The DOI matches its Crossref record; 188 of the 188 references it cites were found in a registry or an index.
The circadian clock and glucocorticoids – Interactions across many time scales
Abstract
Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of the stress response and regulate many physiological processes, including metabolism and immune response. Their release into the blood is highly dynamic and occurs in about hourly pulses, the amplitude of which is modulated in a daytime dependent fashion. In addition, in many species seasonal changes in basal glucocorticoid levels have been reported. In their target tissues, glucocorticoids bind to cytoplasmic receptors of the nuclear receptor superfamily. Upon binding, these receptors regulate transcription in a highly dynamic fashion, which involves stochastic binding to regulatory DNA elements on a time scale of seconds and heat shock protein mediated receptor-ligand complex recycling within minutes. The glucocorticoid hormone system interacts with another highly dynamic system, the circadian clock. The circadian clock is an endogenous biological timing mechanism that allows organisms to anticipate regular daily changes in their environment. It regulates daily rhythms of glucocorticoid release by a variety of mechanisms, modulates glucocorticoid signaling and is itself influenced by glucocorticoids. Here, we discuss mechanisms, functions and interactions of the circadian and glucocorticoid systems across time scales ranging from seconds (DNA binding by transcriptional regulators) to years (seasonal rhythms).
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In the citing paper
“In fact, the current literature provides additional evidence about those alternative sources (9).”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]
In the citing paper
“Based on the literature, the suprachiasmatic nucleus (SCN) projects the circadian rhythm through both the paraventricular nucleus (PVN) of the hypothalamus and adrenal gland (9).”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]
In the citing paper
“The current understanding of the system is that the suprachiasmatic nucleus (SCN) of the hypothalamus controls the circadian system, but it is not limited to SCN (9).”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]
In the citing paper
“In sum, the circadian clock includes the SCN and cellular clocks in almost all tissues of the body which regulate the system in a hierarchical manner.”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]
In the citing paper
“It is also consistent with the literature of the circadian clock (9) which claims that the circadian cycles is regulated by neural signals from the SCN to the PVN of the hypothalamus and by SCN projection to the adrenal gland through the autonomic nervous system.”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]
In the citing paper
“In addition, sometimes ACTH and glucocorticoids dissociate substantially from each other (9, 52).”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]
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Metadata
- Authors
- Dickmeis, T., Weger, B. D., & Weger, M.
- Affiliations
- Karlsruhe Institute of Technology (DE)
- Corresponding author
- Dickmeis, Thomas
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 380
- Issue
- 1-2
- Pages
- 2-15
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2027635336
- Cited by
- 144
- References
- 188
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 12 · 2021: 7 · 2020: 14 · 2019: 8 · 2018: 13 · 2017: 17 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- circadian clock, glucocorticoids, glucocorticoid receptor, nuclear receptor superfamily, seasonal rhythms, transcriptional regulation, stress response, steroid hormone signaling
- MeSH terms
- Adrenal Glands, Animals, Gene Expression Regulation, Glucocorticoids, Humans, Seasons, Transcription, Genetic, Signal Transduction, Feedback, Physiological, Circadian Clocks
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