Myeloid suppressor cells in cancer and autoimmunity
Abstract
A bottleneck for immunotherapy of cancer is the immunosuppressive microenvironment in which the tumor cells proliferate. Cancers harness the immune regulatory mechanism that prevents autoimmunity from evading immunosurveillance and promoting immune destruction. Regulatory T cells, myeloid suppressor cells, inhibitory cytokines and immune checkpoint receptors are the major components of the immune system acting in concert with cancer cells and causing the subversion of anti-tumor immunity. This redundant immunosuppressive network poses an impediment to efficacious immunotherapy by facilitating tumor progression. Tumor-associated myeloid cells comprise heterogeneous populations acting systemically (myeloid-derived suppressor cells/MDSCs) and/or locally in the tumor microenvironment (MDSCs and tumor-associated macrophages/TAMs). Both populations promote cancer cell proliferation and survival, angiogenesis and lymphangiogenesis and elicit immunosuppression through different pathways, including the expression of immunosuppressive cytokines and checkpoint inhibitors. Several evidences have demonstrated that myeloid cells can express different functional programs in response to different microenvironmental signals, a property defined as functional plasticity. The opposed extremes of this functional flexibility are generally represented by the classical macrophage activation, which identifies inflammatory and cytotoxic M1 polarized macrophages, and the alternative state of macrophage activation, which identifies M2 polarized anti-inflammatory and immunosuppressive macrophages. Functional skewing of myeloid cells occurs in vivo under physiological and pathological conditions, including cancer and autoimmunity. Here we discuss how myeloid suppressor cells can on one hand support tumor growth and, on the other, limit autoimmune responses, indicating that their therapeutic reprogramming can generate opportunities in relieving immunosuppression in the tumor microenvironment or reinstating tolerance in autoimmune conditions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cancer patients have greater vulnerability to infection than people without cancer, owing to immune suppression from the malignancy and treatments such as chemotherapy or surgery.
“Patients with cancer are more susceptible to infection than individuals without cancer because of their systemic immunosuppressive state caused by the malignancy and anticancer treatments, such as chemotherapy or surgery.5, 6, 7, 8”
From Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China (2020) · cites this paper as [8]
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · see citing works
Self-citationMacrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works
Self-citationMacrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · see citing works
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works
Tumour-associated macrophages as treatment targets in oncology
Mantovani, A., Marchesi, F., Malesci, A., Laghi, L., & Allavena, P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.217 · Cited by 4,065 · see citing works
Commensal <i>Bifidobacterium</i> promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888 · see citing works
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works
Coordinated regulation of myeloid cells by tumours
Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544 · see citing works
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Vétizou, M., Pitt, J. M., Daillère, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M. P., Duong, C. P. M., et al. (2015) · Science · doi:10.1126/science.aad1329 · Cited by 3,488 · see citing works
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874 · see citing works
Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis
Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., Blanchard, C., Junt, T., Nicod, L. P., Harris, N. L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3444 · Cited by 2,862 · see citing works
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Bronte, V., Brandau, S., Chen, S.-H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12150 · Cited by 2,751 · see citing works
Self-citationMacrophage plasticity and polarization in tissue repair and remodelling
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384 · see citing works
Self-citationSingh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368 · see citing works
Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
Iida, N., Dzutsev, A., Stewart, C. A., Smith, L., Bouladoux, N., Weingarten, R. A., Molina, D. A., Salcedo, R., Back, T., Cramer, S., et al. (2013) · Science · doi:10.1126/science.1240527 · Cited by 2,251 · see citing works
Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science · doi:10.1126/science.1175202 · Cited by 2,221 · see citing works
Chang, P. V., Hao, L., Offermanns, S., & Medzhitov, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322269111 · Cited by 2,175 · see citing works
The microbiome and innate immunity
Thaiss, C. A., Zmora, N., Levy, M., & Elinav, E. (2016) · Nature · doi:10.1038/nature18847 · Cited by 2,012 · see citing works
Macrophages, innate immunity and cancer: balance, tolerance, and diversity
Mantovani, A., & Sica, A. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.009 · Cited by 1,484 · see citing works
Self-citationJenkins, S., Ruckerl, D., Cook, P., Jones, L., Finkelman, F., van Rooijen, N., MacDonald, A., & Allen, J. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,427 · see citing works
Vincent, J., Mignot, G., Chalmin, F., Ladoire, S., Bruchard, M., Chevriaux, A., Martin, F., Apetoh, L., Rébé, C., & Ghiringhelli, F. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3690 · Cited by 1,245 · see citing works
Altered macrophage differentiation and immune dysfunction in tumor development
Sica, A., & Bronte, V. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31422 · Cited by 1,239 · see citing works
Self-citationDiaz-Montero, C. M., Salem, M. L., Nishimura, M. I., Garrett-Mayer, E. S., Cole, D. J., & Montero, A. J. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0523-4 · Cited by 1,217 · see citing works
Bain, C. C., Bravo-Blas, A., Scott, C. L., Gomez Perdiguero, E., Geissmann, F., Henri, S., Malissen, B., Osborne, L. C., Artis, D., & Mowat, A. M. (2014) · Nature Immunology · doi:10.1038/ni.2967 · Cited by 1,178 · see citing works
Kostic, A. D., Gevers, D., Siljander, H., Vatanen, T., Hyötyläinen, T., Hämäläinen, A., Peet, A., Tillmann, V., Pöhö, P., Mattila, I. M., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.01.001 · Cited by 1,165 · see citing works
Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., Hainzl, A., Schatz, S., Qi, Y., Schlecht, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44490 · Cited by 1,100 · see citing works
Suzuki, E., Kapoor, V., Jassar, A. S., Kaiser, L. R., & Albelda, S. M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0883 · Cited by 1,054 · see citing works
Pitt, J. M., Vétizou, M., Daillère, R., Roberti, M. P., Yamazaki, T., Routy, B., Lepage, P., Boneca, I. G., Chamaillard, M., Kroemer, G., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.001 · Cited by 1,040 · see citing works
Neutrophil ageing is regulated by the microbiome
Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J.-E., Scheiermann, C., et al. (2015) · Nature · doi:10.1038/nature15367 · Cited by 839 · see citing works
Scher, J. U., Úbeda, C., Artacho, A., Attur, M. G., Isaac, S., Reddy, S. M., Marmon, S., Neimann, A. L., Brusca, S. B., Patel, T., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38892 · Cited by 820 · see citing works
Tamoutounour, S., Guilliams, M., Montanana Sanchis, F., Liu, H., Terhorst, D., Malosse, C., Pollet, E., Ardouin, L., Luche, H., Sanchez, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.004 · Cited by 783 · see citing works
Hume, D. A., & MacDonald, K. P. A. (2011) · Blood · doi:10.1182/blood-2011-09-379214 · Cited by 757 · see citing works
Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility
Muller, P. A., Koscsó, B., Rajani, G. M., Stevanovic, K. D., Berres, M., Hashimoto, D., Mortha, A., Leboeuf, M., Li, X.-M., Mucida, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.050 · Cited by 727 · see citing works
Immunity, inflammation, and cancer: an eternal fight between good and evil
Shalapour, S., & Karin, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80007 · Cited by 703 · see citing works
Macrophage polarization in pathology
Sica, A., Erreni, M., Allavena, P., & Porta, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1995-y · Cited by 673 · see citing works
Self-citationGut Microbiota Promote Hematopoiesis to Control Bacterial Infection
Khosravi, A., Yáñez, A., Price, J. G., Chow, A. T., Mérad, M., Goodridge, H. S., & Mazmanian, S. K. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.006 · Cited by 651 · see citing works
Orchestration of Metabolism by Macrophages
Biswas, S. K., & Mantovani, A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.013 · Cited by 586 · see citing works
Deshmukh, H. S., Liu, Y., Menkiti, O. R., Mei, J., Dai, N., O'Leary, C. E., Oliver, P. M., Kolls, J. K., Weiser, J. N., & Worthen, G. S. (2014) · Nature Medicine · doi:10.1038/nm.3542 · Cited by 579 · see citing works
Ugel, S., Sanctis, F. D., Mandruzzato, S., & Bronte, V. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80006 · Cited by 563 · see citing works
Characteristics of Intestinal Dendritic Cells in Inflammatory Bowel Diseases
Hart, A. L., Al-Hassi, H. O., Rigby, R. J., Bell, S., Emmanuel, A. V., Knight, S. C., Kamm, M. A., & Stagg, A. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.013 · Cited by 562 · see citing works
Metcalf, D. (2008) · Blood · doi:10.1182/blood-2007-03-079681 · Cited by 527 · see citing works
Lineage Relationship Analysis of RORγt + Innate Lymphoid Cells
Sawa, S., Cherrier, M., Lochner, M., Satoh‐Takayama, N., Fehling, H. J., Vives, F. L., Santo, J. P. D., & Eberl, G. (2010) · Science · doi:10.1126/science.1194597 · Cited by 502 · see citing works
The microbiome and rheumatoid arthritis
Scher, J. U., & Abramson, S. B. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.121 · Cited by 479 · see citing works
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation
Hill, D. A., Siracusa, M. C., Abt, M. C., Kim, B. S., Kobuley, D., Kubo, M., Kambayashi, T., LaRosa, D. F., Renner, E. D., Orange, J. S., et al. (2012) · Nature Medicine · doi:10.1038/nm.2657 · Cited by 468 · see citing works
Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer
Nefedova, Y., Huang, M., Kusmartsev, S., Bhattacharya, R., Cheng, P., Salup, R., Jove, R., & Gabrilovich, D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.464 · Cited by 464 · see citing works
Transcriptional control of granulocyte and monocyte development
Friedman, A. D. (2007) · Oncogene · doi:10.1038/sj.onc.1210764 · Cited by 427 · see citing works
Cui, T. X., Kryczek, I., Zhao, L., Zhao, E., Kuick, R. D., Roh, M. H., Vatan, L., Szeliga, W., Mao, Y., Thomas, D. G., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.025 · Cited by 426 · see citing works
Faecal microbiota study reveals specific dysbiosis in spondyloarthritis
Bréban, M., Tap, J., Leboime, A., Said‐Nahal, R., Langella, P., Chiocchia, G., Furet, J., & Sokol, H. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-211064 · Cited by 396 · see citing works
Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis
Taylor, P., & Feldmann, M. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.181 · Cited by 391 · see citing works
Allavena, P., & Mantovani, A. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04515.x · Cited by 383 · see citing works
Kumar, V., Cheng, P., Condamine, T., Mony, S., Languino, L. R., McCaffrey, J. C., Hockstein, N., Guarino, M., Masters, G., Penman, E., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.014 · Cited by 371 · see citing works
Kim, Y.-G., Udayanga, K. G. S., Totsuka, N., Weinberg, J. B., Núñez, G., & Shibuya, A. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2013.12.010 · Cited by 366 · see citing works
Regulation of the Macrophage Content of Neoplasms by Chemoattractants
Bottazzi, B., Polentarutti, N., Acero, R., Balsari, A., Boraschi, D., Ghezzi, P., Salmona, M., & Mantovani, A. (1983) · Science · doi:10.1126/science.6828888 · Cited by 352 · see citing works
Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases
Perl, A. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.172 · Cited by 335 · see citing works
Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease: A New Immunoregulatory Pathway
Haile, L. A., von Wasielewski, R., Gamrekelashvili, J., Krüger, C., Bachmann, O. P., Westendorf, A. M., Buer, J., Liblau, R., Manns, M. P., Korangy, F., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.032 · Cited by 308 · see citing works
Schwab, L., Goroncy, L., Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mócsai, A., Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., et al. (2014) · Nature Medicine · doi:10.1038/nm.3517 · Cited by 302 · see citing works
Microbiota-dependent sequelae of acute infection compromise tissue-specific immunity
Fonseca, D. M. D., Hand, T. W., Han, S.-J., Gerner, M. Y., Zaretsky, A. G., Byrd, A. L., Harrison, O. J., Ortiz, A. M., Quinones, M., Trinchieri, G., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.030 · Cited by 281 · see citing works
Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling
Balmer, M. L., Schürch, C. M., Saito, Y., Geuking, M. B., Li, H., Miguelangel Cuenca, V., Kovtonyuk, L. V., McCoy, K. D., Hapfelmeier, S., Ochsenbein, A. F., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400762 · Cited by 274 · see citing works
Immunomodulatory dendritic cells in intestinal lamina propria
Chirdo, F. G., Millington, O. R., Beacock‐Sharp, H., & Mowat, A. M. (2005) · European Journal of Immunology · doi:10.1002/eji.200425882 · Cited by 229 · see citing works
Hrnčíř, T., Štëpánková, R., Kozáková, H., Hudcovic, T., & Tlaskalová-Hogenová, H. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-65 · Cited by 211 · see citing works
Inflammation boosts bacteriophage transfer between Salmonella spp.
Diard, M., Bakkeren, E., Cornuault, J. K., Moor, K., Hausmann, A., Sellin, M. E., Loverdo, C., Aertsen, A., Ackermann, M., Paepe, M. D., et al. (2017) · Science · doi:10.1126/science.aaf8451 · Cited by 205 · see citing works
RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis
Strauss, L., Sangaletti, S., Consonni, F. M., Szebeni, G. J., Morlacchi, S., Totaro, M. G., Porta, C., Anselmo, A., Tartari, S., Doni, A., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.07.006 · Cited by 204 · see citing works
Self-citationSignaling pathways involved in MDSC regulation
Trikha, P., & Carson, W. E. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.003 · Cited by 201 · see citing works
DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance
Condé, P., Rodríguez, M., van der Touw, W., Jimenez, A., Burns, M., Miller, J. C., Brahmachary, M., Chen, H.-M., Boros, P., Rausell-Palamos, F., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.009 · Cited by 188 · see citing works
Rojas, A., Jiang, J., Ganesh, T., Yang, M., Lelutiu, N. B., Gueorguieva, P., & Dingledine, R. J. (2013) · Epilepsia · doi:10.1111/epi.12461 · Cited by 182 · see citing works
Inflammatory Bowel Disease: Autoimmune or Immune‐mediated Pathogenesis?
Wen, Z., & Fiocchi, C. (2004) · Journal of Immunology Research · doi:10.1080/17402520400004201 · Cited by 158 · see citing works
Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment
Lahmar, Q., Keirsse, J., Laoui, D., Movahedi, K., Overmeire, E. V., & Ginderachter, J. A. V. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.06.009 · Cited by 151 · see citing works
Fujii, W., Ashihara, E., Hirai, H., Nagahara, H., Kajitani, N., Fujioka, K., Murakami, K., Seno, T., Yamamoto, A., Ishino, H., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203535 · Cited by 151 · see citing works
Allen, E., Walters, I. B., & Hanahan, D. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2847 · Cited by 148 · see citing works
Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance
Khan, I. S., Mouchess, M. L., Zhu, M., Conley, B. E., Fasano, K. J., Hou, Y., Fong, L. H., Su, M. A., & Anderson, M. S. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131889 · Cited by 134 · see citing works
Gnerlich, J. L., Mitchem, J. B., Weir, J. S., Sankpal, N. V., Kashiwagi, H., Belt, B. A., Porembka, M. R., Herndon, J. M., Eberlein, T. J., Goedegebuure, P. S., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902609 · Cited by 133 · see citing works
Chou, H.-S., Hsieh, C., Yang, H.-R., Wang, L., Arakawa, Y., Brown, K., Wu, Q., Lin, F., Peters, M. G., Fung, J. J., et al. (2011) · Hepatology · doi:10.1002/hep.24162 · Cited by 126 · see citing works
Zoso, A., Mazza, E. M. C., Bicciato, S., Mandruzzato, S., Bronte, V., Serafini, P., & Inverardi, L. (2014) · European Journal of Immunology · doi:10.1002/eji.201444522 · Cited by 123 · see citing works
Vacchelli, E., Galluzzi, L., Eggermont, A. M. M., Galon, J., Tartour, É., Zitvogel, L., & Kroemer, G. (2012) · OncoImmunology · doi:10.4161/onci.20459 · Cited by 120 · see citing works
Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis
Kalisperati, P., Spanou, E., Pateras, I. S., Korkolopoulou, P. A., Varvarigou, A. A., Karavokyros, I., Gorgoulis, V. G., Vlachoyiannopoulos, P. G., & Sougioultzis, S. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00020 · Cited by 108 · see citing works
Myeloid-derived suppressor cells regulate T cell and B cell responses during autoimmune disease
Crook, K. R., Jin, M., Weeks, M. F., Rampersad, R. R., Baldi, R. M., Glekas, A. S., Shen, Y., Esserman, D. A., Little, P., Schwartz, T. A., et al. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.4a0314-139r · Cited by 106 · see citing works
Chou, H.-S., Hsieh, C., Charles, R., Wang, L., Wagner, T., Fung, J. J., Qian, S., & Lu, L. L. (2011) · Transplantation · doi:10.1097/tp.0b013e31823ffd39 · Cited by 105 · see citing works
Microbiota—myeloid cell crosstalk beyond the gut
Gorjifard, S., & Goldszmid, R. S. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0516-222r · Cited by 97 · see citing works
Myeloid cell population dynamics in healthy and tumor-bearing mice
Ueha, S., Shand, F. H. W., & Matsushima, K. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.03.003 · Cited by 96 · see citing works
Kesselring, R., Thiel, A., Pries, R., Trenkle, T., & Wollenberg, B. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605891 · Cited by 94 · see citing works
Molecular Imaging of Innate Immune Cell Function in Transplant Rejection
Christen, T., Nahrendorf, M., Wildgruber, M., Świrski, F. K., Aïkawa, E., Waterman, P. R., Shimizu, K., Weissleder, R., & Libby, P. (2009) · Circulation · doi:10.1161/circulationaha.108.796888 · Cited by 93 · see citing works
Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes
Tudek, B., Zdżalik-Bielecka, D., Tudek, A., Kosicki, K., Fabisiewicz, A., & Speina, E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.043 · Cited by 92 · see citing works
Cai, D. H., Wang, D., Keefer, J., Yeamans, C., Hensley, K., & Friedman, A. D. (2008) · Oncogene · doi:10.1038/sj.onc.1210940 · Cited by 86 · see citing works
Role of myeloid-derived suppressor cells in autoimmune disease
Crook, K. R. (2014) · World Journal of Immunology · doi:10.5411/wji.v4.i1.26 · Cited by 83 · see citing works
Re‐adapting T cells for cancer therapy: from mouse models to clinical trials
Stromnes, I. M., Schmitt, T. M., Chapuis, A. G., Hingorani, S. R., & Greenberg, P. D. (2013) · Immunological Reviews · doi:10.1111/imr.12141 · Cited by 81 · see citing works
Hammami, I., Chen, J., Murschel, F., Bronte, V., Crescenzo, G. D., & Jolicœur, M. (2012) · BMC Cell Biology · doi:10.1186/1471-2121-13-18 · Cited by 74 · see citing works
The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases
Cuda, C. M., Pope, R. M., & Perlman, H. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.132 · Cited by 72 · see citing works
Björkgren, I., Gylling, H., Turunen, H., Huhtaniemi, I. T., Strauss, L., POUTANEN, M. H., & Sipilä, P. (2014) · The FASEB Journal · doi:10.1096/fj.14-259382 · Cited by 65 · see citing works
Boyle, K. B., Győri, D., Sindrilaru, A., Scharffetter‐Kochanek, K., Taylor, P. R., Mócsai, A., Stephens, L., & Hawkins, P. T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002268 · Cited by 64 · see citing works
Lan, C., Huang, X., Lin, S., Huang, H., Cai, Q.-C., Lu, J., & Liu, J. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1567-0 · Cited by 62 · see citing works
Akagi, T., Saitoh, T., O’Kelly, J., Akira, S., Gombart, A. F., & Koeffler, H. P. (2007) · Blood · doi:10.1182/blood-2007-04-087213 · Cited by 60 · see citing works
Guan, Q., Moreno, S., Qing, G., Weiss, C. R., Lü, L., Bernstein, C. N., Warrington, R., Ma, Y., & Peng, Z. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0113050 · Cited by 60 · see citing works
Zhang, R., Ito, S., Nishio, N., Cheng, Z., Suzuki, H., & Isobe, K.-I. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04374.x · Cited by 58 · see citing works
Zhang, R., Ito, S., Nishio, N., et al. (2011) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152811794352114 · Cited by 57 · see citing works
Ahanda, M.-L. E., Fritz, E., Estellé, J., Hu, Z.-L., Madsen, O., Groenen, M. A. M., Beraldi, D., Kapétanovic, R., Hume, D. A., Rowland, R. R. R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048607 · Cited by 56 · see citing works
Hematopoietic defects in the Ts1Cje mouse model of Down syndrome
Carmichael, C., Majewski, I. J., Alexander, W. S., Metcalf, D., Hilton, D. J., Hewitt, C., & Scott, H. S. (2008) · Blood · doi:10.1182/blood-2008-06-161422 · Cited by 56 · see citing works
Akagi, T., Luong, Q. T., Gui, D., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604544 · Cited by 49 · see citing works
Tu, Z., Li, Y., Smith, D. G., Doller, C. M., Sugita, S., Chan, C., Qian, S., Fung, J. J., Caspi, R. R., Lü, L., et al. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8377 · Cited by 46 · see citing works
Ji, Y., Sun, S., Goodrich, J. K., Kim, H., Poole, A. C., Duhamel, G. E., Ley, R. E., & Qi, L. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.040 · Cited by 45 · see citing works
Myeloid‐derived suppressor cells mediate tolerance induction in autoimmune disease
Wegner, A., Verhagen, J., & Wraith, D. C. (2017) · Immunology · doi:10.1111/imm.12718 · Cited by 44 · see citing works
Energy metabolism drives myeloid-derived suppressor cell differentiation and functions in pathology
Sica, A., & Strauss, L. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr1116-476r · Cited by 40 · see citing works
Self-citationPreferential killing of p53-deficient cancer cells by reversine
Jèmaà, M., Galluzzi, L., Kepp, O., Boilève, A., Lissa, D., Senovilla, L., Harper, F., Pierron, G., Berardinelli, F., Antoccia, A., et al. (2012) · Cell Cycle · doi:10.4161/cc.20621 · Cited by 37 · see citing works
Gerspach, J., Pfizenmaier, K., & Wajant, H. (2009) · BioFactors · doi:10.1002/biof.50 · Cited by 20 · see citing works
Tolentino, Y. F. M., Elia, P. P., Fogaça, H. S., Carneiro, A. J., Zaltman, C., Moura-Neto, R. S., Luiz, R. R., Carvalho, M. D. G., & de Souza, H. S. P. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4172-8 · Cited by 13 · see citing works
Andersen, M. H. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-016-0617-6 · Cited by 9 · see citing works
Heo, J.-S., Park, J., Lee, E., Kim, T. H., Jang, A., Park, S., Kim, J., Kim, Y. G., Uh, S., Choi, J.-S., et al. (2013) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.3109/15412555.2013.828028 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China
Liang, W., Guan, W., Chen, R., Wang, W., Li, J., Xu, K., Li, C., Ai, Q., Lu, W., Liang, H., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30096-6 · Cited by 4,384 · see citing works
The extracellular matrix in tumor progression and metastasis
Eble, J. A., & Niland, S. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09966-1 · Cited by 613 · see citing works
Inflammatory bone marrow microenvironment
Leimkühler, N. B., & Schneider, R. K. (2019) · Hematology · doi:10.1182/hematology.2019000045 · Cited by 82 · see citing works
Wei, C., Wang, Y., Ma, L., Wang, X., Chi, H., Zhang, S., Liu, T., Li, Z., Xiang, D., Dong, Y., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02283 · Cited by 38 · see citing works
- Authors
- Sica, A., & Massarotti, M.
- Affiliations
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University Hospitals of Morecambe Bay NHS Foundation Trust (GB)
- Corresponding author
- Sica, Antonio
- Venue
- Journal of Autoimmunity
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 85
- Pages
- 117-125
- ISSN
- 0896-8411 (ISSN-L)
- OpenAlex
- W2735586502
- Cited by
- 201
- References
- 107
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 9 · 2023: 21 · 2022: 27 · 2021: 37 · 2020: 54 · 2019: 22 · 2018: 11 · 2017: 2
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Autoimmunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Associazione Italiana Ricerca sul Cancro (AIRC) (15585)
- Fondazione Cariplo (2016-0871, RBNE01XHB2 002, RBAP11H2R9 005)
- Ministero Università Ricerca (MIUR) (RBAU01PTYW)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- myeloid-derived suppressor cells, tumor-associated macrophages, tumor microenvironment, immunosuppression, cancer immunotherapy, autoimmunity, regulatory T cells, immune checkpoint receptors, macrophage polarization, immunosuppressive cytokines, tumor angiogenesis, lymphangiogenesis, immune surveillance
- MeSH terms
- Myeloid-Derived Suppressor Cells, Animals, Humans, Immunosuppression Therapy, Immunotherapy, Neoplasms, Autoimmunity, Myeloid Cells, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
