The role of the TOR pathway in mediating the link between nutrition and longevity
Abstract
The target of rapamycin (TOR) pathway integrates signals from extracellular and intracellular agents, such as growth factors, nutrients, mediators of energy balance, oxygen availability and other environmental cues. It allows the regulation of multiple cellular processes including protein and lipid synthesis, ribosome biogenesis, autophagy and metabolic processes. Being conserved across different phyla, TOR regulates longevity of various organisms in response to dietary conditions. In this review we described the main components of the TOR pathway and its upstream effectors and downstream processes in relation to aging. The potential contribution of the TOR pathway in lifespan-extending effects of varied dietary interventions, and the anti-aging drugs rapamycin and metformin direct or indirect regulation of TOR activity in yeasts, worms, flies and mammals are also discussed.
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Nutrient-sensing mTOR and insulin/IGF1 pathways mediate the effect of dietary restriction on aging.
“It is evident that the nutrient-sensing mTOR and the insulin/IGF1 pathways mediate the effect of dietary restriction on aging [149,291].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [149]
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- Authors
- Lushchak, O., Strilbytska, O., Piskovatska, V., Storey, K. B., Koliada, A., & Vaiserman, A.
- Affiliations
- Vasyl Stefanyk Carpathian National University (UA)
- Odessa National Medical University (UA)
- Carleton University (CA)
- D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine (UA)
- Corresponding author
- Lushchak, Oleh
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 164
- Pages
- 127-138
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2596739663
- Cited by
- 73
- References
- 162
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 13 · 2020: 18 · 2019: 4 · 2018: 8 · 2017: 4
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada (6793)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- TOR signaling, target of rapamycin, aging, longevity, nutrition and aging, dietary intervention, rapamycin, metformin, autophagy, energy balance, nutrient sensing, lifespan extension, anti-aging drugs, yeast, Caenorhabditis elegans, Drosophila, mammals
- MeSH terms
- Animals, Humans, Longevity, Metformin, Nutritional Physiological Phenomena, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases
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