Gastrointestinal issues in autism spectrum disorder
Abstract
While autism spectrum disorder (ASD) is characterized by communication impairments, social abnormalities, and stereotypic behaviors, several medical comorbidities are observed in autistic individuals. Of these, gastrointestinal (GI) abnormalities are of particular interest given their reported prevalence and correlation with the severity of core autism-related behavioral abnormalities. This review discusses the GI pathologies seen in ASD individuals and the association of particular GI conditions with known genetic and environmental risk factors for autism. It further addresses how GI abnormalities can affect the neuropathological and behavioral features of ASD, as well as the development of autism-related endophenotypes such as immune dysregulation, hyperserotonemia, and metabolic dysfunction. Finally, it presents emerging evidence for a gut-brain connection in autism, wherein GI dysfunction may contribute to the pathogenesis or severity of ASD symptoms.
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Previous studies assessing GI symptoms in ASD versus NT children suffer from methodological differences in assessing GI symptoms.
“Review of previous studies suggest that GI symptoms are more common in ASD children than in NT children, but these studies suffer from methodological differences in assessing GI symptoms [28–31].”
From Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection (2015) · cites this paper as [29]
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Tognini, P. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00025 · Cited by 163 · see citing works
The Impact of Neuroimmune Alterations in Autism Spectrum Disorder
Gottfried, C., Bambini-Junior, V., Francis, F., Riesgo, R., & Savino, W. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00121 · Cited by 143 · see citing works
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Eating and feeding problems and gastrointestinal dysfunction in Autism Spectrum Disorders
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- Authors
- Hsiao, E. Y.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Hsiao, Elaine Y
- ORCID
- Hsiao, Elaine Y
- Venue
- Harvard Review of Psychiatry
- Published
- 2014-03
- Volume
- 22
- Issue
- 2
- Pages
- 104-111
- ISSN
- 1067-3229 (ISSN-L)
- OpenAlex
- W2087373760
- Cited by
- 209
- References
- 92
- Citations by year
- 2026: 15 · 2025: 19 · 2024: 16 · 2023: 12 · 2022: 23 · 2021: 22 · 2020: 23 · 2019: 20 · 2018: 16 · 2017: 13 · 2016: 11 · 2015: 13 · 2014: 6
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Harvard Review of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institute of Mental Health (F31MH090749)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- autism spectrum disorder, gastrointestinal anomalies, autism comorbidity, gut-brain axis, immune dysregulation, hyperserotonemia, metabolic dysfunction, endophenotypes, genetic risk factors, environmental risk factors, autism pathogenesis, behavioral symptoms
- MeSH terms
- Child Development Disorders, Pervasive, Gastrointestinal Diseases, Humans, Endophenotypes
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