Physical activity and sedentary behavior in people with bipolar disorder: A systematic review and meta-analysis
Open accessAbstract
Background Mortality rates are approximately two to three times higher in people with bipolar disorder (BD) than in general population. Lack of physical activity (PA) and sedentary behavior (SB) are independent risk factors for cardiovascular disease and premature mortality.Aims We conducted a meta-analysis to investigate PA and SB levels and its predictors in BD.Methods Major electronic databases were searched from inception till 02/2016 for articles measuring PA and SB with a self-report questionnaire (SRQ) or objective measure (e.g. accelerometer) in BD. A random effects meta-analysis and meta-regression analysis were conducted.Results Six studies were eligible including 279 (129♂) people with BD (mean age=43.9 years; range: 32.0-51.5 years). The trim and fill analysis demonstrated people with BD spent in total 210.1min (95%CI=146.3-273.9min) per day being physically active and 613.3min (95%CI=389.9-836.6min) during waking hours being sedentary. No significant difference in total PA per day was observed between people with BD and controls (g=-0.62, 95% CI=-1.55 to 0.31, I(2)=88.5%, n BD =82, n controls =86). Objective measures of PA recorded significantly lower levels (P=0.03) compared to self-report PA. Meta-regression demonstrated that older age and a higher body mass index predicted lower PA levels.Limitations Only a limited number of studies were identified assessing SB in people with BD.Conclusions Adults with BD engage in high levels of sedentary behavior during waking hours. Given that sedentary behavior is an independent predictor of cardiovascular disease, future lifestyle interventions specifically targeting the prevention of sedentary behavior are warranted.
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People with major depressive disorder, bipolar disorder and schizophrenia have been found to be less physically active than controls.
“although people with major depressive disorder, bipolar disorder and schizophrenia have been found to be more sedentary and less physically active than controls 21-24”
From Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis (2017) · cites this paper as [22]
The comparison with age- and gender-matched controls (p. 11) found that the lower physical activity observed in people with bipolar disorder was not statistically significant. The conclusion (p. 14) explicitly says the data did not show that they were less physically active than healthy controls. This paper does not establish the claim for major depressive disorder or schizophrenia. (LLM, conf=0.91)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredPeople with major depressive disorder, bipolar disorder and schizophrenia have been found to be more sedentary than controls.
“although people with major depressive disorder, bipolar disorder and schizophrenia have been found to be more sedentary and less physically active than controls 21-24”
From Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis (2017) · cites this paper as [22]
The discussion (p. 13) reports that people with bipolar disorder spent more than 10 hours per day sedentary, a higher level than reported for older people. But the controls analysis (p. 11) says there were insufficient data to compare sedentary behavior in people with bipolar disorder and matched healthy controls, so this source does not establish that comparison. (LLM, conf=0.83)
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- Authors
- Vancampfort, D., Firth, J., Schuch, F., Rosenbaum, S., De Hert, M., Mugisha, J., Probst, M., & Stubbs, B.
- Affiliations
- KU Leuven (BE)
- University of Manchester (GB)
- Universidade Federal do Rio Grande do Sul (BR)
- UNSW Sydney (AU)
- Butabika Hospital (UG)
- King's College London (GB)
- Corresponding author
- Vancampfort, Davy
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 201
- Pages
- 145-152
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2364307501
- Cited by
- 159
- References
- 46
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 15 · 2023: 12 · 2022: 13 · 2021: 10 · 2020: 25 · 2019: 21 · 2018: 17 · 2017: 17 · 2016: 5
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- Lirias (KU Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, physical activity, sedentary behavior, cardiovascular risk, premature mortality, body mass index, age, lifestyle intervention
- MeSH terms
- Adult, Bipolar Disorder, Female, Humans, Life Style, Male, Middle Aged, Surveys and Questionnaires, Regression Analysis, Exercise, Body Mass Index, Databases, Factual, Sedentary Behavior, Self Report
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