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Nanotechnology for protein delivery: Overview and perspectives
Open accessAbstract
Protein-based therapeutics have made a significant impact in the treatment of a variety of important human diseases. However, given their intrinsically vulnerable structure and susceptibility to enzymatic degradation, many therapeutic proteins such as enzymes, growth factors, hormones, and cytokines suffer from poor physicochemical/biological stability and immunogenicity that may limit their potential benefits, and in some cases limit their utility. Furthermore, when protein therapeutics are developed for intracellular targets, their internalization and biological activity may be limited by inefficient membrane permeability and/or endosomal escape. Development of effective protein delivery strategies is therefore essential to further enhance therapeutic outcomes to enable widespread medical applications. This review discusses the advantages and limitations of marketed and developmental-stage protein delivery strategies, and provides a focused overview of recent advances in nanotechnology platforms for the systemic delivery of therapeutic proteins. In addition, we also highlight nanoparticle-mediated non-invasive administration approaches (e.g., oral, nasal, pulmonary, and transdermal routes) for protein delivery.
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“Delivery of proteins such as catalase raises a few concerns such as its instability in vivo due to the presence of numerous physiological proteases, unpredictable protein immunogenicity, and poor in vivo half-life.27,28”
From Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor (2019) · cites this paper as [27]
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Self-citationPushko, P., Pumpens, P., & Grens, E. (2013) · Intervirology · doi:10.1159/000346773 · Cited by 5,975
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Cancer immunotherapy comes of age
Mellman, I., Coukos, G., & Dranoff, G. (2011) · Nature · doi:10.1038/nature10673 · Cited by 3,893
Prausnitz, M. R., & Langer, R. (2008) · Nature Biotechnology · doi:10.1038/nbt.1504 · Cited by 3,691
Biodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,951
Bertrand, N., Wu, J., Xu, X., Kamaly, N., & Farokhzad, O. C. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.009 · Cited by 2,925
Self-citationGold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity
Boisselier, É., & Astruc, D. (2009) · Chemical Society Reviews · doi:10.1039/b806051g · Cited by 2,832
Nanoparticles in Medicine: Therapeutic Applications and Developments
Zhang, L., Gu, F., Chan, J. M., Wang, A. Z., Langer, R., & Farokhzad, O. C. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100400 · Cited by 2,685
Self-citationPolymeric systems for controlled drug release
Uhrich, K. E., Cannizzaro, S. M., Langer, R. S., & Shakesheff, K. M. (1999) · Chemical Reviews · doi:10.1021/cr940351u · Cited by 2,633
Protein Therapeutics: A Summary and Pharmacological Classification
Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161
Cancer immunotherapy via dendritic cells
Palucka, K., & Banchereau, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3258 · Cited by 2,114
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic‐Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,774
Self-citationActive targeting schemes for nanoparticle systems in cancer therapeutics
Byrne, J. D., Betancourt, T., & Brannon‐Peppas, L. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.08.005 · Cited by 1,762
Vertebrate protein glycosylation: diversity, synthesis and function
Moremen, K. W., Tiemeyer, M., & Nairn, A. V. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3383 · Cited by 1,733
Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies
Mitragotri, S., Burke, P. A., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4363 · Cited by 1,702
Magnetic nanoparticles for drug delivery
Arruebo, M., Fernández‐Pacheco, R., Ibarra, M. R., & Santamarı́a, J. (2007) · Nano Today · doi:10.1016/s1748-0132(07)70084-1 · Cited by 1,646
Normalization of the Vasculature for Treatment of Cancer and Other Diseases
Goel, S., Duda, D. G., Xu, L., Munn, L. L., Boucher, Y., Fukumura, D., & Jain, R. K. (2011) · Physiological Reviews · doi:10.1152/physrev.00038.2010 · Cited by 1,605
Pharmacokinetics and Biodistribution of Nanoparticles
Li, S., & Huang, L. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800049w · Cited by 1,603
Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities
Kabanov, A. V., & Vinogradov, S. V. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900441 · Cited by 1,320
Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers
Jain, R. K. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.46.3653 · Cited by 1,248
Large Porous Particles for Pulmonary Drug Delivery
Edwards, D. A., Hanes, J. S., Caponetti, G., Hrkach, J. S., Ben-Jebria, A., Eskew, M. L., Mintzes, J. D., Deaver, D. R., Lotan, N., & Langer, R. (1997) · Science · doi:10.1126/science.276.5320.1868 · Cited by 1,184
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akinc, A., Zumbuehl, A., Goldberg, M., Leshchiner, E. S., Busini, V., Hossain, N., Bacallado, S. A., Nguyen, D. N., Fuller, J., Alvarez, R., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1402 · Cited by 1,150
Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popović, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., & Jain, R. K. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.45 · Cited by 1,101
Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic
Puri, A., Loomis, K. H., Smith, B. J., Lee, J. H., Yavlovich, A., Heldman, E., & Blumenthal, R. P. (2009) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v26.i6.10 · Cited by 1,099
The big picture on nanomedicine: the state of investigational and approved nanomedicine products
Etheridge, M. L., Campbell, S. A., Erdman, A. G., Haynes, C. L., Wolf, S. M., & McCullough, J. (2013) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2012.05.013 · Cited by 1,088 · cited 2×
“Since the first nanotherapeutic Doxil (pegylated liposomal doxorubicin) received FDA approval in 1995, the pipeline of nanomedicines for the management of various diseases has greatly expanded [9, 136].”
BackgroundMundargi, R. C., Babu, V. R., Rangaswamy, V., Patel, P., & Aminabhavi, T. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.09.013 · Cited by 1,025
Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles
Rodriguez, P. L., Harada, T., Christian, D. A., Pantano, D. A., Tsai, R. K., & Discher, D. E. (2013) · Science · doi:10.1126/science.1229568 · Cited by 1,001
Targeting nanoparticles to cancer
Wang, M., & Thanou, M. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.03.005 · Cited by 949
Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy
Yu, M. K., Park, J., & Jon, S. (2012) · Theranostics · doi:10.7150/thno.3463 · Cited by 907
Self-citationYu, J., Zhang, Y., Ye, Y., DiSanto, R., Sun, W., Ranson, D., Ligler, F. S., Buse, J. B., & Gu, Z. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505405112 · Cited by 867
Biodegradable microspheres for protein delivery
Sinha, V. R., & Trehan, A. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00194-9 · Cited by 833
Strategies for advancing cancer nanomedicine
Chauhan, V. P., & Jain, R. K. (2013) · Nature Materials · doi:10.1038/nmat3792 · Cited by 821
Design considerations for tumour-targeted nanoparticles
Choi, H. S., Liu, W., Liu, F., Nasr, K., Misra, P., Bawendi, M. G., & Frangioni, J. V. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.314 · Cited by 754
Parameters influencing the stealthiness of colloidal drug delivery systems
Vonarbourg, A., Passirani, C., Saulnier, P., & Benoit, J.-P. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.03.039 · Cited by 740
Chen, Y., Chen, H., & Shi, J. (2013) · Advanced Materials · doi:10.1002/adma.201205292 · Cited by 733
Self-citationTransport of drugs across the blood–brain barrier by nanoparticles.
Wohlfart, S., Gelperina, S., & Kreuter, J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.017 · Cited by 715
Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
Gu, F., Zhang, L., Teply, B. A., Mann, N., Wang, A. Z., Radovic‐Moreno, A. F., Langer, R., & Farokhzad, O. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711714105 · Cited by 714
Self-citationManaging diabetes with nanomedicine: challenges and opportunities
Omid Veiseh, A., Tang, B. C., Whitehead, K. A., Anderson, D. G., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4477 · Cited by 623
Chitosan-based delivery systems for protein therapeutics and antigens
Amidi, M., Mastrobattista, E., Jiskoot, W., & Hennink, W. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.009 · Cited by 622
Engineering synthetic vaccines using cues from natural immunity
Irvine, D. J., Swartz, M. A., & Szeto, G. L. (2013) · Nature Materials · doi:10.1038/nmat3775 · Cited by 605
How Tolerogenic Dendritic Cells Induce Regulatory T Cells
Maldonado, R., & von Andrian, U. H. (2010) · Advances in immunology · doi:10.1016/b978-0-12-380995-7.00004-5 · Cited by 568
Moon, J. J., Suh, H., Bershteyn, A., Stephan, M. T., Liu, H., Huang, B., Sohail, M., Luo, S., Um, S. H., Khant, H. A., et al. (2011) · Nature Materials · doi:10.1038/nmat2960 · Cited by 564
Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging
Park, J., von Maltzahn, G., Zhang, L., Schwartz, M. P., Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2008) · Advanced Materials · doi:10.1002/adma.200800004 · Cited by 555
Tailoring nanocarriers for intracellular protein delivery
Gu, Z., Biswas, A., Zhao, M., & Tang, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00227e · Cited by 543
Delivery of Therapeutic Proteins
Pisal, D. S., Kosloski, M. P., & Balu-Iyer, S. V. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22054 · Cited by 532
Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles
Gulyaev, A. E., Gelperina, S. E., Skidan, I. N., Antropov, A. S., Kivman, G. Y., & Kreuter, J. (1999) · Pharmaceutical Research · doi:10.1023/a:1018983904537 · Cited by 521
Park, J. Y., Wrzesinski, S. H., Stern, E., Look, M., Criscione, J. M., Ragheb, R. R. T., Jay, S. M., Demento, S. L., Agawu, A., Licona-Limón, P., et al. (2012) · Nature Materials · doi:10.1038/nmat3355 · Cited by 498
Fc‐fusion proteins: new developments and future perspectives
Czajkowsky, D. M., Hu, J., Shao, Z., & Pleass, R. J. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201379 · Cited by 491
Self-Assembled Targeted Nanoparticles: Evolution of Technologies and Bench to Bedside Translation
Shi, J., Xiao, Z., Kamaly, N., & Farokhzad, O. C. (2011) · Accounts of Chemical Research · doi:10.1021/ar200054n · Cited by 489
Self-citationNanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines
Nochi, T., Yuki, Y., Takahashi, H., Sawada, S., Mejima, M., Kohda, T., Harada, N., Kong, I. G., Sato, A., Kataoka, N., et al. (2010) · Nature Materials · doi:10.1038/nmat2784 · Cited by 469
Injectable Nano-Network for Glucose-Mediated Insulin Delivery
Gu, Z., Aimetti, A. A., Wang, Q., Dang, T. T., Zhang, Y., Omid Veiseh, A., Cheng, H., Langer, R., & Anderson, D. G. (2013) · ACS Nano · doi:10.1021/nn400630x · Cited by 463
A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner
Schellenberger, V., Wang, C., Geething, N. C., Spink, B. J., Campbell, A., To, W., Scholle, M. D., Yin, Y., Yao, Y., Bogin, O., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1588 · Cited by 462
Cell-penetrating and cell-targeting peptides in drug delivery
Vivès, É., Schmidt, J., & Pèlegrin, A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.03.001 · Cited by 453
Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance
Maldonado, R. A., LaMothe, R. A., Ferrari, J. D., Zhang, A.-H., Rossi, R. J., Kolte, P. N., Griset, A. P., O’Neil, C., Altreuter, D. H., Browning, E., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408686111 · Cited by 441
Self-citationCell Penetrating Peptides: Intracellular Pathways and Pharmaceutical Perspectives
Patel, L. N., Zaro, J. L., & Shen, W. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9303-7 · Cited by 435
A novel intracellular protein delivery platform based on single-protein nanocapsules
Yan, M., Du, J., Gu, Z., Liang, M., Hu, Y., Zhang, W., Priceman, S. J., Wu, L., Zhou, Z. H., Liu, Z., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.341 · Cited by 424
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423
Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery
Pridgen, E. M., Alexis, F., Kuo, T. T., Levy‐Nissenbaum, E., Karnik, R., Blumberg, R. S., Langer, R., & Farokhzad, O. C. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007049 · Cited by 415
Self-citationThe two faces of protein misfolding: gain‐ and loss‐of‐function in neurodegenerative diseases
Winklhofer, K. F., Tatzelt, J., & Haass, C. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601930 · Cited by 410
Shan, W., Zhu, X. D., Liu, M., Li, L., Zhong, J., Sun, W., Zhang, Z., & Huang, Y. (2015) · ACS Nano · doi:10.1021/acsnano.5b00028 · Cited by 395
Issues in long-term protein delivery using biodegradable microparticles
Ye, M., Kim, S., & Park, K. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.05.011 · Cited by 386
The coming of age of virus-like particle vaccines
Jennings, G. T., & Bachmann, M. F. (2008) · Biological Chemistry · doi:10.1515/bc.2008.064 · Cited by 382
Haschek and Rousseaux's Handbook of Toxicologic Pathology
Haschek, W. M., Rousseaux, C. G., & Wallig, M. A. (2013) · Elsevier eBooks · doi:10.1016/c2010-1-67850-9 · Cited by 353
Batchelor, T. T., Gerstner, E. R., Emblem, K. E., Duda, D. G., Kalpathy–Cramer, J., Snuderl, M., Ancukiewicz, M., Polaskova, P., Pinho, M. C., Jennings, D. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318022110 · Cited by 353
Flögel, U., Ding, Z., Hardung, H., Jander, S., Reichmann, G., Jacoby, C., Schubert, R., & Schrader, J. (2008) · Circulation · doi:10.1161/circulationaha.107.737890 · Cited by 350
Nanoparticle-detained toxins for safe and effective vaccination
Hu, C. J., Fang, R. H., Luk, B. T., & Zhang, L. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.254 · Cited by 342
Design and Chemical Synthesis of a Homogeneous Polymer-Modified Erythropoiesis Protein
Kochendoerfer, G. G., Chen, S.-Y., Mao, F., Cressman, S., Traviglia, S. L., Shao, H., Hunter, C. L., Low, D. W., Cagle, E. N., Carnevali, M., et al. (2003) · Science · doi:10.1126/science.1079085 · Cited by 312
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
Gaj, T., Guo, J., Kato, Y., Sirk, S. J., & Barbas, C. F. (2012) · Nature Methods · doi:10.1038/nmeth.2030 · Cited by 306
Wilson, J. T., Keller, S., Manganiello, M. J., Cheng, C., Lee, C.-C., Opara, C. C., Convertine, A. J., & Stayton, P. (2013) · ACS Nano · doi:10.1021/nn305466z · Cited by 294
Sonaje, K., Chen, Y., Chen, H., Wey, S., Juang, J., Nguyen, H.-N., Hsu, C., Lin, K., & Sung, H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.042 · Cited by 282
Patel, Z. S., Yamamoto, M., Ueda, H. R., Tabata, Y., & Mikos, A. G. (2008) · Acta Biomaterialia · doi:10.1016/j.actbio.2008.04.002 · Cited by 278
Hong, R., Fischer, N. O., Verma, A., Goodman, C. M., Emrick, T. S., & Rotello, V. M. (2004) · Journal of the American Chemical Society · doi:10.1021/ja037470o · Cited by 273
Shang, L., Bian, T., Zhang, B., Zhang, D., Wu, L., Tung, C., Yin, Y., & Zhang, T. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201310508 · Cited by 255
The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy
Sockolosky, J. T., & Szoka, F. C. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.02.005 · Cited by 253
Salvador-Morales, C., Zhang, L., Langer, R., & Farokhzad, O. C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.005 · Cited by 251
Self-citationWang, M., Alberti, K. A., Sun, S., Arellano, C. L., & Xu, Q. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201311245 · Cited by 250
Potential of Albiglutide, a Long-Acting GLP-1 Receptor Agonist, in Type 2 Diabetes
Rosenstock, J., Reusch, J. E. B., Bush, M., Yang, F., Stewart, M. W., & for the Albiglutide Study Group (2009) · Diabetes Care · doi:10.2337/dc09-0366 · Cited by 241
Bitonti, A. J., Dumont, J. A., Low, S. C., Peters, R., Kropp, K. E., Palombella, V. J., Stattel, J. M., Lu, Y., Tan, C. A., Song, J. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403235101 · Cited by 234
Jiang, T., Sun, W., Zhu, Q., Burns, N. A., Khan, S. A., Mo, R., & Gu, Z. (2014) · Advanced Materials · doi:10.1002/adma.201404498 · Cited by 228
Estey, T., Kang, J., Schwendeman, S. P., & Carpenter, J. F. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20625 · Cited by 228
Protein delivery using engineered virus-like particles
Kaczmarczyk, S. J., Sitaraman, K., Young, H. A., Hughes, S. H., & Chatterjee, D. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101874108 · Cited by 220
Therapeutic antibodies: past, present and future
Leavy, O. (2010) · Nature reviews. Immunology · doi:10.1038/nri2763 · Cited by 216
DeMuth, P. C., Moon, J. J., Suh, H., Hammond, P. T., & Irvine, D. J. (2012) · ACS Nano · doi:10.1021/nn302639r · Cited by 195
Fc fusion as a platform technology: potential for modulating immunogenicity
Levin, D., Golding, B., Strome, S. E., & Sauna, Z. E. (2014) · Trends in biotechnology · doi:10.1016/j.tibtech.2014.11.001 · Cited by 193
Ghosh, P., Yang, X., Arvizo, R. R., Zhu, Z., Agasti, S. S., Mo, Z., & Rotello, V. M. (2010) · Journal of the American Chemical Society · doi:10.1021/ja907887z · Cited by 192
Tang, R., Kim, C. S., Solfiell, D. J., Rana, S., Mout, R., Velázquez-Delgado, E. M., Chompoosor, A., Jeong, Y., Yan, B., Zhu, Z.-J., et al. (2013) · ACS Nano · doi:10.1021/nn402753y · Cited by 188
Li, A. V., Moon, J. J., Abraham, W. D., Suh, H., Elkhader, J. A., Seidman, M. A., Yen, M., Im, E., Foley, M. H., Barouch, D. H., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006516 · Cited by 187
Applications of inorganic nanoparticles as therapeutic agents
Kim, T., & Hyeon, T. (2013) · Nanotechnology · doi:10.1088/0957-4484/25/1/012001 · Cited by 184
Thornton, E. E., Looney, M. R., Bose, O., Sen, D., Sheppard, D., Locksley, R. M., Huang, X., & Krummel, M. F. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112667 · Cited by 179
Targeted Delivery of Nanoparticles to Ischemic Muscle for Imaging and Therapeutic Angiogenesis
Kim, J., Cao, L., Shvartsman, D., Silva, E. A., & Mooney, D. J. (2011) · Nano Letters · doi:10.1021/nl103812a · Cited by 150
Low‐Density Lipoprotein Receptor on Endothelium of Brain Capillaries
Méresse, S., Delbart, C., Fruchart, J., & Cecchelli, R. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07340.x · Cited by 143
Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers
Wu, J., Kamaly, N., Shi, J., Zhao, L., Xiao, Z., Hollett, G., John, R. A., Ray, S., Xu, X., Zhang, X., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201404766 · Cited by 141
Self-citationKim, S. K., Foote, M. B., & Huang, L. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.010 · Cited by 136
Iordanov, M. S., Ryabinina, O. P., Wong, J., Dinh, T.-H., Newton, D. L., Rybak, S. M., & Magun, B. E. (2000) · PubMed · Cited by 131
Functional Protein Delivery into Neurons Using Polymeric Nanoparticles
Hasadsri, L., Kreuter, J., Hattori, H., Iwasaki, T., & George, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805956200 · Cited by 129
Cell Penetrating Peptides in the Delivery of Biopharmaceuticals
Munyendo, W. L. L., Lv, H., Benza-Ingoula, H., Baraza, L. D., & Zhou, J. (2012) · Biomolecules · doi:10.3390/biom2020187 · Cited by 128
Yoshizaki, Y., Yuba, E., Sakaguchi, N., Koiwai, K., Harada, A., & Kono, K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.077 · Cited by 123
Xiao, C., Ding, J., Ma, L., Yang, C., Zhuang, X., & Chen, X. (2014) · Polymer Chemistry · doi:10.1039/c4py01156b · Cited by 115
Morlock, M. M., Kissel, T., Li, Y. X., Koll, H., & Winter, G. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00070-4 · Cited by 112
Site-specific PEGylation of Proteins: Recent Developments
Nischan, N., & Hackenberger, C. P. R. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo502136n · Cited by 109
Efficient skin permeation of soluble proteins via flexible and functional nano-carrier
Choi, W. I., Lee, J., Kim, J., Kim, J., Kim, Y., & Tae, G. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.013 · Cited by 107
Lipid-based systems for the enhanced delivery of poorly water soluble drugs
Porter, C. J. H., Wasan, K. M., & Constantinides, P. P. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.10.009 · Cited by 99
Ramqvist, T., Andreasson, K., & Dalianis, T. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.7.7.997 · Cited by 94
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Chiellini, E., Piras, A. M., Errico, C., & Chiellini, E. (2008) · Nanomedicine · doi:10.2217/17435889.3.3.367 · Cited by 94
Fast, J. L., Cordes, A. A., Carpenter, J. F., & Randolph, T. W. (2009) · Biochemistry · doi:10.1021/bi900853v · Cited by 92
Zhao, M., Hu, B., Gu, Z., Joo, K., Wang, P., & Tang, Y. (2013) · Nano Today · doi:10.1016/j.nantod.2012.12.003 · Cited by 88
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Keijzer, C., Slütter, B., van der Zee, R., Jiskoot, W., van Eden, W., & Broere, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026684 · Cited by 87
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Green, I., Christison, R., Voyce, C. J., Bundell, K. R., & Lindsay, M. A. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00076-2 · Cited by 78
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He, W., Guo, X., & Zhang, M. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.12.050 · Cited by 75
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Weeks, B. S., Lieberman, D. M., Johnson, B., Roque, E., Green, M., Loewenstein, P. M., Oldfield, E. H., & Kleinman, H. K. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490420105 · Cited by 74
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Dömling, A. S. S., & Holak, T. A. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201307906 · Cited by 72
Han, K., Lee, K.-D., Gao, Z., & Park, J. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00400-x · Cited by 70
Woitiski, C. B., Carvalho, R. A., Ribeiro, A. J., Neufeld, R. J., & Veiga, F. (2008) · BioDrugs · doi:10.2165/00063030-200822040-00002 · Cited by 69
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Burnham, N. L. (1994) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/51.2.210 · Cited by 68
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Bluestone, J. A., & Bour-Jordan, H. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007542 · Cited by 67
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Jo, J., Hong, S., Choi, W. Y., & Lee, D. R. (2014) · Scientific Reports · doi:10.1038/srep04378 · Cited by 63
Karagiannis, S. N., Josephs, D. H., Karagiannis, P., Gilbert, A. E., Saul, L., Rudman, S. M., Dodev, T. S., Koers, A., Blower, P. J., Corrigan, C. J., et al. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1162-8 · Cited by 60
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Zhang, J., Shin, M. C., David, A. E., Zhou, J., Lee, K., He, H., & Yang, V. C.-M. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400360q · Cited by 57
Muda, M., Gross, A. W., Dawson, J., He, C., Kurosawa, E., Schweickhardt, R. L., Dugas, M., Soloviev, M., Bernhardt, A., Fischer, D., et al. (2011) · Protein Engineering Design and Selection · doi:10.1093/protein/gzq123 · Cited by 54
Miyaji, Y., Walter, S. A., Chen, L., Kurihara, A., Ishizuka, T., Saito, M., Kawai, K., & Okazaki, O. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.040725 · Cited by 46
Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice
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Zhou, P., An, T., Zhao, C., Li, Y., Li, R., Yang, R., Wang, Y., & Gao, X. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.12.017 · Cited by 27
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Windisch, M., Wolf, H.-J., Hutter‐Paier, B., & Wronski, R. (2008) · Neurodegenerative Diseases · doi:10.1159/000113707 · Cited by 16
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Metadata
- Authors
- Yu, M., Wu, J., Shi, J., & Farokhzad, O. C.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Shi, Jinjun
- Farokhzad, Omid C.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 240
- Pages
- 24-37
- ISSN
- 0168-3659 (ISSN-L)
- PMC
- PMC4833694
- OpenAlex
- W2173147935
- Cited by
- 410
- References
- 138
- Citations by year
- 2026: 29 · 2025: 47 · 2024: 34 · 2023: 40 · 2022: 44 · 2021: 65 · 2020: 47 · 2019: 48 · 2018: 26 · 2017: 21 · 2016: 9
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Institutes of Health (NIH) (EB015419, R00CA160350, U54-CA151884)
- Movember-Prostate Cancer Foundation (PCF)
- National Research Foundation of Korea (K1A1A2048701)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- protein delivery, nanotechnology, therapeutic proteins, nanoparticle drug delivery, systemic drug delivery, intracellular delivery, endosomal escape, membrane permeability, protein stability, immunogenicity, oral drug delivery, intranasal drug delivery, pulmonary drug delivery, transdermal drug delivery
- MeSH terms
- Animals, Humans, Proteins, Tissue Distribution, Drug Delivery Systems, Nanotechnology, Nanoparticles
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