Cited by 73Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

The role of the TOR pathway in mediating the link between nutrition and longevity

Lushchak, Oleh, Strilbytska, Olha, Piskovatska, Veronika, Storey, Kenneth B., Koliada, Alexander, Vaiserman, Alexander·2017·Mechanisms of Ageing and Development

Abstract

The target of rapamycin (TOR) pathway integrates signals from extracellular and intracellular agents, such as growth factors, nutrients, mediators of energy balance, oxygen availability and other environmental cues. It allows the regulation of multiple cellular processes including protein and lipid synthesis, ribosome biogenesis, autophagy and metabolic processes. Being conserved across different phyla, TOR regulates longevity of various organisms in response to dietary conditions. In this review we described the main components of the TOR pathway and its upstream effectors and downstream processes in relation to aging. The potential contribution of the TOR pathway in lifespan-extending effects of varied dietary interventions, and the anti-aging drugs rapamycin and metformin direct or indirect regulation of TOR activity in yeasts, worms, flies and mammals are also discussed.

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Crossref · 10.1016/j.mad.2017.03.005

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Authors
Lushchak, O., Strilbytska, O., Piskovatska, V., Storey, K. B., Koliada, A., & Vaiserman, A.
Affiliations
  • Vasyl Stefanyk Carpathian National University (UA)
  • Odessa National Medical University (UA)
  • Carleton University (CA)
  • D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine (UA)
Corresponding author
Lushchak, Oleh
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
2017-06
Volume
164
Pages
127-138
ISSN
0047-6374 (ISSN-L)
OpenAlex
W2596739663
Cited by
73
References
162
Citations by year
2026: 4 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 13 · 2020: 18 · 2019: 4 · 2018: 8 · 2017: 4
FWCI
1.05
Type
journal article
Language
en
Open access
closed
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Sciences and Engineering Research Council of Canada (6793)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
TOR signaling, target of rapamycin, aging, longevity, nutrition and aging, dietary intervention, rapamycin, metformin, autophagy, energy balance, nutrient sensing, lifespan extension, anti-aging drugs, yeast, Caenorhabditis elegans, Drosophila, mammals
MeSH terms
Animals, Humans, Longevity, Metformin, Nutritional Physiological Phenomena, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases

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