Neural correlates of cognitive behavioral therapy response in youth with negative valence disorders: A systematic review of the literature
Abstract
Background Cognitive-behavioral therapy (CBT) is the gold-standard psychotherapeutic treatment for pediatric negative valence disorders. However, some youths do not respond optimally to treatment, which may be due to variations in neural functioning. Methods We systematically reviewed functional magnetic resonance imaging studies in youths with negative valence disorders to identify pre- and post-treatment neural correlates of CBT response. Results A total of 21 studies were identified, of overall weak to moderate quality. The most consistent findings across negative valence disorders consisted of associations of treatment response with pre- and post-treatment task-based activation and/or functional connectivity within and between the prefrontal cortex, the medial temporal lobe, and other limbic regions. Associations of CBT response with baseline and/or post-treatment activity in the striatum, precentral and postcentral gyri, medial and posterior cingulate cortices, and parietal cortex, connectivity within and between the default-mode, cognitive control, salience, and frontoparietal networks, and metrics of large-scale brain network organization, were also reported, although less consistently. Limitations The poor quality and limited number of studies and the important heterogeneity of study designs and results considerably limit the conclusions that can be drawn from this literature. Conclusions Despite these limitations, these findings provide preliminary evidence suggestin…
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Meta-analyses and systematic reviews have described initial symptom severity, personality characteristics, heredity, childhood stressful events, neurophysiological markers, and genetic determinants as possible predictors of psychotherapy outcome in anxiety and depressive disorders.
“В метаанализах и систематических обзорах в качестве возможных предикторов исхода психотерапии тревожных и депрессивных расстройств описаны изначальная тяжесть клинических симптомов [7-9], личностные характеристики пациентов [10], насле дственность [8], стрессовые события в детстве [9], нейрофизиологические маркеры [9, 11], генетические детерминанты [9].”
From Positive-Dialogue Psychotherapy Outcome Predictors in Patients with General Anxiety Disorder and Mixed Anxiety and Depressive Disorder (2024) · cites this paper as [11]
Cites
The brain's default mode network
Raichle, M. E. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014030 · Cited by 3,904 · see citing works
Thomas, B. H., Ciliska, D., Dobbins, M., & Micucci, S. (2004) · Worldviews on Evidence-Based Nursing · doi:10.1111/j.1524-475x.2004.04006.x · Cited by 2,118 · see citing works
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Explicit and implicit emotion regulation: a dual-process framework.
Gyurak, A., Gross, J. J., & Etkin, A. (2011) · Cognition and Emotion · doi:10.1080/02699931.2010.544160 · Cited by 1,015 · see citing works
Neural network of cognitive emotion regulation—an ALE meta-analysis and MACM analysis
Kohn, N., Eickhoff, S. B., Scheller, M., Laird, A. R., Fox, P. T., & Habel, U. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.11.001 · Cited by 956 · see citing works
LeDoux, J. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400335111 · Cited by 891 · see citing works
Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways
Milad, M. R., & Rauch, S. L. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.003 · Cited by 847 · see citing works
Duits, P., Cath, D. C., Lissek, S., Hox, J. J., Hamm, A. O., Engelhard, I. M., van den Hout, M. A., & Baas, J. M. P. (2015) · Depression and Anxiety · doi:10.1002/da.22353 · Cited by 726 · see citing works
The role of the amygdala in human fear: automatic detection of threat
Öhman, A. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.03.019 · Cited by 691 · see citing works
Evidence for the Default Network's Role in Spontaneous Cognition
Andrews-Hanna, J. R., Reidler, J. S., Huang, C., & Buckner, R. L. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00830.2009 · Cited by 685 · see citing works
Brown, T. A., & Barlow, D. H. (2009) · Psychological Assessment · doi:10.1037/a0016608 · Cited by 639 · see citing works
Neurocognitive bases of emotion regulation development in adolescence
Ahmed, S. P., Bittencourt-Hewitt, A., & Sebastian, C. L. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.07.006 · Cited by 621 · see citing works
Ptak, R. (2012) · The Neuroscientist · doi:10.1177/1073858411409051 · Cited by 597 · see citing works
Evidence Base Update of Psychosocial Treatments for Child and Adolescent Depression
Weersing, V. R., Jeffreys, M., Do, M.-C. T., Schwartz, K. T. G., & Bolano, C. (2017) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2016.1220310 · Cited by 505 · see citing works
How psychotherapy changes the brain – the contribution of functional neuroimaging
Linden, D. E. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001816 · Cited by 491 · see citing works
McCrory, E. J., Gerin, M. I., & Viding, E. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12713 · Cited by 402 · see citing works
Adults with early-onset obsessive-compulsive disorder
do Rosario-Campos, M. C., Leckman, J. F., Mercadante, M. T., Shavitt, R. G., Prado, H. D. S., Sada, P., Zamignani, D., & Miguel, E. C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1899 · Cited by 373 · see citing works
Cognitive functioning in obsessive-compulsive disorder: A meta-analysis
Shin, N. Y., Lee, T. Y., Kim, E., & Kwon, J. S. (2014) · Psychological Medicine · doi:10.1017/s0033291713001803 · Cited by 334 · see citing works
Thalamic structures and associated cognitive functions: Relations with age and aging
Fama, R., & Sullivan, E. V. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.03.008 · Cited by 323 · see citing works
Trauma, PTSD, and the Developing Brain
Herringa, R. J. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0825-3 · Cited by 248 · see citing works
Nakao, T., Okada, K., & Kanba, S. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12195 · Cited by 231 · see citing works
fMRI predictors of treatment outcome in pediatric anxiety disorders
McClure, E. B., Adler, A., Monk, C. S., Cameron, J., Smith, S., Nelson, E. E., Leibenluft, E., Ernst, M., & Pine, D. S. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0542-9 · Cited by 165 · see citing works
Imaging the mental components of a planning task
Rowe, J. B., Owen, A. M., Johnsrude, I. S., & Passingham, R. E. (2001) · Neuropsychologia · doi:10.1016/s0028-3932(00)00109-3 · Cited by 151 · see citing works
A systematic review of the neural bases of psychotherapy for anxiety and related disorders
Brooks, S. J., & Stein, D. J. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/sbrooks · Cited by 134 · see citing works
Prefrontal–Amygdala Dysregulation to Threat in Pediatric Posttraumatic Stress Disorder
Wolf, R. C., & Herringa, R. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.209 · Cited by 128 · see citing works
Maslowsky, J., Mogg, K., Bradley, B. P., McClure-Tone, E., Ernst, M., Pine, D. S., & Monk, C. S. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2009.0049 · Cited by 125 · see citing works
Kalisch, R., & Gerlicher, A. M. V. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.002 · Cited by 118 · see citing works
Phan, K. L., Coccaro, E. F., Angstadt, M., Kreger, K. J., Mayberg, H. S., Liberzon, I., & Stein, M. B. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.003 · Cited by 114 · see citing works
Sankar, A., Melin, A., Lorenzetti, V., Horton, P., Costafreda, S. G., & Fu, C. H. Y. (2018) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2018.07.002 · Cited by 114 · see citing works
Scaini, S., Belotti, R., & Ogliari, A. (2014) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2014.07.002 · Cited by 111 · see citing works
Paediatric obsessive-compulsive disorder, a neurodevelopmental disorder?
Huyser, C., Veltman, D. J., de Haan, E., & Boer, F. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.003 · Cited by 108 · see citing works
Huyser, C., Veltman, D. J., Wolters, L. H., de Haan, E., & Boer, F. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02439.x · Cited by 100 · see citing works
Falconer, E., Allen, A., Felmingham, K. L., Williams, L. M., & Bryant, R. A. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m08020 · Cited by 100 · see citing works
Self-citationNeurostructural abnormalities in pediatric anxiety disorders
Strawn, J. R., Hamm, L., Fitzgerald, D. A., Fitzgerald, K. D., Monk, C. S., & Phan, K. L. (2015) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2015.03.004 · Cited by 81 · see citing works
Self-citationDefault-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder
Patriat, R., Birn, R. M., Keding, T. J., & Herringa, R. J. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.01.010 · Cited by 78 · see citing works
McGuire, J. F., Orr, S. P., Essoe, J. K.-Y., McCracken, J. T., Storch, E. A., & Piacentini, J. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1199276 · Cited by 67 · see citing works
Self-citationCognitive behavioural therapy for depression: systematic review of imaging studies
Franklin, G., Carson, A. J., & Welch, K. A. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.41 · Cited by 63 · see citing works
Flessner, C. A., Allgair, A., Garcia, A., Freeman, J., Sapyta, J., Franklin, M. E., Foa, E., & March, J. (2010) · Depression and Anxiety · doi:10.1002/da.20626 · Cited by 62 · see citing works
Neuroimaging of psychotherapy for obsessive–compulsive disorder: A systematic review
Thorsen, A. L., van den Heuvel, O. A., Hansen, B., & Kvale, G. (2015) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2015.05.004 · Cited by 46 · see citing works
McNamara, J. P. H., Reid, A. M., Balkhi, A. M., Bussing, R., Storch, E. A., Murphy, T. K., Graziano, P. A., Guzick, A. G., & Geffken, G. R. (2014) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-014-9408-3 · Cited by 38 · see citing works
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Time for a paradigm shift: the adolescent brain in addiction treatment
Mackiewicz Seghete, K. L., Filbey, F. M., Hudson, K. A., Hyun, B., & Feldstein Ewing, S. W. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2022.102960 · Cited by 8 · see citing works
“…is increasingly being found as relevant in systematic reviews of the broader mood/affective adolescent behavioral therapy response literature (La Buissonniere-Ariza et al., 2021), in this initial translational adolescent addiction study, we found that responses to the complex reflection in DFM…”
BackgroundТукаев, Р. Д., & Срывкова, К. А. (2024) · Психиатрия психотерапия и клиническая психология · doi:10.34883/pi.2024.15.1.002
- Authors
- La Buissonniere-Ariza, V., Fitzgerald, K., Meoded, A., Williams, L. L., Liu, G., Goodman, W. K., & Storch, E. A.
- Affiliations
- University of Michigan (US)
- Baylor College of Medicine (US)
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 282
- Pages
- 1288-1307
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W3117240179
- Cited by
- 29
- References
- 41
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 2
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- cognitive behavioral therapy, treatment response, youth, neural correlates, prefrontal cortex, medial temporal lobe, limbic system, functional connectivity, default mode network, cognitive control network, salience network, frontoparietal network, striatum, cingulate cortex, parietal cortex, brain network organization
- MeSH terms
- Adolescent, Brain, Brain Mapping, Child, Humans, Magnetic Resonance Imaging, Cognitive Behavioral Therapy, Prefrontal Cortex
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