Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Sarbassov, Dos D., Ali, Siraj M., Sengupta, Shomit, Sheen, Joon-Ho, Hsu, Peggy P., Bagley, Alex F., Markhard, Andrew L., Sabatini, David M.·2006·Molecular Cell
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- mTOR regulates the expression of DNA damage response enzymes in long‐lived Snell dwarf, GHRKO, and PAPPA‐KO miceDominick, Graham, Bowman, Jacqueline, Li, Xinna, Miller, Richard A., Garcia, Gonzalo G. · 2017 · Aging Cell
- Mammalian Target of Rapamycin (mTOR) Inhibitors: Potential Uses and a Review of Haematological Adverse EffectsSofroniadou, Sofia, Goldsmith, David · 2011 · Drug Safety
- mTORC2 (Rictor) in Alzheimer’s Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical NeuronsLee, Han-Kyu, Kwon, Bumsup, Lemere, Cynthia A., de la Monte, Suzanne, Itamura, Kyohei, Ha, Austin Y., Querfurth, Henry W. · 2017 · Journal of Alzheimer's Disease
- Suppression of Hypoxia-Inducible Factor 1α (HIF-1α) by Tirapazamine Is Dependent on eIF2α Phosphorylation Rather Than the mTORC1/4E-BP1 PathwayZhang, Jun, Cao, Ji, Weng, Qinjie, Wu, Rui, Yan, Yan, Jing, Hui, Zhu, Hong, He, Qiaojun, Yang, Bo · 2010 · PLoS ONE
- Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersEvangelisti, Camilla, Cenni, Vittoria, Lattanzi, Giovanna · 2016 · British Journal of Clinical Pharmacology
- Insulin-Like Growth Factor Signaling as a Therapeutic Target in Pancreatic CancerRieder, Simon, W. Michalski, Christoph, Friess, Helmut, Kleeff, > · 2011 · Anti-Cancer Agents in Medicinal Chemistry
- Therapeutic Use of mTOR Inhibitors in Renal Diseases: Advances, Drawbacks, and ChallengesViana, Sofia D., Reis, Flávio, Alves, Rui · 2018 · Oxidative Medicine and Cellular Longevity
- Insulin Regulation of Hepatic Lipid HomeostasisUehara, Kahealani, Santoleri, Dominic, Whitlock, Anna E. Garcia, Titchenell, Paul M. · 2023 · Comprehensive Physiology
- Rapamycin treatment dose‐dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC 1 and cell‐cycle‐associated CDK 1/cyclin axisLi, Ao, Fan, Song, Xu, Yuchen, Meng, Jialin, Shen, Xufeng, Mao, Jun, Zhang, Li, Zhang, Xiansheng, Moeckel, Gilbert, Wu, Dianqing et al. · 2017 · Journal of Cellular and Molecular Medicine
- Foxo3a is essential for maintenance of the hematopoietic stem cell pool.Miyamoto, Kana, Araki, Kiyomi Y., Naka, Kazuhito, Arai, Fumio, Takubo, Keiyo, Yamazaki, Satoshi, Matsuoka, Sahoko, Miyamoto, Takeshi, Ito, Keisuke, Ohmura, Masako et al. · 2007 · Cell stem cell
- Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustionZhu, Chen, Dixon, Karen O., Newcomer, Kathleen, Gu, Guangxiang, Xiao, Sheng, Zaghouani, Sarah, Schramm, Markus A., Wang, Chao, Zhang, Huiyuan, Goto, Kouichiro et al. · 2021 · Science Advances
- Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen SpeciesReho, John J., Guo, Deng‐Fu, Rahmouni, Kamal · 2019 · Journal of the American Heart Association
- Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasisZhang, Qing, Duplany, Agnès, Moncollin, Vincent, Mouradian, Sandrine, Goillot, Evelyne, Mazelin, Laetitia, Gauthier, Karine, Streichenberger, Nathalie, Angleraux, Céline, Chen, Jie et al. · 2019 · Journal of Cachexia, Sarcopenia and Muscle
- AKT/mTORC pathway in antiphospholipid-related vasculopathy: a new player in the gameCanaud, G, Legendre, C, Terzi, F · 2015 · Lupus
- Tuberous sclerosis complex–associated CNS abnormalities depend on hyperactivation of mTORC1 and AktZordan, Paola, Cominelli, Manuela, Cascino, Federica, Tratta, Elisa, Poliani, Pietro L., Galli, Rossella · 2018 · Journal of Clinical Investigation
- A targeted approach to phosphoinositide-3-kinase/Akt/mammalian target of rapamycin-induced hyperglycemiaCheung, Yee-Ming Melody, McDonnell, Marie, Hamnvik, Ole-Petter Riksfjord · 2022 · Current Problems in Cancer
- Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 SignalingSpinosa, Phillip C., Kinnunen, Patrick C., Humphries, Brock A., Luker, Gary D., Luker, Kathryn E., Linderman, Jennifer J. · 2021 · Cellular and Molecular Bioengineering