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The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China

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Zhang, Guqin, Hu, Chang, Luo, Linjie, Fang, Fang, Chen, Yongfeng, Li, Jianguo, Peng, Zhiyong, Pan, Huaqin·2020·Journal of Clinical Virology
DOI 10.1016/j.jcv.2020.104364

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Abstract

Background In late December 2019, an outbreak of acute respiratory illness, coronavirus disease 2019 (COVID-19), emerged in Wuhan, China. We aimed to study the epidemiology, clinical features and short-term outcomes of patients with COVID-19 in Wuhan, China. Methods We performed a single center, retrospective case series study in 221 patients with laboratory confirmed SARS-CoV-2 pneumonia at a university hospital, including 55 severe patients and 166 non-severe patients, from January 2, 2020 to February 10, 2020. Results Of the 221 patients with COVID-19, the median age was 55.0 years and 48.9% were male and only 8 (3.6%) patients had a history of exposure to the Huanan Seafood Market. Compared to the non-severe pneumonia patients, the median age of the severe patients was significantly older, and they were more likely to have chronic comorbidities. Most common symptoms in severe patients were high fever, anorexia and dyspnea. On admission, 33.0% patients showed leukopenia and 73.8% showed lymphopenia. In addition, the severe patients suffered a higher rate of co-infections with bacteria or fungus and they were more likely to developing complications. As of February 15, 2020, 19.0% patients had been discharged and 5.4% patients died. 80% of severe cases received ICU (intensive care unit) care, and 52.3% of them transferred to the general wards due to relieved symptoms, and the mortality rate of severe patients in ICU was 20.5%. Conclusions Patients with elder age, chronic comorbidities, blood leukocyte/lymphocyte count, procalcitonin level, co-infection and severe complications might increase the risk of poor clinical outcomes.

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Metadata

Authors
Zhang, G., Hu, C., Luo, L., Fang, F., Chen, Y., Li, J., Peng, Z., & Pan, H.
Venue
Journal of Clinical Virology
Publisher
Elsevier BV
Published
2020-06
Volume
127
Pages
104364
ISSN
1386-6532 (ISSN-L)
DOI
10.1016/j.jcv.2020.104364
OpenAlex
W3015678834
Cited by
694
References
10
FWCI
19.47
Type
journal article
Language
en
Open access
green
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Funders
National Natural Science Foundation of China

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CoChat. (2026). Citation check: Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China. https://app.cochat.ai/papers/10.1016/j.jcv.2020.104364
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Zhang, G., Hu, C., Luo, L., Fang, F., Chen, Y., Li, J., Peng, Z., & Pan, H. (2020). Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China. Journal of Clinical Virology. https://doi.org/10.1016/j.jcv.2020.104364

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