The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

Toll-Like Receptors

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Neuronal plasticity: Increasing the gain in pain

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TLR 2 and 4 Responsiveness from Isolated Peripheral Blood Mononuclear Cells from Rats and Humans as Potential Chronic Pain Biomarkers

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Effect of Histone Deacetylase Inhibitor JNJ-26481585 in Pain

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Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model

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Minocycline Effects on IL-6 Concentration in Macrophage and Microglial Cells in a Rat Model of Neuropathic Pain.

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The Effect of Repeated Electroacupuncture Analgesia on Neurotrophic and Cytokine Factors in Neuropathic Pain Rats

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Changes in neurotrophic and inflammatory factors in the cerebrospinal fluid of patients with postherpetic neuralgia

Zhao, W., Wang, Y., Fang, Q.-W., Wu, J., Gao, X.-Y., Liu, H., Cao, L., & An, J. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.041 · Cited by 24

Indirectly stimulation of DCs by Ganoderma atrum polysaccharide in intestinal-like Caco-2/DCs co-culture model based on RNA-seq

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Determination of Toll-Like Receptor-Induced Cytokine Profiles in the Blood and Cerebrospinal Fluid of Chikungunya Patients

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The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation

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Effects of joint and nerve mobilisation on neuroimmune responses in animals and humans with neuromusculoskeletal conditions: a systematic review and meta-analysis

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RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling

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The effects of aerobic exercise on neuroimmune responses in animals with traumatic peripheral nerve injury: a systematic review with meta-analyses

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Psychological Stress as a Modulator of Functional Recovery Following Spinal Cord Injury

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Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain

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Opioids and TRPV1 in the peripheral control of neuropathic pain – Defining a target site in the injured nerve

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Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE)

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Usefulness of Inflammatory Markers for the Prediction of Postherpetic Neuralgia in Patients with Acute Herpes Zoster

Kim, J. Y., Park, G.-H., Kim, M. J., Sim, H. B., Lee, W. J., Lee, S., Kim, S., Jeon, Y., Jang, Y. H., & Kim, D. W. (2018) · Annals of Dermatology · doi:10.5021/ad.2018.30.2.158 · Cited by 23

M1 macrophage infiltration exacerbate muscle/bone atrophy after peripheral nerve injury

Shimada, N., Sakata, A., Igarashi, T., Takeuchi, M., & Nishimura, S. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-3069-z · Cited by 22

The anti-inflammatory and analgesic effects of intraperitoneal melatonin after spinal nerve ligation are mediated by inhibition of the NF-κB/NLRP3 inflammasome signaling pathway

Wang, Y., Tang, Y., Gao, X. W., Liu, J., Zhang, N., Liang, Z., Li, Y., & Pan, L.-X. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.01.015 · Cited by 22

Houttuynia cordata Thunb reverses oxaliplatin-induced neuropathic pain in rat by regulating Th17/Treg balance.

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Treatment of pain following cancer: applying neuro-immunology in rehabilitation practice

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Impaired mechanical, heat, and cold nociception in a murine model of genetic TACE/ADAM17 knockdown

Quarta, S., Mitrić, M. M., Kalpachidou, T., Mair, N., Schiefermeier-Mach, N., Andratsch, M., Qi, Y., Langeslag, M., Malsch, P., Rose‐John, S., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201801901r · Cited by 22

Tramadol and Propentofylline Coadministration Exerted Synergistic Effects on Rat Spinal Nerve Ligation-Induced Neuropathic Pain

Zhang, J., Wu, D., Xie, C., Wang, H., Wang, W., Zhang, H., Liu, R., Xu, L.-X., & Mei, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072943 · Cited by 21

MiR-19a targets suppressor of cytokine signaling 1 to modulate the progression of neuropathic pain.

Wang, C., Jiang, Q., Wang, M., & Li, D. (2015) · PubMed Central · Cited by 21

Neuroimmune mechanisms of pain: Basic science and potential therapeutic modulators

Lim, J. S., & Kam, P. C. A. (2020) · Anaesthesia and Intensive Care · doi:10.1177/0310057x20902774 · Cited by 21

The ceramide-S1P pathway as a druggable target to alleviate peripheral neuropathic pain

Langeslag, M., & Kress, M. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1787989 · Cited by 19

AAAPT Diagnostic Criteria for Acute Neuropathic Pain

Doshi, T. L., Dworkin, R. H., Polomano, R. C., Carr, D. B., Edwards, R. R., Finnerup, N. B., Freeman, R. L., Paice, J. A., Weisman, S. J., & Raja, S. N. (2020) · Pain Medicine · doi:10.1093/pm/pnaa407 · Cited by 23

Muscle-brain communication in pain: The key role of myokines

Wang, Y., Wu, Z., Wang, D., Huang, C., Xu, J., Liu, C., & Yang, C. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.11.017 · Cited by 21

Role of Exercise on Inflammation Cytokines of Neuropathic Pain in Animal Models

Zheng, Y.-N., Zheng, Y.-L., Wang, X., & Chen, P. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04214-4 · Cited by 21

Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows

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Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors

Jurga, A. M., Rojewska, E., Makuch, W., & Mika, J. (2018) · Pharmaceutical Biology · doi:10.1080/13880209.2018.1457061 · Cited by 21

Interleukin-35 alleviates neuropathic pain and induces an anti-inflammatory shift in spinal microglia in nerve-injured male mice

Fiore, N. T., Hayes, J. P., Williams, S. I., & Moalem‐Taylor, G. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.07.043 · Cited by 20

Treating Chronic Pain with Mesenchymal Stem Cells: A Therapeutic Approach Worthy of Continued Investigation

Waterman, R. S., & Betancourt, A. M. (2011) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.s2-001 · Cited by 20

Selenium Effects on Oxidative Stress-Induced Calcium Signaling Pathways in Parkinson’s Disease

Salaramoli, S., Joshaghani, H., & Hashemy, S. I. (2022) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-022-01031-1 · Cited by 21

Contributions of neuroimmune interactions to chemotherapy-induced peripheral neuropathy development and its prevention/therapy

Ollodart, J., Steele, L. R., Romero-Sandoval, E. A., Strowd, R. E., III, & Shiozawa, Y. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116070 · Cited by 20

The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain

Buckley, D. A., Jennings, E. M., Burke, N. N., Roche, M., McInerney, V., Wren, J. D., Finn, D. P., & McHugh, P. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0492-8 · Cited by 20

Association of Interleukin-6 and Other Cytokines with Self-Reported Pain in Prostate Cancer Patients Receiving Chemotherapy

Al-Mazidi, S. H., Farhat, K. H., Nedjadi, T., Chaudhary, A., Al-Abdin, O. Z., Rabah, D. M., Alzoghaibi, M., & Djouhri, L. (2017) · Pain Medicine · doi:10.1093/pm/pnx145 · Cited by 20

Loss of intraepidermal nerve fiber density during SIV peripheral neuropathy is mediated by monocyte activation and elevated monocyte chemotactic proteins

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Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation

Zhang, B., Yu, Y., Aori, G., Wang, Q., Kong, D.-W., Yang, W., Guo, Z., & Zhang, L. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/2789847 · Cited by 20

Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

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Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain

Roversi, K., Callai-Silva, N., Roversi, K., Griffith, M., Boutopoulos, C., Prediger, R. D., & Talbot, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.759679 · Cited by 19

Bibliometric Analysis Reveals a 20-Year Research Trend for Chemotherapy-Induced Peripheral Neuropathy

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Botulinum Neurotoxins beyond Neurons: Interplay with Glial Cells

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Contribution of immune cells to cancer-related neuropathic pain: An updated review

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Advances in Neuropathic Pain Research: Selected Intracellular Factors as Potential Targets for Multidirectional Analgesics

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The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury

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Skin cytokine expression in patients with fibromyalgia syndrome is not different from controls

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Supraspinal neuroimmune crosstalk in chronic pain states

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Characterization of transgenic mouse lines for selectively targeting satellite glial cells and macrophages in dorsal root ganglia

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T lymphocyte and monocyte subsets are dysregulated in type 1 diabetes patients with peripheral neuropathic pain

O'Brien, J. A., McGuire, H. M., Shinko, D., Groth, B. F. D. S., Russo, M. A., Bailey, D., Santarelli, D. M., Wynne, K., & Austin, P. J. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100283 · Cited by 19

The Red Nucleus TNF-α Participates in the Initiation and Maintenance of Neuropathic Pain Through Different Signaling Pathways

Zhang, Q., Yu, J., Wang, J., Cui-pin, D., Han, S.-P., Zeng, X., & Wang, J. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1599-9 · Cited by 19

An Evidence Based Review of Epidurolysis for the Management of Epidural Adhesions

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Resolvin D1 Alleviates Mechanical Allodynia via ALX/FPR2 Receptor Targeted Nod-like Receptor Protein 3/Extracellular Signal-Related Kinase Signaling in a Neuropathic Pain Model

Wang, Y., Gao, X. W., Tang, Y., Chen, F., Yu, Y., Sun, M., & Li, Y. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.04.019 · Cited by 20

Bilateral tactile hypersensitivity and neuroimmune responses after spared nerve injury in mice lacking vasoactive intestinal peptide

Gallo, A., Leerink, M., Michot, B., Ahmed, E., Forget, P., Mouraux, A., Hermans, E., & Deumens, R. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.03.019 · Cited by 18

MiR-30b-5p attenuates neuropathic pain by the CYP24A1-Wnt/β-catenin signaling in CCI rats

Liao, J., Liu, J. L., Long, G., & Lv, X. (2021) · Experimental Brain Research · doi:10.1007/s00221-021-06253-y · Cited by 19

Local and Systemic Cytokine Expression in Patients with Postherpetic Neuralgia

Üçeyler, N., Valet, M., Kafke, W., Tölle, T. R., & Sommer, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105269 · Cited by 18

Genetically predicted immune cells mediate the association between gut microbiota and neuropathy pain

Lan, Z., Wei, Y., Yue, K., He, R., & Jiang, Z. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01514-y · Cited by 17

TRPV1 Blocker HCRG21 Suppresses TNF-α Production and Prevents the Development of Edema and Hypersensitivity in Carrageenan-Induced Acute Local Inflammation

Sintsova, O. V., Gladkikh, I. N., Климович, А. А., Palikova, Y. A., Паликов, В. А., Styshova, O. N., Monastyrnaya, M., Dyachenko, I. A., Kozlov, S. A., & Leychenko, E. V. (2021) · Biomedicines · doi:10.3390/biomedicines9070716 · Cited by 17

Effect of Physiotherapeutic Interventions on Biomarkers of Neuropathic Pain: A Systematic Review of Preclinical Literature

Matesanz-García, L., Schmid, A. B., Cáceres-Pajuelo, J. E., Cuenca‐Martínez, F., Arribas‐Romano, A., González‐Zamorano, Y., Goicoechea, C., & Fernández‐Carnero, J. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.06.007 · Cited by 17

Trigeminal neuralgia: peripheral and central mechanisms

Costa, G. M. F., & Leite, C. M. D. A. (2015) · Revista Dor · doi:10.5935/1806-0013.20150061 · Cited by 17

In Vivo Neuroelectrophysiological Monitoring of Atomically Precise Au25 Clusters at an Ultrahigh Injected Dose

Hao, W., Liu, S., Liu, H., Mu, X., Chen, K., Qi, X., & Zhang, X. (2020) · ACS Omega · doi:10.1021/acsomega.0c03005 · Cited by 17

Analgesic effect of total flavonoids from Sanguis draxonis on spared nerve injury rat model of neuropathic pain

Chen, F.-F., Huo, F., Xiong, H., Wan, Q., Zheng, Y., Du, W., & Mei, Z. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.08.011 · Cited by 17

Bilateral activation of glial cells and cellular distribution of the chemokine CCL2 and its receptor CCR2 in the trigeminal subnucleus caudalis of trigeminal neuropathic pain model

Kubíčková, L., Klusáková, I., & Dubový, P. (2020) · Histochemistry and Cell Biology · doi:10.1007/s00418-020-01850-4 · Cited by 16

Neuroprotective and anti-neuropathic actions of pulsed magnetic fields with low frequencies in rats with chronic peripheral neuropathic pain

Mert, T., Metin, T. Ö., Şahın, E., Yaman, S., & Sahin, M. A. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.10.012 · Cited by 16

Polysaccharide glucomannan isolated from Heterodermia obscurata attenuates acute and chronic pain in mice

Córdova, M. M., Martins, D. F., da Silva, M. D., Baggio, C. H., Carbonero, E. R., Ruthes, A. C., Iacomini, M., & Santos, A. R. S. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.11.041 · Cited by 16

Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation

Bollenbach, M., Salvat, É., Daubeuf, F., Wagner, P., Yalçın, İ., Humo, M., Letellier, B., Becker, L. J., Bihel, F. J. ‐., Bourguignon, J., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.01.049 · Cited by 16

Interleukin-4 protects from chemotherapy-induced peripheral neuropathy in mice modal via the stimulation of IL-4/STAT6 signaling

Shi, Q., Cai, X., Shi, G., Lv, X., Yu, J., & Wang, F. (2018) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-865020180060000003 · Cited by 16

Pulsed radiofrequency alleviated neuropathic pain by down-regulating the expression of substance P in chronic constriction injury rat model

Wang, J.-A., Niu, S.-N., & Luo, F. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000619 · Cited by 15

The emerging role of pyroptosis in neuropathic pain

Li, B., Guo, J., Zhou, X., Li, W., Wang, N., Cao, R., & Cui, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110562 · Cited by 14

Evaluation of photobiomodulation therapy (117 and 90s) on pain, regeneration, and epigenetic factors (HDAC 2, DNMT3a) expression following spinal cord injury in a rat model

Nezhad, A. M., Behroozi, Z., Kookli, K., Ghadaksaz, A., Fazeli, S. M., Moshiri, A., Ramezani, F., Shooshtari, M. G., & Janzadeh, A. (2023) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-023-00467-5 · Cited by 15

Effects of active immunisation with myelin basic protein and myelin-derived altered peptide ligand on pain hypersensitivity and neuroinflammation

Perera, C. J., Lees, J. G., Duffy, S. S., Makker, P. G. S., Fivelman, B., Apostolopoulos, V., & Moalem‐Taylor, G. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.07.004 · Cited by 15

Effects of Vaccination with Altered Peptide Ligand on Chronic Pain in Experimental Autoimmune Encephalomyelitis, an Animal Model of Multiple Sclerosis

Tian, D. H., Perera, C. J., Apostolopoulos, V., & Moalem‐Taylor, G. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00168 · Cited by 15

sec -Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain

Kaufmann, D., West, P. J., Smith, M. D., Yagen, B., Bialer, M., Devor, M. G., White, H. S., & Brennan, K. C. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.030 · Cited by 15

Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain

Garrido‐Suárez, B. B., Garrido, G., Piñeros, O., & Delgado, R. (2019) · Phytotherapy Research · doi:10.1002/ptr.6546 · Cited by 15

Local Inflammatory Mediators Involved in Neuropathic Pain

García-Fernández, P., Reinhold, C., Üçeyler, N., & Sommer, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097814 · Cited by 14

Evaluation of the protein biomarkers and the analgesic response to systemic methylene blue in patients with refractory neuropathic pain: a double-blind, controlled study

Miclescu, A. A., Svahn, M., & Gordh, T. (2015) · Journal of Pain Research · doi:10.2147/jpr.s84685 · Cited by 14

LASSBio-1135: A Dual TRPV1 Antagonist and Anti-TNF-Alpha Compound Orally Effective in Models of Inflammatory and Neuropathic Pain

de Lima, C. K. F., Silva, R. M., Lacerda, R. B., dos Santos, B. L. R., Silva, R. V., Amaral, L. S., Quintas, L. E. M., Fraga, C. A. M., Barreiro, E. J., Guimarães, M. Z. P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099510 · Cited by 14

Acute Cytokine Response During Breast Cancer Surgery: Potential Role of Dexamethasone and Lidocaine and Relationship with Postoperative Pain and Complications – Analysis of Three Pooled Pilot Randomized Controlled Trials

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Siwei Jianbu decoction improves painful paclitaxel-induced peripheral neuropathy in mouse model by modulating the NF-κB and MAPK signaling pathways

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