Cited by 144Circadian rhythm and melatoninEstrogen and related hormone effectsStress Responses and Cortisol

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The circadian clock and glucocorticoids – Interactions across many time scales

Dickmeis, Thomas, Weger, Benjamin D., Weger, Meltem·2013·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2013.05.012

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Abstract

Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of the stress response and regulate many physiological processes, including metabolism and immune response. Their release into the blood is highly dynamic and occurs in about hourly pulses, the amplitude of which is modulated in a daytime dependent fashion. In addition, in many species seasonal changes in basal glucocorticoid levels have been reported. In their target tissues, glucocorticoids bind to cytoplasmic receptors of the nuclear receptor superfamily. Upon binding, these receptors regulate transcription in a highly dynamic fashion, which involves stochastic binding to regulatory DNA elements on a time scale of seconds and heat shock protein mediated receptor-ligand complex recycling within minutes. The glucocorticoid hormone system interacts with another highly dynamic system, the circadian clock. The circadian clock is an endogenous biological timing mechanism that allows organisms to anticipate regular daily changes in their environment. It regulates daily rhythms of glucocorticoid release by a variety of mechanisms, modulates glucocorticoid signaling and is itself influenced by glucocorticoids. Here, we discuss mechanisms, functions and interactions of the circadian and glucocorticoid systems across time scales ranging from seconds (DNA binding by transcriptional regulators) to years (seasonal rhythms).

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Authors: Dickmeis, T., Weger, B. D., & Weger, M.
Affiliations: Karlsruhe Institute of Technology (DE)
Corresponding author: Dickmeis, Thomas
ORCID: Dickmeis, Thomas
Weger, Benjamin D.
Weger, Meltem
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2013-11
Volume: 380
Issue: 1-2
Pages: 2-15
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2013.05.012
OpenAlex: W2027635336
Cited by: 144
References: 188
Citations by year: 2026: 9 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 12 · 2021: 7 · 2020: 14 · 2019: 8 · 2018: 13 · 2017: 17 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 1
FWCI: 1.21
Type: journal article
Language: en
Open access: closed
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: circadian clock, glucocorticoids, glucocorticoid receptor, nuclear receptor superfamily, seasonal rhythms, transcriptional regulation, stress response, steroid hormone signaling
MeSH terms: Adrenal Glands, Animals, Gene Expression Regulation, Glucocorticoids, Humans, Seasons, Transcription, Genetic, Signal Transduction, Feedback, Physiological, Circadian Clocks

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The circadian clock and glucocorticoids – Interactions across many time scales

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