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Cited by 477Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroinflammation and Neurodegeneration Mechanisms

Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus

Kronenberg, Golo, Bick-Sander, Anika, Bunk, Eva, Wolf, Claudia, Ehninger, Dan, Kempermann, Gerd·2006·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2005.09.016
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Abstract

Physical activity induces adult hippocampal neurogenesis. We here show that the acute up-regulating effect of voluntary wheel running on precursor cell proliferation decreases with continued exercise, but that continued exercise reduces the age-dependent decline in adult neurogenesis. Cell proliferation peaked at 3 days of running. After 32 days of exercise this response returned to baseline. Running-induced proliferation of transiently amplifying progenitor cells led to a consecutive increase in the number of more mature cells. Increasing age reduced adult neurogenesis at 9 months to 50% of the value at 6 weeks and to 17% at the age of 2 years. At both 1 and 2 years, precursor cell divisions remained inducible by physical activity. Exercise from 3 to 9 months of age significantly reduced the age-dependent decline in cell proliferation but (presumably in the absence of additional stimuli) did not maintain net neurogenesis at levels corresponding to a younger age. We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells.

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Crossref · 10.1016/j.neurobiolaging.2005.09.016

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  • Physical exercise increases the number of new neurons by stimulating the proliferation of radial stem cells and amplifying progenitor cells, leading to an increase in the production of neuroblasts.

    “In some of these cases, e.g., physical exercise, evidence suggests that the number of new neurons is increased by actions at multiple stages in the adult neurogenesis process, including by stimulating the proliferation of radial stem cells and amplifying progenitor cells, leading to an increase in the production of neuroblasts (Bednarczyk et al., 2010; Kronenberg et al., 2006; Lugert et al., 2010;”

    From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Kronenberg et al., 2006

  • Exercise may preserve neurons and promote neurogenesis, synaptogenesis, and neuronal plasticity.

    “Exercise may also preserve neurons and promote neurogenesis, synaptogenesis, (48–50), and neuronal plasticity (51–55).”

    From The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment (2018) · cites this paper as [49]

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Authors
Kronenberg, G., Bick-Sander, A., Bunk, E., Wolf, C., Ehninger, D., & Kempermann, G.
Affiliations
  • Max Delbrück Center (DE)
  • Volkswagen Foundation (DE)
Corresponding author
Kempermann, Gerd
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2006-10
Volume
27
Issue
10
Pages
1505-1513
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2005.09.016
OpenAlex
W2002161951
Cited by
477
References
62
Citations by year
2026: 5 · 2025: 15 · 2024: 11 · 2023: 18 · 2022: 17 · 2021: 30 · 2020: 14 · 2019: 19 · 2018: 22 · 2017: 32 · 2016: 32 · 2015: 32 · 2014: 30 · 2013: 29 · 2012: 38
FWCI
4.57
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
physical activity, adult hippocampal neurogenesis, dentate gyrus, precursor cell proliferation, aging, voluntary wheel running, age-related decline, successful aging
MeSH terms
Aging, Animals, Cell Differentiation, Cerebellar Nuclei, Exercise Therapy, Physical Exertion, Male, Mice, Inbred C57BL, Nerve Regeneration, Neurons, Physical Conditioning, Animal, Stem Cells, Dentate Gyrus, Cell Proliferation, Mice

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