The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Alternative miRNA Biogenesis Pathways and the Interpretation of Core miRNA Pathway Mutants
Open accessAbstract
Since the establishment of a canonical animal microRNA biogenesis pathway driven by the RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that generate functional microRNAs have emerged. We review here the many Drosha-independent and Dicer-independent microRNA biogenesis strategies characterized over the past few years. Beyond reflecting the flexibility of small RNA machineries, the existence of non-canonical pathways has consequences for interpreting mutants in the core microRNA machinery. Such mutants are commonly used to assess the consequences of “total” microRNA loss, and indeed, they exhibit many overall phenotypic similarities. Nevertheless, ongoing studies reveal a growing number of settings in which alternative microRNA pathways contribute to distinct phenotypes amongst core microRNA biogenesis mutants.
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Cited by
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462
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Self-citation
Metadata
- Authors
- Yang, J.-S., & Lai, E. C.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 43
- Issue
- 6
- Pages
- 892-903
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2018045673
- Cited by
- 496
- References
- 10
- FWCI
- 18.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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