Cited by 188Spaceflight effects on biologyEffects of Radiation ExposureRadiation Therapy and Dosimetry

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Biological effects of space radiation and development of effective countermeasures

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Kennedy, Ann R.·2014·Life Sciences in Space Research

DOI 10.1016/j.lssr.2014.02.004PMC PMC4170231

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Abstract

As part of a program to assess the adverse biological effects expected from astronaut exposure to space radiation, numerous different biological effects relating to astronaut health have been evaluated. There has been major focus recently on the assessment of risks related to exposure to solar particle event (SPE) radiation. The effects related to various types of space radiation exposure that have been evaluated are: gene expression changes (primarily associated with programmed cell death and extracellular matrix (ECM) remodeling), oxidative stress, gastrointestinal tract bacterial translocation and immune system activation, peripheral hematopoietic cell counts, emesis, blood coagulation, skin, behavior/fatigue (including social exploration, submaximal exercise treadmill and spontaneous locomotor activity), heart functions, alterations in biological endpoints related to astronaut vision problems (lumbar puncture/intracranial pressure, ocular ultrasound and histopathology studies), and survival, as well as long-term effects such as cancer and cataract development. A number of different countermeasures have been identified that can potentially mitigate or prevent the adverse biological effects resulting from exposure to space radiation.

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Rabin, B. M., Hunt, W. A., Wilson, M. E., & Joseph, J. A. (1992) · PubMed · Cited by 14
Accomplishments in bioastronautics research aboard International Space Station
Uri, J. J., & Haven, C. P. (2005) · Acta Astronautica · doi:10.1016/j.actaastro.2005.01.014 · Cited by 14
Relative radiation sensitivity of circulating small and large lymphocytes.
Neff, R. D., & CASSEN, B. (1968) · PubMed · Cited by 14
Protective effects of l-selenomethionine on space radiation induced changes in gene expression
Stewart, J., Ko, Y. H., & Kennedy, A. R. (2007) · Radiation and Environmental Biophysics · doi:10.1007/s00411-006-0089-5 · Cited by 14
Self-citation
The Bowman-Birk protease inhibitor enhances clonogenic cell survival of ionizing radiation-treated nucleotide excision repair-competent cells but not of xeroderma pigmentosum cells
Dittmann, E. D. K. H. (2000) · International Journal of Radiation Biology · doi:10.1080/095530000138871 · Cited by 14
Microbiological Contamination
Pierson, D. L., McGinnis, M. R., & Viktorov, A. N. (1994) · American Institute of Aeronautics and Astronautics eBooks · doi:10.2514/5.9781624104664.0077.0094 · Cited by 14
Mechanism of Radiation Carcinogenesis: Role of the TGFBI Gene and the Inflammatory Signaling Cascade
Hei, T. K., Zhao, Y., Zhou, H., & Ivanov, V. N. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0254-1_13 · Cited by 13
Effects of Solar Particle Event-Like Proton Radiation and/or Simulated Microgravity on Circulating Mouse Blood Cells
Romero-Weaver, A. L., Lin, L., Cárabe, A., & Kennedy, A. R. (2014) · Gravitational and Space Research · doi:10.2478/gsr-2014-0004 · Cited by 13
Self-citation
Comparison of Two Methods for the Determination of the Effects of Ionizing Radiation on Blood Cell Counts in Mice.
Romero-Weaver, A. L., & Kennedy, A. R. (2012) · PubMed · Cited by 13
Self-citation
L-selenomethionine modulates high LET radiation-induced alterations of gene expression in cultured human thyroid cells
Stewart, J., Ware, J. H., Fortina, P. M., Breaux, J., Gulati, S., & Kennedy, A. R. (2006) · Oncology Reports · doi:10.3892/or.16.3.569 · Cited by 13
Self-citation
Neurobehavioral Effects of Head-only Gamma-Radiation Exposure in Rats
Hienz, R. D., Brady, J. V., Gooden, V. L., Vazquez, M. E., & Weed, M. R. (2008) · Radiation Research · doi:10.1667/rr1222.1 · Cited by 13
Murine Prkdc polymorphisms impact DNA-PKcs function
Fabre, K. M., Ramaiah, L., Dregalla, R. C., Desaintes, C., Weil, M. M., Bailey, S. M., & Ullrich, R. L. (2011) · Radiation Research · doi:10.1667/rr2431.1 · Cited by 13
The Role of Age, Sex and Steroid Sex Hormones in Radiation Cataractogenesis
Dynlacht, J. R. (2013) · Radiation Research · doi:10.1667/rr13549.1 · Cited by 13
Comparison of Two Methods for the Determination of the Effects of Ionizing Radiation on Blood Cell Counts in Mice
Department of Radiation Oncology, U. O. P. S. O. M., Kennedy, A. R., & Romero-Weaver, A. L. (2012) · International Journal of Biomedical Science · doi:10.59566/ijbs.2012.8007 · Cited by 13 · cited 2×
“Whole blood samples were collected up to 30 days post-irradiation and complete blood counts were analyzed using automated technology as previously described (Maks et al., 2011; Romero-Weaver et al., 2013b; Romero-Weaver and Kennedy, 2012).”
MethodResultSelf-citation
Disuse bone loss in hindquarter suspended rats: partial weightbearing, exercise and ibandronate treatment as countermeasures.
Schultheis, L., Ruff, C. B., Rastogi, S., Bloomfield, S. A., Hogan, H. A., Fedarko, N. S., Thierry-Palmer, M., Ruiz, J. D., Bauss, F., & Shapiro, J. R. (2000) · PubMed · Cited by 12
Radiation-induced Hemorrhagic Diathesis in Dogs Unassociated with Thrombocytopenia: Association with an Intravascular Protein-Polysaccharide Particle
Winchell, H. S., Anderson, A. C., & Pollycove, M. (1964) · Blood · doi:10.1182/blood.v23.2.186.186 · Cited by 12
Medically important micro-organisms recovered from Apollo-Soyuz Test Project (ASTP) crew members.
Gr, T., & Sn, Z. (1977) · PubMed · Cited by 12
The combined effects of reduced weightbearing and ionizing radiation on splenic lymphocyte population and function
Sanzari, J. K., Wilson, J. M., Wagner, E. B., & Kennedy, A. R. (2011) · International Journal of Radiation Biology · doi:10.3109/09553002.2011.595875 · Cited by 11
Self-citation
Amifostine (WR2721) Confers DNA Protection to in Vivo Cisplatin-Treated Murine Peripheral Blood Leukocytes
González, E. A. P., Fuchs, A. G., & Sánchez, G. S. (2009) · Dose-Response · doi:10.2203/dose-response.08-026.prieto · Cited by 11
Rapid-SF: A Rapid Whole-Blood Screen for Soluble Fibrin Monomer
Hay, K. L., & Bull, B. S. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613301 · Cited by 10
The effects of antioxidants on gene expression following gamma-radiation (GR) and proton radiation (PR) in mice in vivo
Finnberg, N. K., Wambi, C. O., Kennedy, A. R., & El‐Deiry, W. S. (2013) · Cell Cycle · doi:10.4161/cc.25324 · Cited by 9
Self-citation
Orally administered fructose increases the numbers of peripheral lymphocytes reduced by exposure of mice to gamma or SPE-like proton radiation
Romero-Weaver, A. L., Ni, J., Lin, L., & Kennedy, A. R. (2014) · Life Sciences in Space Research · doi:10.1016/j.lssr.2014.01.001 · Cited by 8
Self-citation
Increased intracranial pressure in mini-pigs exposed to simulated solar particle event radiation
Sanzari, J. K., Muehlmatt, A., Savage, A. R., Lin, L., & Kennedy, A. R. (2013) · Acta Astronautica · doi:10.1016/j.actaastro.2013.10.006 · Cited by 7
Self-citation
PROPERTIES OF WR2721 (ETHIOFOS) AS MODULATOR OF CISPLATIN-INDUCED NEUROTOXICITY STUDIED AT THE ULTRASTRUCTURAL LEVEL IN THE POND SNAIL LYMNAEA-STAGNALIS
MULLER, L., MOORERVANDELFT, C., Treskes, M., Vermorken, J. B., VANDERVIJGH, W., & Boer, H. H. (1993) · International Journal of Oncology · doi:10.3892/ijo.2.4.701 · Cited by 7
Effect of gamma irradiation with 30 Gy on the coagulation system in leukoreduced fresh‐frozen plasma
Weisbach, V., Strobel, J., Hahn, B., Rödel, F., Lotter, M., Zingsem, J., Ringwald, J., & Eckstein, R. (2007) · Transfusion · doi:10.1111/j.1537-2995.2007.01338.x · Cited by 7
Countermeasure development: future research targets.
Shapiro, J. R., & Schneider, V. (2000) · PubMed · Cited by 7
A Substance Observed within the Vascular System of Dogs Receiving Lethal Exposures of Whole-Body X-Irradiation
Andersen, A. C. (1957) · Radiation Research · doi:10.2307/3570617 · Cited by 6
Effects of Selenomethionine in Irradiated Human Thyroid Epithelial Cells and Tumorigenicity Studies
Ware, J. H., Zhou, Z., Romero-Weaver, A. L., Wan, X. S., Newberne, P. M., & Kennedy, A. R. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2011.605981 · Cited by 6
Self-citation
Leg vein hemodynamics during bedrests simulating lunar trip.
Louisy, F., Guezennec, C. Y., & Güell, A. (1994) · PubMed · Cited by 6
Bacteriological Evaluations of Swine Exposed to Lethal Levels of Gamma Radiation
Eisele, G. R., & West, J. L. (1973) · Journal of Animal Science · doi:10.2527/jas1973.37127x · Cited by 5
Mitigating effects of L-selenomethionine on low-dose iron ion radiation-induced changes in gene expression associated with cellular stress
Nuth, M., & Kennedy, A. R. (2013) · Oncology Letters · doi:10.3892/ol.2013.1362 · Cited by 5
Self-citation
Microgravity and drug effects on bone.
Shapiro, J. R. (2006) · PubMed · Cited by 5
Influence of gravity changes induced by parabolic flight on cytokine production in mouse spleen.
Kita, M., Yamamoto, T., Imanishi, J., & Fuse, A. (2004) · PubMed · Cited by 5
Monte Carlo modeling in CT-based geometries: dosimetry for biological modeling experiments with particle beam radiation
Diffenderfer, E. S., Dolney, D., Schaettler, M., Sanzari, J. K., McDonough, J. E., & Cengel, K. A. (2013) · Journal of Radiation Research · doi:10.1093/jrr/rrt118 · Cited by 4
Effects of murine endotoxemia on lymphocyte subsets and clearance of staphylococcal pulmonary infection
Holub, M., Lawrence, D. A., & Mondal, T. K. (2006) · Folia Microbiologica · doi:10.1007/bf02931593 · Cited by 3
Single dose irradiation response of pig skin: a comparison of brachytherapy using a single, high dose rate iridium-192 stepping source with 200 kV X-rays.
Hamm, P. C. J., Bakker, E., van den Berg, A. P., van den Aardweg, G. J., Visser, A. G., & Levendag, P. C. (2000) · British Journal of Radiology · doi:10.1259/bjr.73.871.11089469 · Cited by 3
Behavioral change in response to low-grade non-infectious stimuli: Findings and potential neuroimmune mechanisms
York, J. M. (2012) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 2
TUMOR-ASSOCIATED ANTIGEN EXPRESSION AND GROWTH REQUIREMENTS PREDICT TUMORIGENESIS IN SQUAMOUS CELL CARCINOMA
Sauter, E. R., Tichansky, D. S., Furth, E. E., & Herlyn, M. (2001) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1290/1071-2690(2001)037 · Cited by 1

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4 of the 330 references couldn’t be matched to a known paper.

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Space Radiation: The number one risk to astronaut health beyond low earth orbit
Chancellor, J., Scott, G., & Sutton, J. (2014) · Life · doi:10.3390/life4030491 · Cited by 455
Human Pathophysiological Adaptations to the Space Environment
Demontis, G. C., Germani, M. M., Caiani, E. G., Barravecchia, I., Passino, C., & Angeloni, D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00547 · Cited by 354
Space radiation protection: Destination Mars
Durante, M. (2014) · Life Sciences in Space Research · doi:10.1016/j.lssr.2014.01.002 · Cited by 202
Limitations in predicting the space radiation health risk for exploration astronauts
Chancellor, J. C., Blue, R. S., Cengel, K. A., Auñón-Chancellor, S. M., Rubins, K. H., Katzgraber, H. G., & Kennedy, A. R. (2018) · npj Microgravity · doi:10.1038/s41526-018-0043-2 · Cited by 183
Self-citation
Limitations in predicting the space radiation health risk for exploration astronauts
Chancellor, J. C., Blue, R. S., Cengel, K. A., Auñón-Chancellor, S. M., Rubins, K., Katzgraber, H. G., & Kennedy, A. R. (2018) · Civil War Book Review · Cited by 174
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Authors: Kennedy, A. R.
Affiliations: University of Pennsylvania (US)
Corresponding author: Kennedy, Ann R.
ORCID: Kennedy, Ann R.
Venue: Life Sciences in Space Research
Publisher: Elsevier BV
Published: 2014-04
Volume: 1
Pages: 10-43
ISSN: 2214-5524 (ISSN-L)
DOI: 10.1016/j.lssr.2014.02.004
PMC: PMC4170231
OpenAlex: W2119240968
Cited by: 188
References: 330
Citations by year: 2026: 8 · 2025: 11 · 2024: 15 · 2023: 15 · 2022: 19 · 2021: 33 · 2020: 23 · 2019: 15 · 2018: 17 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 3
FWCI: 7.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Life Sciences in Space Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (T32CA009677)
National Aeronautics and Space Administration (NCC 9-58, NAG9-1517)
National Space Biomedical Research Institute
Topics: Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Keywords: space radiation, astronaut health, solar energetic particle events, radiation countermeasures, gene expression, programmed cell death, extracellular matrix remodeling, oxidative stress, bacterial translocation, immune activation, vomiting, coagulation, skin effect, fatigue, cardiac function, visual impairment, cataract, cancer risk, survival

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Biological effects of space radiation and development of effective countermeasures

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