Association between obsessive-compulsive and related disorders and experiential avoidance: A systematic review and meta-analysis
Abstract
The associations between the distinct types of obsessive-compulsive and related disorders and experiential avoidance have received mixed evidence. We, thus, undertook this meta-analysis to i) re-examine the association between obsessive-compulsive disorder and experiential avoidance, ii) extend this association to hoarding disorder, trichotillomania, and body dysmorphic disorder, and iii) identify potential variables affecting these associations. Five databases, including Medline, Embase, PsychINFO, Web of Science and CINAHL, were searched until March 15th, 2021. Meta-analyses based on random-effect models were performed. Heterogeneity and publication bias tests were applied using the I 2 statistic and the Egger's test. Meta-regression analyses were performed to identify potential moderators affecting the strength of these associations. Thirty-six unique studies based on n = 11,859 participants were identified. The association between obsessive-compulsive disorder and experiential avoidance was moderate (SMD = 0.75, 95% CI = 0.57-0.92), whereas the associations between individual obsessive-compulsive symptoms, including obsessions, responsibility for harm, ordering, checking, washing and neutralizing, and experiential avoidance ranged from low to strong (SMD ranged between 0.41 and 1.06, 95% CI = 0.25 to 1.40). The associations between hoarding disorder (SMD = 0.93, 95% CI = 0.46-1.40), trichotillomania (SMD = 0.56, 95% CI = 0.48-0.63), body dysmorphic disorder (SMD = 1.55, 95% CI = 0.72-2.37) and experiential avoidance were moderate to strong. Meta-regression analyses demonstrated that studies using the AAQ/AAQ-II scales for measuring experiential avoidance, and/or self-report scales for assessing OCRDs contributed smaller effect sizes. These findings suggest that reducing experiential avoidance may be a viable way of complementing exposure strategies in alleviating obsessive-compulsive and related symptoms.
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Psychological inflexibility and experiential avoidance are associated with obsessive-compulsive symptoms and psychological distress.
“Psychological inflexibility and experiential avoidance are also associated with OCS and psychological distress (Angelakis and Pseftogianni, 2021;Bond et al., 2011).”
From A pilot study of experiencing racial microaggressions, obsessive-compulsive symptoms, and the role of psychological flexibility (2023) · cites this paper as Angelakis and Pseftogianni, 2021
Experiential avoidance plays a crucial role in the development and maintenance of obsessive-compulsive symptoms.
“Experiential avoidance, the avoidance of unpleasant inner experiences such as fear, discomfort and bodily sensations is found to play a crucial role in the development and maintenance of obsessive–compulsive symptoms [15–19].”
The effect of experiential avoidance on obsessive-compulsive symptoms differed between OCD subtypes; patients with a focus on obsessions and responsibility for harm seem to benefit more from a reduction in experiential avoidance.
“Also, meta-analysis showed that this effect differed between the different subtypes of OCD, patients with the focus on obsessions and responsibility for harm seem to benefit more from a reduction in experiential avoidance [17].”
Destructive and rigid experiential avoidance is reflected in transdiagnostic mental illnesses such as depressive disorders, anxiety disorders, obsessive-compulsive disorder, substance use disorder, eating disorders, and post-traumatic stress disorder.
“Various studies have reported the adverse consequences of destructive and rigid EA, which are reflected in transdiagnostic mental illnesses such as depressive disorders [3], anxiety disorders [4], obsessive–compulsive disorder [5], substance use disorder, [6] eating disorders [7], and post-traumatic stress disorder [8].”
From Acceptance and Commitment Therapy for Destructive Experiential Avoidance (ACT-DEA): A Feasibility Study (2022) · cites this paper as [5]
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Incremental validity of the AAQ-II for anxiety disorder symptomology
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Hellberg, S. N., DuBois, C. M., Myers, N. S., Rodriguez, C., Butcher, M. W., Ojalehto, H. J., Riemann, B. C., & Abramowitz, J. S. (2023) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2023.102728 · Cited by 6 · see citing works
Soumee, Z. N., Rasouli, A., Krafft, J., & Mousavi, S. E. (2025) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.70065 · Cited by 5 · see citing works
Browning, M. E., Lloyd-Richardson, E. E., Satterfield, S. L., & Trisal, A. V. (2023) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465823000188 · Cited by 4 · see citing works
“Generally, we expected (based on past research) that experiences of racial microaggressions would relate positively and strongly to total OCS and all subscales in addition to psychological distress (Angelakis and Pseftogianni, 2021; Williams et al., 2017b).”
BackgroundRodgers, R. F. (2025) · Body Image · doi:10.1016/j.bodyim.2025.101930 · Cited by 4 · see citing works
Cervin, M., Andrén, P., & Perrin, S. G. (2025) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.70184 · Cited by 3 · see citing works
Khosravani, V., Sharifibastan, F., Ardestani, S. M. S., & Wahl, K. (2024) · International Journal of Cognitive Therapy · doi:10.1007/s41811-024-00224-1 · Cited by 3 · see citing works
“…used in the treatment of OCD (Bluett et al., 2014; Twohig et al., 2018), which encourage OCD patients to confront their obsessional thoughts and accept their unpleasant internal experiences, rather than avoiding them, may be effective in alleviating OCD symptoms (Angelakis & Pseftogianni, 2021).”
The link between hoarding symptoms and interpersonal difficulties during the COVID-19 pandemic
Broos, H. C., Kushner, M. L., Stamatis, C. A., & Timpano, K. (2024) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2024.100899 · Cited by 3 · see citing works
Miegel, F. S., Schröder, J., Schultz, J., Müller, J. C., & Jelinek, L. (2023) · International Journal of Psychology · doi:10.1002/ijop.12919 · Cited by 3 · see citing works
Gamlı, İ. S., Kaçar, A. Ş., Eyupoglu, N., Karakuş, O. B., & Adak, İ. (2025) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.70083 · Cited by 3 · see citing works
Soumee, Z. N., Rasouli, A., Lee, E. B., & Mousavi, S. E. (2025) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2025.100924 · Cited by 2 · see citing works
Rehm, I. C., Moulding, R., & Nedeljkovic, M. (2024) · Australian Psychologist · doi:10.1080/00050067.2024.2376881 · Cited by 2 · see citing works
“Following a meta-analysis that indicated the relationship between experiential avoidance and HPD severity is of moderate effect size, Angelakis and Pseftogianni (2021) cautioned the AAQ/AAQ-II may primarily measure psychological distress and negative affectivity rather than experiential avoidance…”
Wheaton, M. G. (2025) · CBT: science into practice · doi:10.1007/978-3-031-91439-3_14 · Cited by 2 · see citing works
Bewley, A., & Taylor, R. E. (2024) · doi:10.1002/9781119709268.rook084 · Cited by 2 · see citing works
Hoogerwerf, E., Greeven, A., Goekoop, R., & Spinhoven, P. (2024) · Trials · doi:10.1186/s13063-023-07780-5 · Cited by 1 · see citing works
“Also, meta-analysis showed that this effect differed between the different subtypes of OCD, patients with the focus on obsessions and responsibility for harm seem to benefit more from a reduction in experiential avoidance [17].”
BackgroundTreating Adolescent OCD: Recommendations for Systemic Clinical Competence
Smedley, D. K., Lovell, T. W., & Bean, R. A. (2024) · American Journal of Family Therapy · doi:10.1080/01926187.2024.2354323 · Cited by 1 · see citing works
“It is suggested that this reluctance is associated with the therapist’s level of experiential avoidance (defined as “the inability to tolerate unpleasant thoughts, emotions and/ or bodily sensations,” (Angelakis & Pseftogianni, 2021).”
Loureiro, C. P., dos Santos‐Ribeiro, S., Moreira‐de‐Oliveira, M. E., Laurito, L. D., Hühne, V., Torres, B., Twohig, M. P., de Menezes, G. B., & Fontenelle, L. F. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.01.035 · Cited by 2 · see citing works
Assessing Experiential Avoidance: Further Testing of the AAQ-II and the MEAQ
Jimenez, A., Rochefort, C., & Chmielewski, M. S. (2026) · Assessment · doi:10.1177/10731911261423143 · Cited by 1 · see citing works
Lewis, M. M., Naugle, A. E., DiBacco, T. A., Katte, K., Smith, C. A., & Blematl, A. R. (2022) · Current Psychology · doi:10.1007/s12144-022-03447-7
Nazari, F., Gharraee, B., & Tajrishi, K. Z. (2023) · Iranian Journal of Psychiatry and Clinical Psychology · doi:10.32598/ijpcp.28.4.4377.1
Dissociative episodes characterised by hair-pulling in a late adolescent woman
Healey, D. N., Lee, J. J., Testa, E. G., & Gautam, R. (2023) · BMJ Case Reports · doi:10.1136/bcr-2022-254100
The Effect of Compulsive Hoarding Behavior on Consumers’ Two-Sided Responses
Lee, E.-K., & Park, H.-H. (2025) · Sustainability · doi:10.3390/su17052230 · Cited by 1 · see citing works
Shahri, G. N. K., Khorasgani, E. G., Mohammadi, S. M., Asl, F. M., & Afsarpour, S. A. (2025) · Quarterly Journal of Child Mental Health · doi:10.61882/jcmh.12.1.117 · Cited by 1 · see citing works
Hummelen, B., Brovold, F., Moen, E. M., Meland, K. J., Andersen, A., Johnsen, D. S., Dammen, T., Woods, D. W., & Grøtte, T. (2025) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2025.100972
Hoogerwerf, E., Greeven, A., Goekoop, R., & Spinhoven, P. (2024) · Figshare · doi:10.6084/m9.figshare.24993705
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“Experiential avoidance, defined as the struggle to tolerate distressing internal experiences, has been shown to play a significant role in the development and persistence of OCD (Arabatzoudis et al. 2017 , Blakey et al. 2017 , Angelakis and Gooding 2020 , Angelakis and Pseftogianni 2021).”
A novel approach-avoidance task to study decision making under outcome uncertainty
Cheng, Z., Ging-Jehli, N. R., Tarlow, M., Kim, J., Chase, H. W., Arora, M., Bonar, L. K., Stiffler, R., Grattery, A., Graur, S., et al. (2026) · Psychonomic Bulletin & Review · doi:10.3758/s13423-026-02885-9
“Suboptimal evaluation or integration of these factors may lead to maladaptive motivated behavior and prolonged negative mood (Angelakis & Pseftogianni, 2021; Akbari et al., 2022; Loijen et al., 2020; Trew, 2011).”
Nielsen, S. K. K., Stuart, A. C., Pedersen, M. Ø., Winding, C., Rosenberg, N., Hageman, I., Jørgensen, M. B., & Vangkilde, S. (2026) · Psychotherapy Research · doi:10.1080/10503307.2026.2671186
Hamre, T. A., Kutcher, T., Hanish, R. R., Soubra, S. S., Bentley, H., Mansourian, K. A., Nitcheu, G. L. T., Belavadi, V., Chamarthi, S., Jourahmad, Z., et al. (2026) · medRxiv · doi:10.64898/2026.07.20.26357997
Abramowitz, J. S., Myers, N. S., Hord, C. M., Friedman, J. B., Juel, E. K., Laskowski, G. E., & Receveur, A. M. (2026) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2026.101048
The indirect effects of trauma-related shame and experiential avoidance on PTSD and suicidality
Quiroga, J., Johnson, D. H., & Albanese, B. J. (2026) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2026.2736051
From Topography to Function: Rethinking the Conceptualization of Obsessive-Compulsive Disorder
Abramowitz, J. S., & Melli, G. (2026) · Behavior Therapy · doi:10.1016/j.beth.2026.10.001
Patel, R., & Lippert, A. M. (2026) · Journal of American College Health · doi:10.1080/07448481.2026.2745120
- Authors
- Angelakis, I., & Pseftogianni, F.
- Affiliations
- University of South Wales (GB)
- Norfolk and Suffolk NHS Foundation Trust (GB)
- Corresponding author
- Angelakis, Ioannis
- ORCID
- Angelakis, Ioannis
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 138
- Pages
- 228-239
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W3139885204
- Cited by
- 47
- References
- 77
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 11 · 2023: 7 · 2022: 5 · 2021: 3
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive and related disorders, experiential avoidance, obsessive-compulsive disorder, hoarding disorder, trichotillomania, body dysmorphic disorder, obsession, exposure therapy, acceptance and commitment therapy
- MeSH terms
- Hoarding Disorder, Humans, Obsessive-Compulsive Disorder, Trichotillomania, Body Dysmorphic Disorders, Self Report
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