Identification of immunoreactive proteins from the dog heartworm (Dirofilaria immitis) differentially recognized by the sera from dogs with patent or occult infections
Abstract
Heartworm disease caused by Dirofilaria immitis affects canine and feline hosts. Moreover, the parasite can infect humans, causing pulmonary dirofilariosis. Most affected dogs have patent infections with circulating microfilariae in peripheral blood, although infected dogs sometimes develop occult infections characterized by the absence of microfilariae. Microfilaremic infections (mf+) are associated with a predominant Th2-type immune response, whereas a Th1-type response predominates in amicrofilaremic infections (mf-), suggesting a role for this response in the suppression of circulating microfilariae. However, nothing is known about the molecules involved in the immune regulation of these infections. The objective of the present work was to identify the parasite proteins recognized differentially by the immune response of dogs with patent or occult infections, using two-dimensional electrophoresis and mass spectrometry. Nineteen proteins of D. immitis were identified, of which 6 were immunoreactive against serum samples from both mf+ and mf- dogs, while another two groups of 6 and 7 different proteins were differentially recognized by sera from mf+ or mf- dogs, respectively. The results point to the existence of differential antigen recognition in patent and occult infections due to D. immitis. Several proteins that could be involved in the immune regulation of these infections are identified. Additionally, the findings seem to suggest that some antigens of D. immitis, together with Wolbachia antigens, could contribute to the stimulation of the Th1-type response.
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Proteomics with mass spectrometry allowed the simultaneous identification of numerous proteins, comprising 39 proteins from D. immitis and 15 from D. repens, many represented by several isoforms.
“Together with mass spectrometry, proteomics allowed the simultaneous identification of numerous proteins, comprising 39 proteins from D. immitis and 15 from D. repens, many of which were represented by several isoforms (157,158,313).”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [313]
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CASTRAÇÃO DE CÃES E GATOS COMO MÉTODO EFICAZ NO CONTROLE E PREVENÇÃO DE ZOONOSES
de Araújo, R. R., Lima, M. O. V., Ferreira, M. R., ALVES, L. D. S., Lages, S. A., da Silva, Á. T. R., Silva, M. E. S. E., da Silva, F. A., Santana, J. L. D. S., Cruz, L. G. D. S., et al. (2021) · Editora In Vivo eBooks · doi:10.47242/978-65-993899-0-0-10
BRUCELOSE BOVINA NO MUNICÍPIO DO RIO DE JANEIRO, RIO DE JANEIRO, BRASIL – RELATO DE CASO
da Silva, L. A. M., da Conceição, R. B., Pontes, A. L. D. S., PALMEIRA, J. L. T., & Pittigliani, T. M. C. (2021) · Editora In Vivo eBooks · doi:10.47242/978-65-993899-0-0-5
ASPECTOS CLÍNICOS DE CÁLCULOS URINÁRIOS EM FELINOS-REVISÃO DE LITERATURA
Carneiro, N. F., Tavares, J. R. R., Canela, L. A. D. O., Mendes, A. B. D. S., Petelinkar, M. C., Lima, G. R. F., Júnior, F. H. M. S., & Rodrigues, V. H. V. (2021) · Editora In Vivo eBooks · doi:10.47242/978-65-993899-0-0-1
- Authors
- Oleaga, A., Pérez-Sánchez, R., Pagés, E., Marcos-Atxutegi, C., & Simón, F.
- Affiliations
- Instituto de Recursos Naturales y Agrobiología de Salamanca (ES)
- University of Puerto Rico, Medical Sciences Campus (PR)
- Universidad de Salamanca (ES)
- Corresponding author
- Oleaga, Ana
- Venue
- Molecular and Biochemical Parasitology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 166
- Issue
- 2
- Pages
- 134-141
- ISSN
- 0166-6851 (ISSN-L)
- OpenAlex
- W2048802976
- Cited by
- 41
- References
- 50
- Citations by year
- 2026: 1 · 2023: 2 · 2021: 16 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Biochemical Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Junta de Castilla y León
- European Regional Development Fund
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- Dirofilaria immitis, canine heartworm disease, occult infection, patent infection, microfilaremia, immunoreactive proteins, Th1 response, Th2 immune response, immune regulation
- MeSH terms
- Amino Acid Sequence, Animals, Antibodies, Helminth, Dirofilaria immitis, Dirofilariasis, Dog Diseases, Dogs, Molecular Sequence Data, Electrophoresis, Gel, Two-Dimensional, Helminth Proteins, Sequence Alignment
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