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Mast cells occupy stable clonal territories in adult steady‐state skin

Weitzmann, Anke, Naumann, Ronald, Dudeck, Anne, Zerjatke, Thomas, Gerbaulet, Alexander, Roers, Axel·2020·Journal of Investigative Dermatology
DOI 10.1016/j.jid.2020.03.963
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Abstract

Mast cells (MCs) are tissue-resident hematopoietic cells intensely studied for their role as effectors in allergic immune responses. Yolk sac-derived embryonic MCs first populate tissues and are later replaced by definitive MCs. We show that definitive MC progenitors expand locally in skin and form clonal colonies that cover stable territories. In MC-deficient skin, colonies grow by proliferation of MCs at the border of the clonal territory. Clonal growth ceases at common borders of neighboring colonies. In steady state, colony self-renewal is independent of bone marrow contribution, and the clonal architecture remains fixed if not disturbed by skin inflammation. Inflammatory cues increase MC density setpoint, stimulating the influx of new progenitors from the bone marrow as well as proliferation of skin-resident cells. The expanding new arrivals disrespect territories of preexisting MC clones. We conclude that during a limited window early in development, definitive MC precursors efficiently enter the skin, expand, and self-maintain, occupying stable territories. In adulthood, circulating progenitors, excluded from steady-state skin, are recruited only into inflamed skin where they clonally expand alongside proliferating skin-resident MCs, disorganizing the original architecture of clonal territories.

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Metadata

Authors
Weitzmann, A., Naumann, R., Dudeck, A., Zerjatke, T., Gerbaulet, A., & Roers, A.
ORCID
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2020-12
Volume
140
Issue
12
Pages
2433-2441.e5
ISSN
0022-202X
DOI
10.1016/j.jid.2020.03.963
Cited by
29
References
3
Language
en
Licence
Funders
Deutsche Forschungsgemeinschaft (DU1172/1-1, RO2133/9-1, INST515/14-1 FUGG, FOR2599)

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