Cited by 103Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD

Leo, Damiana, Sorrentino, Eleonora, Volpicelli, Floriana, Eyman, Maria, Greco, Dario, Viggiano, Davide, di Porzio, Umberto, Perrone-Capano, Carla·2003·Neuroscience & Biobehavioral Reviews

Abstract

To understand the onset and the molecular mechanisms triggering dopaminergic (DA) dysregulation in Attention-Deficit Hyperactivity Disorder (ADHD), we have used the Spontaneously Hypertensive Rats (SHR), the most widely studied animal model for this disease. We have studied the pattern of expression of specific genes involved in DA neuron differentiation, survival and function during postnatal (P) development of the ventral midbrain in SHR males. Our results show that tyrosine hydroxylase and DA transporter gene expression are significantly and transiently reduced in the SHR midbrain during the first month of postnatal development, although with a different kinetic. The other genes analyzed do not show significant variation between SHR and control rats. In addition, high-affinity DA uptake activity is significantly reduced in synaptosomes obtained from the striatum of 1-month-old SHR, when compared to controls. Our data suggest that down-regulation of DA neurotransmission occurs in the midbrain of SHR in a developmentally regulated temporal window during postnatal development, thus strengthening the hypodopaminergic hypothesis in the pathogenesis of ADHD.

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Crossref · 10.1016/j.neubiorev.2003.08.009

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  • DAT gene expression is transiently reduced in the SHR midbrain during the first month after birth, and increased in adult SHR compared with controls, resulting in abnormal mesostriatal DA transmission during postnatal development and possibly adulthood.

    “DAT gene expression is transiently reduced in the SHR midbrain during the first month after birth, and increased in adult SHR compared with controls [457], which results in abnormal mesostriatal DA transmission in the rats during postnatal development, and possibly in adulthood [458].”

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Authors
Leo, D., Sorrentino, E., Volpicelli, F., Eyman, M., Greco, D., Viggiano, D., di Porzio, U., & Perrone-Capano, C.
Affiliations
  • Institute of Genetics and Biophysics (IT)
  • University of Naples Federico II (IT)
  • University of Campania "Luigi Vanvitelli" (IT)
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2003-11
Volume
27
Issue
7
Pages
661-669
ISSN
0149-7634 (ISSN-L)
OpenAlex
W1971910459
Cited by
103
References
63
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 8
FWCI
3.06
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
attention deficit hyperactivity disorder, midbrain dopaminergic neurons, spontaneously hypertensive rats, animal model of ADHD, postnatal development, tyrosine hydroxylase, dopamine transporter, dopamine signaling, gene expression
MeSH terms
Animals, Attention Deficit Disorder with Hyperactivity, Brain Chemistry, Cell Differentiation, Disease Models, Animal, Dopamine, Male, Mesencephalon, Synaptic Transmission, Neurons, Rats, Inbred SHR, Rats, Inbred WKY, Down-Regulation, Gene Expression Regulation, Developmental, Rats

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