The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers
Open accessAbstract
The Hippo/YAP signaling pathway is a crucial regulator of tissue growth, stem cell activity, and tumorigenesis. However, the mechanism by which YAP controls transcription remains to be fully elucidated. Here, we utilize global chromatin occupancy analyses to demonstrate that robust YAP binding is restricted to a relatively small number of distal regulatory elements in the genome. YAP occupancy defines a subset of enhancers and superenhancers with the highest transcriptional outputs. YAP modulates transcription from these elements predominantly by regulating promoter-proximal polymerase II (Pol II) pause release. Mechanistically, YAP interacts and recruits the Mediator complex to enhancers, allowing the recruitment of the CDK9 elongating kinase. Genetic and chemical perturbation experiments demonstrate the requirement for Mediator and CDK9 in YAP-driven phenotypes of overgrowth and tumorigenesis. Our results here uncover the molecular mechanisms employed by YAP to exert its growth and oncogenic functions, and suggest strategies for intervention.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Third, YAP/TEAD bind distal regulatory elements to regulate transcription of target genes (73-75).”
From A Tumour-Specific Molecular Network Promotes Tumour Growth in Drosophila by Enforcing a JNK-YKI Feedforward Loop (2023) · cites this paper as [73]
The cited source says what the claim attributes to it.
In the citing paper
“Consistently, published ChIP-seq datasets34,38,39 reveal a similar phenomenon in human cancer cell lines (Figure S7F).”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [34]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Super-enhancers in the control of cell identity and disease
Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961
Histone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533
TEAD mediates YAP-dependent gene induction and growth control
Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498
Elucidation of a universal size-control mechanism in Drosophila and mammals
Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370
Mediator and cohesin connect gene expression and chromatin architecture
Kagey, M. H., Newman, J. J., Bilodeau, S., Zhan, Y., Orlando, D. A., van Berkum, N. L., Ebmeier, C. C., Goossens, J., Rahl, P. B., Levine, S. S., et al. (2010) · Nature · doi:10.1038/nature09380 · Cited by 1,939
Modification of Enhancer Chromatin: What, How, and Why?
Calo, E., & Wysocka, J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.038 · Cited by 1,457
YAP1 increases organ size and expands undifferentiated progenitor cells
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252
Self-citationPromoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
Adelman, K., & Lis, J. T. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3293 · Cited by 1,221
Cohesin mediates transcriptional insulation by CCCTC-binding factor
Wendt, K. S., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, K., Mishiro, T., et al. (2008) · Nature · doi:10.1038/nature06634 · Cited by 1,193
Cited by
Sorted by citations
YAP/TAZ at the Roots of Cancer
Zanconato, F., Cordenonsi, M., & Piccolo, S. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.005 · Cited by 1,970
Mechanisms of Hippo pathway regulation
Meng, Z., Moroishi, T., & Guan, K.-L. (2016) · Genes & Development · doi:10.1101/gad.274027.115 · Cited by 1,667
Mechanobiology of YAP and TAZ in physiology and disease
Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461
The Hippo Pathway: Biology and Pathophysiology
Ma, S., Meng, Z., Chen, R., & Guan, K.-L. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111829 · Cited by 1,387
YAP/TAZ upstream signals and downstream responses
Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981
The Hippo Signaling Pathway in Development and Disease
Zheng, Y., & Pan, D. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.06.003 · Cited by 867
The roles of signaling pathways in bone repair and regeneration
Majidinia, M., Sadeghpour, A., & Yousefi, B. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26042 · Cited by 526
Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
Wang, Y., Xu, X., Maglic, D., Dill, M. T., Mojumdar, K., Ng, P. K.-S., Jeong, K. J., Tsang, Y. H., Moreno, D., Bhavana, V. H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.001 · Cited by 500
The Hippo Signaling Network and Its Biological Functions
Misra, J. R., & Irvine, K. D. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031621 · Cited by 514
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
Dupont, S. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.034 · Cited by 449
YAP/TAZ Signaling and Resistance to Cancer Therapy
Nguyen, C. D. K., & Yi, C. (2019) · Trends in Cancer · doi:10.1016/j.trecan.2019.02.010 · Cited by 437
Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression
Cai, D., Feliciano, D., Dong, P., Flores, E., Gruebele, M., Porat‐Shliom, N., Sukenik, S., Liu, Z. J., & Lippincott‐Schwartz, J. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0433-z · Cited by 426
YAP and TAZ: a signalling hub of the tumour microenvironment
Zanconato, F., Cordenonsi, M., & Piccolo, S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0168-y · Cited by 388
YAP/TAZ functions and their regulation at a glance
Pocaterra, A., Romani, P., & Dupont, S. (2020) · Journal of Cell Science · doi:10.1242/jcs.230425 · Cited by 389
Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression
Lu, Y., Wu, T., Gutman, O., Lu, H., Zhou, Q., Henis, Y. I., & Luo, K. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0485-0 · Cited by 375
Super-Enhancer-Driven Transcriptional Dependencies in Cancer
Sengupta, S., & George, R. E. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.03.006 · Cited by 354
Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4
Zanconato, F., Battilana, G., Forcato, M., Filippi, L., Azzolin, L., Manfrin, A., Quaranta, E. G., Biagio, D. D., Sigismondo, G., Guzzardo, V., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0158-8 · Cited by 314
Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis
Patel, S. H., Camargo, F. D., & Yimlamai, D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.047 · Cited by 303
Self-citationYAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo
Monroe, T. O., Hill, M. C., Morikawa, Y., Leach, J. P., Heallen, T., Cao, S., Krijger, P. H. L., de Laat, W., Wehrens, X. H. T., Rodney, G. G., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.017 · Cited by 289
Single tumor-initiating cells evade immune clearance by recruiting type II macrophagesPreprint
Guo, X., Zhao, Y., Yan, H., Yang, Y., Shen, S., Dai, X., Ji, X., Ji, F., Gong, X., Li, L., et al. (2017) · Genes & Development · doi:10.1101/gad.294348.116 · Cited by 290
Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury
Tao, G., Kahr, P. C., Morikawa, Y., Zhang, M., Rahmani, M., Heallen, T. R., Li, L., Sun, Z. Q., Olson, E. N., Amendt, B. A., et al. (2016) · Nature · doi:10.1038/nature17959 · Cited by 284
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Tang, F., Xu, D., Wang, S., Wong, C. K., Martinez‐Fundichely, A., Lee, C. J., Cohen, S. M., Park, J., Hill, C. E., Eng, K. W., et al. (2022) · Science · doi:10.1126/science.abe1505 · Cited by 272
Pepe-Mooney, B. J., Dill, M. T., Alemany, A., Ordovas-Montanes, J., Matsushita, Y., Rao, A., Sen, A., Miyazaki, M., Anakk, S., Dawson, P. A., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.004 · Cited by 266
Self-citationRegulation of TEAD Transcription Factors in Cancer Biology
Huh, H., Kim, D., Jeong, H.-S., & Park, H. (2019) · Cells · doi:10.3390/cells8060600 · Cited by 259
Nascent RNA analyses: tracking transcription and its regulation
Wissink, E. M., Vihervaara, A., Tippens, N. D., & Lis, J. T. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0159-6 · Cited by 258
Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation
Yu, M., Peng, Z., Qin, M., Liu, Y., Wang, J., Zhang, C., Lin, J., Dong, T., Wang, L., Li, S., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.01.010 · Cited by 250
Tang, T. T., Konradi, A. W., Feng, Y., Peng, X., Ma, M., Li, J., Yu, F.-X., Guan, K.-L., & Post, L. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0717 · Cited by 245
The Hippo Pathway in Liver Homeostasis and Pathophysiology
Driskill, J. H., & Pan, D. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-030420-105050 · Cited by 236
Integrative pathway enrichment analysis of multivariate omics data
Paczkowska, M., Barenboim, J., Sintupisut, N., Fox, N. S., Zhu, H., Abd-Rabbo, D., Mee, M. W., Boutros, P. C., PCAWG Drivers and Functional Interpretation Working Group, Abascal, F., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13983-9 · Cited by 236
A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy
Pobbati, A. V., & Hong, W. (2020) · Theranostics · doi:10.7150/thno.40889 · Cited by 230
YAP/TAZ as therapeutic targets in cancer
Zanconato, F., Battilana, G., Cordenonsi, M., & Piccolo, S. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.05.002 · Cited by 219
Hagenbeek, T. J., Zbieg, J. R., Hafner, M., Mroue, R., Lacap, J. A., Sodir, N. M., Noland, C. L., Afghani, S., Kishore, A., Bhat, K. P., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00577-0 · Cited by 215
Insights into recent findings and clinical application of YAP and TAZ in cancer
Franklin, J. M., Wu, Z., & Guan, K.-L. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-023-00579-1 · Cited by 213
Tang, Y., Feinberg, T. Y., Keller, E. T., Li, X.-Y., & Weiss, S. J. (2016) · Nature Cell Biology · doi:10.1038/ncb3394 · Cited by 208
CDK9: a signaling hub for transcriptional control
Bacon, C. W., & D’Orso, I. (2018) · Transcription · doi:10.1080/21541264.2018.1523668 · Cited by 206
Hsu, P., Jablons, D. M., Yang, C., & You, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153821 · Cited by 215
The Mediator Complex: At the Nexus of RNA Polymerase II Transcription
Jerónimo, C., & Robert, F. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.07.001 · Cited by 189
YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility
Mason, D. E., Collins, J. M., Dawahare, J. H., Nguyen, T. D., Lin, Y., Voytik‐Harbin, S. L., Zorlutuna, P., Yöder, M. C., & Boerckel, J. D. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201806065 · Cited by 193
Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors
Holden, J. K., & Cunningham, C. N. (2018) · Cancers · doi:10.3390/cancers10030081 · Cited by 181
Holden, J. K., Crawford, J. J., Noland, C. L., Schmidt, S., Zbieg, J. R., Lacap, J. A., Zang, R., Miller, G. M., Zhang, Y., Beroza, P., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107809 · Cited by 172
Small-molecule targeting of brachyury transcription factor addiction in chordoma
Sharifnia, T., Wawer, M. J., Chen, T., Huang, Q., Weir, B. A., Sizemore, A. E., Lawlor, M. A., Goodale, A. B., Cowley, G. S., Vázquez, F., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0312-3 · Cited by 159
Self-citationChapeau, E. A., Sansregret, L., Galli, G. G., Chêne, P., Wartmann, M., Mourikis, T. P., Jaaks, P., Baltschukat, S., Barbosa, I. A. M., Bauer, D., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00754-9 · Cited by 168
Self-citationChen, Y.-A., Lu, C.-Y., Cheng, T., Pan, S., Chen, H., & Chang, N. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00060 · Cited by 160
YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance
Szulzewsky, F., Holland, E. C., & Vasioukhin, V. I. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2020.12.018 · Cited by 155
Immunotherapy in Treating EGFR-Mutant Lung Cancer: Current Challenges and New Strategies
To, K. K. W., Fong, W., & Cho, W. C. S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.635007 · Cited by 157
Xiao, Y., Hill, M. C., Li, L., Deshmukh, V., Martin, T. J., Wang, J., & Martin, J. F. (2019) · Genes & Development · doi:10.1101/gad.329763.119 · Cited by 146
Sansó, M., Levin, R. S., Lipp, J., Wang, V. Y., Greifenberg, A. K., Quezada, E. M., Ali, A., Ghosh, A., Larochelle, S., Rana, T. M., et al. (2016) · Genes & Development · doi:10.1101/gad.269589.115 · Cited by 137
Cell Junctions in Hippo SignalingPreprint
Karaman, R., & Halder, G. A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028753 · Cited by 137
Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growthPreprint
Koo, J. H., Plouffe, S. W., Meng, Z., Lee, D.-H., Yang, D., Lim, D., Wang, C., & Guan, K. (2019) · Genes & Development · doi:10.1101/gad.331546.119 · Cited by 133
Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export
Ege, N., Dowbaj, A. M., Jiang, M., Howell, M. T., Hooper, S., Foster, C., Jenkins, R. P., & Sahai, E. A. (2018) · Cell Systems · doi:10.1016/j.cels.2018.05.006 · Cited by 134
NUAK2 is a critical YAP target in liver cancer
Yuan, W.-C., Pepe-Mooney, B. J., Galli, G. G., Dill, M. T., Huang, H., Hao, M., Wang, Y., Liang, H., Calogero, R., & Camargo, F. D. (2018) · Nature Communications · doi:10.1038/s41467-018-07394-5 · Cited by 129
Self-citationSun, C., Mello, V. D., Mohamed, A. D., Quiroga, H. P. O., García-Muñoz, A., Bloshi, A. A., Tremblay, A., von Kriegsheim, A., Collie-Duguid, E. S. R., Vargesson, N., et al. (2017) · Stem Cells · doi:10.1002/stem.2652 · Cited by 135
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
Cox, A. G., Tsomides, A., Yimlamai, D., Hwang, K. L., Miesfeld, J. B., Galli, G. G., Fowl, B. H., Fort, M. W., Kimberly, Y., Sullivan, M. R., et al. (2018) · The EMBO Journal · doi:10.15252/embj.2018100294 · Cited by 116
Self-citationZhou, Y. M., Wang, Y., Zhou, W., Chen, T., Wu, Q., Chutturghoon, V. K., Lin, B., Geng, L., Yang, Z., Zhou, L., et al. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0898-7 · Cited by 118
The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number
Lavado, A., Park, J. Y., Paré, J., Finkelstein, D., Pan, H., Xu, B., Fan, Y., Kumar, R. P., Neale, G. A. M., Kwak, Y. D., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.09.021 · Cited by 119
Protein phase separation and its role in tumorigenesis
Jiang, S., Fagman, J. B., Chen, C., Alberti, S., & Liu, B. (2020) · eLife · doi:10.7554/elife.60264 · Cited by 119
Hypertranscription in Development, Stem Cells, and Regeneration
Percharde, M., Bulut-Karslıoğlu, A., & Ramalho‐Santos, M. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.11.010 · Cited by 122
MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis
Kim, T., Hwang, D., Lee, D., Kim, J., Kim, S., & Lim, D. (2017) · The EMBO Journal · doi:10.15252/embj.201695137 · Cited by 114
Aranda-Orgillés, B., Saldaña-Meyer, R., Wang, E., Trompouki, E., Fassl, A., Lau, S., Mullenders, J., Rocha, P. P., Raviram, R., Guillamot, M., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.08.004 · Cited by 111
Tang, Y., & Weiss, S. J. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1280643 · Cited by 114
Enhancer RNAs in cancer: regulation, mechanisms and therapeutic potential
Lee, J., Xiong, F., & Li, W. (2020) · RNA Biology · doi:10.1080/15476286.2020.1712895 · Cited by 108
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth
Lin, Z., Guo, H.-D., Cao, Y., Zohrabian, S., Zhou, P., Ma, Q., VanDusen, N. J., Guo, Y., Zhang, J., Stevens, S. M., et al. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.09.005 · Cited by 106
Pajtler, K. W., Wei, Y., Okonechnikov, K., Silva, P. B. G., Vouri, M., Zhang, L., Brabetz, S., Sieber, L., Gulley, M., Mauermann, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11884-5 · Cited by 108
Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ
Kwon, H., Kim, J.-Y., & Jho, E. (2021) · FEBS Journal · doi:10.1111/febs.16091 · Cited by 105
YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis
Li, H., Wu, B.-K., Kanchwala, M., Cai, J., Wang, L., Xing, C., Zheng, Y., & Pan, D. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00848-5 · Cited by 106
The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin
Rognoni, E., & Walko, G. (2019) · Cells · doi:10.3390/cells8050411 · Cited by 106
Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies
Kim, M. H., & Kim, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2412-x · Cited by 102
YAP/TAZ initiate and maintain Schwann cell myelination
Grove, M., Kim, H., Santerre, M., Krupka, A. J., Han, S. B., Zhai, J., Cho, J. Y., Park, R., Harris, M. Y., Kim, S., et al. (2017) · eLife · doi:10.7554/elife.20982 · Cited by 101
Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues
Tharp, K. M., Kang, M. S., Timblin, G. A., Dempersmier, J. M., Dempsey, G., Zushin, P. H., Benavides, J., Choi, C., Li, C. X., Jha, A. K., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.005 · Cited by 104
The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis
Zinatizadeh, M. R., Miri, S. R., Zarandi, P. K., Chalbatani, G. M., Rapôso, C., Mirzaei, H. R., Akbari, M. E., & Mahmoodzadeh, H. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.11.003 · Cited by 98
Talukdar, P. D., & Chatterji, U. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01651-w · Cited by 103
Small genomic insertions form enhancers that misregulate oncogenes
Abraham, B. J., Hnisz, D., Weintraub, A. S., Kwiatkowski, N. P., Li, C. H., Li, Z., Weichert‐Leahey, N., Rahman, S., Liu, Y., Etchin, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14385 · Cited by 96
Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo
Manning, S. A., Dent, L., Kondo, S., Zhao, Z., Plachta, N., & Harvey, K. F. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.018 · Cited by 87
The Hippo Signaling Pathway in Drug Resistance in Cancer
Zeng, R., & Dong, J. (2021) · Cancers · doi:10.3390/cancers13020318 · Cited by 89
The Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective
Xiao, Y., & Dong, J. (2021) · Cancers · doi:10.3390/cancers13246214 · Cited by 84
TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
Elster, D., Tollot, M., Schlegelmilch, K., Ori, A., Rosenwald, A., Sahai, E. A., & von Eyß, B. (2018) · Nature Communications · doi:10.1038/s41467-018-05370-7 · Cited by 88
Regulation of localization and function of the transcriptional co-activator YAP by angiomotin
Moleirinho, S., Hoxha, S., Mandati, V., Curtale, G., Troutman, S. A., Ehmer, U., & Kissil, J. L. (2017) · eLife · doi:10.7554/elife.23966 · Cited by 86
New insights into the ambivalent role of YAP/TAZ in human cancers
Luo, J., Deng, L., Zou, H., Guo, Y., Tong, T., Huang, M., Ling, G., & Li, P. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02704-2 · Cited by 89
The Crosstalk between Src and Hippo/YAP Signaling Pathways in Non-Small Cell Lung Cancer (NSCLC)
Hsu, P., Yang, C., Jablons, D. M., & You, L. (2020) · Cancers · doi:10.3390/cancers12061361 · Cited by 85
Nie, M., Chen, N., Pang, H., Jiang, T., Jiang, W., Tian, P., Yao, L., Chen, Y., DeBerardinis, R. J., Li, W., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci160152 · Cited by 83
CellOracle: Dissecting cell identity via network inference and in silico gene perturbation
Kamimoto, K., Hoffmann, C. M., & Morris, S. A. (2020) · doi:10.1101/2020.02.17.947416 · Cited by 81
Szulzewsky, F., Arora, S., Hoellerbauer, P., King, C., Nathan, E., Chan, M., Cimino, P. J., Ozawa, T., Kawauchi, D., Pajtler, K. W., et al. (2020) · Genes & Development · doi:10.1101/gad.338681.120 · Cited by 82
The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function
Watt, K. I., Goodman, C. A., Hornberger, T. A., & Gregorevic, P. (2018) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000142 · Cited by 80
Transcriptional control by enhancers and enhancer RNAs
Lewis, M. W., Shen, L., & Franco, H. L. (2019) · Transcription · doi:10.1080/21541264.2019.1695492 · Cited by 84
YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer
Quinn, H. M., Vogel, R., Popp, O., Mertins, P., Lan, L., Messerschmidt, C., Landshammer, A., Lisek, K., Château‐Joubert, S., Marangoni, E., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2801 · Cited by 83
Watanabe, Y., Miyasaka, K. Y., Kubo, A., Kida, Y. S., Nakagawa, O., Hirate, Y., Sasaki, H., & Ogura, T. (2017) · Scientific Reports · doi:10.1038/srep46135 · Cited by 80
Mechanical cue‐induced YAP instructs Skp2‐dependent cell cycle exit and oncogenic signaling
Jang, W., Kim, T., Koo, J. S., Kim, S. K., & Lim, D. (2017) · The EMBO Journal · doi:10.15252/embj.201696089 · Cited by 76
YAP‐TEAD signaling promotes basal cell carcinoma development via a c‐JUN/AP1 axis
Maglic, D., Schlegelmilch, K., Dost, A. F. M., Panero, R., Dill, M. T., Calogero, R., & Camargo, F. D. (2018) · The EMBO Journal · doi:10.15252/embj.201798642 · Cited by 75
Self-citationYAP repression of the WNT3 gene controls hESC differentiation along the cardiac mesoderm lineagePreprint
Estarás, C., Hsu, H.-T., Huang, L., & Jones, K. A. (2017) · Genes & Development · doi:10.1101/gad.307512.117 · Cited by 71
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma
Bleu, M., Gaulis, S., Lopes, R., Sprouffske, K., Apfel, V., Holwerda, S. J. B., Pregnolato, M., Yildiz, U., Cordo’, V., Dost, A. F. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11672-1 · Cited by 69
Self-citationActivation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51
Hazan, I., Monin, J., Bouwman, B. A. M., Crosetto, N., & Aqeilan, R. I. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.001 · Cited by 70
A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Shreberk‐Shaked, M., Dassa, B., Sinha, S., Agostino, S. D., Azuri, I., Mukherjee, S., Aylon, Y., Blandino, G., Ruppin, E., & Oren, M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0125 · Cited by 70
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
Fan, M., Lu, W., Che, J., Kwiatkowski, N. P., Gao, Y., Seo, H.-S., Ficarro, S. B., Gokhale, P. C., Liu, Y., Geffken, E. A., et al. (2022) · eLife · doi:10.7554/elife.78810 · Cited by 68
Self-citationThe oncogenic roles and clinical implications of YAP/TAZ in breast cancer
Luo, J., Zou, H., Guo, Y., Tong, T., Chen, Y., Xiao, Y., Pan, Y., & Li, P. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02182-5 · Cited by 72
The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes
Pattschull, G., Walz, S., Gründl, M., Schwab, M., Rühl, E., Baluapuri, A., Vranesic, A. C., Kneitz, S., Wolf, E., Ade, C. P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.071 · Cited by 68
Targeting the Hippo pathway in cancer
Harvey, K. F., & Tang, T. T.-L. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01234-0 · Cited by 68
A Novel Notch–YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma
Slemmons, K. K., Crose, L. E. S., Riedel, S., Sushnitha, M., Belyea, B., & Linardic, C. M. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0004 · Cited by 62
The roles of signaling pathways in liver repair and regeneration
Valizadeh, A., Majidinia, M., Kafil, H. S., Yousefi, M., & Yousefi, B. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28336 · Cited by 63
Merritt, N. M., Garcia, K. C., Rajendran, D., Lin, Z., Zhang, X., Mitchell, K. A., Borcherding, N. C., Fullenkamp, C. A., Chimenti, M. S., Gingras, A., et al. (2021) · eLife · doi:10.7554/elife.62857 · Cited by 65
Metadata
- Authors
- Galli, G. G., Carrara, M., Yuan, W.-C., Valdes-Quezada, C., Gurung, B., Pepe-Mooney, B., Zhang, T., Geeven, G., Gray, N. S., de Laat, W., Calogero, R. A., & Camargo, F. D.
- Affiliations
- Boston Children's Hospital (US)
- University of Turin (IT)
- Dana-Farber Cancer Institute (US)
- University Medical Center Utrecht (NL)
- Corresponding author
- Camargo, Fernando D.
- ORCID
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 60
- Issue
- 2
- Pages
- 328-337
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC4624327
- OpenAlex
- W2121761542
- Cited by
- 290
- References
- 38
- Citations by year
- 2026: 21 · 2025: 21 · 2024: 31 · 2023: 29 · 2022: 23 · 2021: 29 · 2020: 33 · 2019: 34 · 2018: 26 · 2017: 25 · 2016: 16 · 2015: 1
- FWCI
- 12.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK099559, DK099559)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR064036, AR064036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- YAP, Hippo signaling pathway, Mediator complex, CDK9, super-enhancers, enhancers, distal regulatory elements, transcription elongation, tissue overgrowth, carcinogenesis, chromatin occupancy
- MeSH terms
- YAP-Signaling Proteins, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Animals, Antineoplastic Agents, Bile Duct Neoplasms, Chromatin, DNA Polymerase II, Enhancer Elements, Genetic, Flavonoids, Humans, Mice, Transgenic, Phosphoproteins, Piperidines, Protein Binding, Transcription Factors, Transcription, Genetic, Signal Transduction, Trans-Activators, Gene Expression Regulation, Neoplastic, Cholangiocarcinoma, Xenograft Model Antitumor Assays, Cyclin-Dependent Kinase 9, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Mice, Mediator Complex, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
