Galectin and aldolase‐like molecules are responsible for the specific IgE response in humans exposed to Dirofilaria immitis
Abstract
Dirofilaria immitis is the agent of the heartworm disease in canids and felids, and of pulmonary dirofilariosis in man. Like other filariae, D. immitis harbours endosymbion Wolbachia bacteriae. In this work we analyse the response of specific IgE antibodies against both D. immitis antigens and the Wolbachia surface protein (WSP) in two groups of persons living in an area of canine endemia, one presenting high levels of total IgE (group 1) and other with normal levels (group 2). Infections with D. immitis were demonstrated by the presence of specific IgG in 228 individuals(48.8%) of the group 1 and only in one of the group 2. Specific IgE antibody response against D. immitis antigens was detected only in individuals of the group 1. IgE response against WSP was not detected in any group. The IgE response was directed mainly against two molecules of 33 and 42 kDa of the antigenic extract of D. immitis. These molecules were identified by mass spectrometry as a galectin and an aldolase, respectively. Their possible role in the survival mechanisms of the parasite and their contribution to development of allergic reactions in individuals resident in areas with heartworm disease are discussed.
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Seroepidemiological studies of residents of areas of endemicity reported high rates of human infection similar to those of canine reservoirs in the same areas.
“Seroepidemiological studies of residents of areas of endemicity reported high rates of infection similar to those of canine reservoirs of the same areas: 21% and 28% for D. immitis in the western Iberian Peninsula and Tenerife (Canary Islands), respectively (129, 344, 395); 10 to 30% in different isoclimatic regions of Grand Canary Island (282); 32.3% for D. immitis in northern Italy and 19.5% for”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [344]
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- Authors
- POU‐BARRETO, C., QUISPE‐RICALDE, M. A., MORCHÓN, R., VÁZQUEZ, C., GENCHI, M., POSTIGO, I., VALLADARES, B., & SIMÓN, F.
- Affiliations
- Universidad de Salamanca (ES)
- Hospital Universitario Nuestra Señora de Candelaria (ES)
- University of Milan (IT)
- University of the Basque Country (ES)
- Universidad de La Laguna (ES)
- Corresponding author
- SIMÓN, F.
- Venue
- Parasite Immunology
- Publisher
- Wiley
- Published
- 2008-10-29
- Volume
- 30
- Issue
- 11-12
- Pages
- 596-602
- ISSN
- 0141-9838 (ISSN-L)
- 1365-3024
- OpenAlex
- W2085385585
- Cited by
- 20
- References
- 35
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2012: 2
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parasite Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Keywords
- Dirofilaria immitis, heartworm disease, specific IgE, galectins, aldolase, Wolbachia surface protein, total IgE, allergic reactions, filarial antigens
- MeSH terms
- Aldehyde-Lyases, Animals, Antibodies, Bacterial, Antibodies, Helminth, Antigens, Helminth, Dirofilaria immitis, Dirofilariasis, Humans, Immunoglobulin E, Immunoglobulin G, Lung Diseases, Male, Molecular Weight, Mass Spectrometry, Symbiosis, Helminth Proteins, Wolbachia, Galectins
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