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Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA

Jadhav, Unmesh, Cavazza, Alessia, Banerjee, Kushal K., Xie, Huafeng, O’Neill, Nicholas K., Saenz-Vash, Veronica, Herbert, Zachary, Madha, Shariq, Orkin, Stuart H., Zhai, Huili, Shivdasani, Ramesh A.·2019·Molecular Cell
DOI 10.1016/j.molcel.2019.02.024PMC PMC6499659
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  • The reacquisition of somatic fate may be the result of persisting epigenetic memory at enhancers, which is not erased until the SP, as well as persistent expression of some fibroblast genes.

    “This may be the result of persisting epigenetic memory at enhancers (Jadhav et al., 2019), which notably we find is not erased until the SP, as well as persistent expression of some fibroblast genes.”

    From Multi-omic rejuvenation of human cells by maturation phase transient reprogramming (2022) · cites this paper as Jadhav et al., 2019

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Metadata

Authors
Jadhav, U., Cavazza, A., Banerjee, K. K., Xie, H., O’Neill, N. K., Saenz-Vash, V., Herbert, Z., Madha, S., Orkin, S. H., Zhai, H., & Shivdasani, R. A.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2019-05
Volume
74
Issue
3
Pages
542-554.e5
ISSN
1097-2765
DOI
10.1016/j.molcel.2019.02.024
PMC
PMC6499659
Cited by
86
References
11
Language
en
Licence
Funders
  • NIH (R01DK081113, R01DK082889, U01DK103152, F32DK103453, K01DK113067, P50CA127003)
  • DFCI-Novartis Drug Discovery Program
  • Italian American Cancer Foundation
  • Lind family

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