Cited by 245Birth, Development, and HealthFatty Acid Research and HealthNutritional Studies and Diet

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Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet

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White, Christy L., Pistell, Paul J., Purpera, Megan N., Gupta, Sunita, Fernandez-Kim, Sun-Ok, Hise, Taylor L., Keller, Jeffrey N., Ingram, Donald K., Morrison, Christopher D., Bruce-Keller, Annadora J.·2009·Neurobiology of Disease

DOI 10.1016/j.nbd.2009.04.002PMC PMC2699188

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Abstract

This study was undertaken to investigate the effects of prenatal and postnatal exposure to high fat diet on the brain. Female rats were divided into high fat diet (HFD) and control diet (CD) groups 4 weeks prior to breeding and throughout gestation and lactation. After weaning, male progeny were placed on a chow diet until 8 weeks old, and then segregated into HFD or CD groups. At 20 weeks old, rats were evaluated in the Morris water maze, and markers of oxidative stress and inflammation were documented in the brain. In comparison to rats fed CD, cognitive decline in HFD progeny from HFD dams manifested as a decline in retention, but not acquisition, in the water maze. HFD was also associated with significant increases in 3-nitrotyrosine, inducible nitric oxide synthase, IL-6, and glial markers Iba-1 and GFAP, with the largest increases frequently observed in HFD animals born to HFD dams. Thus, these data collectively suggest that HFD increases oxidative and inflammatory signaling in the brain, and further indicate that maternal HFD consumption might sensitize offspring to the detrimental effects of HFD.

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Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Obesity
Haslam, D. W., & James, W. P. T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67483-1 · Cited by 3,757
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Free radical-mediated oxidation of free amino acids and amino acid residues in proteins
Stadtman, E. R., & Levine, R. L. (2003) · Amino Acids · doi:10.1007/s00726-003-0011-2 · Cited by 1,968
High‐fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents
Buettner, R., Schölmerich, J., & Bollheimer, L. C. (2007) · Obesity · doi:10.1038/oby.2007.608 · Cited by 1,284
Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents
Mei, Z., Grummer‐Strawn, L. M., Pietrobelli, A., Goulding, A., Goran, M. I., & Dietz, W. H. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.6.978 · Cited by 986
A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
Molteni, R., Barnard, R. J., Ying, Z., Roberts, C. K., & Gómez‐Pinilla, F. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00123-9 · Cited by 918
Oxidative damage in Alzheimer's
Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897
Oxidative Stress and Neurotoxicity
Sayre, L. M., Perry, G. L., & Smith, M. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700210j · Cited by 884
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.
Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7001 · Cited by 766

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Church, M. W., Jen, K. ‐. C., Anumba, J. I., Jackson, D. A., Adams, B. R., & Hotra, J. W. (2009) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.09.006 · Cited by 61
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Fusco, S., Spinelli, M., Cocco, S., Ripoli, C., Mastrodonato, A., Natale, F., Rinaudo, M., Livrizzi, G., & Grassi, C. (2019) · Nature Communications · doi:10.1038/s41467-019-12793-3 · Cited by 63
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Tomlinson, L., Leiton, C. V., & Colognato, H. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.016 · Cited by 65
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Texel, S. J., & Mattson, M. P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3569 · Cited by 58
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Alves, J. M., LUO, S. H., Chow, T., Herting, M. M., Xiang, A. H., & Page, K. A. (2020) · Brain and Behavior · doi:10.1002/brb3.1522 · Cited by 42
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Blaisdell, A. P., Lau, Y. L. M., Telminova, E., Lim, H. C., Fan, B., Fast, C. D., Garlick, D., & Pendergrass, D. C. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.025 · Cited by 39
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Carey, A. N., Gildawie, K. R., Rovnak, A., Thangthaeng, N., Fisher, D. R., & Shukitt‐Hale, B. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1376472 · Cited by 40
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Wolfrum, C., & Peleg‐Raibstein, D. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1432096 · Cited by 43

Authors: White, C. L., Pistell, P. J., Purpera, M. N., Gupta, S., Fernandez-Kim, S.-O., Hise, T. L., Keller, J. N., Ingram, D. K., Morrison, C. D., & Bruce-Keller, A. J.
Affiliations: Pennington Biomedical Research Center (US)
ORCID: Keller, Jeffrey N.
Ingram, Donald K.
Morrison, Christopher D.
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2009-07
Volume: 35
Issue: 1
Pages: 3-13
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2009.04.002
PMC: PMC2699188
OpenAlex: W2007371413
Cited by: 245
References: 99
Citations by year: 2026: 4 · 2025: 14 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 14 · 2020: 12 · 2019: 18 · 2018: 21 · 2017: 23 · 2016: 16 · 2015: 23 · 2014: 26 · 2013: 12 · 2012: 11
FWCI: 9.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Civil War Book Review (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health
National Institute on Aging (P01AG005119, AG0 5119)
National Institute on Drug Abuse (DA 19398, P01DA019398)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 07246, P30DK072476)
National Institute of Neurological Disorders and Stroke (NS-051570, NS46267, R01NS046267, R03NS051570)
National Center for Research Resources (RR 021945, P20RR021945)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: high-fat diet, maternal diet, prenatal exposure, postnatal exposure, cognitive decline, spatial learning and memory, oxidative stress, neuroinflammation, nitrotyrosine, inducible nitric oxide synthase, interleukin-6, glial activation, glial fibrillary acidic protein, Iba1, brain
MeSH terms: Analysis of Variance, Animals, Animals, Newborn, Body Composition, Body Weight, Brain, Calcium-Binding Proteins, Dietary Fats, Disease Models, Animal, Embryo, Mammalian, Enzyme-Linked Immunosorbent Assay, Female, Glial Fibrillary Acidic Protein, Inflammation, Lactation, Male, Microfilament Proteins, Nerve Tissue Proteins, Pregnancy, Prenatal Exposure Delayed Effects, Cytokines, Oxidative Stress, Gene Expression Regulation, Developmental, Maze Learning, Rats, Long-Evans, Prenatal Nutritional Physiological Phenomena, Rats, Nitric Oxide Synthase Type II

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Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet

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