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Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance

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Irisin stimulates cell proliferation and invasion by targeting the PI3K/AKT pathway in human hepatocellular carcinoma

Shi, G., Tang, N., Qiu, J., Zhang, D., Huang, F., Cheng, Y., Ding, K., Li, W., Zhang, P., & Tan, X. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.148 · Cited by 86 · see citing works

Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery

Ebert, T., Stepan, H., Schrey-Petersen, S., Kralisch, S., Hindricks, J., Hopf, L., Platz, M., Lössner, U., Jeßnitzer, B., Drewlo, S., et al. (2013) · Cytokine · doi:10.1016/j.cyto.2013.11.009 · Cited by 85 · see citing works

The relationship between circulating irisin levels and endothelial function in lean and obese subjects

Hou, N., Han, F., & Sun, X. (2014) · Clinical Endocrinology · doi:10.1111/cen.12658 · Cited by 84 · see citing works

Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population

Oelmann, S., Nauck, M., Völzke, H., Bahls, M., & Friedrich, N. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154319 · Cited by 83 · see citing works

Non-alcoholic fatty liver disease-related fibrosis and sarcopenia: An altered liver-muscle crosstalk leading to increased mortality risk

Kuchay, M. S., Martínez‐Montoro, J. I., Kaur, P., Fernández‐García, J. C., & Ramos‐Molina, B. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101696 · Cited by 85 · see citing works

A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3′UTR

Metwally, M., Bayoumi, A., Romero‐Gómez, M., Thabet, K., John, M., Adams, L. A., Huo, X., Aller, R., García‐Monzón, C., Arias, M., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.021 · Cited by 81 · see citing works

Interaction between sarcopenia and nonalcoholic fatty liver disease

Joo, S. K., & Kim, W. (2023) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0358 · Cited by 78 · see citing works

Age-Related Decrease in Skeletal Muscle Mass Is an Independent Risk Factor for Incident Nonalcoholic Fatty Liver Disease: A 10-Year Retrospective Cohort Study

Lee, M. J., Kim, E., Bae, S.-J., Kim, G., Park, S. W., Choe, J., Jung, C. H., Lee, W. J., & Kim, H. (2018) · Gut and Liver · doi:10.5009/gnl18070 · Cited by 78 · see citing works

Irisin in humans: recent advances and questions for future research

Boström, P., Fernández‐Real, J. M., & Mantzoros, C. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.11.009 · Cited by 77 · see citing works

The “irisin system”: From biological roles to pharmacological and nutraceutical perspectives

Flori, L., Testai, L., & Calderone, V. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118954 · Cited by 79 · see citing works

Irisin: A New Code Uncover the Relationship of Skeletal Muscle and Cardiovascular Health During Exercise

Ma, C., Ding, H., Deng, Y., Liu, H., Xiong, X., & Yang, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.620608 · Cited by 75 · see citing works

Postconditioning with Irisin Attenuates Lung Ischemia/Reperfusion Injury by Suppressing Ferroptosis via Induction of the Nrf2/HO‐1 Signal Axis

Wang, Y., Dong, Z., Zhang, Z., Wang, Y., Yang, K., & Li, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9911167 · Cited by 73 · see citing works

Skeletal Muscle Dysfunction in the Development and Progression of Nonalcoholic Fatty Liver Disease

Altajar, S., & Baffy, G. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00065 · Cited by 70 · see citing works

Sarcopenia and risk of nonalcoholic fatty liver disease: A meta-analysis

Wijarnpreecha, K., Panjawatanan, P., Thongprayoon, C., Jaruvongvanich, V., & Ungprasert, P. (2018) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_237_17 · Cited by 72 · see citing works

Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects

Lopez‐Legarrea, P., de la Iglesia, R., Crujeiras, A. B., Pardo, M., Casanueva, F. F., Zulet, M. Á., & Martínez, J. A. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2014.7 · Cited by 70 · see citing works

Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid

Huerta, A. E., Prieto-Hontoria, P. L., Fernández‐Galilea, M., Sáinź, N., Cuervo, M., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0400-5 · Cited by 69 · see citing works

Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes

Ge, X., Sathiakumar, D., Lua, B.-N., Kukreti, H., Lee, M., & McFarlane, C. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.110 · Cited by 68 · see citing works

Distinctive Roles of Sirtuins on Diabetes, Protective or Detrimental?

Song, J., Yang, B., Jia, X., Li, M., Tan, W. F., Ma, S., Shi, X., & Feng, L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00724 · Cited by 66 · see citing works

Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients

de la Iglesia, R., Lopez‐Legarrea, P., Crujeiras, A. B., Pardo, M., Casanueva, F. F., Zulet, M. Á., & Martínez, J. A. (2013) · Clinical Endocrinology · doi:10.1111/cen.12383 · Cited by 64 · see citing works

Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis

Filip, R., Radzki, R., & Bieńko, M. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s170533 · Cited by 60 · see citing works

Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes

Gao, S., Li, F., Li, H., Yi, H., Liu, Y., & Chen, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147480 · Cited by 63 · see citing works

Combined training, FNDC5/irisin levels and metabolic markers in obese men: A randomised controlled trial

Bonfante, I. L. P., Chacon‐Mikahil, M. P. T., Brunelli, D. T., Gáspari, A. F., Duft, R. G., Lopes, W. A., Bonganha, V., Libardi, C. A., & Cavaglieri, C. R. (2017) · European Journal of Sport Science · doi:10.1080/17461391.2017.1296025 · Cited by 60 · see citing works

Irisin, a newly discovered myokine, is a novel biomarker associated with physical activity in patients with chronic obstructive pulmonary disease

Ijiri, N., Kanazawa, H., Asai, K., Watanabe, T., & Hirata, K. (2015) · Respirology · doi:10.1111/resp.12513 · Cited by 59 · see citing works

Association between Serum Irisin Levels and Non-Alcoholic Fatty Liver Disease in Health Screen Examinees

Choi, E. S., Kim, M. K., Song, M. K., Kim, J., Kim, E. S., Chung, W. J., Park, K. S., Cho, K. B., Hwang, J. S., & Jang, B. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110680 · Cited by 58 · see citing works

Green cardamom supplementation improves serum irisin, glucose indices, and lipid profiles in overweight or obese non-alcoholic fatty liver disease patients: a double-blind randomized placebo-controlled clinical trial

Daneshi‐Maskooni, M., Keshavarz, S. A., Qorbani, M., Mansouri, S., Alavian, S. M., Badri-Fariman, M., Jazayeri-Tehrani, S. A., & Sotoudeh, G. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2465-0 · Cited by 57 · see citing works

Hepatic estrogen receptor α improves hepatosteatosis through upregulation of small heterodimer partner

Wang, X., Lu, Y., Wang, E., Zhang, Z., Xiong, X., Zhang, H., Lu, J., Zheng, S., Yang, J., Xia, X., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.029 · Cited by 57 · see citing works

Lower circulating irisin is associated with nonalcoholic fatty liver disease and type 2 diabetes

Shanaki, M., Moradi, N., Emamgholipour, S., Fadaei, R., & Poustchi, H. (2017) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2017.03.037 · Cited by 57 · see citing works

Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis

Pérez-Sotelo, D., Roca-Rivada, A., de la Torre, I. B., Baltar, J., Castro, A. I., Domínguez, E., Collado, M., Casanueva, F. F., & Pardo, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-16602-z · Cited by 59 · see citing works

Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart

Zhao, Y., Wang, J., Yano, N., Zhang, L. X., Wang, H., Zhang, S.-Y., Qin, G., Dubielecka, P., Zhuang, S., Liu, P., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27037 · Cited by 57 · see citing works

Non‐alcoholic fatty liver disease and sarcopenia additively increase mortality: a Korean nationwide survey

Moon, J. H., Koo, B. K., & Kim, W. K. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12719 · Cited by 56 · see citing works

An update on the validity of irisin assays and the link between irisin and hepatic metabolism

Pοlyzos, S. A., & Mantzoros, C. S. (2015) · Metabolism · doi:10.1016/j.metabol.2015.06.005 · Cited by 56 · see citing works

Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children

Binay, Ç., Paketçi, C., Güzel, S., & Samancı, N. (2017) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.3963 · Cited by 55 · see citing works

Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels

Tanisawa, K., Taniguchi, H., Sun, X., Ito, T., Cao, Z., Sakamoto, S., & Higuchi, M. (2014) · Metabolism · doi:10.1016/j.metabol.2014.01.005 · Cited by 51 · see citing works

Fibronectin Type III Domain–Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Petta, S., Valenti, L. V. C., Svegliati‐Baroni, G., Ruscica, M., Pipitone, R. M., Dongiovanni, P., Rychlicki, C., Ferri, N., Cammà, C., Fracanzani, A. L., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00056 · Cited by 50 · see citing works

Exenatide treatment increases serum irisin levels in patients with obesity and newly diagnosed type 2 diabetes.

Liu, J., Hu, Y., Zhang, H., Xu, Y., & Wang, G. (2016) · Journal of diabetes and its complications · doi:10.1016/j.jdiacomp.2016.07.020 · Cited by 51 · see citing works

The relationships of irisin with bone mineral density and body composition in PCOS patients

Gao, S., Cheng, Y., Zhao, L., Chen, Y., & Liu, Y. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2767 · Cited by 48 · see citing works

Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection—Liver: The “Musketeer” in the Spotlight

Ballestri, S., Nascimbeni, F., Romagnoli, D., Baldelli, E., Targher, G., & Lonardo, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030355 · Cited by 48 · see citing works

Metabolic cross-talk between skeletal muscle and adipose tissue in high-intensity interval training vs. moderate-intensity continuous training by regulation of PGC-1α

Shirvani, H., & Arabzadeh, E. (2018) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-018-0491-4 · Cited by 47 · see citing works

Update on genetics and epigenetics in metabolic associated fatty liver disease

Zhu, X., Xia, M., & Gao, X. (2022) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221132138 · Cited by 48 · see citing works

Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle

Poggiogalle, E., Donini, L. M., Lenzi, A., Chiesa, C., & Pacifico, L. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i10.1747 · Cited by 47 · see citing works

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú, E., Homs, J., & Boadas‐Vaello, P. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182413333 · Cited by 54 · see citing works

Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus — correlation with pancreatic β-cell function

Yang, M., Chen, P., Jin, H., Xie, X., Gao, T., Yang, L., & Yu, X. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-133 · Cited by 46 · see citing works

CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression

Yang, Z. H., Li, P., Shang, Q., Wang, Y. A., He, J., Ge, S., Jia, R., & Fan, X. (2020) · Science Advances · doi:10.1126/sciadv.abc5022 · Cited by 45 · see citing works

Locus Characterization and Gene Expression of Bovine FNDC5: Is the Myokine Irisin Relevant in Cattle?

Komolka, K., Albrecht, E., Schering, L., Brenmoehl, J., Hoeflich, A., & Maak, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088060 · Cited by 44 · see citing works

Hepatic FNDC5 is a potential local protective factor against Non-Alcoholic Fatty Liver

Canivet, C. M., Bonnafous, S., Rousseau, D., Leclère, P. S., Lacas‐Gervais, S., Patouraux, S., Sans, A., Luci, C., Bailly‐Maitre, B., Iannelli, A., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165705 · Cited by 44 · see citing works

Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Pervin, S., Reddy, S. T., & Singh, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.653179 · Cited by 42 · see citing works

Impact of exercise on muscle and nonmuscle organs

Boström, P., Graham, E. L., Georgiadi, A., & Ma, X. (2013) · IUBMB Life · doi:10.1002/iub.1209 · Cited by 42 · see citing works

Fetuin-B links nonalcoholic fatty liver disease to type 2 diabetes via inducing insulin resistance: Association and path analyses

Li, Z., Lin, M., Liu, C., Wang, D., Shi, X., Zheng, C., Liu, Y., Yang, S., & Li, X. (2018) · Cytokine · doi:10.1016/j.cyto.2018.03.023 · Cited by 43 · see citing works

Irisin-encoding gene (FNDC5) variant is associated with changes in blood pressure and lipid profile in type 2 diabetic women but not in men

Brondani, L. D. A., Boelter, G., Assmann, T. S., Leitão, C. B., Canani, L. H. S., & Crispim, D. (2015) · Metabolism · doi:10.1016/j.metabol.2015.05.005 · Cited by 41 · see citing works

Association of serum irisin and body composition with chronic kidney disease in obese Chinese adults: a cross-sectional study

Yang, S., Xiao, F., Pan, L., Zhang, H., Ma, Z., Liu, S., Liu, Y., Zhang, W., Zeng, X. Y., Liu, C., et al. (2015) · BMC Nephrology · doi:10.1186/s12882-015-0009-5 · Cited by 41 · see citing works

Relation of serum irisin levels to obesity and non-alcoholic fatty liver disease

Ulualan, G., Kiraz, Z. K., & Kırel, B. (2022) · The Turkish Journal of Pediatrics · doi:10.24953/turkjped.2020.3003 · Cited by 22 · see citing works

Irisin in patients with nonalcoholic fatty liver disease

Polyzos, S. A., Kountouras, J., Anastasilakis, A. D., Geladari, E. V., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2013.09.013 · Cited by 215 · see citing works

Association between Serum Irisin Levels and Non-Alcoholic Fatty Liver Disease in Health Screen Examinees

Choi, E. S., Kim, M. K., Song, M. K., Kim, J., Kim, E. S., Chung, W. J., Park, K. S., Cho, K. B., Hwang, J. S., & Jang, B. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110680 · Cited by 58 · see citing works

Irisin Is Related to Non-Alcoholic Fatty Liver Disease (NAFLD)

Kosmalski, M., Drzewoski, J., Szymczak-Pajor, I., Zieleniak, A., Mikołajczyk-Solińska, M., Kasznicki, J., & Śliwińska, A. (2022) · Biomedicines · doi:10.3390/biomedicines10092253 · Cited by 17 · see citing works

Irisin in nonalcoholic fatty liver disease: Need for an updated meta-analysis

Pοlyzos, S. A., Kountouras, J., & Anastasilakis, A. D. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154818 · Cited by 4 · see citing works