Cited by 557Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionEicosanoids and Hypertension Pharmacology

The DOI matches its Crossref record; 165 of the 166 references it cites were found in a registry or an index.

The role of nitric oxide in cardiovascular diseases

NASEEM, K·2005·Molecular Aspects of Medicine

DOI 10.1016/j.mam.2004.09.003

Open this paper in CoChat — free account

Abstract

Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and endothelial NOS (eNOS). NO plays an important role in the protection against the onset and progression of cardiovascular disease. Cardiovascular disease is associated with a number of different disorders including hypercholesterolaemia, hypertension and diabetes. The underlying pathology for most cardiovascular diseases is atherosclerosis, which is in turn associated with endothelial dysfunctional. The cardioprotective roles of NO include regulation of blood pressure and vascular tone, inhibition of platelet aggregation and leukocyte adhesion, and prevention smooth muscle cell proliferation. Reduced bioavailability of NO is thought to be one of the central factors common to cardiovascular disease, although it is unclear whether this is a cause of, or result of, endothelial dysfunction. Disturbances in NO bioavailability leads to a loss of the cardio protective actions and in some case may even increase disease progression. In this chapter the cellular and biochemical mechanisms leading to reduced NO bioavailability are discussed and evidence for the prevalence of these mechanisms in cardiovascular disease evaluated.

Integrity signals

Registry

Crossref · 10.1016/j.mam.2004.09.003

Cites

165 of 165 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

The biochemistry of apoptosis
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,036
Diabetes and Atherosclerosis
Beckman, J. A., Creager, M. A., & Libby, P. (2002) · JAMA · doi:10.1001/jama.287.19.2570 · Cited by 2,765
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.
Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., & Fishman, M. C. (1995) · Nature · doi:10.1038/377239a0 · Cited by 2,070
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765
Platelets in atherothrombosis
Ruggeri, Z. M. (2002) · Nature Medicine · doi:10.1038/nm1102-1227 · Cited by 1,605
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
MacMicking, J. D., Nathan, C., Hom, G. J., Chartrain, N. A., Fletcher, D. S., Trumbauer, M. E., Stevens, K. A., Xie, Q. W., Sokol, K. A., Hutchinson, N. I., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90085-3 · Cited by 1,445
ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91481-4 · Cited by 1,437

Flagged first, then by citations

Show all 166 references

1 of the 166 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–200 of 556

Role of endothelial nitric oxide synthase (eNOS) in chronic stress‐promoted tumour growth
Barbieri, A., Palma, G., Rosati, A., Giudice, A., Falco, A., Petrillo, A., Petrillo, M., Bimonte, S., Benedetto, M. D., Esposito, G., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01375.x · Cited by 50
Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation
Blonder, J. P., Mutka, S. C., Sun, X., Qiu, J., Green, L. H., Mehra, N. K., Boyanapalli, R., Suniga, M., Look, K., Delany, C., et al. (2014) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-14-3 · Cited by 50
Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high‐glucose stress and inflammation
Yehuda, I., Madar, Z., Leikin-Frenkel, A. I., & Tamir, S. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400876 · Cited by 49
Extraction, Identification, and Health Benefits of Anthocyanins in Blackcurrants (Ribes nigrum L.)
Cao, L., Park, Y., Lee, S. G., & Kim, D. (2021) · Applied Sciences · doi:10.3390/app11041863 · Cited by 49
Nitric oxide in blood
Elahi, M. M., Naseem, K. M., & Matata, B. M. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05660.x · Cited by 53
Meta-analysis of exercise training on vascular endothelial function in cancer survivors
Beaudry, R. I., Liang, Y., Boyton, S. T., Tucker, W. J., Brothers, R. M., Daniel, K. M., Rao, R., & Haykowsky, M. J. (2018) · Integrative Cancer Therapies · doi:10.1177/1534735418756193 · Cited by 48
Efficacy, Safety, and Tolerability of the Cyclooxygenase-Inhibiting Nitric Oxide Donator Naproxcinod in Treating Osteoarthritis of the Hip or Knee
Karlsson, J., Pivodic, A., Aguirre, D., & Schnitzer, T. J. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.081011 · Cited by 48
Blockade of AT1 receptor partially restores vasoreactivity, NOS expression, and superoxide levels in cerebral and carotid arteries of hindlimb unweighting rats
Zhang, R., Bai, Y.-G., Lin, L.-J., Bao, J.-X., Zhang, Y.-Y., Tang, H., Cheng, J.-H., Jia, G.-L., Ren, X.-L., & Ma, J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01278.2007 · Cited by 47
Minireview: Rapid Actions of Sex Steroids in the Endothelium
Chow, R., Handelsman, D. J., & Ng, M. K. C. (2010) · Endocrinology · doi:10.1210/en.2009-1456 · Cited by 48
Effect of Chito-oligosaccharide Supplementation on Immunity in Broiler Chickens
Deng, X., Li, X., Liu, P., Yuan, S., Zang, J., Li, S., & Piao, X. (2008) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2008.80056 · Cited by 46
Chronic Hyperhomocysteinemia Increases Inflammatory Markers in Hippocampus and Serum of Rats
da Cunha, A. A., Ferreira, A. G. K., Loureiro, S. O., da Cunha, M. J., Schmitz, F., Netto, C. A., & Wyse, Â. T. D. S. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0769-2 · Cited by 45
Reducing cardiovascular disease risk in patients with type 2 diabetes and concomitant macrovascular disease: can insulin be too much of a good thing?
Rensing, K. L., Reuwer, A. Q., Arsenault, B. J., von der Thüsen, J. H., Hoekstra, J. B. L., Kastelein, J. J. P., & Twickler, T. B. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01468.x · Cited by 45
Paradoxical effect of l-arginine: Acceleration of endothelial cell senescence
Scalera, F., Closs, E. I., Flick, E., Martens‐Lobenhoffer, J., Boissel, J., Lendeckel, U., Heimburg, A., & Bode‐Böger, S. M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.06.091 · Cited by 45
Biological Functional Relevance of Asymmetric Dimethylarginine (ADMA) in Cardiovascular Disease
Franceschelli, S., Ferrone, A., Pesce, M., Riccioni, G., & Speranza, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141224412 · Cited by 44
The Role of Nitric Oxide in Health and Diseases
Khazan, M., & Hdayati, M. (2014) · Scimetr · doi:10.5812/scimetr.20987 · Cited by 44
The integrated stress response system in cardiovascular disease
Santos‐Ribeiro, D., Godinas, L., Pilette, C., & Perros, F. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.02.008 · Cited by 44
Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats
Wang, S., Xu, J., Zheng, J., Zhang, X., Shao, J., Zhao, L., & Hao, J. (2020) · Medical Science Monitor · doi:10.12659/msm.920250 · Cited by 44
The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil
Feng, Y., Feng, Y., Gu, L., Liu, P., Cao, J., & Zhang, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.720632 · Cited by 44
Miyabenol A Inhibits LPS-Induced NO Production via IKK/IκB Inactivation in RAW 264.7 Macrophages: Possible Involvement of the p38 and PI3K Pathways
Ku, K.-T., Huang, Y., Huang, Y.-J., & Chiou, W. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8019369 · Cited by 44
Characterization of Porcine Circulating Progenitor Cells: Toward a Functional Endothelium
Allen, J. B., Khan, S. S., Serrano, M. C., & Ameer, G. A. (2008) · Tissue Engineering Part A · doi:10.1089/ten.a.2007.0265 · Cited by 44
Endothelial glutathione-S-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-κB translocation
Yang, Y., Yang, Y., Xu, Y. F., Lick, S. D., Awasthi, S., & Boor, P. J. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.03.018 · Cited by 43
The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts
Saji, N., Francis, N., Schwarz, L. J., BLANCHARD, C. L., & Santhakumar, A. B. (2020) · Foods · doi:10.3390/foods9060829 · Cited by 43
Endothelial Nitric Oxide Synthase and Calcium Production in Arterial Geometries: An Integrated Fluid Mechanics/Cell Model
Comerford, A., Plank, M. J., & David, T. (2008) · Journal of Biomechanical Engineering · doi:10.1115/1.2838026 · Cited by 43
Methods and potential biomarkers for the evaluation of endothelial dysfunction in chronic kidney disease: A critical approach
Hogas, S. M., Voroneanu, L. E., Șerban, D. N., Segall, L., Hogas, M. M., Șerban, I. L., & Covic, A. C. (2010) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2010.03.008 · Cited by 43
Comparative study on the composition of free amino acids and derivatives in the two botanical origins of an edible Chinese herb “Xiebai”, i.e., Allium chinense G. Don and Allium macrostemon Bunge species
He, Q., Huang, S., Wu, Y., Zhang, W., Wang, F., Cao, J., Sheng, Q., Liang, Z., Liu, L., & Ou, W. (2018) · Food Research International · doi:10.1016/j.foodres.2018.01.007 · Cited by 41
Development of an electrochemical sensor for nitric oxide based on carbon paste electrode modified with Nafion, gold nanoparticles and graphene nanoribbons
Wenninger, N., Bračič, U., Kollau, A., Pungjunun, K., Leitinger, G., Kalcher, K., & Ortner, A. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.130532 · Cited by 42
Piper Sarmentosum Increases Nitric Oxide Production in Oxidative Stress: A Study on Human Umbilical Vein Endothelial Cells
Ugusman, A., Zakaria, Z., Hui, C. K., & Nordin, N. A. M. M. (2010) · Clinics · doi:10.1590/s1807-59322010000700010 · Cited by 42
Interfacial Residues Promote an Optimal Alignment of the Catalytic Center in Human Soluble Guanylate Cyclase: Heterodimerization Is Required but Not Sufficient for Activity
Seeger, F., Quintyn, R. S., Tanimoto, A., Williams, G. J., Tainer, J. A., Wysocki, V. H., & Garcin, E. D. (2014) · Biochemistry · doi:10.1021/bi500129k · Cited by 43
Biomimetic modification of metallic cardiovascular biomaterials: from function mimicking to endothelialization in vivo
Weng, Y., Chen, J., Tu, Q., Li, Q., Maitz, M. F., & Huang, N. (2012) · Interface Focus · doi:10.1098/rsfs.2011.0126 · Cited by 42
Effect of Citrulline and Glutamine on Nitric Oxide Production in RAW 264.7 Cells in an Arginine‐Depleted Environment
Bryk, J., Ochoa, J. B., Correia, M. I., Munera‐Seeley, V., & Popovič, P. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108319807 · Cited by 42
Statins and oxidative stress in chronic heart failure
Costa, S., Reina‐Couto, M., Albino‐Teixeira, A., & Sousa, T. (2016) · Revista Portuguesa de Cardiologia (English Edition) · doi:10.1016/j.repce.2015.12.016 · Cited by 41
Lespedeza cuneata protects the endothelial dysfunction via eNOS phosphorylation of PI3K/Akt signaling pathway in HUVECs
Lee, J. H., Parveen, A., Do, M. H., Lim, Y., Shim, S. H., & Kim, S. Y. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.05.005 · Cited by 40
Compartmentalized nitric oxide signaling in the resistance vasculature
Mutchler, S. M., & Straub, A. C. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.05.003 · Cited by 40
Plant Foods and Brain Aging: A Critical Appraisal
Schaffer, S., Eckert, G. P., Schmitt-Schillig, S., & Müller, W. E. G. (2006) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000095209 · Cited by 41
l-Arginine ameliorates cardiac left ventricular oxidative stress by upregulating eNOS and Nrf2 target genes in alloxan-induced hyperglycemic rats
Ramprasath, T., Kumar, P. H., Puhari, S. S. M., Murugan, P. S., Vasudevan, V., & Selvam, G. S. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.064 · Cited by 39
8-Prenylkaempferol suppresses inducible nitric oxide synthase expression through interfering with JNK-mediated AP-1 pathway in murine macrophages
Chen, C., Tsai, P.-C., Wei, B., & Chiou, W. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.05.018 · Cited by 39
Low SOD activity is associated with overproduction of peroxynitrite and nitric oxide in patients with acute coronary syndrome
Gheddouchi, S., Mokhtari-Soulimane, N. A., Merzouk, H., Bekhti, F., Soulimane, F., Guermouche, B., Tani, A. M., & Narce, M. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.05.007 · Cited by 38
Virtual electrochemical nitric oxide analyzer using copper, zinc superoxide dismutase immobilized on carbon nanotubes in polypyrrole matrix
Thangamuthu, M., Manickam, P., Balamurugan, M., Karnewar, S., Benjamin, A. R., Venkatesh, K., Kanagavel, V., Kotamraju, S., & Karunakaran, C. (2012) · Talanta · doi:10.1016/j.talanta.2012.08.033 · Cited by 37
Dietary nitrate and population health: a narrative review of the translational potential of existing laboratory studies
Shannon, O. M., Easton, C., Shepherd, A. I., Siervo, M., Bailey, S. J., & Clifford, T. (2021) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-021-00292-2 · Cited by 41
The effects of the inhibition of inducible nitric oxide synthase on angiogenesis of epithelial ovarian cancer
Malone, J. M., Saed, G. M., Diamond, M. P., Sokol, R. J., & Munkarah, A. R. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.12.019 · Cited by 38
Effects of acute and chronic endurance exercise on intracellular nitric oxide and superoxide in circulating CD34+ and CD34− cells
Jenkins, N. T., Landers‐Ramos, R. Q., Prior, S. J., Soni, N., Spangenburg, E. E., & Hagberg, J. M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00541.2011 · Cited by 37
Nitrite-derived nitric oxide reduces hypoxia-inducible factor 1α-mediated extracellular vesicle production by endothelial cells
Burnley-Hall, N., Willis, G. R., Davis, J., Rees, A., & James, P. E. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.12.005 · Cited by 39
The effects of nitrate on the oral microbiome: a systematic review investigating prebiotic potential
Moran, S. P., Rosier, B. T., Henriquez, F. L., & Burleigh, M. C. (2024) · Journal of Oral Microbiology · doi:10.1080/20002297.2024.2322228 · Cited by 37
Nitric oxide synthases and diabetic cardiomyopathy
Khanna, S., Singh, G. B., & Khullar, M. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.08.004 · Cited by 37
Characterisation and comparison of temporal release profiles of nitric oxide generating donors
Bradley, S. A., & Steinert, J. R. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.02.024 · Cited by 37
Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives
Leong, S. W., Faudzi, S. M. M., Abas, F., Aluwi, M. F. F. M., Rullah, K., Lam, K. W., Bahari, M. N. A., Ahmad, S., Tham, C. L., Shaari, K., et al. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.05.056 · Cited by 37
Sex differences in the formation of atherosclerosis lesion in apoE-/-mice and the effect of 17β-estrodiol on protein S-nitrosylation
Zhang, G., Li, C., Zhu, N., Chen, Y., Yu, Q., Liu, E., & Wang, R. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.145 · Cited by 37
Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage
Barna, L., Walter, F. R., Harazin, A., Bocsik, A., Kincses, A., Tubak, V., Jósvay, K., Zvara, Á., Campos‐Bedolla, P., & Deli, M. A. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-019-0166-1 · Cited by 37
Novel amino acids: synthesis of furoxan and sydnonimine containing amino acids and peptides as potential nitric oxide releasing motifs
Nortcliffe, A., Botting, N. P., & O’Hagan, D. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob41047a · Cited by 37
Vascular risk in obesity: Facts, misconceptions and the unknown
King, R., & Ajjan, R. (2016) · Diabetes and Vascular Disease Research · doi:10.1177/1479164116675488 · Cited by 39
Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population
Alp, E., Menevşe, S., Tulmaç, M., Kan, D., Yalçin, R., Erkan, A. F., & Çengel, A. (2009) · DNA and Cell Biology · doi:10.1089/dna.2009.0866 · Cited by 35
eNOSpolymorphisms and clinical outcome in advanced HCC patients receiving sorafenib: final results of the ePHAS study
Gardini, A. C., Marisi, G., Faloppi, L., Scarpi, E., Foschi, F. G., Iavarone, M. A., Lauletta, G., Corbelli, J., Valgiusti, M., Facchetti, F., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8569 · Cited by 34
Nitric Oxide and Mechano-Electrical Transduction in Cardiomyocytes
Boycott, H. E., Nguyen, M., Vrellaku, B., Gehmlich, K., & Robinson, P. J. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.606740 · Cited by 35
The Tragedy of TRIUMPH for Nitric Oxide Synthesis Inhibition in Cardiogenic Shock
Bailey, A. L., POPE, T. W., Moore, S. A., & Campbell, C. L. (2007) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200707050-00003 · Cited by 33
Dietary L-arginine intake and the incidence of coronary heart disease: Tehran lipid and glucose study
Bahadoran, Z., Mirmiran, P., Tahmasebinejad, Z., & Azizi, F. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0084-z · Cited by 36
Free radical scavenging injectable hydrogels for regenerative therapy
Komeri, R., Thankam, F. G., & Jayabalan, M. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.09.087 · Cited by 34
Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions
Louisa, M., Patintingan, C. G. H., & Wardhani, B. W. K. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.792794 · Cited by 38
Site‐specific gene delivery to stented arteries using magnetically guided zinc oleate‐based nanoparticles loaded with adenoviral vectors
Chorny, M., Fishbein, I., Tengood, J. E., Adamo, R. F., Alferiev, I. S., & Levy, R. J. (2013) · The FASEB Journal · doi:10.1096/fj.12-224659 · Cited by 33
Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer’s Type Dementia
Pretorius, L., Kell, D. B., & Pretorius, E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00851 · Cited by 36
Nitric oxide in exercise physiology: past and present perspectives
Mueller, B. J., Roberts, M. D., Mobley, C. B., Judd, R. L., & Kavazis, A. N. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2024.1504978 · Cited by 32
Zinc nanoparticles ameliorated obesity-induced cardiovascular disease: role of metabolic syndrome and iron overload
Bashandy, S. A. E., El‐Seidy, A. M. A., Ibrahim, F. A. A., Abdelrahman, S. S. M., Moussa, S. A. A., & Elbaset, M. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-42550-y · Cited by 33
Sulfur-based fluorescent probes for biological analysis: A review
Hu, G., Xu, H.-D., & Fang, J. (2024) · Talanta · doi:10.1016/j.talanta.2024.126515 · Cited by 32
Design of amino acid-based self-assembled nano-drugs for therapeutic applications
Vong, L. B., Trinh, N., & Nagasaki, Y. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.06.009 · Cited by 33
Predominance of Heart Failure With Preserved Ejection Fraction in Postmenopausal Women: Intra- and Extra-Cardiomyocyte Maladaptive Alterations Scaffolded by Estrogen Deficiency
Adekunle, A. O., Adzika, G. K., Mprah, R., Noah, M. L. N., Adu‐Amankwaah, J., Rizvi, R., Akhter, N., & Sun, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.685996 · Cited by 32
Expression and Function of Endothelial Nitric Oxide Synthase Messenger RNA and Protein Are Higher in Internal Mammary Than in Radial Arteries
He, G., Fan, L., Grove, K. L., Furnary, A. P., & Yang, Q. (2011) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2011.04.063 · Cited by 32
Rhodiola crenulata extract counteracts the effect of hypobaric hypoxia in rat heart via redirection of the nitric oxide and arginase 1 pathway
Hsu, S., Chang, T., Wu, Y.-K., Lin, K., Shi, L.-S., & Lee, S. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1524-z · Cited by 33
Oxidative stress in the brain and retina after traumatic injury
Ryan, A. K., Rich, W. W., & Reilly, M. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1021152 · Cited by 33
Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor
Lee, J., Song, S.-H., Kim, J., Shin, I., Kim, K. L., Suh, Y., Kim, H.-Z., Koh, G. Y., Byun, J., Jeon, E., et al. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn048 · Cited by 31
In VivoImaging of Nitric Oxide by Magnetic Resonance Imaging Techniques
Sharma, R. D., Seo, J.-W., & Kwon, S. (2014) · Journal of Nanomaterials · doi:10.1155/2014/523646 · Cited by 32
Impaired HDL function in obese adolescents: Impact of lifestyle intervention and bariatric surgery
Matsuo, Y., Oberbach, A., Till, H., Inge, T. H., Wabitsch, M., Moß, A., Jehmlich, N., Völker, U., Müller, U., Siegfried, W., et al. (2013) · Obesity · doi:10.1002/oby.20538 · Cited by 33
Porphyromonas gingivalisstimulates the release of nitric oxide by inducing expression of inducible nitric oxide synthases and inhibiting endothelial nitric oxide synthases
Sun, W., Wu, J., Lin, L., Huang, Y. Y., Chen, Q., & Ji, Y. H. (2010) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2009.01249.x · Cited by 30
Doença renal crônica, inflamação e aterosclerose: novos conceitos de um velho problema
Dummer, C. D., Thomé, F. S., & Veronese, F. V. (2007) · Revista da Associação Médica Brasileira · doi:10.1590/s0104-42302007000500022 · Cited by 29
Endothelial nitric oxide synthase mediates protective effects of hypoxic preconditioning in lungs
Kaminski, A., Kasch, C., Zhang, L., Kumar, S., Sponholz, C., Choi, Y., Ma, N., Liebold, A., Ladilov, Y. V., Steinhoff, G., et al. (2006) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2006.06.005 · Cited by 29
Metabolomic Profiling of Cellular Responses to Carvedilol Enantiomers in Vascular Smooth Muscle Cells
Wang, M., Bai, J., Chen, W. N., & Ching, C. B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015441 · Cited by 28
Sitagliptin prevents isoproterenol-induced myocardial infarction in rats by modulating nitric oxide synthase enzymes
Ibrahim, M. A., Geddawy, A., & Abdelwahab, S. A. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.04.005 · Cited by 28
Zingerone attenuates aortic banding‐induced cardiac remodelling via activating the eNOS/Nrf2 pathway
Liu, C., Wu, Q., Cai, Z., Xie, S., Duan, M., Xie, Q., Yuan, Y., Deng, W., & Tang, Q. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14540 · Cited by 28
The Association Between Psoriasis and Cardiovascular Diseases
Zwain, A., Aldiwani, M., & Taqi, H. (2021) · European Cardiology Review · doi:10.15420/ecr.2020.15.r2 · Cited by 30
Interaction Between Endothelial Nitric Oxide Synthase Gene Polymorphisms (−786T>C, 894G>T and Intron 4 a/b) and Cardiovascular Risk Factors in Acute Coronary Syndromes
Piccoli, J. D. C. E., Manfredini, V., Hamester, F. I. R., Bandinelli, J. B., Turkienicz, I. M., Chies, J. A. B., Peres, A., Bodanese, L. C., & Bogo, M. R. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.03.011 · Cited by 28
The 2-nitrate-1,3-dibuthoxypropan, a new nitric oxide donor, induces vasorelaxation in mesenteric arteries of the rat
França-Silva, M. S., Luciano, M. N., Ribeiro, T. P., Silva, J. S. F., Santos, A. F. D., França, K. C., Nakao, L. S., de Athayde-Filho, P. F., Braga, V. A., & de Medeiros, I. A. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.043 · Cited by 28
Orchidectomy increases the formation of prostanoids and modulates their role in the acetylcholine-induced relaxation in the rat aorta
Martorell, A., Blanco‐Rivero, J., Aras‐López, R., Sagredo, A., Balfagón, G., & Ferrer, M. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm059 · Cited by 28
Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
Ichim, T. E., Minev, B., Braciak, T. A., Luna, B., Hunninghake, R., Mikirova, N. A., Jackson, J. A., González, M. J., Miranda-Massari, J. R., Alexandrescu, D. T., et al. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-25 · Cited by 26
Site-specific gene therapy for cardiovascular disease.
Fishbein, I., Chorny, M., & Levy, R. J. (2010) · PubMed · Cited by 27
Regulation of Airway Contractility by Plasminogen Activators through N-Methyl-D-Aspartate Receptor–1
Nassar, T., Yarovoi, S. V., Fanne, R. A., Akkawi, S., Jammal, M., Allen, T. C., Idell, S., Cines, D. B., & Higazi, A. A. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0257oc · Cited by 27
Poly(ethylene glycol)-lysine dendrimers for targeted delivery of nitric oxide
Taite, L. J., & West, J. L. (2006) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856206778530696 · Cited by 27
Sprint Interval and Sprint Continuous Training Increases Circulating CD34+ Cells and Cardio-Respiratory Fitness in Young Healthy Women
Harris, E., Rakobowchuk, M., & Birch, K. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108720 · Cited by 26
Mitochondrial Nitric Oxide Synthesis During Plant–Pathogen Interactions: Role of Nitrate Reductase in Providing Substrates
Salgado, I., Modolo, L. V., Augusto, O., Braga, M. R., & Oliveira, H. C. (2007) · Springer eBooks · doi:10.1007/7089_2006_095 · Cited by 26
Human Metabolic Transformation of Quercetin Blocks Its Capacity To Decrease Endothelial Nitric Oxide Synthase (eNOS) Expression and Endothelin-1 Secretion by Human Endothelial Cells
Tribolo, S., Lodi, F., Winterbone, M. S., Saha, S., Needs, P. W., Hughes, D. A., & Kroon, P. A. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf402511c · Cited by 26
Theoretical Studies on the Engagement of Interleukin 18 in the Immuno-Inflammatory Processes Underlying Atherosclerosis
Formanowicz, D., Gutowska, K., & Formanowicz, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113476 · Cited by 28
A Review on the Most Important Medicinal Plants Effective in Cardiac Ischemia-Reperfusion Injury
Sedighi, M., Sewell, R. D. E., Nazari, A., Abbaszadeh, S., Cheraghi, M., Amini, A., Heydari, Z., & Rafieian‐Kopaei, M. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190329144016 · Cited by 26
The Release of Nitric Oxide from S-Nitrosothiols Promotes Angiogenesis
Al‐Ani, B., Hewett, P. W., Ahmed, S., Cudmore, M., Fujisawa, T., Ahmad, S., & Ahmed, A. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000025 · Cited by 26
Resolving Biofilm Infections: Current Therapy and Drug Discovery Strategies
Ranall, M. V., Butler, M. S., Blaskovich, M. A. T., & Cooper, M. A. (2012) · Current Drug Targets · doi:10.2174/138945012803530251 · Cited by 26
In vivo and molecular docking studies using whole extract and phytocompounds of Aegle marmelos fruit protective effects against Isoproterenol-induced Myocardial infarction in rats
Krushna, G. S., Shivaranjani, V. L., Umamaheswari, J., Cheemanapalli, S., Hussain, S. A., Kareem, M. A., Reddy, V. D., Ali, D., Lokhande, K. B., Swamy, K. V., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.115 · Cited by 26
The effects of sustained-release-L-arginine formulation on blood pressure and vascular compliance in 29 healthy individuals.
Miller, A. L. (2006) · PubMed · Cited by 26
NITRIC OXIDE: ROLE IN HUMAN BIOLOGY
Omer, N., Rohilla, A., Rohilla, S., & Kushnoor, A. (2012) · International Journal of Pharmaceutical Sciences and Drug Research · doi:10.25004/ijpsdr.2012.040203 · Cited by 25
Nitric Oxide: The Missing Factor in COVID-19 Severity?
Nikolaidis, A., Kramer, R., & Ostojić, S. M. (2021) · Medical Sciences · doi:10.3390/medsci10010003 · Cited by 25
Fabrication of CO-releasing surface to enhance the blood compatibility and endothelialization of TiO2 nanotubes on titanium surface
Ma, W., Liu, X., Yang, M., Hong, Q., Meng, L., Zhang, Q., Chen, J., & Pan, C. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213393 · Cited by 25
Platelet inhibitory effects of juices from Pachyrhizus erosus L. root and Psidium guajava L. fruit: a randomized controlled trial in healthy volunteers
Thaptimthong, T., Kasemsuk, T., Sibmooh, N., & Unchern, S. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1255-1 · Cited by 25
Treatment of Danhong Injection Combined with Naoxintong Capsule in Acute Coronary Syndrome Patients Undergoing PCI Operation: Study for a Randomized Controlled and Double‐Blind Trial
Zhao, S., Tang, Y., Cai, H., Liu, W., Zhang, L., Chen, D., & Chen, B. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/8485472 · Cited by 25
Bone tissue engineering using adipose‐derived stem cells and endothelial cells: Effects of the cell ratio
Mutschall, H., Winkler, S., Weisbach, V., Arkudas, A., Horch, R. E., & Steiner, D. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15374 · Cited by 25
Neuronal nitric oxide synthase protects neuroblastoma cells from oxidative stress mediated by garlic derivatives
Aquilano, K., Filomeni, G., Baldelli, S., Piccirillo, S., Martino, A. D., Rotilio, G., & Ciriolo, M. R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04431.x · Cited by 25

Authors: NASEEM, K.
Affiliations: University of Bradford (GB)
Corresponding author: NASEEM, K
ORCID: NASEEM, K
Venue: Molecular Aspects of Medicine
Publisher: Elsevier BV
Published: 2005-04
Volume: 26
Issue: 1-2
Pages: 33-65
ISSN: 0098-2997 (ISSN-L)
DOI: 10.1016/j.mam.2004.09.003
OpenAlex: W1974081986
Cited by: 557
References: 166
Citations by year: 2026: 20 · 2025: 28 · 2024: 32 · 2023: 35 · 2022: 19 · 2021: 34 · 2020: 32 · 2019: 23 · 2018: 34 · 2017: 20 · 2016: 24 · 2015: 22 · 2014: 24 · 2013: 29 · 2012: 31
FWCI: 15.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Aspects of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: nitric oxide, cardiovascular disease, nitric oxide synthase, endothelial dysfunction, NO bioavailability, atherosclerosis, hypertension, hypercholesterolemia, diabetes mellitus, platelet aggregation, leukocyte adhesion, vascular tone, smooth muscle cell proliferation, cardioprotection
MeSH terms: Arteriosclerosis, Blood Platelets, Cardiovascular Diseases, Diabetes Mellitus, Humans, Hypercholesterolemia, Hypertension, Lipoproteins, LDL, Nitric Oxide, Oxidation-Reduction, Shock, Septic, Reactive Oxygen Species

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of nitric oxide in cardiovascular diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Citations

Cites

Cited by

Related

Metadata

Record

About these checks