The DOI matches its Crossref record; 156 of the 159 references it cites were found in a registry or an index.
Electrical stimulation of excitable tissue: design of efficacious and safe protocols
Abstract
The physical basis for electrical stimulation of excitable tissue, as used by electrophysiological researchers and clinicians in functional electrical stimulation, is presented with emphasis on the fundamental mechanisms of charge injection at the electrode/tissue interface. Faradaic and non-Faradaic charge transfer mechanisms are presented and contrasted. An electrical model of the electrode/tissue interface is given. The physical basis for the origin of electrode potentials is given. Various methods of controlling charge delivery during pulsing are presented. Electrochemical reversibility is discussed. Commonly used electrode materials and stimulation protocols are reviewed in terms of stimulation efficacy and safety. Principles of stimulation of excitable tissue are reviewed with emphasis on efficacy and safety. Mechanisms of damage to tissue and the electrode are reviewed.
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“For instance, all data used in this study to fit and validate the model used symmetric, biphasic pulse trains, while other pulse shapes might lead to different neural or behavioral responses (Merrill et al., 2005).”
From Towards biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses (2024) · cites this paper as Merrill et al., 2005
In the citing paper
“A critical aspect of electrical stimulation is its higher level of safety risk compared to recording electrical activity, which can result in both electrode and tissue damage.”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [16]
In the citing paper
“Similarly, Merrill et al. noted that a narrow pulse is desirable to decrease occurrence of electrochemical reactions, and therefore reduce electrode degradation [2].”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [2]
In the citing paper
“In terms of electrode corrosion, however, slightly unbalanced biphasic pulses might be advantageous [2, 77].”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [2]
In the citing paper
“Charge injection at an electrode occurs through capacitive charge transfer, with no electron transfer across the electrodeelectrolyte interface, and Faradaic charge transfer, where electron transfer and reduction and oxidation (redox) reactions occur [101], [114].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [101]
In the citing paper
“To minimise potentially toxic redox reaction products, biphasic stimulation reverses the charge injection in a second phase of a stimulation pulse aiming to reverse Faradaic reactions.”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [101]
In the citing paper
“Faradaic reactions where products are not available for the reverse reaction are not reversed, for example hydrolysis of water or 'water window' which places safety limits on electrode-electrolyte interface potentials [101].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [101]
In the citing paper
“In a biphasic pulse neuron activation occurs at a lower threshold for cathodic (sink) currents [101], [119], compared to positive anodic (source) currents.”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [101]
In the citing paper
“Typical stimulation pulse widths range up to a few hundred μs , and current amplitudes vary from tens of μA to a few mA in peripheral nerve interfaces [9], [101].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [101]
Citations
Cites
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004764 · Cited by 23,191
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,150
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
Ionic channels of excitable membranes
(1985) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(85)90172-7 · Cited by 7,134
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
The Electrical Double Layer and the Theory of Electrocapillarity.
Grahame, D. C. (1947) · Chemical Reviews · doi:10.1021/cr60130a002 · Cited by 3,324
Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
Rosenberg, B., Camp, L. V., & Krigas, T. (1965) · Nature · doi:10.1038/205698a0 · Cited by 3,052
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
(1981) · Handbook of exploration geochemistry · doi:10.1016/b978-0-444-41930-9.50014-3 · Cited by 2,903
Flagged first, then by citations
3 of the 159 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- Bhargava A. Long-term effects of quasi-trapezoidal pulses on the structure and function of sacral anterior roots. M.S. thesis, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 1993.
- Guoy, 1910, Constitution of the electric charge at the surface of an electrolyte, J Physique, 9, 457
- Kennedy, 1999, Neural activity during acquisition of cursor control in a locked-in patient, Soc Neurosci Abstr, 25, 894
- Rall, 1977, vol.1/part 1
- Sevanian, 1988, Lipid peroxidation, membrane damage, and phospholipase A2 action: cellular antioxidant defense mechanisms, CRC Rev., II, 77
Cited by
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Mobini, S., González, M. U., Caballero‐Calero, O., Patrick, E. E., Martín‐González, M., & García‐Martín, J. M. (2022) · Nanoscale · doi:10.1039/d1nr06280h · Cited by 23
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Wilson, D. D., & Moehlis, J. (2022) · Annual Reviews in Control · doi:10.1016/j.arcontrol.2022.05.002 · Cited by 24
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Moffitt, M. A., Lee, D. C., & Bradley, K. (2009) · Biological and medical physics series · doi:10.1007/978-0-387-77261-5_5 · Cited by 24
Zhou, Y., Bi, Z.-Y., Ji, M., Chen, S., Wang, W., Wang, K., Hu, B., Lü, X., & Wang, Z. (2020) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2020.2980294 · Cited by 24
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Khadka, N., Rahman, A., Sarantos, C. H., Truong, D. Q., & Bikson, M. (2014) · Brain stimulation · doi:10.1016/j.brs.2014.10.004 · Cited by 23
Self-citationJackson, N., & Stam, F. (2014) · Journal of Applied Polymer Science · doi:10.1002/app.41687 · Cited by 23
Su, S., Chai, G., Shu, X., Sheng, X., & Zhu, X. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab5ee9 · Cited by 23
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Kwon, J., Lee, J. S., Lee, J.-J., Na, J., Sung, J., Lee, H., Kwak, H., Cheong, E., Cho, S., & Choi, H. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c04635 · Cited by 23
Chakraborty, B., Joshi‐Imre, A., & Cogan, S. F. (2021) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34906 · Cited by 24
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Krukiewicz, K., Janas, D. W., Vallejo‐Giraldo, C., & Biggs, M. J. P. (2018) · Electrochimica Acta · doi:10.1016/j.electacta.2018.10.157 · Cited by 23
Krueger, E., Magri, L., Botelho, A. S., Bach, F. S., Rebellato, C. L. K., Fracaro, L., Fragoso, F. Y. I., Villanova, J. A., Brofman, P. R. S., & Popović‐Maneski, L. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.12.004 · Cited by 23
Khalifa, A., Zaeimbashi, M., Zhou, T. X., Abrishami, S. M. S., Sun, N., Park, S., Šumarac, T., Qu, J., Zohar, I., Yacoby, A., et al. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00320-8 · Cited by 23
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Self-citationJiang, S., Song, J., Zhang, Y., Nie, M., Kim, J., Marcano, A. L., Kadlec, K. M., Mills, W. A., Yan, X., Liu, H., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c19187 · Cited by 20
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Mendes, A. X., do Nascimento, A. T., Duchi, S., Quigley, A. F., Aguilar, L. M. C., Dekiwadia, C. D., Kapsa, R. M. I., Silva, S. M., & Moulton, S. E. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb02387c · Cited by 22
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Giagka, V., Demosthenous, A., & Donaldson, N. (2015) · Biomedical Microdevices · doi:10.1007/s10544-015-0011-5 · Cited by 22
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Chen, S., & Allen, M. G. (2012) · MRS Bulletin · doi:10.1557/mrs.2012.120 · Cited by 23
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Cruz, A. M., & Casañ-Pastor, N. (2013) · Thin Solid Films · doi:10.1016/j.tsf.2013.02.031 · Cited by 22
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Li, S., Alam, M., Ahmed, R. U., Zhong, H., Wang, X., Ng, S., & Zheng, Y. (2020) · Bioelectronic Medicine · doi:10.1186/s42234-020-00048-2 · Cited by 22
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Regnacq, L., Wu, Y., Neshatvar, N., Jiang, D., & Demosthenous, A. (2021) · IEEE Transactions on Circuits & Systems II Express Briefs · doi:10.1109/tcsii.2021.3092069 · Cited by 22
Malone, I. G., Nosacka, R. L., Nash, M. A., Otto, K. J., & Dale, E. A. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00625.2020 · Cited by 25
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Chua, T. E. H., Bachman, M., & Zeng, F. (2011) · Ear and Hearing · doi:10.1097/aud.0b013e31821a47df · Cited by 22
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Pouliquen, P. O., Vogelstein, R. J., & Etienne‐Cummings, R. (2008) · IEEE Biomedical Circuits and Systems Conference (BioCAS) · doi:10.1109/biocas.2008.4696867 · Cited by 22
Design and fabrication of a multi-electrode array for spinal cord epidural stimulation
Chang, C.-W., Lo, Y., Gad, P. N., Edgerton, V. R., & Liu, W. (2014) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2014.6945198 · Cited by 20
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Greenspon, C. M., Shelchkova, N. D., Valle, G., Hobbs, T. G., Berger-Wolf, E. I., Hutchison, B. C., Dogruoz, E., Verbaarschot, C., Callier, T., Sobinov, A. R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.23.545425 · Cited by 22
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Carpenter, C. W., Malinao, M. G., Rafeedi, T., Rodriquez, D., Tan, S. T. M., Root, N., Skelil, K., Ramírez, J., Polat, B., Root, S. E., et al. (2020) · Advanced Materials Technologies · doi:10.1002/admt.201901119 · Cited by 21
Kosta, P., Mize, J. T., Warren, D. J., & Lazzi, G. (2020) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2020.3038406 · Cited by 21
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Matter, L., Harland, B. C., Raos, B. J., Svirskis, D. M., & Asplund, M. (2023) · APL Bioengineering · doi:10.1063/5.0152669 · Cited by 20
Wang, Z., Huang, Z., Lv, X., Zhou, Y., Wang, H., & Zong, S.-H. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.147938 · Cited by 20
Kim, B., Gutierrez, C. A., & Meng, E. F. (2015) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2015.2420043 · Cited by 20
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Metadata
- Authors
- Merrill, D. R., Bikson, M., & Jefferys, J. G. R.
- Affiliations
- University of Utah (US)
- City College of New York (US)
- University of Birmingham (GB)
- Corresponding author
- Merrill, Daniel R.
- Venue
- Journal of Neuroscience Methods
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 141
- Issue
- 2
- Pages
- 171-198
- ISSN
- 0165-0270 (ISSN-L)
- OpenAlex
- W2153787766
- Cited by
- 2,078
- References
- 159
- Citations by year
- 2026: 100 · 2025: 136 · 2024: 116 · 2023: 126 · 2022: 132 · 2021: 163 · 2020: 119 · 2019: 132 · 2018: 137 · 2017: 115 · 2016: 109 · 2015: 100 · 2014: 98 · 2013: 91 · 2012: 80
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Methods (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- National Institutes of Health (5f32ns045454-03)
- National Institute of Neurological Disorders and Stroke (5F32NS045454)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- functional electrical stimulation, electrode-tissue interface, charge injection, Faradaic charge transfer, electrode potential, electrochemical reversibility, stimulation protocols, stimulation safety, tissue damage mechanisms, electrode damage, electrode materials
- MeSH terms
- Animals, Biomedical Engineering, Electric Stimulation, Electrochemistry, Electrodes, Electrolytes, Electrophysiology, Electric Stimulation Therapy, Equipment Design, Humans
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