Rodehacke, S., Mennigen, E., Schmidt, D., Kroemer, N. B., et al. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.02.010 · Cited by 34 · see citing works
Profiling coping strategies in male and female rats: Potential neurobehavioral markers of increased resilience to depressive symptoms
Kent, M., Bardi, M., Hazelgrove, A., Sewell, K., Kirk, E., Thompson, B., Trexler, K. R., Terhune‐Cotter, B., & Lambert, K. G. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.07.011 · Cited by 34 · see citing works
Feasibility and preliminary efficacy of a novel RDoC-based treatment program for adolescent depression: "Training for Awareness Resilience and Action" (TARA)-A pilot study
Henje Blom, E., Tymofiyeva, O., Chesney, M. A., Ho, T. C., Moran, P., Connolly, C. G., Duncan, L. G., Baldini, L., Weng, H. Y., Acree, M., et al. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00208 · Cited by 33 · see citing works
“Previous and current fMRI studies from our group and others consistently show that depressed adolescents demonstrate increased hyperactivation of the amygdala, a key limbic structure involved in emotion generative processing (18) and aberrant functional connectivity between the amygdala and other emotional regulation…”
ResultSelf-citation
Neural substrates for processing task‐irrelevant emotional distracters in maltreated adolescents with depressive disorders: A pilot study
Bellis, M. D. D., & Hooper, S. R. (2012) · Journal of Traumatic Stress · doi:10.1002/jts.21682 · Cited by 33 · see citing works
Sex‐differentiated associations among negative parenting, emotion‐related brain function, and adolescent substance use and psychopathology symptoms
Chaplin, T. M., Poon, J. A., Thompson, J. C., Hansen, A., Dziura, S. L., Turpyn, C. C., Niehaus, C. E., Sinha, R., Chassin, L., & Ansell, E. B. (2019) · Social Development · doi:10.1111/sode.12364 · Cited by 34 · see citing works
Negative bias effects during audiovisual emotional processing in major depression disorder
Li, L., Li, R., Shen, F., Wang, X., Zou, T., Deng, C., Wang, C., Li, J., Wang, H., Huang, X., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25735 · Cited by 32 · see citing works
Using animal models for the studies of schizophrenia and depression: The value of translational models for treatment and prevention
Uliana, D. L., Zhu, X., Gomes, F. V., & Grace, A. A. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.935320 · Cited by 32 · see citing works
Cholecystokinin B receptor antagonists for the treatment of depression via blocking long-term potentiation in the basolateral amygdala
Zhang, X., Asim, M., Fang, W., Monir, H. M., Wang, H., Kim, K., Feng, H., Wang, S., Gao, Q.-Q., Lai, Y., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02127-7 · Cited by 26 · see citing works
The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies
Gou, X.-Y., Li, Y., Guo, L.-X., Zhao, J., Zhong, D., Liu, X., Xia, H., Fan, J., Zhang, Y., Ai, S., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1099426 · Cited by 31 · see citing works
Deficits in emotion recognition are associated with depressive symptoms in youth with disruptive mood dysregulation disorder
Vidal‐Ribas, P., Brotman, M. A., Salum, G. A., Kaiser, A. J. E., Meffert, L., Pine, D. S., Leibenluft, E., & Stringaris, A. K. (2018) · Depression and Anxiety · doi:10.1002/da.22810 · Cited by 31 · see citing works
Affective Modulation after High-Intensity Exercise Is Associated with Prolonged Amygdalar-Insular Functional Connectivity Increase
Schmitt, A., Upadhyay, N., Martin, J. A., Vega, S. R., Strüder, H. K., & Boecker, H. (2020) · Neural Plasticity · doi:10.1155/2020/7905387 · Cited by 32 · see citing works
Maternal depressive symptoms during pregnancy are associated with amygdala hyperresponsivity in children
van der Knaap, N. J. F., Klumpers, F., El Marroun, H., Mous, S., Schubert, D., Jaddoe, V., Hofman, A., Homberg, J. R., Tiemeier, H., White, T., et al. (2018) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-1015-x · Cited by 30 · see citing works
Aberrant function of frontoamygdala circuits in adolescents with previous verbal abuse experiences
Lee, S. W., Yoo, J. H., Kim, K. W., Lee, J.-S., Kim, D., Park, H., Choi, J., & Jeong, B. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.10.029 · Cited by 30 · see citing works
Emergent Emotions in Adolescence
Coe-Odess, S., Narr, R. K., & Allen, J. P. (2019) · Springer eBooks · doi:10.1007/978-3-030-17332-6_23 · Cited by 30 · see citing works
Amygdala activity to angry and fearful faces relates to bullying and victimization in adolescents
Swartz, J. R., Carranza, A. F., & Knodt, A. R. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz084 · Cited by 29 · see citing works
Invisible emotional expressions influence social judgments and pupillary responses of both depressed and non-depressed individuals
Laeng, B., Sæther, L., Holmlund, T. B., Wang, C. E. A., Waterloo, K. K., Eisemann, M. R., & Halvorsen, M. B. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00291 · Cited by 27 · see citing works
Functional MRI of emotional memory in adolescent depression
Holt, R., Graham, J. M., Whitaker, K. J., Hagan, C. C., Ooi, C., Wilkinson, P. O., van Nieuwenhuizen, A. O., Lennox, B., Sahakian, B. J., Goodyer, I. M., et al. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.12.013 · Cited by 27 · see citing works
Altered neural function to happy faces in adolescents with and at risk for depression
Kerestes, R., Segreti, A. M., Pan, L. A., Phillips, M. L., Birmaher, B. B., Brent, D. A., & Ladouceur, C. D. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.013 · Cited by 25 · see citing works
Functional brain activation to emotional and nonemotional faces in healthy children: Evidence for developmentally undifferentiated amygdala function during the school-age period
Pagliaccio, D., Luby, J. L., Gaffrey, M. S., Belden, A. C., Botteron, K. N., Harms, M. P., & Barch, D. M. (2013) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-013-0167-5 · Cited by 26 · see citing works
Adolescents’ depressive symptoms moderate neural responses to their mothers’ positive behavior
Whittle, S., Yücel, M., Forbes, E. E., Davey, C. G., Harding, I. H., Sheeber, L., Yap, M. B. H., & Allen, N. B. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr049 · Cited by 23 · see citing works

P-354 - Adolescents with major depression demonstrate altered amygdala functional connectivity: A 3-t functional MRI study
Yang, T. T. (2012) · European Psychiatry · doi:10.1016/s0924-9338(12)74521-2
Self-citation
Amygdala response and functional connectivity during emotion regulation: A study of 14 depressed adolescents
Perlman, G., Simmons, A. N., Wu, J., Hahn, K. S., Tapert, S. F., Max, J. E., Paulus, M. P., Brown, G. G., Frank, G. K., Campbell-Sills, L., et al. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.01.044 · Cited by 190 · see citing works
Self-citation
P.2.a.026 Significant clinical, cognitive and imaging findings of bilateral magnetic seizure therapy in 26 treatment-resistant depression patients
Kayser, S., Bewernick, B. H., Hurlemann, R., & Schlaepfer, T. E. (2012) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(12)70355-3
An fMRI study of emotional face processing in adolescent major depression
Hall, L. M. J., Klimes‐Dougan, B., Hunt, R. H., Thomas, K. M., Houri, A. K., Noack, E., Mueller, B. A., Lim, K. O., & Cullen, K. R. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.037 · Cited by 87 · see citing works
Disrupted Amygdala Reactivity in Depressed 4- to 6-Year-Old Children
Gaffrey, M. S., Barch, D. M., Singer, J., Shenoy, R., & Luby, J. L. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.04.009 · Cited by 62 · see citing works

Authors: Yang, T. T., Simmons, A. N., Matthews, S. C., Tapert, S. F., Frank, G. K., Max, J. E., Bischoff-Grethe, A., Lansing, A. E., Brown, G., Strigo, I. A., Wu, J., & Paulus, M. P.
Affiliations: University of California San Diego (US)
University of Colorado Denver (US)
Corresponding author: Yang, Tony T.
ORCID: Yang, Tony T.
Simmons, Alan N.
Tapert, Susan F.
Frank, Guido K.
Max, Jeffrey E.
Lansing, Amy E.
Brown, Gregory
Strigo, Irina A.
Wu, Jing
Paulus, Martin P.
Venue: Journal of the American Academy of Child & Adolescent Psychiatry
Publisher: Elsevier BV
Published: 2010-01
Volume: 49
Issue: 1
Pages: 42-51
ISSN: 0890-8567 (ISSN-L)
DOI: 10.1016/j.jaac.2009.09.004
PMC: PMC2935523
OpenAlex: W2163349072
Cited by: 176
References: 47
Citations by year: 2026: 2 · 2025: 6 · 2024: 13 · 2023: 15 · 2022: 8 · 2021: 9 · 2020: 12 · 2019: 15 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 14 · 2014: 11 · 2013: 15 · 2012: 12
FWCI: 7.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institute of Mental Health (K23MH70791, K23MH070791, K23MH080135)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: adolescent depression, major depressive disorder, amygdala activation, amygdala hyperactivity, facial emotion recognition, emotional processing
MeSH terms: Adolescent, Amygdala, Brain Mapping, Major Depressive Disorder, Depressive Disorder, Major, Dominance, Cerebral, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual, Reference Values

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adolescents with major depression demonstrate increased amygdala activation

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks