Cited by 149Suicide and Self-Harm StudiesNeural and Behavioral Psychology StudiesPersonality Disorders and Psychopathology

Prone to excitement: Adolescent females with Non-suicidal self-injury (NSSI) show altered cortical pattern to emotional and NSS-related material

Plener, Paul L., Bubalo, Nikola, Fladung, Anne K., Ludolph, Andrea G., Lulé, Dorothée·2012·Psychiatry Research Neuroimaging

Abstract

Emotion-regulation difficulties have been identified as one of the core components in Non-suicidal self-injury (NSSI), a behaviour often beginning in adolescence. This pilot study evaluated differences in emotion processing between 18 female adolescents with and without NSSI by using verbal responses and functional magnetic resonance imaging (fMRI). Responses to pictures taken from the International Affective Picture System and slides with reference to NSSI were recorded both by verbal rating of valence and arousal and by fMRI. The NSSI group rated pictures with self-injurious reference as significantly more arousing than controls. For emotional pictures, the NSSI group showed a significantly stronger brain response in the amygdala, hippocampus and anterior cingulate cortex bilaterally. Depression explained differences between groups in the limbic area. Furthermore, the NSSI group also showed increased activity in the middle orbitofrontal cortex, and inferior and middle frontal cortex when viewing NSSI picture material. Participants with NSSI showed decreased activity in correlation to arousal in the occipital cortex and to valence in inferior frontal cortex when watching emotional pictures. The fMRI data support the notion that individuals with NSSI show an altered neural pattern for emotional and NSSI pictures. Behavioural data highlight proneness to excitement regarding NSSI topics. This fMRI study provides evidence for emotion-regulation deficits in the developing brain of adolescents with NSSI.

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Crossref · 10.1016/j.pscychresns.2011.12.012

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  • Compared to healthy youth, self-injurers exhibit greater activation in OFC, inferior parietal cortex, and inferior/middle frontal cortex to NSSI stimuli.

    “Compared to healthy youth, self-injurers exhibit greater activation in OFC, inferior parietal cortex, and inferior/middle frontal cortex to NSSI stimuli (95).”

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Authors
Plener, P. L., Bubalo, N., Fladung, A. K., Ludolph, A. G., & Lulé, D.
Affiliations
Universität Ulm (DE)
Corresponding author
Ludolph, Andrea G.
Venue
Psychiatry Research Neuroimaging
Publisher
Elsevier BV
Published
2012-08
Volume
203
Issue
2-3
Pages
146-152
ISSN
0925-4927 (ISSN-L)
OpenAlex
W2170344916
Cited by
149
References
57
Citations by year
2026: 14 · 2025: 11 · 2024: 14 · 2023: 22 · 2022: 17 · 2021: 14 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 12 · 2014: 5 · 2013: 4 · 2012: 1
FWCI
7.97
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
non-suicidal self-injury, adolescent girls, emotion regulation, emotional picture processing, amygdala, hippocampus, anterior cingulate cortex, orbitofrontal cortex, arousal, valence, depression, limbic system, adolescent brain development
MeSH terms
Adolescent, Arousal, Bipolar Disorder, Brain Mapping, Cerebral Cortex, Major Depressive Disorder, Depressive Disorder, Dominance, Cerebral, Emotions, Female, Frontal Lobe, Humans, Image Interpretation, Computer-Assisted, Internal-External Control, Interview, Psychological, Magnetic Resonance Imaging, Occipital Lobe, Organ Size, Pattern Recognition, Visual, Reference Values, Statistics as Topic, Stress Disorders, Post-Traumatic, Self-Injurious Behavior

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