Physical activity and sedentary behavior in people with major depressive disorder: A systematic review and meta-analysis
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Background Low levels of physical activity (PA) and sedentary behavior (SB) are independent risk factors for cardiovascular disease and premature mortality in people with major depressive disorder (MDD).Aims Investigate levels of PA and SB and their predictors in people with MDD.Methods Electronic databases were searched from inception till 04/2016 for articles measuring PA and SB with a self-report questionnaire (SRQ) or objective measure (e.g. accelerometer) in people with MDD. Random-effects meta-analyses and meta-regression analyses were conducted.Results Twenty-four eligible studies were identified including 2901 people with MDD (78.4% female, mean age=54 years; range: 21-77 years). People with MDD spent 126.0min (95%CI=91.9-160.1) per day engaging in all types of PA and spent 8.5hours (95%CI=7.51-9.62) during their waking day being sedentary. Compared to controls, people with MDD spent less time in total PA (SMD=-0.25, 95%CI=-0.03 to 0.15) and moderate to vigorous PA (SMD=-0.30, 95%CI=-0.40 to 0.21) and engaged in higher levels of SB (SMD=0.09, 95%CI=0.01-0.18). The proportion of people with MDD not meeting the recommended PA guidelines was 67.8% (n=13 studies), which was higher in studies relying on objective versus self-report measures (85.7% v 62.1%, p=0.04). People with MDD were more likely than controls to not meeting the recommended PA guidelines (OR = 1.50, 95%CI = 1.10–2.10).Limitations Heterogeneity was evident in most analyses.Conclusions Adults with MDD engage in low levels of PA and high levels of SB. PA and SB are independent predictors of mortality, therefore, future lifestyle interventions targeting both the prevention of SB and adoption and maintenance of PA are warranted.
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- Authors
- Schuch, F., Vancampfort, D., Firth, J., Rosenbaum, S., Ward, P., Reichert, T., Bagatini, N. C., Bgeginski, R., & Stubbs, B.
- Affiliations
- Hospital de Clínicas de Porto Alegre (BR)
- KU Leuven (BE)
- University of Manchester (GB)
- Black Dog Institute (AU)
- Ingham Institute (AU)
- Universidade Federal do Rio Grande do Sul (BR)
- King's College London (GB)
- Corresponding author
- Schuch, Felipe
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 210
- Pages
- 139-150
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2559312125
- Semantic Scholar
- cdb17101b25dff6b0109ddfaa2cc3c7f2b2e2c6d
- Cited by
- 663
- References
- 77
- Citations by year
- 2026: 57 · 2025: 89 · 2024: 81 · 2023: 77 · 2022: 74 · 2021: 74 · 2020: 71 · 2019: 62 · 2018: 45 · 2017: 31
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-01-01)
- Open access
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- Lirias (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- major depressive disorder, physical activity, sedentary behavior, moderate-to-vigorous physical activity, physical activity guidelines, cardiovascular risk, mortality, lifestyle intervention
- MeSH terms
- Adult, Aged, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Exercise, Young Adult, Sedentary Behavior, Self Report
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