Cognitive performances associate with measures of white matter integrity in bipolar disorder
Abstract
Background Neuropsychological deficits constitute enduring trait-like features in bipolar disorder (BD), and persist in euthymia. White matter (WM) abnormalities are one of the most consistently reported findings in neuroimaging studies of BD. We hypothesized that neuropsychological performances could correlate with WM integrity in a sample of bipolar patients in core WM tracts.Methods Seventy-eight patients affected by BD were evaluated for verbal memory, working memory, psychomotor coordination, executive functions, attention and information processing, and verbal fluency through the Brief Assessment of Cognition in Schizophrenia. White matter integrity was evaluated using DTI and tract-based spatial statistics with threshold free cluster enhancement (p>0.949).Results We observed that cognitive performances in attention and information processing, working memory, executive functions and psychomotor coordination were associated with DTI measures of WM integrity in several association fibres: inferior and superior longitudinal fasciculus, inferior fronto-occipital fasciculus, cingulum bundle, corpus callosum, and corona radiata.Limitation The drug treatments administered during the course of the illness could have influenced DTI measures and neurocognitive function. Other limitations include issues such as generalizability due to the lack of a control group, possible undetected past comorbidities, population stratification, and the presence of a 28% of patients which previously experienced delusions.Conclusions This is the first study to use a validated cognitive battery to investigate the principal cognitive domains in BD. Our data confirm the importance of WM integrity as a neurobiological underpinning of cognitive deficits.
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Correlations between executive functions and cingulum white matter properties have been reported in depression, bipolar disorder, and schizophrenia.
“This overall pattern is continued in clinical brain imaging studies as correlations between executive functions and cingulum white matter properties have been reported in depression (with DTI in Schermuly et al., 2010), in bipolar disorder (with DTI in Poletti et al., 2015; with Positron Emission Tomography in Li et al., 2012), and schizophrenia (with DTI in Kubicki et al., 2009; Takei et al., 200”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Poletti et al., 2015
The white matter phenotype is associated with neurocognitive dysfunctions.
“We also associated this WM phenotype with neurocognitive dysfunctions (Poletti et al., 2015)”
From Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up (2021) · cites this paper as Poletti et al., 2015
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Buchsbaum, M. S., Hazlett, E., Haznedar, M. M., et al. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb05992.x · Cited by 41 · see citing works
Bipolar Disorders: Basic Mechanisms and Therapeutic Implications
Baron, D. A., & Sosland, M. D. (2001) · Psychiatric Services · doi:10.1176/appi.ps.52.6.844 · Cited by 31 · see citing works
(2000) · CRC Press eBooks · doi:10.1201/9780824741891 · Cited by 29 · see citing works
Neuropsychological deficits in bipolar depression persist after successful antidepressant treatment
Poletti, S., Papa, G. S., Locatelli, C., Colombo, C., & Benedetti, F. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.11.023 · Cited by 17 · see citing works
Self-citationNeurocognitive Findings in Bipolar Disorder
Glahn, D. C., & Bearden, C. E. (2007) · CRC Press eBooks · doi:10.3109/9781420021158-17 · Cited by 2 · see citing works
Flagged first, then by citations
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Sorted by citations
The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740 · see citing works
Mazza, M. G., Palladini, M., De Lorenzo, R., Magnaghi, C., Poletti, S., Furlan, R., Ciceri, F., Rovere-Querini, P., & Benedetti, F. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.02.021 · Cited by 513 · see citing works
“We also associated this WM phenotype with neurocognitive dysfunctions (Poletti et al., 2015), an effect proportional to illness duration (Melloni et al.”
Self-citationInflammatory cytokines influence measures of white matter integrity in Bipolar Disorder
Benedetti, F., Poletti, S., Hoogenboezem, T. A., Mazza, E., Ambrée, O., de Wit, H., Wijkhuijs, A. J. M., Locatelli, C., Bollettini, I., Colombo, C., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.047 · Cited by 151 · see citing works
Self-citationBenedetti, F., Poletti, S., Locatelli, C., Mazza, E., Lorenzi, C., Vitali, A., Riberto, M., Brioschi, S., Vai, B., Bollettini, I., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.011 · Cited by 64 · see citing works
Lippard, E. T. C., Johnston, J. A. Y., Spencer, L., Quatrano, S., Fan, S., Sankar, A., Weathers, J., Pittman, B., Oquendo, M. A., & Blumberg, H. P. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.097 · Cited by 44 · see citing works
Melloni, E. M. T., Poletti, S., Vai, B., Bollettini, I., Colombo, C., & Benedetti, F. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.02.015 · Cited by 34 · see citing works
- Authors
- Poletti, S., Bollettini, I., Mazza, E., Locatelli, C., Radaelli, D., Vai, B., Smeraldi, E., Colombo, C., & Benedetti, F.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 174
- Pages
- 342-352
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W1979165638
- Cited by
- 102
- References
- 90
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 10 · 2023: 6 · 2022: 5 · 2021: 11 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 10 · 2016: 16 · 2015: 6
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- bipolar disorder, white matter integrity, cognitive impairment, neuropsychological performance, diffusion tensor imaging, working memory, executive function, attention, psychomotor coordination, longitudinal fasciculus, inferior fronto-occipital fasciculus, cingulum, corpus callosum, corona radiata, Brief Assessment of Cognition in Schizophrenia
- MeSH terms
- Adult, Bipolar Disorder, Cognition, Corpus Callosum, Female, Humans, Male, Memory, Short-Term, Middle Aged, Nerve Net, Psychomotor Performance, Schizophrenia, Schizophrenic Psychology, Executive Function, Neuroimaging, Cognitive Dysfunction, White Matter
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