2019 Alzheimer’s disease facts and figures.

Alzheimer's Association·2019·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2019.01.010

Cited by (1,017)

Items 301–400 of 1,017

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Designing Socially Assistive Robots for Alzheimer’s Disease and Related Dementia Patients and Their Caregivers: Where We Are and Where We Are Headed
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Katherine Hackett, Sarah M. Lehman, Ross M. Divers, Matthew Ambrogi, Likhon Gomes, Chiu C. Tan, Tania Giovannetti · 2020 · Neuropsychological Rehabilitation
Integrated meta-analysis, network pharmacology, and molecular docking to investigate the efficacy and potential pharmacological mechanism of Kai-Xin-San on Alzheimer's disease
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Functions and dysfunctions of oligodendrocytes in neurodegenerative diseases
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Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease
Chia‐Chen Liu, Yu Yamazaki, Michael G. Heckman, Yuka A. Martens, Lin Jia, Akari Yamazaki, Nancy N. Diehl, Jing Zhao, Na Zhao, Michael A. Deture et al. · 2020 · Alzheimer s & Dementia
Residential Setting and the Cumulative Financial Burden of Dementia in the 7 Years Before Death
Kelley, Amy S., McGarry, Kathleen, Bollens‐Lund, Evan, Rahman, Omari‐Khalid, Husain, Mohammed, Ferreira, Katelyn B., Skinner, Jonathan S. · 2020 · Journal of the American Geriatrics Society
Virtual Reality for Therapeutic Recreation in Dementia Hospice Care: A Feasibility Study
Ferguson, Claire, Shade, Marcia Y., Blaskewicz Boron, Julie, Lyden, Elizabeth, Manley, Natalie A. · 2020 · American Journal of Hospice and Palliative Medicine®
Cognitive decline negatively impacts physical function
Michelle Gray, Joshua L. Gills, Jordan M. Glenn, Jennifer L. Vincenzo, Christopher S. Walter, Erica N. Madero, Aidan Hall, Nami Fuseya, Nick Bott · 2020 · Experimental Gerontology
Early Stages of Alzheimer's Disease: Evolving the Care Team for Optimal Patient Management
James E. Galvin, Paul S. S Aisen, Jessica B. S. Langbaum, Eric Rodríguez, Marwan Noel Sabbagh, Richard G. Stefanacci, Robert A. Stern, Elizabeth A. Vassey, Arno de Wilde, Neva C. West et al. · 2021 · Frontiers in Neurology
Biosensor approaches on the diagnosis of neurodegenerative diseases: Sensing the past to the future
Münteha Nur Sonuç Karaboğa, Mustafa Kemal Sezgintürk · 2021 · Journal of Pharmaceutical and Biomedical Analysis
Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling
Xia Zhao, Xiaosu Huang, Chao Yang, Yi‐Zhou Jiang, Wenshu Zhou, Wenhua Zheng · 2022 · International Journal of Molecular Sciences
Abundance of P‐Glycoprotein and Other Drug Transporters at the Human Blood‐Brain Barrier in Alzheimer’s Disease: A Quantitative Targeted Proteomic Study
Flavia Storelli, Sarah Faye Billington, Aditya R. Kumar, Jashvant D. Unadkat · 2020 · Clinical Pharmacology & Therapeutics
Gut Microbiota Alterations and Cognitive Impairment Are Sexually Dissociated in a Transgenic Mice Model of Alzheimer’s Disease
Daniel Cuervo-Zanatta, Jaime Garcı́a-Mena, Claudia Perez‐Cruz · 2021 · Journal of Alzheimer s Disease
Learning Language and Acoustic Models for Identifying Alzheimer’s Dementia From Speech
Zehra Shah, Jeffrey Sawalha, Mashrura Tasnim, Shi-ang Qi, Eleni Stroulia, Russell Greiner · 2021 · Frontiers in Computer Science
Multimodal Representations Learning and Adversarial Hypergraph Fusion for Early Alzheimer’s Disease Prediction
Qiankun Zuo, Baiying Lei, Yanyan Shen, Yong Liu, Zhiguang Feng, Shuqiang Wang · 2021 · Lecture notes in computer science
Genistein: A focus on several neurodegenerative diseases
Rongzi Li, Megan Robinson, Xiao-Wen Ding, Thangiah Geetha, Layla Al‐Nakkash, Tom L. Broderick, Jeganathan Ramesh Babu · 2022 · Journal of Food Biochemistry
Sex-Linked Biology and Gender-Related Research Is Essential to Advancing Hearing Health
Kelly M. Reavis, Nikolai Bisgaard, Barbara Canlon, Judy R. Dubno, Robert D. Frisina, Ronna P. Hertzano, Larry E. Humes, Paul Thomas Mick, Natalie A. Phillips, Margaret Kathleen Pichora-Fuller et al. · 2022 · Ear and Hearing
Biomarkers of Alzheimer Disease
Melissa M. Budelier, Randall John Bateman · 2019 · The Journal of Applied Laboratory Medicine
The Use of Antimicrobial and Antiviral Drugs in Alzheimer’s Disease
Umar Iqbal, Emma Zeng, Giulio Maria Pasinetti · 2020 · International Journal of Molecular Sciences
Increasing awareness, sensitivity, and empathy for Alzheimer's dementia patients using simulation
Denise J. Campbell, Suzanne Lugger, Gina S. Sigler, Carman L. Turkelson · 2021 · Nurse Education Today
Can Visual Art Therapy Be Implemented With Illiterate Older Adults With Mild Cognitive Impairment? A Pilot Mixed-Method Randomized Controlled Trial
Golden Mwakibo Masika, Doris Sau Fung Yu, Polly W.C. Li · 2020 · Journal of Geriatric Psychiatry and Neurology
A deep ensemble hippocampal CNN model for brain age estimation applied to Alzheimer’s diagnosis
Katia Maria Poloni, Ricardo José Ferrari · 2022 · Expert Systems with Applications
The journey of boswellic acids from synthesis to pharmacological activities
Ehab A. Ragab, Mohammed F. Abdelwahab, Ahmed Soliman Doghish, Rania M. Salama, Nermin Eissa, Samar F. Darwish · 2023 · Naunyn-Schmiedeberg s Archives of Pharmacology
Alzheimer’s disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role?
Arrona Cardoza, Pablo, Spillane, Micheil B, Morales Marroquin, Elisa · 2022 · Nutrition Reviews
Identifying associations among genomic, proteomic and imaging biomarkers via adaptive sparse multi-view canonical correlation analysis
Du, Lei, Zhang, Jin, Liu, Fang, Wang, Huiai, Guo, Lei, Han, Junwei, Disease Neuroimaging Initiative, the Alzheimer’s · 2021 · Medical Image Analysis
Characteristics of Sexual and Gender Minority Caregivers of People With Dementia
Joel G. Anderson, Jason D. Flatt, Jennifer M. Jabson, Alden L. Gross, Karen Moomaw Rose · 2021 · Journal of Aging and Health
Sex Differences between Neuronal Loss and the Early Onset of Amyloid Deposits and Behavioral Consequences in 5xFAD Transgenic Mouse as a Model for Alzheimer’s Disease
Chi Him Poon, San Tung Nicholas Wong, Jaydeep Roy, Yingyi Wang, Hui Wang Hujo Chan, Harry W.M. Steinbusch, Arjan Blokland, Yasin Temel, Luca Aquili, Lee Wei Lim · 2023 · Cells
Multi-relation graph convolutional network for Alzheimer’s disease diagnosis using structural MRI
Jin Zhang, Xiaohai He, Linbo Qing, Xiang Chen, Yan Liu, Honggang Chen · 2023 · Knowledge-Based Systems
Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer’s Disease
Márcia Martins, Renata Silva, Madalena M. M. Pinto, Emı́lia Sousa · 2020 · Pharmaceuticals
Alzheimer’s Disease: An Overview of Major Hypotheses and Therapeutic Options in Nanotechnology
Mugdha Agarwal, Rizwan Alam, Mohd Kabir Haider, Md. Zubbair Malik, Dae-Kwang Kim · 2020 · Nanomaterials
Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid “hesperidin”
Dalia A. Mandour, Mohamed Bendary, Amira Ebrahim Alsemeh · 2021 · Journal of Molecular Histology
Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
Aisha Siddiqui, Zahoor Shah, Rao Nargis Jahan, Iekhsan Othman, Yatinesh Kumari · 2021 · Biomedicine & Pharmacotherapy
A partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic Tau mouse model of Alzheimer disease
Ramesh J. L. Kandimalla, Maria Mańczak, Jangampalli Adi Pradeepkiran, Hallie Morton, P. Hemachandra Reddy · 2021 · Human Molecular Genetics · Retracted
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease
Leonardo Brunetti, Rosalba Leuci, Antonio Carrieri, Marco Catto, Sara Occhineri, Giuseppe Vinci, Lucia Gambacorta, Hanna Baltrukevich, Sı́lvia Chaves, Antonio Laghezza et al. · 2022 · European Journal of Medicinal Chemistry
Development of framework by combining CNN with KNN to detect Alzheimer’s disease using MRI images
Madhusudan G. Lanjewar, Jivan Shrikrishna Parab, Arman Yusuf Shaikh · 2022 · Multimedia Tools and Applications
Recent Uses of Lipid Nanoparticles, Cell-Penetrating and Bioactive Peptides for the Development of Brain-Targeted Nanomedicines against Neurodegenerative Disorders
Yu Wu, Angelina Angelova · 2023 · Nanomaterials
Multimodality Imaging of Dementia: Clinical Importance and Role of Integrated Anatomic and Molecular Imaging
Kunal P. Patel, David T. Wymer, Vinay K. Bhatia, Ranjan Duara, Chetan D. Rajadhyaksha · 2020 · Radiographics
A Multifunctional Chemical Agent as an Attenuator of Amyloid Burden and Neuroinflammation in Alzheimer’s Disease
Hong‐Jun Cho, Anuj K. Sharma, Ying Zhang, Michael L. Gross, Liviu M. Mirica · 2020 · ACS Chemical Neuroscience
Clinical significance of fluid biomarkers in Alzheimer’s Disease
Piotr Lewczuk, Marta Łukaszewicz‐Zając, Piotr Mroczko, Johannes Kornhuber · 2020 · Pharmacological Reports
Fast-food for thought: Retail food environments as resources for cognitive health and wellbeing among aging Americans?
Jessica Finlay, Michael H. Esposito, Sandra Tang, Iris Gomez-Lopez, Dominique L. Sylvers, Suzanne E. Judd, Philippa J Clarke · 2020 · Health & Place
Fine Particle Exposure and Clinical Aggravation in Neurodegenerative Diseases in New York State
Yanelli Nunez, Amelia K. Boehme, Marc G. Weisskopf, Diane Bérangère Ré, Ana Navas‐Acién, Aaron van Donkelaar, Randall V. Martin, Marianthi‐Anna Kioumourtzoglou · 2021 · Environmental Health Perspectives
Feed-forward LPQNet based Automatic Alzheimer's Disease Detection Model
Ela Kaplan, Şengül Doğan, Türker Tuncer, Mehmet Bayğın, Erman Altunışık · 2021 · Computers in Biology and Medicine
Social Networks and Cognitive Reserve: Network Structure Moderates the Association Between Amygdalar Volume and Cognitive Outcomes
Brea Louise Perry, Adam R. Roth, Siyun Peng, Shannon L. Risacher, Andrew J. Saykin, Liana G. Apostolova · 2021 · The Journals of Gerontology Series B
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease
Yuanbing Jiang, Xiaopu Zhou, Hiu Yi Wong, Li Ouyang, Fanny C.F. Ip, Vicky M. N. Chau, Shun‐Fat Lau, Wei Wu, Daniel Y. K. Wong, Heukjin Seo et al. · 2022 · Nature Aging
Trustworthy artificial intelligence in Alzheimer’s disease: state of the art, opportunities, and challenges
Shaker El–Sappagh, José M. Alonso, Tamer Abuhmed, Farman Ali, Alberto Bugarín · 2023 · Artificial Intelligence Review
Modifiable cardiovascular risk factors and genetics for targeted prevention of dementia
Ida Juul Rasmussen, Ruth Frikke‐Schmidt · 2023 · European Heart Journal
A systematic review and methodological analysis of EEG-based biomarkers of Alzheimer's disease
Aslan Modir, Sina Shamekhi, Peyvand Ghaderyan · 2023 · Measurement
Brain Structure-Function Fusing Representation Learning Using Adversarial Decomposed-VAE for Analyzing MCI
Qiankun Zuo, Na Zhong, Yi Feng Pan, Huisi Wu, Baiying Lei, Shuqiang Wang · 2023 · IEEE Transactions on Neural Systems and Rehabilitation Engineering
Characteristics of Epigenetic Clocks Across Blood and Brain Tissue in Older Women and Men
Francine Grodstein, Bernardo Lemos, Lei Yu, Artemis Iatrou, Philip L. De Jager, David Alan Bennett · 2021 · Frontiers in Neuroscience
A high-generalizability machine learning framework for predicting the progression of Alzheimer’s disease using limited data
Wang, Caihua, Li, Yuanzhong, Tsuboshita, Yukihiro, Sakurai, Takuya, Goto, Tsubasa, Yamaguchi, Hiroyuki, Yamashita, Yuichi, Sekiguchi, Atsushi, Tachimori, Hisateru, for the Alzheimer’s Disease Neuroimaging Initiative et al. · 2022 · npj Digital Medicine
Racial Differences in Respite Use among Black and White Caregivers for People Living with Dementia
Parker, Lauren J., Fabius, Chanee D. · 2020 · Journal of Aging and Health
Inflammation, Cognition, and White Matter in Older Adults: An Examination by Race
Elizabeth Anne Boots, Karla J. Castellanos, Liang Zhan, Lisa Laverne Barnes, Lisa Marie Tussing-Humphreys, Sean Deoni, Melissa Lamar · 2020 · Frontiers in Aging Neuroscience
Detecting dementia from speech and transcripts using transformers
Loukas Ilias, Dimitris Askounis, John E. Psarras · 2023 · Computer Speech & Language
Cognitive impairment and World Trade Centre-related exposures
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Smart-Data-Driven System for Alzheimer Disease Detection through Electroencephalographic Signals
Teresa Araújo, João Paulo Teixeira, Pedro Miguel Rodrigues · 2022 · Bioengineering
Mesenchymal stromal cells for the treatment of Alzheimer’s disease: Strategies and limitations
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Extra-Virgin Olive Oil in Alzheimer’s Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies
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BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
Liansheng Zhang, Yun Qian, Jie Li, Xuan Zhou, He Jax Xu, Jie Yan, Jialing Xiang, Xiang Yuan, Beicheng Sun, Sangram S. Sisodia et al. · 2021 · iScience
Predictive classification of Alzheimer’s disease using brain imaging and genetic data
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Transition metal nickel prevents Tau aggregation in Alzheimer's disease
Nalini Vijay Gorantla, Rashmi Das, Ekambaram Balaraman, Subashchandrabose Chinnathambi · 2019 · International Journal of Biological Macromolecules
Zinc Therapy in Early Alzheimer’s Disease: Safety and Potential Therapeutic Efficacy
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Rural depopulation and the rural‐urban gap in cognitive functioning among older adults
Rebecca Glauber · 2022 · The Journal of Rural Health
A new strategy for the early detection of alzheimer disease stages using multifractal geometry analysis based on K-Nearest Neighbor algorithm
Yasmina M. Elgammal, M. A. Zahran, Mohamed Moawad Abdelsalam · 2022 · Scientific Reports
mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-Dependent
Khaled S. Abd‐Elrahman, Alison Hamilton, Awatif B. Albaker, Stephen S. G. Ferguson · 2020 · ACS Pharmacology & Translational Science
A role for sodium glucose cotransporter 2 inhibitors (SGLT2is) in the treatment of Alzheimer's disease?
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Feature selection using efficient fusion of Fisher Score and greedy searching for Alzheimer’s classification
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Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial damages in cells
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The heterogeneity of microglial activation and its epigenetic and non-coding RNA regulations in the immunopathogenesis of neurodegenerative diseases
Chaoyi Li, Jie Ren, Mengfei Zhang, Huakun Wang, Yi Fang, Junjiao Wu, Yu Tang · 2022 · Cellular and Molecular Life Sciences
Anti-Inflammatory Effects of Flavonoids in Common Neurological Disorders Associated with Aging
Hilda Martínez‐Coria, Isabel Arrieta‐Cruz, Roger Gutiérrez Juárez, Héctor Eduardo López-Valdés · 2023 · International Journal of Molecular Sciences
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Emily Ann Baker, Ganna Leonenko, Karl Michael Schmidt, Matthew Hill, Amanda Myers, Maryam Shoai, Itziar de Rojas, Niccoló Tesi, Henne H. Holstege, Wiesje M. van der Flier et al. · 2023 · PLoS ONE
The Effect of the “ Great Village ” on Psychological Outcomes, Burden, and Mastery in African American Caregivers of Persons Living With Dementia
Glenna S. Brewster, Fayron R. Epps, Clinton Dye, Kenneth W. Hepburn, Melinda Kay Higgins, Monica L. Parker · 2019 · Journal of Applied Gerontology
Buildout of Methodology for Meticulous Diagnosis of K-Complex in EEG for Aiding the Detection of Alzheimer’s by Artificial Intelligence
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Missing the Mark: The Complexity of African American Dementia Family Caregiving
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c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer’s Diseases
Stephanie Cristine Hepp Rehfeldt, Fernanda Majolo, Márcia Inês Goettert, Stefan Laufer · 2020 · International Journal of Molecular Sciences
Benzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementia
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Prevalence of psychotropic polypharmacy in nursing home residents with dementia: a meta-analysis
Dylan J. Jester, Victor Molinari, Janice C. Zgibor, Ladislav Volicer · 2021 · International Psychogeriatrics
Validity and Cultural Generalisability of a 5-Minute AI-Based, Computerised Cognitive Assessment in Mild Cognitive Impairment and Alzheimer's Dementia
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Is Dementia-Specific Caregiving Compared With Non-Dementia Caregiving Associated With Physical Difficulty Among Caregivers for Community-Dwelling Adults?
Parker, Lauren J., Fabius, Chanee, Rivers, Emerald, Taylor, Janiece L. · 2022 · Journal of Applied Gerontology
Association of work-family experience with mid- and late-life memory decline in US women
Mayeda, Elizabeth Rose, Mobley, Taylor M., Weiss, Robert E., Murchland, Audrey R., Berkman, Lisa F., Sabbath, Erika L. · 2020 · Neurology
Analysis of the Human Plasma Proteome Using Multi‐Nanoparticle Protein Corona for Detection of Alzheimer's Disease
Claudia Corbo, Andrew A. Li, Hossein Poustchi, Gha Young Lee, Sabrina Stacks, Roberto Molinaro, Philip Ma, Theo Platt, Shahed Behzadi, Róbert Langer et al. · 2020 · Advanced Healthcare Materials
Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration
Nader Morshed, William T. Ralvenius, Alexi Nott, Lauren Ashley Watson, Felicia H. Rodriguez, Leyla Anne Akay, Brian A. Joughin, Ping‐Chieh Pao, Jay Penney, Lauren M. LaRocque et al. · 2020 · Molecular Systems Biology
Learn-Explain-Reinforce: Counterfactual Reasoning and its Guidance to Reinforce an Alzheimer's Disease Diagnosis Model
Kwanseok Oh, Jeeseok Yoon, Heung-Il Suk · 2021 · IEEE Transactions on Pattern Analysis and Machine Intelligence
Multi-modal sequence learning for Alzheimer’s disease progression prediction with incomplete variable-length longitudinal data
Lei Xu, Hui Ming Wu, Chunming He, Jun Wang, Changqing Zhang, Feiping Nie, Lei Chen · 2022 · Medical Image Analysis
Attitudes toward advance care planning among persons with dementia and their caregivers
Corinne A. Pettigrew, Rottislav Brichko, Betty Smith Black, Maureen K. O’Connor, Mary Guerriero Austrom, Maisha T. Robinson, Allison Lindauer, Raj C. Shah, Guerry M. Peavy, Kayla Meyer et al. · 2019 · International Psychogeriatrics
Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease
María Victoria Moreno-Arribas, Begoña Bartolomé, José Luis Peñalvo, Patricia Pérez‐Matute, María‐José Motilva · 2020 · Nutrients
Bridging Scales in Alzheimer's Disease: Biological Framework for Brain Simulation With The Virtual Brain
Leon Stefanovski, Jil Mona Meier, Roopa Kalsank Pai, Paul Triebkorn, Tristram A. P. Lett, Leon Martin, Konstantin Bülau, Martin Hofmann‐Apitius, Ana Solodkin, Anthony Randal McIntosh et al. · 2021 · Frontiers in Neuroinformatics
Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model
Chen Chen, Junfeng Lu, Weijia Peng, Shinghung Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Jin Zhou, Wen‐Jun Xin et al. · 2021 · Pharmacological Research
Changes in physical and mental health of Black, Hispanic, and White caregivers and non‐caregivers associated with onset of spousal dementia
Chen, Cynthia, Thunell, Johanna, Zissimopoulos, Julie · 2020 · Alzheimer's & Dementia: Translational Research & Clinical Interventions
Systemic Actions of SGLT2 Inhibition on Chronic mTOR Activation as a Shared Pathogenic Mechanism between Alzheimer’s Disease and Diabetes
Stanciu, Gabriela Dumitrita, Rusu, Razvan Nicolae, Bild, Veronica, Filipiuc, Leontina Elena, Tamba, Bogdan-Ionel, Ababei, Daniela Carmen · 2021 · Biomedicines
Sleep difficulties, incident dementia and all‐cause mortality among older adults across 8 years: Findings from the National Health and Aging Trends Study
Rebecca Robbins, Matthew D. Weaver, Laura K. Barger, Wei Wang, Stuart F. Quan, Charles Andrew Czeisler · 2021 · Journal of Sleep Research
Distinct types of amyloid‐β oligomers displaying diverse neurotoxicity mechanisms in Alzheimer's disease
Priyanka Madhu, Samrat Mukhopadhyay · 2021 · Journal of Cellular Biochemistry
Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes
Sang‐Hyuk Jung, Hang‐Rai Kim, Min Young Chun, Hyemin Jang, Minyoung Cho, Beomsu Kim, Soyeon Kim, Jee Hyang Jeong, Soo Jin Yoon, Kyung Won Park et al. · 2022 · JAMA Network Open
A novel fluorescent protein chromophore analogue to simultaneously probe lysosome viscosity and β-amyloid fibrils
Han Sun, Huaxiang Leng, Jinsheng Liu, Gaurab Roy, Jinwu Yan, Lei Zhang · 2019 · Sensors and Actuators B Chemical
The Association of Osteoarthritis and Related Pain Burden to Incident Alzheimer’s Disease and Related Dementias: A Retrospective Cohort Study of U.S. Medicare Beneficiaries
Kim E. Innes, Usha Sambamoorthi · 2020 · Journal of Alzheimer s Disease