Stress, age, and immune function: toward a lifespan approach

Graham, Jennifer E.; Christian, Lisa M.; Kiecolt-Glaser, Janice K.

doi:10.1007/s10865-006-9057-4

Cited by 329Stress Responses and CortisolCancer, Stress, Anesthesia, and Immune ResponseTryptophan and brain disorders

Stress, age, and immune function: toward a lifespan approach

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Graham, Jennifer E., Christian, Lisa M., Kiecolt-Glaser, Janice K.·2006·Journal of Behavioral Medicine

DOI 10.1007/s10865-006-9057-4PMC PMC2805089

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Abstract

Both aging processes and psychological stress affect the immune system: Each can dysregulate immune function with a potentially substantial impact on physical health. Worse, the effects of stress and age are interactive. Psychological stress can both mimic and exacerbate the effects of aging, with older adults often showing greater immunological impairment to stress than younger adults. In addition, stressful experiences very early in life can alter the responsiveness of the nervous system and immune system. We review the unique impact of aging and stress on immune function, followed by evidence of interactions between age and stress. Further, we suggest that prenatal or early life stress may increase the likelihood of maladaptive immune responses to stress in late life. An understanding of the interactive effects of stress and age is critical to efforts to determine underlying mechanisms, clarify the directionality of effects, and develop effective interventions in early and late life.

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Authors: Graham, J. E., Christian, L. M., & Kiecolt-Glaser, J. K.
Affiliations: The Ohio State University (US)
ORCID: Christian, Lisa M.
Venue: Journal of Behavioral Medicine
Publisher: Springer Science and Business Media LLC
Published: 2006-05-19
Volume: 29
Issue: 4
Pages: 389-400
ISSN: 0160-7715 (ISSN-L)
1573-3521
DOI: 10.1007/s10865-006-9057-4
PMC: PMC2805089
OpenAlex: W2113187839
Cited by: 329
References: 132
Citations by year: 2026: 7 · 2025: 8 · 2024: 17 · 2023: 15 · 2022: 16 · 2021: 15 · 2020: 23 · 2019: 12 · 2018: 17 · 2017: 18 · 2016: 14 · 2015: 26 · 2014: 20 · 2013: 21 · 2012: 26
FWCI: 1.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Behavioral Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA100243, CA16058, R01CA100243, P30CA016058)
National Institute of Allergy and Infectious Diseases (T32 AI 55411, T32AI055411)
National Center for Research Resources (M01-RR0034, M01RR000034)
National Center for Complementary and Integrative Health (R21AT002122, AT002971, R21AT002971, AT002122)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: psychological stress, aging, immune function, lifespan development, immunosenescence, early life stress, prenatal stress, neuroimmune interactions, older adults
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Arousal, Child, Child, Preschool, Female, Humans, Immune System, Infant, Infant, Newborn, Life Change Events, Male, Middle Aged, Pregnancy, Psychoneuroimmunology, Risk Factors

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Stress, age, and immune function: toward a lifespan approach

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