Cited by 46Probiotics and Fermented FoodsExercise and Physiological ResponsesMuscle metabolism and nutrition

Effects of Lactobacillus gasseri OLL2809 and α-lactalbumin on university-student athletes: a randomized, double-blind, placebo-controlled clinical trial

Sashihara, Toshihiro, Nagata, Masashi, Mori, Takeshi, Ikegami, Shuji, Gotoh, Minoru, Okubo, Kimihiro, Uchida, Masayuki, Itoh, Hiroyuki·2013·Applied Physiology, Nutrition, and Metabolism

Abstract

Strenuous exercise reduces immune cell function and increases the risk of respiratory and gastrointestinal infections. In addition, it affects mood state and causes physical fatigue. Athletes require both mental and physical conditioning to execute good performance. In this study, we conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the immunopotentiation and fatigue-alleviation effects of Lactobacillus gasseri OLL2809 (LG2809) and α-lactalbumin (αLA) in university-student athletes after strenuous exercise. A total of 44 university students who performed strenuous exercise daily were separated into 3 groups to receive a 4-week course of placebo, 100 mg LG2809, or 100 mg LG2809 in combination with 900 mg αLA, respectively. Before and after each dietary treatment, the subjects performed strenuous cycle ergometer exercise for 1 h. Before and after each exercise session, blood samples and visual analogue scale scores for fatigue were obtained. In addition, the mood of each subject before and after the dietary treatment was evaluated using the Profile of Mood States (POMS) questionnaire. LG2809 ingestion was effective in preventing reduced natural killer cell activity due to strenuous exercise and elevating mood from a depressed state. In addition, LG2809 + αLA was found to alleviate minor resting fatigue, which was supported objectively by the significant reduction in the serum reactive oxygen metabolites and transforming growth factor β1 levels. These effects could be helpful for athletes to maintain mental and physical condition.

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Registry

Crossref · 10.1139/apnm-2012-0490

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  • Four weeks of supplementation with Lactobacillus gasseri OLL2809 and alpha-lactalbumin in 44 university-student athletes did not improve cycle ergometer performance.

    “Four weeks of supplementation with Lactobacillus gasseri OLL2809 and alpha-lactalbumin in 44 university-student athletes did not improve cycle ergometer performance [67].”
  • The single strain interventions used in five studies did not produce an aerobic performance benefit.

    “The single strain interventions used in these five studies did not produce an aerobic performance benefit.”
  • L. gasseri OLL2809 supplementation for 4 weeks prevented reduced NK cell activity after strenuous exercise in 44 university-student athletes.

    “The probiotic supplementation prevented reduced NK cell activity after strenuous exercise which may enhance resistance against infections.”

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Authors
Sashihara, T., Nagata, M., Mori, T., Ikegami, S., Gotoh, M., Okubo, K., Uchida, M., & Itoh, H.
Affiliations
  • Meiji (Japan) (JP)
  • Nippon Medical School Hospital (JP)
Venue
Applied Physiology, Nutrition, and Metabolism
Published
2013-12
Volume
38
Issue
12
Pages
1228-1235
ISSN
  • 1715-5312 (ISSN-L)
  • 1715-5320
OpenAlex
W2014515358
Cited by
46
References
61
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 2
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Locations
  • Applied Physiology, Nutrition, and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
alpha-lactalbumin, strenuous exercise, athletes, fatigue, mood, natural killer cells, immune function, reactive oxygen species, TGF-β1, probiotics, dietary supplementation, exercise-induced immunosuppression
MeSH terms
Double-Blind Method, Humans, Lactalbumin, Lactobacillus, Students, Universities, Exercise, Athletes

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