The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

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Intravenous Lidocaine: Old-School Drug, New Purpose—Reduction of Intractable Pain in Patients with Chemotherapy Induced Peripheral Neuropathy

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Age differences in cytokine expression under conditions of health using experimental pain models

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High-Dose Capsaicin for the Treatment of Neuropathic Pain: What We Know and What We Need to Know

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Chemokines as peripheral pain mediators

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Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia

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Increased pro-inflammatory cytokine gene expression in peripheral blood mononuclear cells of patients with polyneuropathies

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Analyses of gene expression profiles in the rat dorsal horn of the spinal cord using RNA sequencing in chronic constriction injury rats

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Atorvastatin Prevents Neuroinflammation in Chronic Constriction Injury Rats through Nuclear NFκB Downregulation in the Dorsal Root Ganglion and Spinal Cord

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Immunotherapy targeting cytokines in neuropathic pain

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Expression Profiling of Genes Modulated by Minocycline in a Rat Model of Neuropathic Pain

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Platelet‐rich plasma and cytokines in neuropathic pain: A narrative review and a clinical perspective

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Role of pro-inflammatory interleukins in osteoarthritis: a narrative review

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Preventive Effects of Bee Venom Derived Phospholipase A2 on Oxaliplatin-Induced Neuropathic Pain in Mice

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Chronic exposure to tumor necrosis factor in vivo induces hyperalgesia, upregulates sodium channel gene expression and alters the cellular electrophysiology of dorsal root ganglion neurons

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MiR‐20b‐5p relieves neuropathic pain by targeting Akt3 in a chronic constriction injury rat model

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Protective role of natural killer cells in neuropathic pain conditions

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A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse

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Biological Correlates of the Effects of Auricular Point Acupressure on Pain

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Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain

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Intrathecal Injection of Spironolactone Attenuates Radicular Pain by Inhibition of Spinal Microglia Activation in a Rat Model

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Preclinical Studies of Low Back Pain

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Histamine H4 receptor agonist‐induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress

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Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane

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Kynurenine, Tetrahydrobiopterin, and Cytokine Inflammatory Biomarkers in Individuals Affected by Diabetic Neuropathic Pain

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Platelet-rich plasma in umbilical cord blood reduces neuropathic pain in spinal cord injury by altering the expression of ATP receptors

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HDAC6: A Key Link Between Mitochondria and Development of Peripheral Neuropathy

English, K., & Barton, M. C. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.684714 · Cited by 37

Role of microglia in neuropathic pain

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The Pain and Movement Reasoning Model: Introduction to a simple tool for integrated pain assessment

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Pulsed magnetic field enhances therapeutic efficiency of mesenchymal stem cells in chronic neuropathic pain model

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Foxp3 plasmid-encapsulated PLGA nanoparticles attenuate pain behavior in rats with spinal nerve ligation

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Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model

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LipoxinA4 induced antinociception and decreased expression of NF‐κB and pro‐inflammatory cytokines after chronic dorsal root ganglia compression in rats

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Inflammation in the avian spleen: timing is everything

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The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons

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NK cells mediate the cumulative analgesic effect of electroacupuncture in a rat model of neuropathic pain

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Upregulation of the sodium channel NaVβ4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation

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Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia–neuron interaction

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Differential expression of systemic inflammatory mediators in amputees with chronic residual limb pain

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The Efficacy of Systemic Lidocaine in the Management of Chronic Pain: A Literature Review

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Spinal cord stimulation prevents paclitaxel-induced mechanical and cold hypersensitivity and modulates spinal gene expression in rats

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IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity

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Intravenous administration of human mesenchymal stem cells derived from adipose tissue and umbilical cord improves neuropathic pain via suppression of neuronal damage and anti-inflammatory actions in rats

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The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice

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Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice

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Silencing of FKBP51 alleviates the mechanical pain threshold, inhibits DRG inflammatory factors and pain mediators through the NF-kappaB signaling pathway

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IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation

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Harnessing pain heterogeneity and RNA transcriptome to identify blood‐based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model

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NF-κB, ERK, p38 MAPK and JNK contribute to the initiation and/or maintenance of mechanical allodynia induced by tumor necrosis factor-alpha in the red nucleus

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Pain in the Blood? Envisioning Mechanism-Based Diagnoses and Biomarkers in Clinical Pain Medicine

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A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients

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Increased Hyperalgesia and Proinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion After Surgery and/or Fentanyl Administration in Rats

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Upregulation of tumor necrosis factor-alpha in the anterior cingulate cortex contributes to neuropathic pain and pain-associated aversion

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Differential Expression of Neuroinflammatory mRNAs in the Rat Sciatic Nerve Following Chronic Constriction Injury and Pain-Relieving Nanoemulsion NSAID Delivery to Infiltrating Macrophages

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Red nucleus IL‐6 mediates the maintenance of neuropathic pain by inducing the productions of TNF‐α and IL‐1β through the JAK2/STAT3 and ERK signaling pathways

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In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain

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Effects of Dexamethasone and Placebo on Symptom Clusters in Advanced Cancer Patients: A Preliminary Report

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miR-99b-3p/Mmp13 axis regulates NLRP3 inflammasome-dependent microglial pyroptosis and alleviates neuropathic pain via the promotion of autophagy

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Stronger Antinociceptive Efficacy of Opioids at the Injured Nerve Trunk Than at Its Peripheral Terminals in Neuropathic Pain

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GS-KG9 ameliorates diabetic neuropathic pain induced by streptozotocin in rats

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Necrostatin-1 Ameliorates Peripheral Nerve Injury-Induced Neuropathic Pain by Inhibiting the RIP1/RIP3 Pathway

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Sexually Dimorphic Immune and Neuroimmune Changes Following Peripheral Nerve Injury in Mice: Novel Insights for Gender Medicine

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Pain-relieving effects of Lawsonia inermis on neuropathic pain induced by chronic constriction injury

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The Role of Extracellular Vesicles in Cancer–Nerve Crosstalk of the Peripheral Nervous System

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Immune dysregulation in patients with carpal tunnel syndrome

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Idiopathic hopping‐like forelimb lameness syndrome in ridden horses: 46 horses (2002–2014)

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Aleurites moluccana and its main active ingredient, the flavonoid 2″-O-rhamnosylswertisin, have promising antinociceptive effects in experimental models of hypersensitivity in mice

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Mediators of Inflammation as Targets for Chronic Pain Treatment

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Role of pattern recognition receptors in chemotherapy-induced neuropathic pain

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Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model

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CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation

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Corneal Confocal Microscopy Features and Tear Molecular Profile in Study Participants with Discordance between Ocular Surface Disease Clinical Signs and Discomfort

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The prokineticin system: an interface between neural inflammation and pain

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Demyelination/remyelination and expression of interleukin-1β, substance P, nerve growth factor, and glial-derived neurotrophic factor during trigeminal neuropathic pain in rats

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Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain

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A future without chronic pain: neuroscience and clinical research.

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miR‐21‐5p inhibits neuropathic pain development via directly targeting C‐C motif ligand 1 and tissue inhibitor of metalloproteinase‐3

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Moderate noise associated oxidative stress with concomitant memory impairment, neuro-inflammation and neurodegeneration

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Immunological mechanism of postherpetic neuralgia and effect of pregabalin treatment on the mechanism: a prospective single-arm observational study

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Differential Effects of Regulatory T Cells in the Meninges and Spinal Cord of Male and Female Mice with Neuropathic Pain

Fiore, N. T., Keating, B. A., Chen, Y., Williams, S. I., & Moalem‐Taylor, G. (2023) · Cells · doi:10.3390/cells12182317 · Cited by 28

Blocking the Mineralocorticoid Receptor Improves Effectiveness of Steroid Treatment for Low Back Pain in Rats

Ye, L., Xie, W., Strong, J. A., & Zhang, J. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000277 · Cited by 27

Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury

Perera, C. J., Duffy, S. S., Lees, J. G., Kim, C. F., Cameron, B., Apostolopoulos, V., & Moalem‐Taylor, G. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0253-4 · Cited by 26

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome

Al‐Rawaf, H. A., Alghadir, A. H., & Gabr, S. A. (2019) · Pain Practice · doi:10.1111/papr.12817 · Cited by 27

Fibroblasts: the neglected cell type in peripheral sensitisation and chronic pain? A review based on a systematic search of the literature

Shinotsuka, N., & Denk, F. (2022) · BMJ Open Science · doi:10.1136/bmjos-2021-100235 · Cited by 32

Estradiol attenuates spinal cord injury-induced pain by suppressing microglial activation in thalamic VPL nuclei of rats

Saghaei, E., Abbaszadeh, F., Naseri, K., Ghorbanpoor, S., Afhami, M., Haeri, A., Rahimi, F., & Jorjani, M. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.01.010 · Cited by 26

The analgesic potential of cytokine neutralization with biologicals

Ebersberger, A. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.07.040 · Cited by 26

Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model

Bollenbach, M., Lugnier, C., Kremer, M., Salvat, É., Megat, S., Bihel, F. J. ‐., Bourguignon, J., Barrot, M., & Schmitt, M. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.05.026 · Cited by 25

Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain

Tagne, A. M., Fotio, Y., Lin, L., Squire, E., Ahmed, F., Rashid, T. I., Azari, E. K., & Piomelli, D. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105545 · Cited by 25

Plasma pro-inflammatory markers in chronic neuropathic pain: A multivariate, comparative, cross-sectional pilot study

Bäckryd, E., Ghafouri, B., Larsson, B. K., & Gerdle, B. U. C. (2015) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2015.06.006 · Cited by 26

Depressing Interleukin-1� Contributed to the Synergistic Effects of Tramadol and Minocycline on Spinal Nerve Ligation-Induced Neuropathic Pain

Mei, X., Sakuma, Y., Xie, C., Wu, D., Ho, I., Kotani, J., & Xu, L. (2013) · Neurosignals · doi:10.1159/000355071 · Cited by 25

Neuropathic Pain in Animal Models of Nervous System Autoimmune Diseases

Tian, D. H., Perera, C. J., & Moalem‐Taylor, G. (2013) · Mediators of Inflammation · doi:10.1155/2013/298326 · Cited by 26

Effects of alpha-7 nicotinic acetylcholine receptor positive allosteric modulator on lipopolysaccharide-induced neuroinflammatory pain in mice

Abbas, M., & Rahman, S. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.05.003 · Cited by 25

Anti-hyperalgesic effect of (-)-α-bisabolol and (-)-α-bisabolol/β-Cyclodextrin complex in a chronic inflammatory pain model is associated with reduced reactive gliosis and cytokine modulation

Fontinele, L. L., Heimfarth, L., Pereira, E. W. M., Rezende, M. M., Lima, N. T., de Carvalho, Y. M. B. G., Pires, E. A. D. M., Guimarães, A. G., Carvalho, M. T. B., Barreto, R. D. S. S., et al. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104530 · Cited by 25

The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model

Gonçalves, N. P., Teixeira-Coelho, M., & Saraiva, M. J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.030 · Cited by 27

Cytokine Levels in Neural Pain in Leprosy

Angst, D. B. M., Pinheiro, R. O., Vieira, J. S. D. S., Cobas, R. A., Hacker, M. A., Pitta, I. J. R., Giesel, L. M., Sarno, E. N., & Jardim, M. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00023 · Cited by 24

Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2–related factor 2 antioxidant signaling in rats

Green‐Fulgham, S. M., Harland, M. E., Ball, J. B., Li, J., Lacagnina, M. J., D'Angelo, H., Dreher, R. A., Willcox, K. F., Lorca, S. A., Kwilasz, A. J., et al. (2022) · Pain · doi:10.1097/j.pain.0000000000002589 · Cited by 25

Can Modulating Inflammatory Response be a Good Strategy to Treat Neuropathic Pain?

Zhang, J., Echeverry, S., Lim, T. K. Y., Lee, S., Shi, X., & Huang, H. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666141027115508 · Cited by 26

REVIEW ARTICLE The Role of Glia and the Immune System in the Development and Maintenance of Neuropathic Pain

Vallejo, R., Tilley, D. M., Vogel, L. A., Benyamin, R. M., & del Dolor, C. (2010)

Role of the immune system in neuropathic pain

Malcangio, M. (2019) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2019-0138 · Cited by 236

The Role of Glia and the Immune System in the Development and Maintenance of Neuropathic Pain

Vallejo, R., Tilley, D. M., Vogel, L. A., & Benyamin, R. M. (2010) · Pain Practice · doi:10.1111/j.1533-2500.2010.00367.x · Cited by 345

Neuroimmune mechanisms of pain: Basic science and potential therapeutic modulators

Lim, J. S., & Kam, P. C. A. (2020) · Anaesthesia and Intensive Care · doi:10.1177/0310057x20902774 · Cited by 21