Cited by 17Fatty Acid Research and HealthLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

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The lipid paradox in neuroprogressive disorders: Causes and consequences

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Morris, Gerwyn, Berk, Michael, Walder, Ken, O’Neil, Adrienne, Maes, Michael, Puri, Basant K.·2021·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2021.06.017

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Abstract

Chronic systemic inflammation is associated with an increased risk of cardiovascular disease in an environment of low low-density lipoprotein (LDL) and low total cholesterol and with the pathophysiology of neuroprogressive disorders. The causes and consequences of this lipid paradox are explored. Circulating activated neutrophils can release inflammatory molecules such as myeloperoxidase and the pro-inflammatory cytokines interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha. Since activated neutrophils are associated with atherosclerosis and cardiovascular disease and with major depressive disorder, bipolar disorder and schizophrenia, it seems reasonable to hypothesise that the inflammatory molecules released by them may act as mediators of the link between systemic inflammation and the development of atherosclerosis in neuroprogressive disorders. This hypothesis is tested by considering the association at a molecular level of systemic inflammation with increased LDL oxidation; increased small dense LDL levels; increased lipoprotein (a) concentration; secretory phospholipase A 2 activation; cytosolic phospholipase A 2 activation; increased platelet activation; decreased apolipoprotein A1 levels and function; decreased paroxonase-1 activity; hyperhomocysteinaemia; and metabolic endotoxaemia. These molecular mechanisms suggest potential therapeutic targets.

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Döring, 2015, Neutrophils in atherosclerosis, Arterioscler. Thromb. Vasc. Biol., 35, 288, 10.1161/ATVBAHA.114.303564 · DOI
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Authors: Morris, G., Berk, M., Walder, K., O’Neil, A., Maes, M., & Puri, B. K.
Affiliations: Barwon Health (AU)
ORCID: Morris, Gerwyn
Berk, Michael
Walder, Ken
Maes, Michael
Puri, Basant K.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2021-09
Volume: 128
Pages: 35-57
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2021.06.017
OpenAlex: W3170312532
Cited by: 17
References: 563
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 2
FWCI: 0.40
Type: journal article
Language: en
Open access: green
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Licence: cc-by
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www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Deakin Research Online (Deakin University) (submittedVersion)
Figshare (submittedVersion, cc-by)
Funders: National Health and Medical Research Council (1059660)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: lipid paradox, neurodegenerative diseases, platelet activation, apolipoprotein A-I, hyperhomocysteinemia, endotoxemia, lipid metabolism, therapeutic target
MeSH terms: Humans, Inflammation, Lipids, Lipoproteins, LDL, Peroxidase, Neutrophils, Cytokines, Neurodegenerative Diseases, Atherosclerosis, Phospholipases A2

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The lipid paradox in neuroprogressive disorders: Causes and consequences

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