Changes in illness perceptions mediated the effect of cognitive behavioural therapy in severe functional somatic syndromes
Abstract
Objective Although there is substantial evidence that cognitive behavioural therapy alleviates symptoms in functional somatic syndromes, the mechanisms of change are less investigated. This study examined whether changes in illness perceptions mediated the effect of cognitive behavioural therapy.Methods We analysed additional data from a randomised controlled trial comparing completers of cognitive behavioural group therapy (46 patients) to an enhanced usual care group (66 patients). Proposed mediators (illness perceptions) and primary (physical health) and secondary (somatic symptoms and illness worry) outcomes were assessed by means of questionnaires at referral, baseline, end of treatment, and 10 and 16 months after randomisation. Multiple mediation analysis determined whether (1) changes in specific illness perceptions during treatment mediated the effect of cognitive behavioural therapy (primary analysis), and (2) whether changes in illness perceptions during the whole trial period were associated with improved outcome (secondary analysis).Results Improvements in illness perceptions during treatment partially mediated the effect of cognitive behavioural therapy on physical health one year after treatment (sum of indirect effects 1.556, BCa 95% CI (0.006; 3.620)). Improving perceived control was particularly important. Changes in illness perceptions from baseline to 16 months after randomisation were associated with clinically meaningful improvements in physical health, somatic symptoms and illness worry during the same period.Conclusion Our results suggest that changing patients' illness perceptions is an important process in cognitive behavioural therapy for functional somatic syndromes. Challenging patients' own understanding of their illness may hence be a key element of successful treatment.
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In a comparable study with adults, changes in illness perceptions partly mediated the effect of treatment on outcome.
“In a comparable study with adults, changes in illness perceptions partly mediated the effect of treatment on outcome.76”
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Osterland, T. B., Kasch, H., Frostholm, L., Bendix, T., Jensen, T. S., Jensen, J. S., & Carstensen, T. B. W. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000683 · Cited by 14 · see citing works
“Evaluation of the Hosmer-Lemeshow fit statistic showed a fine model fit: χ2(8)= 13.”
BackgroundMethodWortman, M. S. H., van der Wouden, J. C., Twisk, J. W. R., Visser, B., Assendelft, W. J., van der Horst, H. E., & Hartman, T. O. (2023) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2023.111178 · Cited by 14 · see citing works
Webb, T. L., & de Bruin, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.037 · Cited by 14 · see citing works
Using Illness Perceptions to Cluster Chronic Pain Patients
Frostholm, L., Hornemann, C., Ørnbøl, E., Fink, P., & Mehlsen, M. Y. (2018) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000627 · Cited by 13 · see citing works
Wolf, J., Sattel, H. C., Limburg, K., & Lahmann, C. (2020) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2020.109934 · Cited by 13 · see citing works
Critical and Qualitative Approaches to Behavior Change
Chamberlain, K., & Lyons, A. C. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.030 · Cited by 12 · see citing works
Kallesøe, K. H., Rimvall, M. K., Schröder, A., Jensen, J. S., Wicksell, R. K., & Rask, C. U. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110430 · Cited by 12 · see citing works
Maximizing User Engagement with Behavior Change Interventions
Yardley, L., Morrison, L. G., Müller, I., & Bradbury, K. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.025 · Cited by 11 · see citing works
The Science of Behavior Change: The Road Ahead
Hagger, M. S., Cameron, L. D., Hamilton, K., Hankonen, N. E., & Lintunen, T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.046 · Cited by 11 · see citing works
Gender and Emotional Representation Matter: Own Illness Beliefs and Their Relationship to Obesity
Henning, C., Schroeder, S., Steins‐Loeber, S., & Wolstein, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.799831 · Cited by 11 · see citing works
“An association between SIRs and treatment outcomes has been confirmed for several chronic diseases, including asthma (51, 52), diabetes (53), cardiovascular diseases (54, 55), chronic fatigue syndrome (56), and functional somatic syndromes (57).”
BackgroundSelinheimo, S., Vuokko, A., Hublin, C., Järnefelt, H., Karvala, K., Sainio, M., Suojalehto, H., & Paunio, T. (2020) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2020.109962 · Cited by 9 · see citing works
Weigel, A., Dantoft, T. M., Jørgensen, T., Carstensen, T. B. W., Löwe, B., Weinman, J. A., & Frostholm, L. (2022) · Clinical Psychology in Europe · doi:10.32872/cpe.7739 · Cited by 9 · see citing works
“, 2002) and severe functional disorders (Christensen et al., 2015).”
BackgroundPankowski, D., Wytrychiewicz‐Pankowska, K., Janowski, K., & Pisula, E. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.111074 · Cited by 9 · see citing works
Autonomy-Supportive Interventions
Reeve, J., & Cheon, S. H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.035 · Cited by 9 · see citing works
Implementation Science and Translation in Behavior Change
Łuszczyńska, A., Łobczowska, K., & Horodyska, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.023 · Cited by 9 · see citing works
ONOFRJ, M. C., Ajdinaj, P., Digiovanni, A., Malek, N., Martinotti, G., Ferro, F. M., Russo, M., Thomas, A., & Sensi, S. L. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1120981 · Cited by 10 · see citing works
“CBT shows both early and longterm efficacy (148) and is effective in the reduction of PNES (149, 150).”
Backgroundde Ridder, D. T. D., Gillebaart, M., & Friese, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.040 · Cited by 9 · see citing works
Epton, T., & Armitage, C. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.038 · Cited by 8 · see citing works
Understanding Perceived Stress in Adolescent Inflammatory Bowel Disease
Sunavsky, A., Moreau, J., & Tripp, D. (2021) · Journal of the Canadian Association of Gastroenterology · doi:10.1093/jcag/gwab036 · Cited by 7 · see citing works
“Addressing illness uncertainty is important; illness uncertainty was shown to be reduced following cognitive behavioural therapy in patients with functional somatic syndrome (49).”
BackgroundEvaluation of Behavior Change Interventions
Matthews, L., & Simpson, S. A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.022 · Cited by 7 · see citing works
Somatic Symptom and Related Disorders
Williams, S. E., Zahka, N. E., & Kullgren, K. A. (2020) · Issues in clinical child psychology · doi:10.1007/978-3-030-35598-2_14 · Cited by 7 · see citing works
Motivational Interviewing Interventions
Berman, A. H., Beckman, M., & Lindqvist, H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.045 · Cited by 7 · see citing works
Economic and Behavioral Economic Approaches to Behavior Change
Brown, P. M., Cameron, L. D., Wilkinson, M., & Taylor, D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.042 · Cited by 6 · see citing works
Changing Behavior Using Integrative Self-Control Theory
Hofmann, W., Dohle, S., & Diel, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.011 · Cited by 6 · see citing works
Conner, M. T., Williams, D. M., & Rhodes, R. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.034 · Cited by 6 · see citing works
Yang, L., Chen, X., Liu, Z., Sun, W., Yu, D., Tang, H., & Zhang, Z. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s342512 · Cited by 5 · see citing works
“Cognitive behavioural therapy improved IPs in patients with functional somatic syndromes, thus improving physical health, somatic symptoms and illness worry.(45) In a randomized controlled trial of patients with IBD, compared with the control group, those who received acceptance and commitment therapy reported greater…”
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“In a recent study, the diagnosis of ‘‘bodily distress syndrome’’ was used as a new criterion for defining FSS (Christensen et al. 2015).”
MethodAddressing Underserved Populations and Disparities in Behavior Change
Schüz, B., & Hooper, M. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.027 · Cited by 5 · see citing works
Associations of Health Symptoms and Perceptions With Work Volition
Bouchard, L., & Nauta, M. M. (2021) · The Career Development Quarterly · doi:10.1002/cdq.12257 · Cited by 5 · see citing works
Changing Behavior in the Digital Age
Kavanagh, D. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.029 · Cited by 4 · see citing works
FuncData - A national database for functional somatic disorders in Denmark
Eefsen, A. M., Petersen, M. W., Vægter, H. B., Fonager, K., Skjernov, M., Gormsen, L. K., & Schröder, A. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.111092 · Cited by 5 · see citing works
Can the pain field learn from the functional somatic disorder field?
Gormsen, L. K., Fink, P., Butler, S. H., Henningsen, P., Loeser, J. D., Rief, W., & Finnerup, N. B. (2025) · Pain · doi:10.1097/j.pain.0000000000003733 · Cited by 3 · see citing works
Kallesøe, K. H., Ørnbøl, E., Wellnitz, K. B., & Rask, C. U. (2025) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2025.2521719 · Cited by 3 · see citing works
“The current findings corroborate results from studies in adults with both single system FSD (IBS) and multisystem FSD, where changes to more adaptive illness perceptions mediated the effect of CBT (Chilcot & Moss-Morris, 2013; Christensen et al., 2015).”
Testal, J. F. R., Márquez, S. F., Senín‐Calderón, C., & Carrasco, M. Á. (2016) · Psicothema · doi:10.7334/psicothema2015.246 · Cited by 2 · see citing works
Changing Behavior Using Control Theory
Mansell, W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.009 · Cited by 2 · see citing works
Implications of Cognitive-Behavioural Therapy in Changing Illness Representations
Păduraru, A. E., & Soponaru, C. (2021) · Journal of Intercultural Management and Ethics · doi:10.35478/jime.2021.1.04 · Cited by 2 · see citing works
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Behavior Change in Community Contexts
Trickett, E. J., & Paterson, S. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.028 · Cited by 2 · see citing works
Humer, E. C., Sattel, H. C., Gündel, H., Henningsen, P., Kruse, J., Schneider, G., Lahmann, C., Pieh, C., & Probst, T. (2021) · Psychotherapy Research · doi:10.1080/10503307.2021.1882711 · Cited by 2 · see citing works
Cost-Effectiveness Evaluations of Behavior Change Interventions
Wang, T., Downes, M., Byrnes, J., & Scuffham, P. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.026 · Cited by 1 · see citing works
The role of illness perceptions in epilepsy throughout the lifespan: A systematic review
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“The significant interaction between CBT and IP is consistent with the finding of Christensen et al. (2015) about severe functional somatic syndromes.”
Loss of Resources and Demoralization in the Chronically Ill: A Mediation Model
Dischinger, T., & Inés, M. (2016)
- Authors
- Christensen, S. S., Frostholm, L., Ørnbøl, E., & Schröder, A.
- Affiliations
- Aarhus University Hospital (DK)
- Corresponding author
- Schröder, Andreas
- Venue
- Journal of Psychosomatic Research
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 78
- Issue
- 4
- Pages
- 363-370
- ISSN
- 0022-3999 (ISSN-L)
- OpenAlex
- W2138752739
- Cited by
- 111
- References
- 44
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 59 · 2019: 8 · 2018: 10 · 2017: 5 · 2016: 6 · 2015: 2
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychosomatic Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- TrygFonden (7-12-1039)
- Torkil Steenbeck's Legat; LundbeckFonden (R129-A11720)
- Foreningen Østifterne (12-081)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- cognitive behavioral therapy, functional somatic syndromes, illness perception, perceived control, mechanisms of change, somatic symptoms, physical health outcomes, group therapy
- MeSH terms
- Adult, Anxiety, Female, Humans, Male, Middle Aged, Psychophysiologic Disorders, Surveys and Questionnaires, Social Perception, Syndrome, Cognitive Behavioral Therapy, Treatment Outcome
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