Early enteral nutrition in patients with out-of-hospital cardiac arrest under target temperature management was associated with a lower 7-day bacteremia rate: A post-hoc analysis of a retrospective cohort study
Open accessAbstract
Introduction Early enteral nutrition (EN) is a nutritional strategy for reducing the incidence of in-hospital infections. However, the benefits of early EN, under targeted temperature management (TTM) in patients with out-of-hospital cardiac arrest (OHCA), remain unclear. We aimed to evaluate the effect of early EN on the infective complications of OHCA patients who underwent TTM. Methods We retrospectively searched the clinical databases of two adult emergency tertiary referral hospitals in southern Taiwan and identified patients admitted for OHCA who underwent TTM between 2017 and 2022. The 85 enrolled patients were divided into two groups based on timing: early EN (EN within 48 h of admission) and delayed EN (EN > 48 h after admission). Clinical outcomes of 7-day infective complications between the two groups were analyzed. Results Early EN was provided to 57 (67 %) of 85 patients and delayed EN was provided to the remaining 28 (33 %) patients. No significant differences in baseline patient characteristics were observed between the two groups. In addition, no differences in clinical outcomes were observed, except that the early EN group had a lower 7-day bacteremia rate (5.3 % vs. 26.9 %, p = 0.013). Gram-negative bacteria were the major pathogen among the 7-day infective complications. Conclusion In OHCA patients treated with TTM, early EN was associated with a lower 7-day bacteremia rate. Furthermore, the application of early EN in this population was well tolerated with…
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Early enteral nutrition may be associated with potential benefits in neurological outcomes and infectious complications after cardiac arrest.
“early EN may be associated with potential benefits in neurological outcomes and infectious complications after cardiac arrest,176,178”
From Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association (2026) · cites this paper as [178]
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- Authors
- Tsai, Y.-C., Yin, C.-H., Chen, J.-S., Chen, Y.-S., Huang, S.-C., & Chen, J.-K.
- Affiliations
- Tri-Service General Hospital (TW)
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Corresponding author
- Chen, Jui-Kuang
- Venue
- Journal of Microbiology, Immunology and Infection
- Publisher
- Elsevier BV
- Published
- 2024-04
- Volume
- 57
- Issue
- 2
- Pages
- 309-319
- ISSN
- 1684-1182 (ISSN-L)
- OpenAlex
- W4390457862
- Cited by
- 9
- References
- 38
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 1
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Microbiology Immunology and Infection (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Veterans Affairs Council
- Topics
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Keywords
- early enteral nutrition, out-of-hospital cardiac arrest, targeted temperature management, bacteremia, post-cardiac arrest syndrome, infection control, Gram-negative bacteria, timing of enteral feeding, post-resuscitation care
- MeSH terms
- Enteral Nutrition, Humans, Retrospective Studies, Temperature, Bacteremia, Out-of-Hospital Cardiac Arrest
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