Psychophysiological activity and reactivity in children and adolescents with conduct problems: a systematic review and meta-analysis

Fanti, Kostas A.; Eisenbarth, Hedwig; Goble, Poppy; Demetriou, Chara; Kyranides, Melina Nicole; Goodwin, Daniel; Zhang, Junhua; Bobak, Billy; Cortese, Samuele

doi:10.1016/j.neubiorev.2019.02.016

Cited by 69Heart Rate Variability and Autonomic ControlChild and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual Offending

Psychophysiological activity and reactivity in children and adolescents with conduct problems: a systematic review and meta-analysis

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Fanti, Kostas A., Eisenbarth, Hedwig, Goble, Poppy, Demetriou, Chara, Kyranides, Melina Nicole, Goodwin, Daniel, Zhang, Junhua, Bobak, Billy +1 more·2019·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2019.02.016

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Abstract

The aim of this study was to conduct a systematic review of the literature and meta-analysis to estimate the association between psychophysiological activity and reactivity at baseline or after a psychological task with conduct problems (CP) among children and adolescents. We systematically reviewed published studies reporting autonomic nervous system activity in youth with CP and meta-analyzed the relationship between CP and autonomic baseline as well as task-related reactivity in 66 studies (N = 10,227). Across 34 included case-control studies that were based on CP cut-off scores, we found a significant pooled effect for task related Skin-Conductance, Respiratory Sinus Arrhythmia, and cardiac Pre-Ejection Period, but no significant group differences for Heart Rate nor for any baseline measures. Findings suggested reduced parasympathetic and sympathetic reactivity to emotional tasks, pointing to co-inhibition of the two systems. However, across 32 studies with correlational design we only found a significant negative correlation of baseline and task-related heart rate with CP. The present meta-analysis derived several conclusions that have the potential to inform biological vulnerability models and biologically driven interventions.

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Authors: Fanti, K. A., Eisenbarth, H., Goble, P., Demetriou, C., Kyranides, M. N., Goodwin, D., Zhang, J., Bobak, B., & Cortese, S.
Affiliations: University of Cyprus (CY)
Victoria University of Wellington (NZ)
University of Edinburgh (GB)
University of Southampton (GB)
Yancheng Teachers University (CN)
University of Nottingham (GB)
Corresponding author: Fanti, Kostas A.
ORCID: Fanti, Kostas A.
Eisenbarth, Hedwig
Demetriou, Chara
Kyranides, Melina Nicole
Goodwin, Daniel
Zhang, Junhua
Cortese, Samuele
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2019-05
Volume: 100
Pages: 98-107
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2019.02.016
OpenAlex: W2915715684
Cited by: 69
References: 104
Citations by year: 2026: 9 · 2025: 6 · 2024: 13 · 2023: 15 · 2022: 11 · 2021: 8 · 2020: 5 · 2019: 2
FWCI: 1.16
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (acceptedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: conduct problems, psychophysiological reactivity, autonomic nervous system, skin conductance, respiratory sinus arrhythmia, pre-ejection period, heart rate, children and adolescents, biological vulnerability
MeSH terms: Adolescent, Arousal, Autonomic Nervous System, Child, Galvanic Skin Response, Heart Rate, Humans, Neuropsychological Tests, Psychophysiology, Stress, Psychological, Conduct Disorder

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Psychophysiological activity and reactivity in children and adolescents with conduct problems: a systematic review and meta-analysis

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