Cited by 245Birth, Development, and HealthFatty Acid Research and HealthNutritional Studies and Diet

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet

Open access

White, Christy L., Pistell, Paul J., Purpera, Megan N., Gupta, Sunita, Fernandez-Kim, Sun-Ok, Hise, Taylor L., Keller, Jeffrey N., Ingram, Donald K., Morrison, Christopher D., Bruce-Keller, Annadora J.·2009·Neurobiology of Disease

DOI 10.1016/j.nbd.2009.04.002PMC PMC2699188

Open this paper in CoChat — free account

Abstract

This study was undertaken to investigate the effects of prenatal and postnatal exposure to high fat diet on the brain. Female rats were divided into high fat diet (HFD) and control diet (CD) groups 4 weeks prior to breeding and throughout gestation and lactation. After weaning, male progeny were placed on a chow diet until 8 weeks old, and then segregated into HFD or CD groups. At 20 weeks old, rats were evaluated in the Morris water maze, and markers of oxidative stress and inflammation were documented in the brain. In comparison to rats fed CD, cognitive decline in HFD progeny from HFD dams manifested as a decline in retention, but not acquisition, in the water maze. HFD was also associated with significant increases in 3-nitrotyrosine, inducible nitric oxide synthase, IL-6, and glial markers Iba-1 and GFAP, with the largest increases frequently observed in HFD animals born to HFD dams. Thus, these data collectively suggest that HFD increases oxidative and inflammatory signaling in the brain, and further indicate that maternal HFD consumption might sensitize offspring to the detrimental effects of HFD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.nbd.2009.04.002

Cites

101 of 101 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Obesity
Haslam, D. W., & James, W. P. T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67483-1 · Cited by 3,757
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Free radical-mediated oxidation of free amino acids and amino acid residues in proteins
Stadtman, E. R., & Levine, R. L. (2003) · Amino Acids · doi:10.1007/s00726-003-0011-2 · Cited by 1,968
High‐fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents
Buettner, R., Schölmerich, J., & Bollheimer, L. C. (2007) · Obesity · doi:10.1038/oby.2007.608 · Cited by 1,284
Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents
Mei, Z., Grummer‐Strawn, L. M., Pietrobelli, A., Goulding, A., Goran, M. I., & Dietz, W. H. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.6.978 · Cited by 986
A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
Molteni, R., Barnard, R. J., Ying, Z., Roberts, C. K., & Gómez‐Pinilla, F. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00123-9 · Cited by 918
Oxidative damage in Alzheimer's
Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897
Oxidative Stress and Neurotoxicity
Sayre, L. M., Perry, G. L., & Smith, M. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700210j · Cited by 884
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.
Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7001 · Cited by 766
Diet‐induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle‐aged rats
Stranahan, A. M., Norman, E. D., Lee, K. M., Cutler, R. G., Telljohann, R. S., Egan, J. M., & Mattson, M. P. (2008) · Hippocampus · doi:10.1002/hipo.20470 · Cited by 765
Adipocytokines and the Metabolic Complications of Obesity
Rasouli, N., & Kern, P. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1613 · Cited by 751
Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta
Challier, J. C., Basu, S., Bintein, T., Minium, J., Hotmire, K., Catalano, P. M., & Hauguel-de Mouzon, S. (2008) · Placenta · doi:10.1016/j.placenta.2007.12.010 · Cited by 712 · cited 2×
“For example, IL-6 and placental inflammatory mediators are elevated with maternal obesity (Challier et al., 2008), (Ramsay et al., 2002), and maternal IL-6 levels are predictive of obesity in the neonatal offspring (Dahlgren et al., 2001).”
Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study
Elias, M. F., Elias, P. K., SULLIVAN, L. M., Wolf, P. A., & D’Agostino, R. B. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.802225 · Cited by 691
Effect of body mass index on pregnancy outcomes in nulliparous women delivering singleton babies
Bhattacharya, S., Campbell, D. M., Liston, W. A., & Bhattacharya, S. (2007) · BMC Public Health · doi:10.1186/1471-2458-7-168 · Cited by 688
Elevated body mass index is associated with executive dysfunction in otherwise healthy adults
Gunstad, J., Paul, R. H., Cohen, R. A., Tate, D. F., Spitznagel, M. B., & Gordon, E. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2006.05.001 · Cited by 668
Maternal Obesity Is Associated with Dysregulation of Metabolic, Vascular, and Inflammatory Pathways
Ramsay, J. E., Ferrell, W. R., Crawford, L., Wallace, A. M., Greer, I. A., & Sattar, N. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020311 · Cited by 659
Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637
Programming by Early Nutrition: An Experimental Approach
Lucas, A. (1998) · Journal of Nutrition · doi:10.1093/jn/128.2.401s · Cited by 616
Evidence of increased oxidative damage in subjects with mild cognitive impairment
Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., & Markesbery, W. R. (2005) · Neurology · doi:10.1212/01.wnl.0000156156.13641.ba · Cited by 539
Self-citation
Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer’s disease
Lester-Coll, N., Rivera, E. J., Soscia, S. J., Doiron, K., Wands, J. R., & de la Monte, S. M. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9102 · Cited by 467
Oxidative Stress and the Pathogenesis of Neurodegenerative Disorders
Reynolds, A., Laurie, C. D., Mosley, R. L., & Gendelman, H. E. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82016-2 · Cited by 441
Intrauterine programming of adult disease
Barker, D. J. P. (1995) · Molecular Medicine Today · doi:10.1016/s1357-4310(95)90793-9 · Cited by 430
A maternal ‘junk food’ diet in pregnancy and lactation promotes an exacerbated taste for ‘junk food’ and a greater propensity for obesity in rat offspring
Bayol, S. A., Farrington, S. J., & Stickland, N. C. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507812037 · Cited by 417
Mechanisms of Liver and Muscle Insulin Resistance Induced by Chronic High-Fat Feeding
Oakes, N. D., Cooney, G. J., Camilleri, S., Chisholm, D. J., & Kraegen, E. W. (1997) · Diabetes · doi:10.2337/diab.46.11.1768 · Cited by 414
The interplay between oxidative stress and brain‐derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition
Wu, A., Ying, Z., & Gómez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03246.x · Cited by 410
Obesity, diabetes and cognitive deficit: The Framingham Heart Study
Elias, M. F., Elias, P. K., Sullivan, L. M., Wolf, P. A., & D’Agostino, R. B. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.019 · Cited by 395
Maternal obesity at conception programs obesity in the offspring
Shankar, K., Harrell, A., Liu, X., Gilchrist, J. M., Ronis, M. J. J., & Badger, T. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00316.2007 · Cited by 385
Obesity and Hypertriglyceridemia Produce Cognitive Impairment
Farr, S. A., Yamada, K. A., Butterfield, D. A., Abdul, H. M., Xu, L., Miller, N. E., Banks, W. A., & Morley, J. E. (2008) · Endocrinology · doi:10.1210/en.2007-1722 · Cited by 382 · cited 2×
“…2006), results from animal studies have been mixed, with some reports describing significant effects of HFDinduced obesity on performance in the Morris maze (Farr et al., 2008) and others failing to detect effects of HFD on spatial learning in this task (Mielke et al., 2006), (Jurdak et al., 2008).”
High‐fat diet impairs hippocampal neurogenesis in male rats
Lindqvist, A., Mohapel, P., Bouter, B., Frielingsdorf, H., Pizzo, D. P., Brundin, P., & Erlanson‐Albertsson, C. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01500.x · Cited by 379
Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity
Chang, G., Gaysinskaya, V. A., Karatayev, O., & LEIBOWITZ, S. F. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2642-08.2008 · Cited by 374
Reactive Nitrogen Species: Molecular Mechanisms and Potential Significance in Health and Disease
Martínez, M. C., & Andriantsitohaina, R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1993 · Cited by 345
High-fat diets, insulin resistance and declining cognitive function
Greenwood, C. E., & Winocur, G. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.017 · Cited by 339
The effect of the increasing prevalence of maternal obesity on perinatal morbidity
Lu, G., Rouse, D. J., DuBard, M. B., Cliver, S., Kimberlin, D. F., & Hauth, J. C. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.117351 · Cited by 332
Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer's disease
de la Monte, S. M., Tong, M., Lester-Coll, N. H., Plater, M. E., & Wands, J. R. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10113 · Cited by 329
Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome X-like alterations in adulthood of neonatally overfed rats
Plagemann, A., Harder, T., Rake, A., Voits, M., Fink, H., Rohde, W., & Dörner, G. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01662-5 · Cited by 327
Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury
Ansari, M. A., Roberts, K. N., & Scheff, S. W. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.038 · Cited by 327
High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex
ZHANG, X., Dong, F., Ren, J. T., Driscoll, M., & Culver, B. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.10.011 · Cited by 290
Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms
Mattson, M. P., Duan, W., & Guo, Z. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01586.x · Cited by 289
Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats
Oomura, Y., Hori, N., Shiraishi, T., Fukunaga, K., Takeda, H., Tsuji, M., Matsumiya, T., Ishibashi, M., Aou, S., Li, X. L., et al. (2006) · Peptides · doi:10.1016/j.peptides.2006.07.001 · Cited by 286
Maternal and Postnatal Overnutrition Differentially Impact Appetite Regulators and Fuel Metabolism
Chen, H., Simar, D., Lambert, K., Mercier, J. G., & Morris, M. J. (2008) · Endocrinology · doi:10.1210/en.2008-0582 · Cited by 272
Actin-binding Proteins Coronin-1a and IBA-1 are Effective Microglial Markers for Immunohistochemistry
Ahmed, Z., Shaw, G., Sharma, V. P., Yang, C., McGowan, E., & Dickson, D. W. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6a7156.2007 · Cited by 258
Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity
O'Callaghan, J. P., & Sriram, K. (2005) · Expert Opinion on Drug Safety · doi:10.1517/14740338.4.3.433 · Cited by 255
Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood
Srinivasan, M., Katewa, S. D., Palaniyappan, A., Pandya, J. D., & Patel, M. S. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00078.2006 · Cited by 254
High-fat feeding during pregnancy and lactation affects offspring metabolism in rats
Guo, F., & Jen, K. ‐. C. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00342-4 · Cited by 250
Studies of the effects of high fat diets on cognitive function in a rat model
Winocur, G., & Greenwood, C. E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.003 · Cited by 250
Involvement of inflammatory cytokines in central nervous system injury
Wang, C. X., & Shuaib, A. M. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00010-2 · Cited by 247
Predictive Adaptive Responses to Maternal High-Fat Diet Prevent Endothelial Dysfunction but Not Hypertension in Adult Rat Offspring
Khan, I. Y., Dekou, V., Hanson, M. A., Poston, L., & Taylor, P. D. (2004) · Circulation · doi:10.1161/01.cir.0000139843.05436.a0 · Cited by 242
Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges
Kamat, C. D., Gadal, S., Mhatre, M., Williamson, K. S., Pye, Q. N., & Hensley, K. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15314 · Cited by 238
Leptin signaling in brain: A link between nutrition and cognition?
Morrison, C. D. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.12.004 · Cited by 229
Self-citation
Cognitive Outcomes of Preschool Children With Prenatal Cocaine Exposure
Singer, L. T. (2004) · JAMA · doi:10.1001/jama.291.20.2448 · Cited by 226
Rodent obesity models: An overview
Tschöp, M. H., & Heiman, M. L. (2001) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2001-17297 · Cited by 220
Maternal obesity is necessary for programming effect of high-fat diet on offspring
White, C. L., Purpera, M. N., & Morrison, C. D. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.91015.2008 · Cited by 206
Self-citation
Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease
Zecca, L., Wilms, H., Geick, S., Claasen, J.-H., Brandenburg, L.-O., Holzknecht, C., Panizza, M. L., Zucca, F. A., Deuschl, G., Sievers, J., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0361-7 · Cited by 205
Insulin, leptin, and food reward: update 2008
Figlewicz, D. P., & Benoit, S. C. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90725.2008 · Cited by 205
Interactive relations of central versus total obesity and blood pressure to cognitive function
Waldstein, S. R., & Katzel, L. I. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803114 · Cited by 200
Obesity and vulnerability of the CNS
Bruce-Keller, A. J., Keller, J. N., & Morrison, C. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.004 · Cited by 200 · cited 1×
“Indeed, epidemiological and experimental data have established that the brain is sensitive to obesity and obesity-induced metabolic dysfunction (reviewed in Bruce-Keller et al., 2008).”
Self-citation
Vascular Lipotoxicity: Endothelial Dysfunction via Fatty-Acid-Induced Reactive Oxygen Species Overproduction in Obese Zucker Diabetic Fatty Rats
Chinen, I., Shimabukuro, M., Yamakawa, K., Higa, N., Matsuzaki, T., Noguchi, K., Ueda, S., Sakanashi, M., & Takasu, N. (2006) · Endocrinology · doi:10.1210/en.2006-1132 · Cited by 195
Body mass index and magnetic resonance markers of brain integrity in adults
Gazdzinski, S., Kornak, J., Weiner, M. W., & Meyerhoff, D. J. (2008) · Annals of Neurology · doi:10.1002/ana.21377 · Cited by 191
Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo
Wayner, M. J., Armstrong, D. L., Phelix, C. F., & Oomura, Y. (2004) · Peptides · doi:10.1016/j.peptides.2004.03.018 · Cited by 190
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells
Greco, S. J., Sarkar, S., Johnston, J. M., & Tezapsidis, N. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.041 · Cited by 190
Altered body composition and metabolism in the male offspring of high fat–fed rats
Buckley, A., Keserü, B., BRIODY, J. N., Thompson, M., Ozanne, S. E., & Thompson, C. H. (2005) · Metabolism · doi:10.1016/j.metabol.2004.11.003 · Cited by 186
Diet‐induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring
Tozuka, Y., Wada, E., & Wada, K. (2009) · The FASEB Journal · doi:10.1096/fj.08-124784 · Cited by 182
A Time Course of Contusion-Induced Oxidative Stress and Synaptic Proteins in Cortex in a Rat Model of TBI
Ansari, M. A., Roberts, K. N., & Scheff, S. W. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0451 · Cited by 181
Gestational obesity accentuates obesity in obesity-prone progeny
Levin, B. E., & Govek, E. K. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.4.r1374 · Cited by 179
Prenatal cytokine exposure results in obesity and gender-specific programming
Dahlgren, J., Nilsson, C., Jennische, E., Ho, H.-P., Eriksson, E., Niklasson, A., Björntorp, P., Wikland, K. A., & Holmäng, A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e326 · Cited by 172
Highly palatable diet consumption increases protein oxidation in rat frontal cortex and anxiety-like behavior
de Souza, C. G., Moreira, J. D., Siqueira, I. R., Pereira, A. G., Rieger, D. K., Souza, D. O., Souza, T. M. E., Portela, L. V., & Perry, M. L. S. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.05.001 · Cited by 168
Prenatal Exposure to Maternal Cigarette Smoking and the Adolescent Cerebral Cortex
Toro, R., Leonard, G. T., Lerner, J. V., Lerner, R. M., Perron, M., Pike, G. B., Richer, L., Veillette, S., Pausová, Z., & Paus, T. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301484 · Cited by 168
Leptin: a potential cognitive enhancer?
Harvey, J., Shanley, L. J., O'Malley, D., & Irving, A. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331029 · Cited by 162
Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials
Signore, A. P., Zhang, F., Weng, Z., Gao, Y., & Chen, J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05457.x · Cited by 157
Inflammatory Mediators and Neonatal Brain Damage
Saliba, É., & Henrot, A. (2001) · Neonatology · doi:10.1159/000047096 · Cited by 156
Diet-induced obesity and spatial cognition in young male rats
Jurdak, N. A., Lichtenstein, A. H., & Kanarek, R. B. (2008) · Nutritional Neuroscience · doi:10.1179/147683008x301333 · Cited by 153
Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: Common links and potential therapeutic targets
Mhatre, M., Floyd, R. A., & Hensley, K. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6206 · Cited by 148
Adipokines in Obesity
Ahima, R. S., & Osei, S. Y. (2008) · Frontiers of hormone research · doi:10.1159/000115365 · Cited by 136
Pro‐inflammatory and pro‐oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17β‐estradiol
Bruce‐Keller, A. J., Barger, S. W., Moss, N. I., Pham, J. T., Keller, J. N., & Nath, A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00511.x · Cited by 121
Self-citation
Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
Oakes, N. D., Cooney, G. J., Camilleri, S., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.11.1768 · Cited by 118
Roscovitine Reduces Neuronal Loss, Glial Activation, and Neurologic Deficits after Brain Trauma
Hilton, G. D., Stoica, B. A., Byrnes, K. R., & Faden, A. I. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.75 · Cited by 108
Effect of neonatal handling and paternal care on offspring cognitive development in the monogamous California mouse (Peromyscus californicus)
Bredy, T. W., Lee, A. W., Meaney, M. J., & Brown, R. E. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2003.09.017 · Cited by 108
Age-related changes in the spinal cord microglial and astrocytic response profile to nerve injury
Vega‐Avelaira, D., Moss, A., & Fitzgerald, M. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.10.007 · Cited by 100
Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity
Choi, J., Jang, E.-H., Park, C., & Kang, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.008 · Cited by 98
Longitudinal study of the effects of a high-fat diet on glucose regulation, hippocampal function, and cerebral insulin sensitivity in C57BL/6 mice
Mielke, J. G., Nicolitch, K., Avellaneda, V., Earlam, K., Ahuja, T. K., Mealing, G. A. R., & Messier, C. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.010 · Cited by 97
Moderate Prenatal Alcohol Exposure and Cognitive Status of Children at Age 10
Willford, J. A., Leech, S. L., & Day, N. L. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00119.x · Cited by 92
An Integrated and Unifying Hypothesis for the Metabolic Basis of Sporadic Alzheimer's Disease
Erol, A. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13302 · Cited by 89
Age-related neurodegeneration and oxidative stress: putative nutritional intervention.
Joseph, J., Denisova, N., Fisher, D., Shukitt-Hale, B., Bickford, P., Prior, R., & Cao, G. (1998) · Neurologic clinics · doi:10.1016/s0733-8619(05)70092-x · Cited by 85
Roles of leptin in prenatal and perinatal brain development
Udagawa, J., Hatta, T., Hashimoto, R., & Otani, H. (2007) · Congenital Anomalies · doi:10.1111/j.1741-4520.2007.00150.x · Cited by 81
Brain myelin of genetically obese mice
Sena, A., Sarliève, L. L., & Rebel, G. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90104-2 · Cited by 79
Obesity exacerbates chemically induced neurodegeneration
Sriram, K., Benkovic, S. A., Miller, D. B., & O’Callaghan, J. P. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00306-8 · Cited by 78
Pregnancy and lactation in the obese rat: Effects on maternal and pup weights
Rolls, B. J., & Rowe, E. A. (1982) · Physiology & Behavior · doi:10.1016/0031-9384(82)90130-5 · Cited by 71
A Metabolic Basis for Alzheimer Disease
Perry, G. L., Nunomura, A., Raina, A. K., Aliev, G., Siedlak, S. L., Harris, P. L. R., Casadesús, G., Petersen, R. B., Bligh-Glover, W. Z., Balraj, E. K., et al. (2003) · Neurochemical Research · doi:10.1023/a:1025678510480 · Cited by 55
Leptin resistance and the response to positive energy balance
Morrison, C. D. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.009 · Cited by 51
Self-citation
Cognitive Outcomes of Preschool Children With Prenatal Cocaine Exposure
Singer, L. T., Minnes, S., Short, E. J., Arendt, R. E., Farkas, K. J., Lewis, B. A., Klein, N., Russ, S. W., Min, M. O., & Kirchner, H. L. (2004) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000143512.57021.70 · Cited by 49
Maternal obesity is a major risk factor for large-for-gestational-infants in pregnancies complicated by gestational diabetes
Ben‐Haroush, A., Hadar, E., Chen, R., Hod, M., & Yogev, Y. (2008) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-008-0767-4 · Cited by 44
What Can Imaging Reveal about Obesity and the Brain?
Jagust, W. J. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362146 · Cited by 43
Hypothalamic orexigenic peptides are overexpressed in young Long–Evans rats after early life exposure to fat-rich diets
Beck, B., Kozak, R., Moar, K. M., & Mercer, J. G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.158 · Cited by 41
The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats
Janas, A. M., Cunningham, S. C., Duffy, K. B., Devan, B. D., Greig, N. H., Holloway, H. W., Yu, Q.-S., Markowska, A. L., Ingram, D. K., & Spangler, E. L. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.06.028 · Cited by 38
Self-citation
Anticonvulsant effects of leptin in epilepsy
Diano, S., & Horváth, T. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci34511 · Cited by 32
Maternal Obesity and Risk of Infant Death Based on Florida Birth Records for 2004
Thompson, D. R., Clark, C. L., Wood, B., & Zeni, M. B. (2008) · Public Health Reports · doi:10.1177/003335490812300410 · Cited by 26
Effects of maternal weight variations and gestational diabetes mellitus on neonatal birth weight
Pezzarossa, A., Orlandi, N., Baggi, V., Dazzi, D., Ricciarelli, E., & Coppola, F. (1996) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(94)00065-4 · Cited by 21
Hypothalamic agouti-related protein immunoreactivity in food-restricted, obese, and insulin-treated animals: evidence for glia cell localization
Dunbar, J. C., Lapanowski, K., Barnes, M. J., & Rafols, J. A. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.09.002 · Cited by 14
Differential Immunoreactivity of Microglial and Astrocytic Marker Protein in the Hippocampus of the Seizure Resistant and Sensitive Gerbils
Lee, C. H., Hwang, I. K., Lee, I. S., Yoo, K., Choi, J. H., Lee, B., & Won, M. (2008) · Journal of Veterinary Medical Science · doi:10.1292/jvms.70.1405 · Cited by 10
Untitled work
Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4

Flagged first, then by citations

Research works printed but not linked: 1

Haslam, 2005, Obesity Lancet Neurol., 366, 1197

Sorted by citations

Obesity and neuroinflammation: A pathway to cognitive impairment
Miller, A. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 834
Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
Kanoski, S. E., & Davidson, T. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.003 · Cited by 710
Cognitive impairment following high fat diet consumption is associated with brain inflammation
Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce‐Keller, A. J. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.010 · Cited by 623
Self-citation
Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
Bilbo, S. D., & Tsang, V. (2010) · The FASEB Journal · doi:10.1096/fj.09-144014 · Cited by 489
Energy intake and exercise as determinants of brain health and vulnerability to injury and disease
Mattson, M. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.012 · Cited by 434

See all 245

Authors: White, C. L., Pistell, P. J., Purpera, M. N., Gupta, S., Fernandez-Kim, S.-O., Hise, T. L., Keller, J. N., Ingram, D. K., Morrison, C. D., & Bruce-Keller, A. J.
Affiliations: Pennington Biomedical Research Center (US)
ORCID: Keller, Jeffrey N.
Ingram, Donald K.
Morrison, Christopher D.
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2009-07
Volume: 35
Issue: 1
Pages: 3-13
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2009.04.002
PMC: PMC2699188
OpenAlex: W2007371413
Cited by: 245
References: 99
Citations by year: 2026: 4 · 2025: 14 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 14 · 2020: 12 · 2019: 18 · 2018: 21 · 2017: 23 · 2016: 16 · 2015: 23 · 2014: 26 · 2013: 12 · 2012: 11
FWCI: 9.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Civil War Book Review (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health
National Institute on Aging (P01AG005119, AG0 5119)
National Institute on Drug Abuse (DA 19398, P01DA019398)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 07246, P30DK072476)
National Institute of Neurological Disorders and Stroke (NS-051570, NS46267, R01NS046267, R03NS051570)
National Center for Research Resources (RR 021945, P20RR021945)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: high-fat diet, maternal diet, prenatal exposure, postnatal exposure, cognitive decline, spatial learning and memory, oxidative stress, neuroinflammation, nitrotyrosine, inducible nitric oxide synthase, interleukin-6, glial activation, glial fibrillary acidic protein, Iba1, brain
MeSH terms: Analysis of Variance, Animals, Animals, Newborn, Body Composition, Body Weight, Brain, Calcium-Binding Proteins, Dietary Fats, Disease Models, Animal, Embryo, Mammalian, Enzyme-Linked Immunosorbent Assay, Female, Glial Fibrillary Acidic Protein, Inflammation, Lactation, Male, Microfilament Proteins, Nerve Tissue Proteins, Pregnancy, Prenatal Exposure Delayed Effects, Cytokines, Oxidative Stress, Gene Expression Regulation, Developmental, Maze Learning, Rats, Long-Evans, Prenatal Nutritional Physiological Phenomena, Rats, Nitric Oxide Synthase Type II

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks