Cited by 98Telomeres, Telomerase, and SenescenceIntimate Partner and Family ViolenceChild Abuse and Trauma

Telomere shortening in formerly abused and never abused women.

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Humphreys, Janice, Epel, Elissa S., Cooper, Bruce A., Lin, Jue, Blackburn, Elizabeth H., Lee, Kathryn A.·2012·Biological Research For Nursing

Abstract

Recent studies suggest that chronic psychological stress may accelerate aging at the cellular level. Telomeres are protective components that stabilize the ends of chromosomes and modulate cellular aging. Women exposed to intimate partner violence (IPV) experience chronic stress and report worse health. The purpose of this exploratory study was to examine telomeric DNA length in women who have experienced chronic stress related to IPV. We hypothesized that IPV exposure would be associated with shorter telomere length. The investigation used a cross-sectional design to study telomere length in women with a history of IPV exposure and control women who reported no prior exposure to IPV. Advertisements and public notices were used to recruit a convenience sample of healthy women. Mean leukocyte telomere length was measured in DNA samples from peripheral blood mononuclear cells (PBMCs) by a quantitative polymerase chain reaction assay (qPCR). Telomere length was significantly shorter in the 61 formerly abused women compared to the 41 controls ( t = 2.4, p = .02). Length of time in the abusive relationship and having children were associated with telomere length after controlling for age and body mass index (BMI) ( F(2, 99) = 10.23, p < .001). Numerous studies suggest that women who experience IPV have poorer overall health. It is often presumed that the stress of IPV may be causing greater morbidity. Findings from this descriptive study suggest a link between IPV exposure, duration of IPV-related stress, and telomere length molecular mechanisms that regulate cellular aging.

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  • Telomeres progressively shorten with repeated cell division and exposure to stress.

    “Telomeres, which protect chromosomal integrity, progressively shorten with repeated cell division and exposure to stress (Humphreys et al., 2012).”

    From From use to abuse: psychological, neurobiological, and spiritual pathways in relational harm and recovery (2026) · cites this paper as Humphreys et al., 2012

    The paper’s introductory passage, labeled Abstract in our copy (page unavailable), says telomeres stabilize chromosome ends and shorten in response to chronic stress. It does not state that repeated cell division progressively shortens them, and its stress claim is specifically about chronic stress. (LLM, conf=0.84)

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  • Emerging evidence indicates that chronic stress shortens telomere length, a biomarker of cellular aging.

    “At the cellular level, emerging evidence indicates that chronic stress shortens telomere length, a biomarker of cellular aging.”

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8 of the 49 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

  1. Haight WL Shim WS Linn LM Swinford L Mothers' strategies for protecting children from batterers: The perspectives of battered women involved in child protective services Child Welfare 2007 86 4 41 62 17953327
  2. Humphreys J Campbell JC Family violence and nursing practice 2011 Springer Publishing Company New York 2nd ed.
  3. Katon W Sullivan M Walker E Medical symptoms without identified pathology: Relationship to psychiatric disorders, childhood Annals of Internal Medicine 2001 134 9 917 11346329
  4. Rand MR Violence-related injuries treated in hospital emergency department. Bureau of Justice statistics special report 1997 U.S. Department of Justice Washington, DC 12295375
  5. Smith PH Earp JA DeVellis R Measuring battering: Development of the Women's Experience with Battering (WEB) scale Women's Health 1995 1 4 273 288 9373384
  6. Wuest J Merritt-Gray M Beyond survival: Reclaiming self after leaving an abusive male partner Canadian Journal of Nursing Research = Revue Canadienne De Recherche En Sciences Infirmieres 2001 32 4 79 94 11928303

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Authors
Humphreys, J., Epel, E. S., Cooper, B. A., Lin, J., Blackburn, E. H., & Lee, K. A.
Affiliations
University of California, San Francisco (US)
Corresponding author
Humphreys, Janice
Venue
Biological Research For Nursing
Published
2011-03-08
Volume
14
Issue
2
Pages
115-123
ISSN
  • 1099-8004 (ISSN-L)
  • 1552-4175
OpenAlex
W1980157348
Cited by
97
References
49
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 13 · 2013: 10 · 2012: 10
FWCI
7.42
Type
journal article
Language
en
Open access
Locations
  • Biological Research For Nursing (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Center for Research Resources (UL1RR024131)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Social Sciences › Health › Intimate Partner and Family Violence
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
telomere length, intimate partner violence, chronic psychological stress, cellular aging, women, leukocyte telomeres, having children, stress biomarkers
MeSH terms
Adolescent, Adult, Base Sequence, Female, Humans, Middle Aged, Biomarkers, Case-Control Studies, Polymerase Chain Reaction, Telomere, Domestic Violence, DNA Primers, Young Adult

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